{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:20:19Z","timestamp":1784751619880,"version":"3.55.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004001","name":"Guizhou Province Science and Technology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82560832"],"award-info":[{"award-number":["82560832"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.burns.2026.108030","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:25:49Z","timestamp":1776871549000},"page":"108030","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptome profile of keloid patients in Zunyi, China via multiple bioinformatic analyses"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6444-8187","authenticated-orcid":false,"given":"Nana","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0968-7094","authenticated-orcid":false,"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-009X","authenticated-orcid":false,"given":"Ni","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1257-694X","authenticated-orcid":false,"given":"Yang","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6090-6353","authenticated-orcid":false,"given":"Yuan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3806-2245","authenticated-orcid":false,"given":"Guangchao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4530-1443","authenticated-orcid":false,"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3420-918X","authenticated-orcid":false,"given":"Jianguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.burns.2026.108030_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18030606","article-title":"Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis","volume":"18","author":"Ogawa","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.burns.2026.108030_bib2","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1016\/j.jid.2020.01.036","article-title":"Hypoxia and HIF-1\u03b1 regulate collagen production in keloids","volume":"140","author":"Kang","year":"2020","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.burns.2026.108030_bib3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2119\/molmed.2009.00153","article-title":"Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies","volume":"17","author":"Gauglitz","year":"2011","journal-title":"Mol Med"},{"key":"10.1016\/j.burns.2026.108030_bib4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.matbio.2016.01.013","article-title":"Keloids: The paradigm of skin fibrosis - Pathomechanisms and treatment","volume":"51","author":"Andrews","year":"2016","journal-title":"Matrix Biol"},{"key":"10.1016\/j.burns.2026.108030_bib5","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/exd.13271","article-title":"Aberrant connective tissue differentiation towards cartilage and bone underlies human keloids in African Americans","volume":"26","author":"Fuentes-Duculan","year":"2017","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.burns.2026.108030_bib6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/exd.14243","article-title":"Keloid disorder: Fibroblast differentiation and gene expression profile in fibrotic skin diseases","volume":"30","author":"Macarak","year":"2021","journal-title":"Exp Dermatol"},{"issue":"1","key":"10.1016\/j.burns.2026.108030_bib7","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/DSS.0000000000000819","article-title":"Keloids and Hypertrophic Scars: Pathophysiology, Classification, and Treatment","volume":"43","author":"Berman","year":"2017","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.burns.2026.108030_bib8","first-page":"1033","article-title":"Functional histopathology of keloid disease","volume":"30","author":"Jumper","year":"2015","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.burns.2026.108030_bib9","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5897907","article-title":"Bioinformatic Analysis of Key Genes and Pathways Related to Keloids","volume":"2021","author":"Bi","year":"2021","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.burns.2026.108030_bib10","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1038\/s41467-021-24110-y","article-title":"Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases","volume":"12","author":"Deng","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.burns.2026.108030_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13818","article-title":"New Anti-Fibrotic Strategies for Keloids: Insights From Single-Cell Multi-Omics","volume":"58","author":"Zhao","year":"2025","journal-title":"Cell Prolif"},{"key":"10.1016\/j.burns.2026.108030_bib12","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkad017","article-title":"Decoding the molecular landscape of keloids: new insights from single-cell transcriptomics","volume":"11","author":"Xia","year":"2023","journal-title":"Burns Trauma"},{"key":"10.1016\/j.burns.2026.108030_bib13","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1111\/iwj.13988","article-title":"Global research status of pathological scar reported over the period 2001-2021: A 20-year bibliometric analysis","volume":"20","author":"Li","year":"2023","journal-title":"Int Wound J"},{"key":"10.1016\/j.burns.2026.108030_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.burns.2026.108030_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114683","article-title":"Identification