{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:59:27Z","timestamp":1792083567818,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.burns.2026.108177","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:33:26Z","timestamp":1786548806000},"page":"108177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adipose-derived stem cells secrete pro- and anti-inflammatory cytokines after major burn injury"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1742-3160","authenticated-orcid":false,"given":"Alison","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1025-8089","authenticated-orcid":false,"given":"Jenna","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Deville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Trinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1919-5800","authenticated-orcid":false,"given":"Cara","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Couvillion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Leonardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asra","family":"Feroze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3589-9162","authenticated-orcid":false,"given":"Tracy","family":"Dewenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3380-9458","authenticated-orcid":false,"given":"Robert","family":"Siggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4857-7901","authenticated-orcid":false,"given":"Patrick","family":"McTernan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3598-384X","authenticated-orcid":false,"given":"Patricia","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herb","family":"Phelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1960-1132","authenticated-orcid":false,"given":"Jonathan","family":"Schoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.burns.2026.108177_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","article-title":"Burn injury","volume":"6","author":"Jeschke","year":"2020","journal-title":"Nat Rev Dis Prim"},{"issue":"3","key":"10.1016\/j.burns.2026.108177_bib2","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/PRS.0000000000010595","article-title":"The Global Macroeconomic Burden of Burn Injuries","volume":"153","author":"Gerstl","year":"2024","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"10.1016\/j.burns.2026.108177_bib3","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/SLA.0000000000002097","article-title":"Pathophysiological response to burn injury in adults","volume":"267","author":"Stanojcic","year":"2018","journal-title":"Ann Surg"},{"issue":"9","key":"10.1016\/j.burns.2026.108177_bib4","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1111\/j.1582-4934.2010.01151.x","article-title":"Evolving paradigms for repair of tissues by adult stem\/progenitor cells (MSCs)","volume":"14","author":"Prockop","year":"2010","journal-title":"J Cell Mol Med"},{"issue":"14","key":"10.1016\/j.burns.2026.108177_bib5","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.yexcr.2010.05.009","article-title":"Mesenchymal stem cells: paracrine signaling and differentiation during cutaneous wound repair","volume":"316","author":"Hocking","year":"2010","journal-title":"Exp Cell Res"},{"issue":"9","key":"10.1016\/j.burns.2026.108177_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ph16091302","article-title":"Application of adipose-tissue derived products for burn wound healing","volume":"16","author":"Malekzadeh","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"issue":"3","key":"10.1016\/j.burns.2026.108177_bib7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.it.2011.11.004","article-title":"How mesenchymal stem cells interact with tissue immune responses","volume":"33","author":"Shi","year":"2012","journal-title":"Trends Immunol"},{"issue":"4","key":"10.1016\/j.burns.2026.108177_bib8","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1089\/wound.2014.0607","article-title":"Stem cells in skin wound healing: are we there yet?","volume":"5","author":"Cerqueira","year":"2016","journal-title":"Adv Wound Care (New Rochelle)"},{"issue":"3","key":"10.1016\/j.burns.2026.108177_bib9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.suc.2023.02.005","article-title":"Infections in burn patients","volume":"103","author":"Kiley","year":"2023","journal-title":"Surg Clin North Am"},{"issue":"11","key":"10.1016\/j.burns.2026.108177_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/cells12111484","article-title":"Adipose tissue inflammation","volume":"12","author":"Gomez-Ambrosi","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.burns.2026.108177_bib11","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s13287-021-02327-4","article-title":"ASCs derived from burn patients are more prone to increased oxidative metabolism and reactive oxygen species upon passaging","volume":"12","author":"Burmeister","year":"2021","journal-title":"Stem Cell Res Ther"},{"issue":"8","key":"10.1016\/j.burns.2026.108177_bib12","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/stem.677","article-title":"Debrided