{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:59:31Z","timestamp":1792083571555,"version":"4.4.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LM2023051"],"award-info":[{"award-number":["LM2023051"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NU22-08\\u201300454"],"award-info":[{"award-number":["NU22-08\\u201300454"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.burns.2026.108174","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T14:55:38Z","timestamp":1786805738000},"page":"108174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stable fibroblast growth factor 2 (FGF2-STAB\u00ae) induced neovascularization in dermal substitutes"],"prefix":"10.1016","volume":"52","author":[{"given":"B\u0159etislav","family":"Lipov\u00fd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-3681","authenticated-orcid":false,"given":"Martin","family":"Knoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-298X","authenticated-orcid":false,"given":"Veronika","family":"Pavli\u0148\u00e1kov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1240-7943","authenticated-orcid":false,"given":"Jakub","family":"Holoubek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1992-8829","authenticated-orcid":false,"given":"Vladim\u00edr","family":"V\u00e1\u0148a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Herudek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edita","family":"Jeklov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3248-4658","authenticated-orcid":false,"given":"Monika","family":"V\u00edcenov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"\u017d\u00eddek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1213-1721","authenticated-orcid":false,"given":"Michaela","family":"Cvanov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zden\u011bk","family":"Pavlovsk\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5448-7235","authenticated-orcid":false,"given":"Martin","family":"Faldyna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5281-7045","authenticated-orcid":false,"given":"Lucy","family":"Vojtov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.burns.2026.108174_bib1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1590\/abd1806-4841.20164741","article-title":"Wound healing \u2013 a literature review","volume":"91","author":"Gonzalez","year":"2016","journal-title":"Bras Dermatol"},{"issue":"3","key":"10.1016\/j.burns.2026.108174_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3390\/biomimetics7030087","article-title":"The role of the extracellular matrix (ECM) in wound healing: a review","volume":"7","author":"Diller","year":"2022","journal-title":"Biomimetics"},{"key":"10.1016\/j.burns.2026.108174_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.copbio.2021.08.019","article-title":"Vascularization in skin wound healing: where do we stand and where do we go?","volume":"73","author":"Moreira","year":"2022","journal-title":"Curr Opin Biotechnol"},{"issue":"10","key":"10.1016\/j.burns.2026.108174_bib4","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1089\/wound.2013.0517","article-title":"Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair","volume":"3","author":"Johnson","year":"2014","journal-title":"Adv Wound Care"},{"issue":"9","key":"10.1016\/j.burns.2026.108174_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13716","article-title":"Endothelial progenitor cells for fabrication of engineered vascular units and angiogenesis induction","volume":"57","author":"Rashidi","year":"2024","journal-title":"Cell Prolif"},{"issue":"21","key":"10.1016\/j.burns.2026.108174_bib6","doi-asserted-by":"crossref","first-page":"10341","DOI":"10.3390\/ijms262110341","article-title":"Active peptides derived from snail mucus promoted wound healing by enhancing endothelial cell proliferation and angiogenesis","volume":"26","author":"Li","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.burns.2026.108174_bib7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jare.2024.01.016","article-title":"The role of endothelial cell-pericyte interactions in vascularization and diseases","volume":"67","author":"Li","year":"2025","journal-title":"J Adv Res"},{"issue":"9","key":"10.1016\/j.burns.2026.108174_bib8","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1016\/j.ymthe.2022.07.016","article-title":"Macrophages as a therapeutic target to promote diabetic wound healing","volume":"30","author":"Sharifiaghdam","year":"2022","journal-title":"Mol Ther"},{"issue":"1","key":"10.1016\/j.burns.2026.108174_bib9","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound healing: a cellular perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol Rev"},{"issue":"2","key":"10.1016\/j.burns.2026.108174_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101530","article-title":"The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation","volume":"298","author":"Moretti","year":"2022","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.burns.2026.108174_bib11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/MOH.0b013e3282f97d98","article-title":"Fibroblast growth factor regulation of neovascularization","volume":"15","author":"Murakami","year":"2008","journal-title":"Curr Opin Hematol"},{"issue":"10","key":"10.1016\/j.burns.2026.108174_bib12","doi-asserted-by":"crossref","first-page":"a009092","DOI":"10.1101\/cshperspect.a009092","article-title":"VEGFR and type-V RTK activation and signaling","volume":"5","author":"Shibuya","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"10.1016\/j.burns.2026.108174_bib13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/biomedicines13010006","article-title":"Vascular endothelial growth factor (VEGF) family and the immune system: activators or