of potential endocrine disrupting chemicals using gene expression biomarkers","volume":"380","author":"Corton","year":"2019","journal-title":"Toxicol Appl Pharm"},{"key":"10.1016\/j.burns.2026.108030_bib16","article-title":"Two Functional TP53 Genetic Variants and Predisposition to Keloid Scarring in Caucasians","volume":"2019","author":"Dmytrzak","year":"2019","journal-title":"Dermatol Res Pr"},{"key":"10.1016\/j.burns.2026.108030_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188438","article-title":"P53 in skin cancer: From a master player to a privileged target for prevention and therapy","volume":"1874","author":"Loureiro","year":"2020","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1016\/j.burns.2026.108030_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4085770","article-title":"Pan-Cancer Analysis of TLE3 Revealed Its Value in Tumor Microenvironment and Prognosis","volume":"2022","author":"Li","year":"2022","journal-title":"J Oncol"},{"key":"10.1016\/j.burns.2026.108030_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/biom11081240","article-title":"Pinocembrin Ameliorates Skin Fibrosis via Inhibiting TGF-\u03b21 Signaling Pathway","volume":"11","author":"Li","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.burns.2026.108030_bib20","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.gene.2016.07.028","article-title":"An evolutionary, structural and functional overview of the mammalian TEAD1 and TEAD2 transcription factors","volume":"591","author":"Landin-Malt","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.burns.2026.108030_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013066","article-title":"Ontology-based meta-analysis of global collections of high-throughput public data","volume":"5","author":"Kupershmidt","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.burns.2026.108030_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006844","article-title":"RNA-Seq of Kaposi's sarcoma reveals alterations in glucose and lipid metabolism","volume":"14","author":"Tso","year":"2018","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.burns.2026.108030_bib23","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/jid.2011.472","article-title":"Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies","volume":"132","author":"Pendergrass","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.burns.2026.108030_bib24","doi-asserted-by":"crossref","first-page":"12319","DOI":"10.1073\/pnas.1635114100","article-title":"Systemic and cell type-specific gene expression patterns in scleroderma skin","volume":"100","author":"Whitfield","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.burns.2026.108030_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004017","article-title":"Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes","volume":"3","author":"S\u00e4\u00e4f","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.burns.2026.108030_bib26","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/j.jid.2020.04.011","article-title":"Lipidomics Profiling of Hidradenitis Suppurativa Skin Lesions Reveals Lipoxygenase Pathway Dysregulation and Accumulation of Proinflammatory Leukotriene B4","volume":"140","author":"Penno","year":"2020","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.burns.2026.108030_bib27","article-title":"Interferon and biologic signatures in dermatomyositis skin: specificity and heterogeneity across diseases","volume":"7","author":"Wong","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.burns.2026.108030_bib28","article-title":"Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by regulating VEGF expression","volume":"26","author":"Zhang","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.burns.2026.108030_bib29","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.drudis.2021.01.007","article-title":"Human ClpP protease, a promising therapy target for diseases of mitochondrial dysfunction","volume":"26","author":"Luo","year":"2021","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.burns.2026.108030_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.65","article-title":"Mitochondria-focused gene expression profile reveals common pathways and CPT1B dysregulation in both rodent stress model and human subjects with PTSD","volume":"5","author":"Zhang","year":"2015","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.burns.2026.108030_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.149078","article-title":"Integrating multiomics sequencing analyses uncover the key mechanisms related to oxidative stress, mitochondria, and immune cells in keloid","volume":"935","author":"Zhang","year":"2025","journal-title":"Gene"},{"key":"10.1016\/j.burns.2026.108030_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/biom11121886","article-title":"Insulin-Responsive Transcription Factors","volume":"11","author":"Thiel","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.burns.2026.108030_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/cells13131135","article-title":"The Role of PGC-1\u03b1 in Aging Skin Barrier