skin as a source of autologous stem cells for wound repair","volume":"29","author":"Natesan","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.burns.2026.108177_bib13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ebiom.2018.10.014","article-title":"Stem cells derived from burned skin - The future of burn care","volume":"37","author":"Amini-Nik","year":"2018","journal-title":"EBioMedicine"},{"issue":"9","key":"10.1016\/j.burns.2026.108177_bib14","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1517\/14712598.2015.1053867","article-title":"Adipose-derived stem cells for wound repair and regeneration","volume":"15","author":"Shingyochi","year":"2015","journal-title":"Expert Opin Biol Ther"},{"issue":"4","key":"10.1016\/j.burns.2026.108177_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041306","article-title":"Hopes and limits of adipose-derived stem cells (ADSCs) and mesenchymal stem cells (MSCs) in wound healing","volume":"21","author":"Mazini","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.burns.2026.108177_bib16","first-page":"379","article-title":"Stem cell therapy for burns: story so far","volume":"15","author":"Abdul Kareem","year":"2021","journal-title":"Biologics"},{"key":"10.1016\/j.burns.2026.108177_bib17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-1-4939-7799-4_13","article-title":"Isolation of human adipose-derived stem cells from lipoaspirates","volume":"1773","author":"Li","year":"2018","journal-title":"Methods Mol Biol"},{"issue":"2","key":"10.1016\/j.burns.2026.108177_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ymeth.2008.03.006","article-title":"Adipose-derived stem cells: isolation, expansion and differentiation","volume":"45","author":"Bunnell","year":"2008","journal-title":"Methods"},{"key":"10.1016\/j.burns.2026.108177_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/jbcr\/iraf005","article-title":"A pilot study on the impact of smoking on adipose derived stem cell function in burn patients","author":"Deville","year":"2025","journal-title":"J Burn Care Res"},{"issue":"6","key":"10.1016\/j.burns.2026.108177_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18061167","article-title":"Implications of extracellular matrix production by adipose tissue-derived stem cells for development of wound healing therapies","volume":"18","author":"Hyldig","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.burns.2026.108177_bib21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/SHK.0000000000000294","article-title":"Predictive value of IL-8 for sepsis and severe infections after burn injury: a clinical study","volume":"43","author":"Kraft","year":"2015","journal-title":"Shock"},{"issue":"5","key":"10.1016\/j.burns.2026.108177_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197744","article-title":"Autologous and not allogeneic adipose-derived stem cells improve acute burn wound healing","volume":"13","author":"Chang","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.burns.2026.108177_bib23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2121-14-34","article-title":"Body mass index affects proliferation and osteogenic differentiation of human subcutaneous adipose tissue-derived stem cells","volume":"14","author":"Frazier","year":"2013","journal-title":"BMC Cell Biol"},{"issue":"11-12","key":"10.1016\/j.burns.2026.108177_bib24","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1089\/ten.tea.2020.0320","article-title":"Adipose-derived stromal cells seeded in pullulan-collagen hydrogels improve healing in murine burns","volume":"27","author":"Barrera","year":"2021","journal-title":"Tissue Eng Part A"},{"issue":"1","key":"10.1016\/j.burns.2026.108177_bib25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/BCR.0b013e3182642c0e","article-title":"Bilayer hydrogel with autologous stem cells derived from debrided human burn skin for improved skin regeneration","volume":"34","author":"Natesan","year":"2013","journal-title":"J Burn Care Res"},{"issue":"12","key":"10.1016\/j.burns.2026.108177_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/polym12122997","article-title":"Enzyme-crosslinked gelatin hydrogel with adipose-derived stem cell spheroid facilitating wound repair in the murine burn model","volume":"12","author":"Lu","year":"2020","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.burns.2026.108177_bib27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.actbio.2020.03.040","article-title":"Conformable hyaluronic acid hydrogel delivers adipose-derived stem cells and promotes regeneration of burn injury","volume":"108","author":"Dong","year":"2020","journal-title":"Acta Biomater"},{"issue":"7","key":"10.1016\/j.burns.2026.108177_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202202309","article-title":"Zwitterionic polysaccharide-based hydrogel dressing as a stem cell carrier to accelerate burn wound