inhibitors?","volume":"13","author":"Failla","year":"2024","journal-title":"Biomedicines"},{"issue":"5","key":"10.1016\/j.burns.2026.108174_bib14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s12272-025-01545-1","article-title":"Targeting vascular endothelial growth receptor-2 (VEGFR-2): structural biology, functional insights, and therapeutic resistance","volume":"48","author":"Shah","year":"2025","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.burns.2026.108174_bib15","article-title":"Molecular bases of VEGFR-2-mediated physiological function and pathological role","volume":"8","author":"Wang","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"9","key":"10.1016\/j.burns.2026.108174_bib16","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1073\/pnas.0611177104","article-title":"The notch ligand delta-like 4 negatively regulates endothelial tip cell formation and vessel branching","volume":"104","author":"Suchting","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.burns.2026.108174_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cmet.2017.10.005","article-title":"Advances in hypoxia-inducible factor biology","volume":"27","author":"Choudhry","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/j.burns.2026.108174_bib18","article-title":"Research progress of HIF-1a on immunotherapy outcomes in immune vascular microenvironment","volume":"16","author":"Shi","year":"2025","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.burns.2026.108174_bib19","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.3390\/ijms25063313","article-title":"A molecular perspective on HIF-1\u03b1 and angiogenic stimulator networks and their role in solid tumors: an update","volume":"25","author":"Magar","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.burns.2026.108174_bib20","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1172\/JCI58832","article-title":"Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling","volume":"122","author":"Felcht","year":"2012","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.burns.2026.108174_bib21","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/s41433-020-01377-x","article-title":"Angiopoietin\/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data","volume":"35","author":"Joussen","year":"2021","journal-title":"Eye"},{"issue":"1","key":"10.1016\/j.burns.2026.108174_bib22","doi-asserted-by":"crossref","first-page":"496","DOI":"10.2353\/ajpath.2010.080642","article-title":"Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo","volume":"176","author":"Ebrahem","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.burns.2026.108174_bib23","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.3389\/fonc.2019.01370","article-title":"Role of matrix metalloproteinases in angiogenesis and cancer","volume":"9","author":"Quintero-Fabi\u00e1n","year":"2019","journal-title":"Front Oncol"},{"issue":"19","key":"10.1016\/j.burns.2026.108174_bib24","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.3390\/cells14191555","article-title":"The role of growth factors and signaling pathways in ovarian angiogenesis","volume":"14","author":"Jankowska-Ziemak","year":"2025","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.burns.2026.108174_bib25","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.burns.2026.108174_bib26","article-title":"Macrophage plasticity: signaling pathways, tissue repair, and regeneration","volume":"5","author":"Yan","year":"2024","journal-title":"MedComm (2020)"},{"issue":"7","key":"10.1016\/j.burns.2026.108174_bib27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1089\/wound.2012.0407","article-title":"Disclosure of the culprits: macrophages-versatile regulators of wound healing","volume":"2","author":"Sindrilaru","year":"2013","journal-title":"Adv Wound Care"},{"issue":"6","key":"10.1016\/j.burns.2026.108174_bib28","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3390\/biomedicines9060590","article-title":"Healing and angiogenic properties of collagen\/chitosan scaffolds enriched with hyperstable FGF2-STAB\u00ae protein: in vitro, ex ovo and in vivo comprehensive evaluation","volume":"9","author":"Vojtov\u00e1","year":"2021","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.burns.2026.108174_bib29","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/bit.26531","article-title":"Computer-assisted engineering of hyperstable fibroblast growth factor 2","volume":"115","author":"Dvorak","year":"2018","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.burns.2026.108174_bib30","unstructured":"https:\/\/patents.google.com\/patent\/EP3380508B1\/e."},{"issue":"1","key":"10.1016\/j.burns.2026.108174_bib31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12951-023-01822-5","article-title":"Accelular nanofibrous bilayer scaffold intrapenetrated with polydopamine network and implemented into a full-thickness wound of a white-pig model affects inflammation and healing process","volume":"21","author":"Kacvinsk\u00e1","year":"2023","journal-title":"J Nanobiotechnol"},{"issue":"6","key":"10.1016\/j.burns.2026.108174_bib32","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.burns.2024.03.020","article-title":"Evaluation of viscoelastic parameters and photo-based assessment of newly developed dermal substitutes modified with thermostabilized fibroblast growth factor 2","volume":"50","author":"Knoz","year":"2024","journal-title":"Burns"},{"key":"10.1016\/j.burns.2026.108174_bib33","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.msec.2016.05.059","article-title":"Novel electrospun gelatin\/oxycellulose nanofibers as a suitable platform for lung disease modeling","volume":"67","author":"\u0160vachov\u00e1","year":"2016","journal-title":"Mater Sci Eng C"},{"issue":"4","key":"10.1016\/j.burns.2026.108174_bib34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.burns.2026.108174_bib35","unstructured":"Wagner, T., Hiner, M. Xraynaud thorstenwagner\/ij-ridgedetection: Ridge Detection 1.4.0 (Version v1.4.0). 