{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:01:09Z","timestamp":1790370069653,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.burns.2026.108110","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:23:31Z","timestamp":1781763811000},"page":"108110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification and validation of mitotic catastrophe\u2013associated biomarkers for keloid"],"prefix":"10.1016","volume":"52","author":[{"given":"Hui","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-wei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.burns.2026.108110_bib1","doi-asserted-by":"crossref","first-page":"adv00582","DOI":"10.2340\/00015555-3923","article-title":"Pruritus in keloid scars: mechanisms and treatments","volume":"101","author":"Hawash","year":"2021","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.burns.2026.108110_bib2","article-title":"Identification and validation of CCR5 linking keloid with atopic dermatitis through comprehensive bioinformatics analysis and machine learning","volume":"15","author":"Zhou","year":"2024","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.burns.2026.108110_bib3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.det.2023.02.010","article-title":"IInd. Keloids and hypertrophic scars","volume":"41","author":"Knowles","year":"2023","journal-title":"Dermatol Clin"},{"issue":"2","key":"10.1016\/j.burns.2026.108110_bib4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/jamadermatol.2022.5607","article-title":"Comorbidities of keloid and hypertrophic scars among participants in UK biobank","volume":"159","author":"Ung","year":"2023","journal-title":"JAMA Dermatol"},{"issue":"10","key":"10.1016\/j.burns.2026.108110_bib5","doi-asserted-by":"crossref","first-page":"e408","DOI":"10.5435\/JAAOS-D-19-00690","article-title":"Keloid and hypertrophic scar formation, prevention, and management: standard review of abnormal scarring in orthopaedic surgery","volume":"28","author":"Grabowski","year":"2020","journal-title":"J Am Acad Orthop Surg"},{"issue":"5","key":"10.1016\/j.burns.2026.108110_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.188965","article-title":"Perspectives and mechanisms for targeting mitotic catastrophe in cancer treatment","volume":"1878","author":"Bai","year":"2023","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1016\/j.burns.2026.108110_bib7","article-title":"IL-17 induces autophagy dysfunction to promote inflammatory cell death and fibrosis in keloid fibroblasts via the STAT3 and HIF-1\u03b1 dependent signaling pathways","volume":"13","author":"Lee","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.burns.2026.108110_bib8","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1038\/s41598-024-51918-7","article-title":"Developing a prognosis and chemotherapy evaluating model for colon adenocarcinoma based on mitotic catastrophe-related genes","volume":"14","author":"Liu","year":"2024","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.burns.2026.108110_bib9","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.burns.2026.108110_bib10","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.2147\/JIR.S452608","article-title":"Identification and analysis of PANoptosis-related genes in sepsis-induced lung injury by bioinformatics and experimental verification","volume":"17","author":"Yang","year":"2024","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.burns.2026.108110_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8258351","article-title":"The construction and analysis of a ceRNA network related to salt-sensitivity hypertensives","volume":"2022","author":"Liu","year":"2022","journal-title":"Biomed Res Int"},{"issue":"15","key":"10.1016\/j.burns.2026.108110_bib12","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1093\/bioinformatics\/btac409","article-title":"ggtranscript: an R package for the visualization and interpretation of transcript isoforms using ggplot2","volume":"38","author":"Gustavsson","year":"2022","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.burns.2026.108110_bib13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.32604\/or.2023.031134","article-title":"Leveraging diverse cell-death patterns to predict the clinical outcome of immune checkpoint therapy in lung adenocarcinoma: based on muti-omics analysis and vitro assay","volume":"32","author":"Liang","year":"2023","journal-title":"Oncol Res"},{"issue":"2","key":"10.1016\/j.burns.2026.108110_bib14","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3892\/etm.2022.11449","article-title":"Inhibition of cell survival and invasion by Tanshinone IIA via FTH1: a key therapeutic target and biomarker in head and neck squamous cell carcinoma","volume":"24","author":"Mao","year":"2022","journal-title":"Exp Ther Med"},{"issue":"5","key":"10.1016\/j.burns.2026.108110_bib15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"issue":"11","key":"10.1016\/j.burns.2026.108110_bib16","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"issue":"1","key":"10.1016\/j.burns.2026.108110_bib17","doi-asserted-by":"crossref","first-page":"360","DOI":"10.7150\/ijbs.66913","article-title":"Integrated machine learning and bioinformatic analyses constructed a novel stemness-related classifier to predict prognosis and immunotherapy responses for hepatocellular carcinoma patients","volume":"18","author":"Chen","year":"2022","journal-title":"Int J Biol Sci"},{"issue":"11","key":"10.1016\/j.burns.2026.108110_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e21147","article-title":"A nomogram for predicting prognosis of patients with cervical