Function","volume":"13","author":"Luo","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.burns.2026.108030_bib34","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1007\/s13238-021-00894-z","article-title":"Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis","volume":"13","author":"Wang","year":"2022","journal-title":"Protein Cell"},{"key":"10.1016\/j.burns.2026.108030_bib35","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jid.2017.05.041","article-title":"Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated RUNX2 Activation in Keloid Fibroblasts","volume":"138","author":"Hsu","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.burns.2026.108030_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.matbio.2022.03.001","article-title":"Schwann cells contribute to keloid formation","volume":"108","author":"Direder","year":"2022","journal-title":"Matrix Biol"},{"key":"10.1016\/j.burns.2026.108030_bib37","article-title":"Asporin inhibits collagen matrix-mediated intercellular mechanocommunications between fibroblasts during keloid progression","volume":"35","author":"Liu","year":"2021","journal-title":"Faseb J"},{"key":"10.1016\/j.burns.2026.108030_bib38","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1111\/iwj.14031","article-title":"Bioinformatics analysis and identification of dysregulated POSTN in the pathogenesis of keloid","volume":"20","author":"Xu","year":"2023","journal-title":"Int Wound J"},{"key":"10.1016\/j.burns.2026.108030_bib39","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-981-13-6657-4_10","article-title":"Involvement of Periostin in Skin Function and the Pathogenesis of Skin Diseases","volume":"1132","author":"Kuwatsuka","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.burns.2026.108030_bib40","article-title":"Metabolism, fibrosis, and apoptosis: The effect of lipids and their derivatives on keloid formation","volume":"21","author":"Li","year":"2024","journal-title":"Int Wound J"},{"key":"10.1016\/j.burns.2026.108030_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.xjidi.2024.100299","article-title":"Update on the Pathogenesis of Keloid Formation","volume":"4","author":"Latoni","year":"2024","journal-title":"JID Innov"},{"key":"10.1016\/j.burns.2026.108030_bib42","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1111\/exd.14630","article-title":"Increased expression of bone\/cartilage-associated genes and core transcription factors in keloids by RNA sequencing","volume":"31","author":"Lin","year":"2022","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.burns.2026.108030_bib43","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.jid.2018.10.038","article-title":"Collagen prolyl hydroxylases are bifunctional growth regulators in melanoma","volume":"139","author":"Atkinson","year":"2019","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.burns.2026.108030_bib44","doi-asserted-by":"crossref","DOI":"10.1111\/iwj.14481","article-title":"Machine learning and single-cell transcriptome profiling reveal regulation of fibroblast activation through THBS2\/TGF\u03b21\/P-Smad2\/3 signalling pathway in hypertrophic scar","volume":"21","author":"Song","year":"2024","journal-title":"Int Wound J"},{"key":"10.1016\/j.burns.2026.108030_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.783907","article-title":"Single-cell sequencing analysis and weighted co-expression network analysis based on public databases identified that TNC is a novel biomarker for keloid","volume":"12","author":"Xie","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.burns.2026.108030_bib46","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1111\/iwj.14097","article-title":"Mechanisms underlying pathological scarring by fibroblasts during wound healing","volume":"20","author":"Ma","year":"2023","journal-title":"Int Wound J"},{"key":"10.1016\/j.burns.2026.108030_bib47","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/iwj.13104","article-title":"Managing keloid scars: From radiation therapy to actual and potential drug deliveries","volume":"16","author":"Huang","year":"2019","journal-title":"Int Wound J"},{"key":"10.1016\/j.burns.2026.108030_bib48","first-page":"299","article-title":"Use of intense pulsed light in the treatment of keloid patients: Efficacy analysis of 156 cases","volume":"23","author":"Sun","year":"2014","journal-title":"Zhongguo Meirong Yixue Za Zhi"},{"key":"10.1016\/j.burns.2026.108030_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8120573","article-title":"Experimental study on blue light interaction with human keloid-derived fibroblasts","volume":"8","author":"Magni","year":"2020","journal-title":"Biomedicines"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417926001828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417926001828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:42:33Z","timestamp":1784749353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417926001828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0305417926001828"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2026.108030","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptome profile of keloid patients in Zunyi, China via multiple bioinformatic analyses","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2026.108030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108030"}}