2017. Zenodo. \u3008https:\/\/doi.org\/10.5281\/ZENODO.845874\u3009."},{"issue":"7","key":"10.1016\/j.burns.2026.108174_bib36","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"10","key":"10.1016\/j.burns.2026.108174_bib37","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1089\/wound.2013.0517","article-title":"Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair","volume":"3","author":"Johnson","year":"2014","journal-title":"Adv Wound Care"},{"key":"10.1016\/j.burns.2026.108174_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1284981","article-title":"Research progress on the mechanism of angiogenesis in wound repair and regeneration","volume":"14","author":"Shi","year":"2023","journal-title":"Front Physiol"},{"key":"10.1016\/j.burns.2026.108174_bib39","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.ijbiomac.2022.09.129","article-title":"A concise review of VEGF, PDGF, FGF, Notch, angiopoietin, and HGF signalling in tumor angiogenesis with a focus on alternative approaches and future directions","volume":"221","author":"Vimalraj","year":"2022","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.burns.2026.108174_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1291969","article-title":"Research progress of vascularization strategies of tissue-engineered bone","volume":"11","author":"Lv","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.burns.2026.108174_bib41","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.copbio.2021.08.019","article-title":"Vascularization in skin wound healing: where do we stand and where do we go?","volume":"73","author":"Moreira","year":"2022","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.burns.2026.108174_bib42","article-title":"Phased affinity-controlled delivery of vascular endothelial growth factor, fibroblast growth factor-2, and platelet derived growth factor enhances in vitro angiogenesis","author":"Svendsen","year":"2025","journal-title":"bioRxiv [Prepr]"},{"key":"10.1016\/j.burns.2026.108174_bib43","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.actbio.2019.08.016","article-title":"Controlled delivery of basic fibroblast growth factor (bFGF) using acoustic droplet vaporization stimulates endothelial network formation","volume":"97","author":"Dong","year":"2019","journal-title":"Acta Biomater"},{"issue":"3","key":"10.1016\/j.burns.2026.108174_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10642","article-title":"Growth factors and growth factor gene therapies for treating chronic wounds","volume":"9","author":"Mullin","year":"2023","journal-title":"Bioeng Transl Med"},{"issue":"1","key":"10.1016\/j.burns.2026.108174_bib45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1152\/physrev.00046.2024","article-title":"Angiocrine and pericrine signaling: how endothelial cells and pericytes drive cancer progression and therapy resistance","volume":"106","author":"Jordan","year":"2026","journal-title":"Physiol Rev"},{"issue":"1","key":"10.1016\/j.burns.2026.108174_bib46","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41392-025-02249-0","article-title":"Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives","volume":"10","author":"Lee","year":"2025","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"10.1016\/j.burns.2026.108174_bib47","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.burns.2022.10.007","article-title":"The future for the application of fibroblast growth factor 2 in modern wound healing","volume":"49","author":"Holoubek","year":"2023","journal-title":"Burns"},{"key":"10.1016\/j.burns.2026.108174_bib48","series-title":"Mechanisms of vascular disease: a reference book for vascular specialists [Internet]","article-title":"Principles of wound healing","author":"Schultz","year":"2011"},{"issue":"11","key":"10.1016\/j.burns.2026.108174_bib49","doi-asserted-by":"crossref","first-page":"19791","DOI":"10.3390\/ijms151119791","article-title":"Hypoxic signaling during tissue repair and regenerative medicine","volume":"15","author":"Nauta","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.burns.2026.108174_bib50","doi-asserted-by":"crossref","first-page":"tkaf036","DOI":"10.1093\/burnst\/tkaf036","article-title":"Engineered sEVs encapsulated in GelMA facilitated diabetic wound healing by promoting angiogenesis via targeting thrombospondin-1","volume":"13","author":"Cong","year":"2025","journal-title":"Burns Trauma"},{"issue":"8","key":"10.1016\/j.burns.2026.108174_bib51","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and molecular mechanisms of skin wound healing","volume":"25","author":"Pe\u00f1a","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.burns.2026.108174_bib52","first-page":"301","article-title":"Fibroblasts and myofibroblasts in wound healing","volume":"7","author":"Darby","year":"2014","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"4","key":"10.1016\/j.burns.2026.108174_bib53","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3390\/biom7040074","article-title":"Friends turned foes: angiogenic growth factors beyond angiogenesis","volume":"7","author":"Matkar","year":"2017","journal-title":"Biomolecules"},{"key":"10.1016\/j.burns.2026.108174_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117585","article-title":"Physiological and tumor-associated angiogenesis: key factors and therapy targeting VEGF\/VEGFR pathway","volume":"180","author":"Lorenc","year":"2024","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10.1016\/j.burns.2026.108174_bib55","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41392-020-00222-7","article-title":"FGF\/FGFR