cerclage","volume":"9","author":"Xu","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.burns.2026.108110_bib19","article-title":"Uncovering ferroptosis in Parkinson's disease via bioinformatics and machine learning, and reversed deducing potential therapeutic natural products","volume":"14","author":"Wang","year":"2023","journal-title":"Front Genet"},{"issue":"21","key":"10.1016\/j.burns.2026.108110_bib20","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1200\/JCO.2015.65.5654","article-title":"Assessing the clinical impact of risk prediction models with decision curves: guidance for correct interpretation and appropriate use","volume":"34","author":"Kerr","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.burns.2026.108110_bib21","article-title":"Identification of aging-related biomarkers and immune infiltration characteristics in osteoarthritis based on bioinformatics analysis and machine learning","volume":"14","author":"Zhou","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.burns.2026.108110_bib22","article-title":"Identification of critical biomarkers and immune infiltration in rheumatoid arthritis based on WGCNA and LASSO algorithm","volume":"13","author":"Jiang","year":"2022","journal-title":"Front Immunol"},{"issue":"16","key":"10.1016\/j.burns.2026.108110_bib23","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J Comput Chem"},{"issue":"9","key":"10.1016\/j.burns.2026.108110_bib24","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1080\/07391102.2020.1852117","article-title":"Virtual screening of phytoconstituents from miracle herb Nigella sativa targeting nucleocapsid protein and papain-like protease of SARS-CoV-2 for COVID-19 treatment [J]","volume":"40","author":"Siddiqi","year":"2022","journal-title":"J Biomol Struct Dyn"},{"issue":"1","key":"10.1016\/j.burns.2026.108110_bib25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12967-023-04033-6","article-title":"Constructing a novel mitochondrial-related gene signature for evaluating the tumor immune microenvironment and predicting survival in stomach adenocarcinoma","volume":"21","author":"Chang","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.burns.2026.108110_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2023.103077","article-title":"Generation of a PPP1CA knockout human pluripotent stem cell line via CRISPR\/Cas9","volume":"69","author":"Wang","year":"2023","journal-title":"Stem Cell Res"},{"key":"10.1016\/j.burns.2026.108110_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108703","article-title":"PPP1CA\/YAP\/GS\/Gln\/mTORC1 pathway activates retinal M\u00fcller cells during diabetic retinopathy","volume":"210","author":"Guo","year":"2021","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.burns.2026.108110_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.826047","article-title":"Cell-crossing functional network driven by microRNA-125a regulates endothelial permeability and monocyte trafficking in acute inflammation","volume":"13","author":"M\u00fcller","year":"2022","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.burns.2026.108110_bib29","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.molcel.2021.12.031","article-title":"NudC guides client transfer between the Hsp40\/70 and Hsp90 chaperone systems","volume":"82","author":"Biebl","year":"2022","journal-title":"Mol Cell"},{"issue":"5","key":"10.1016\/j.burns.2026.108110_bib30","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202301641RR","article-title":"NUDC is critical for rod photoreceptor function, maintenance, and survival","volume":"38","author":"Garner","year":"2024","journal-title":"FASEB J"},{"issue":"8","key":"10.1016\/j.burns.2026.108110_bib31","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1073\/pnas.0914307107","article-title":"NudC-like protein 2 regulates the LIS1\/dynein pathway by stabilizing LIS1 with Hsp90","volume":"107","author":"Yang","year":"2010","journal-title":"Proc Natl Acad Sci"},{"issue":"9","key":"10.1016\/j.burns.2026.108110_bib32","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41419-019-1843-3","article-title":"NudC-like protein 2 restrains centriole amplification by stabilizing HERC2","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.burns.2026.108110_bib33","article-title":"A broad cuproptosis landscape in inflammatory bowel disease","volume":"13","author":"Chen","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.burns.2026.108110_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101674","article-title":"Mitochondrial electron transport chain: oxidative phosphorylation, oxidant production, and methods of measurement","volume":"37","author":"Nolfi-Donegan","year":"2020","journal-title":"Redox Biol"},{"issue":"11","key":"10.1016\/j.burns.2026.108110_bib35","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1158\/1078-0432.CCR-20-3913","article-title":"Targeting oxidative phosphorylation to increase the efficacy of radio- and immune-combination therapy","volume":"27","author":"Boreel","year":"2021","journal-title":"Clin Cancer Res"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417926002627?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417926002627?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:12:57Z","timestamp":1790367177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417926002627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0305417926002627"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2026.108110","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and validation of mitotic catastrophe\u2013associated biomarkers for keloid","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2026.108110","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108110"}}