healing","volume":"12","author":"Yu","year":"2023","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.burns.2026.108177_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/841203","article-title":"Development of a vascularized skin construct using adipose-derived stem cells from debrided burned skin","volume":"2012","author":"Chan","year":"2012","journal-title":"Stem Cells Int"},{"issue":"2","key":"10.1016\/j.burns.2026.108177_bib30","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1056\/NEJMc1600188","article-title":"Glioproliferative lesion of the spinal cord as a complication of \"stem-cell tourism\"","volume":"375","author":"Berkowitz","year":"2016","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.burns.2026.108177_bib31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13287-023-03287-7","article-title":"Mesenchymal stromal\/stem cell (MSC)-derived exosomes in clinical trials","volume":"14","author":"Lotfy","year":"2023","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10.1016\/j.burns.2026.108177_bib32","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13287-021-02697-9","article-title":"The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review","volume":"13","author":"Bian","year":"2022","journal-title":"Stem Cell Res Ther"},{"issue":"9","key":"10.1016\/j.burns.2026.108177_bib33","doi-asserted-by":"crossref","first-page":"10279","DOI":"10.1021\/acsnano.9b03656","article-title":"Efficient angiogenesis-based diabetic wound healing\/skin reconstruction through bioactive antibacterial adhesive ultraviolet shielding nanodressing with exosome release","volume":"13","author":"Wang","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.burns.2026.108177_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2023.156175","article-title":"A therapeutic role of exosomal lncRNA H19 from adipose mesenchymal stem cells in cutaneous wound healing by triggering macrophage M2 polarization","volume":"165","author":"Li","year":"2023","journal-title":"Cytokine"},{"key":"10.1016\/j.burns.2026.108177_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101858","article-title":"The effectiveness of cell-derived exosome therapy for diabetic wound: a systematic review and meta-analysis","volume":"85","author":"Qiao","year":"2023","journal-title":"Ageing Res Rev"},{"issue":"30","key":"10.1016\/j.burns.2026.108177_bib36","article-title":"Adipose-derived mesenchymal stem cell-derived exosomes biopotentiated extracellular matrix hydrogels accelerate diabetic wound healing and skin regeneration","volume":"10","author":"Song","year":"2023","journal-title":"Adv Sci (Weinh)"},{"issue":"4","key":"10.1016\/j.burns.2026.108177_bib37","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1089\/ten.teb.2017.0061","article-title":"The adipose stromal vascular fraction as a complex cellular source for tissue engineering applications","volume":"24","author":"Ramakrishnan","year":"2018","journal-title":"Tissue Eng Part B Rev"},{"issue":"5","key":"10.1016\/j.burns.2026.108177_bib38","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s13577-022-00743-z","article-title":"Adipose stromal vascular fraction: a promising treatment for severe burn injury","volume":"35","author":"Fakiha","year":"2022","journal-title":"Hum Cell"},{"issue":"7","key":"10.1016\/j.burns.2026.108177_bib39","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1089\/wound.2015.0672","article-title":"Adipose-derived regenerative cell therapy for burn wound healing: a comparison of two delivery methods","volume":"5","author":"Foubert","year":"2016","journal-title":"Adv Wound Care (New Roche lle)"},{"issue":"7","key":"10.1016\/j.burns.2026.108177_bib40","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.burns.2014.01.023","article-title":"Stromal vascular fraction improves deep partial thickness burn wound healing","volume":"40","author":"Atalay","year":"2014","journal-title":"Burns"},{"issue":"1-6","key":"10.1016\/j.burns.2026.108177_bib41","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1080\/2000656X.2021.1993234","article-title":"Efficacy of stromal vascular fraction and enzyme-free mechanical isolation therapy in experimental full thickness burn wounds","volume":"57","author":"Karakol","year":"2023","journal-title":"J Plast Surg Hand Surg"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417926003293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417926003293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:29:02Z","timestamp":1792081742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417926003293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S0305417926003293"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2026.108177","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adipose-derived stem cells secrete pro- and anti-inflammatory cytokines after major burn injury","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2026.108177","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd and ISBI. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108177"}}