signaling in health and disease","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"10.1016\/j.burns.2026.108174_bib56","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/cvr\/cvm086","article-title":"Non-canonical fibroblast growth factor signalling in angiogenesis","volume":"78","author":"Murakami","year":"2008","journal-title":"Cardiovasc Res"},{"issue":"6","key":"10.1016\/j.burns.2026.108174_bib57","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in signaling and disease: beyond discovery and development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.burns.2026.108174_bib58","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1161\/ATVBAHA.122.317645","article-title":"PLC\u03b22 promotes VEGF-induced vascular permeability","volume":"42","author":"Phoenix","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"10.1016\/j.burns.2026.108174_bib59","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrm.2016.87","article-title":"Mechanisms and regulation of endothelial VEGF receptor signalling","volume":"17","author":"Simons","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.burns.2026.108174_bib60","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/gb-2005-6-2-209","article-title":"The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease","volume":"6","author":"Holmes","year":"2005","journal-title":"Genome Biol"},{"issue":"4","key":"10.1016\/j.burns.2026.108174_bib61","article-title":"New developments in the biology of fibroblast growth factors","volume":"14","author":"Ornitz","year":"2022","journal-title":"WIREs Mech Dis"},{"issue":"6","key":"10.1016\/j.burns.2026.108174_bib62","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/wsbm.1190","article-title":"Role of fibroblast growth factor signaling in vascular formation and maintenance: orchestrating signaling networks as an integrated system","volume":"4","author":"Murakami","year":"2012","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"10.1016\/j.burns.2026.108174_bib63","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1083\/jcb.141.7.1659","article-title":"Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis","volume":"141","author":"Seghezzi","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1016\/j.burns.2026.108174_bib64","doi-asserted-by":"crossref","first-page":"8868","DOI":"10.1073\/pnas.062040199","article-title":"Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea","volume":"99","author":"Kubo","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Pt 16","key":"10.1016\/j.burns.2026.108174_bib65","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1242\/jcs.02483","article-title":"VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling","volume":"118","author":"Kano","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.burns.2026.108174_bib66","article-title":"The role of extracellular matrix in angiogenesis: beyond adhesion and structure","volume":"15","author":"Libby","year":"2024","journal-title":"Biomater Biosyst"},{"issue":"5","key":"10.1016\/j.burns.2026.108174_bib67","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/01.RES.0000118600.91698.BB","article-title":"Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability","volume":"94","author":"Cao","year":"2004","journal-title":"Circ Res"},{"issue":"10","key":"10.1016\/j.burns.2026.108174_bib68","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1172\/JCI35298","article-title":"The FGF system has a key role in regulating vascular integrity","volume":"118","author":"Murakami","year":"2008","journal-title":"J Clin Invest"},{"issue":"10","key":"10.1016\/j.burns.2026.108174_bib69","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.157874","article-title":"FGF-2 signaling in nasopharyngeal carcinoma modulates pericyte-macrophage crosstalk and metastasis","volume":"7","author":"Wang","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.burns.2026.108174_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1389607","article-title":"Selective mural cell recruitment of pericytes to networks of assembling endothelial cell-lined tubes","volume":"12","author":"Yrigoin","year":"2024","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.burns.2026.108174_bib71","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/nbt1101-1029","article-title":"Polymeric system for dual growth factor delivery","volume":"19","author":"Richardson","year":"2001","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.burns.2026.108174_bib72","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1172\/JCI32479","article-title":"Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization andmetastasis","volume":"117","author":"Nissen","year":"2007","journal-title":"J Clin Invest"},{"issue":"21","key":"10.1016\/j.burns.2026.108174_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e39843","article-title":"The effect of fibroblast growth factor 2 on neovascular vessels depends on the stage of angiogenesis","volume":"10","author":"Hattori","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.burns.2026.108174_bib74","first-page":"1575","article-title":"Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptors. Faseb J","volume":"16","author":"Cao","year":"2002"},{"key":"10.1016\/j.burns.2026.108174_bib75","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nm848","article-title":"Angiogenic synergism, vascular stability and improvement of hindlimb ischemia by a combination of PDGF-BB and FGF-2","volume":"9","author":"Cao","year":"2003","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.burns.2026.108174_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-68019-w","article-title":"Prostaglandin E2 breaks down pericyte-endothelial cell interaction via EP1 and EP4-dependent downregulation of pericyte N-cadherin, connexin-43, and R-Ras","volume":"10","author":"Perrot","year":"2020","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.burns.2026.108174_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104775","article-title":"Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function","volume":"299","author":"Weigel","year":"2023","journal-title":"J Biol Chem"},{"key":"10.1016\/j.burns.2026.108174_bib78","doi-asserted-by":"crossref","first-page":"35208","DOI":"10.1074\/jbc.M608655200","article-title":"The fibroblast growth factor receptor acid box is essential for interactions with N-cadherin and all of the major isoforms of neural cell adhesion molecule","volume":"281","author":"Sanchez-Heras","year":"2006","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.burns.2026.108174_bib79","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cytogfr.2005.01.004","article-title":"Fibroblast growth factor\/fibroblast growth factor receptor system in angiogenesis","volume":"16","author":"Presta","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"issue":"2","key":"10.1016\/j.burns.2026.108174_bib80","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nrc2780","article-title":"Fibroblast growth factor signalling: from development to cancer","volume":"10","author":"Turner","year":"2010","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1016\/j.burns.2026.108174_bib81","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrm2639","article-title":"Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system","volume":"10","author":"Augustin","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"10.1016\/j.burns.2026.108174_bib82","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3390\/cells10061342","article-title":"Negative regulation of FGFR (fibroblast growth factor receptor) signaling","volume":"10","author":"Szybowska","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.burns.2026.108174_bib83","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3390\/ijms27010377","article-title":"Sprouty in tumors of the nervous system","volume":"27","author":"Obexer","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.burns.2026.108174_bib84","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1016\/j.ajpath.2011.09.001","article-title":"A novel enhancer of the wound healing process: the fibroblast growth factor-binding protein","volume":"179","author":"Werner","year":"2011","journal-title":"Am J Pathol"},{"issue":"9","key":"10.1016\/j.burns.2026.108174_bib85","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.3390\/biomedicines11092526","article-title":"Cellular and molecular processes in wound healing","volume":"11","author":"Fern\u00e1ndez-Guarino","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.burns.2026.108174_bib86","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/190561","article-title":"Local regeneration of dentin-pulp complex using controlled release of fgf-2 and naturally derived sponge-like scaffolds","volume":"2012","author":"Kitamura","year":"2012","journal-title":"Int J Dent"},{"issue":"4","key":"10.1016\/j.burns.2026.108174_bib87","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s13555-020-00407-6","article-title":"The Japanese experience with basic fibroblast growth factor in cutaneous wound management and scar prevention: a systematic review of clinical and biological aspects","volume":"10","author":"Abdelhakim","year":"2020","journal-title":"Dermatol Ther"},{"issue":"5","key":"10.1016\/j.burns.2026.108174_bib88","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1524-475X.2008.00414.x","article-title":"Basic fibroblast growth factor accelerates and improves second-degree burn wound healing","volume":"16","author":"Akita","year":"2008","journal-title":"Wound Repair Regen"},{"issue":"1","key":"10.1016\/j.burns.2026.108174_bib89","doi-asserted-by":"crossref","DOI":"10.1111\/j.1067-1927.2005.130116al.x","article-title":"Open wound integrated regenerative therapy with topical bfgf trafermin for deep soft tissue defects with bone exposure","volume":"13","author":"Ohura","year":"2005","journal-title":"Wound Repair Regen"},{"issue":"3","key":"10.1016\/j.burns.2026.108174_bib90","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4236\/mps.2013.33022","article-title":"Wound treatment using growth factors","volume":"3","author":"Okabe","year":"2013","journal-title":"Mod Plast Surg"},{"issue":"6","key":"10.1016\/j.burns.2026.108174_bib91","doi-asserted-by":"crossref","DOI":"10.1097\/GOX.0b013e3182a88787","article-title":"The effect of control-released basic fibroblast growth factor in wound healing: histological analyses and clinical application","volume":"1","author":"Matsumoto","year":"2013","journal-title":"Plast Reconstr Surg Glob Open"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417926003268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417926003268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:30:03Z","timestamp":1792081803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417926003268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":91,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S0305417926003268"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2026.108174","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stable fibroblast growth factor 2 (FGF2-STAB\u00ae) induced neovascularization in dermal substitutes","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2026.108174","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd and ISBI. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108174"}}