{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:59:16Z","timestamp":1792083556413,"version":"4.4.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L2510087"],"award-info":[{"award-number":["L2510087"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.burns.2026.108188","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:08:09Z","timestamp":1787587689000},"page":"108188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term neurological outcomes of burn injury and the potential mediating role of plasma metabolite profiles and brain structural alterations: A prospective cohort study"],"prefix":"10.1016","volume":"52","author":[{"given":"Rui","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.burns.2026.108188_bib1","doi-asserted-by":"crossref","first-page":"e469","DOI":"10.1097\/BCR.0000000000000355","article-title":"Burns: Pathophysiology of Systemic Complications and Current Management","volume":"38","author":"Nielson","year":"2017","journal-title":"J Burn Care & Res Publ Am Burn Assoc"},{"key":"10.1016\/j.burns.2026.108188_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","article-title":"Burn injury","volume":"6","author":"Jeschke","year":"2020","journal-title":"Nat Rev Dis Prim"},{"key":"10.1016\/j.burns.2026.108188_bib3","doi-asserted-by":"crossref","first-page":"tkad037","DOI":"10.1093\/burnst\/tkad037","article-title":"The impact of burn injury on the central nervous system","volume":"12","author":"Allahham","year":"2024","journal-title":"Burns Trauma"},{"key":"10.1016\/j.burns.2026.108188_bib4","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkac061","article-title":"Pathological changes in the brain after peripheral burns","volume":"11","author":"Chen","year":"2023","journal-title":"Burns Trauma"},{"key":"10.1016\/j.burns.2026.108188_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-012668","article-title":"Burn injury and long-term nervous system morbidity: a population-based cohort study","volume":"6","author":"Vetrichevvel","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.burns.2026.108188_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jocn.2018.10.089","article-title":"Neurocognitive sequela of burn injury in the elderly","volume":"59","author":"Esechie","year":"2019","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.burns.2026.108188_bib7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.pmr.2011.01.003","article-title":"Neurologic and musculoskeletal complications of burn injuries","volume":"22","author":"Schneider","year":"2011","journal-title":"Phys Med Rehabil Clin"},{"key":"10.1016\/j.burns.2026.108188_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1451371","article-title":"Metabolic response to burn injury: a comprehensive bibliometric study","volume":"11","author":"Li","year":"2025","journal-title":"Front Med"},{"key":"10.1016\/j.burns.2026.108188_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021245","article-title":"Long-term persistance of the pathophysiologic response to severe burn injury","volume":"6","author":"Jeschke","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.burns.2026.108188_bib10","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/S0140-6736(04)16360-5","article-title":"Support of the metabolic response to burn injury","volume":"363","author":"Herndon","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.burns.2026.108188_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpsurg.2019.100709","article-title":"Current problems in burn hypermetabolism","volume":"57","author":"Sommerhalder","year":"2020","journal-title":"Curr Probl Surg"},{"key":"10.1016\/j.burns.2026.108188_bib12","series-title":"Metabolic Phenotyping the Acute Phase of Burn Injury in Children","author":"Scott","year":"2025"},{"key":"10.1016\/j.burns.2026.108188_bib13","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkae007","article-title":"1H-nuclear magnetic resonance analysis reveals dynamic changes in the metabolic profile of patients with severe burns","volume":"12","author":"Su","year":"2024","journal-title":"Burns Trauma"},{"key":"10.1016\/j.burns.2026.108188_bib14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibtech.2004.03.007","article-title":"Metabolomics by numbers: acquiring and understanding global metabolite data","volume":"22","author":"Goodacre","year":"2004","journal-title":"TRENDS Biotechnol"},{"key":"10.1016\/j.burns.2026.108188_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.burns.2026.108188_bib16","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.burns.2018.06.006","article-title":"Burn induced nervous system morbidity among burn and non-burn trauma patients compared with non-injured people","volume":"45","author":"Duke","year":"2019","journal-title":"Burns"},{"key":"10.1016\/j.burns.2026.108188_bib17","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/jbcr\/irae187","article-title":"Long-term Physical and Mental Health Outcomes of Older Adults Following a Major Burn Injury: A Burn Model System Investigation","volume":"46","author":"Hong","year":"2025","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.burns.2026.108188_bib18","article-title":"Neuropsychiatric Disorders and Burn Trauma: Insights From a Tertiary Care Hospital","volume":"16","author":"Ahmad","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.burns.2026.108188_bib19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jss.2024.09.086","article-title":"Neurologic Complications Associated With Burn Injury and Resuscitation","volume":"304","author":"Kenney","year":"2024","journal-title":"J Surg Res"},{"key":"10.1016\/j.burns.2026.108188_bib20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1161\/CIRCGENETICS.114.000216","article-title":"Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics","volume":"8","author":"Soininen","year":"2015","journal-title":"Circulation Cardiovascular Genetics"},{"key":"10.1016\/j.burns.2026.108188_bib21","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1093\/aje\/kwx016","article-title":"Quantitative serum nuclear magnetic resonance metabolomics in large-scale epidemiology: a primer on-omic technologies","volume":"186","author":"W\u00fcrtz","year":"2017","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.burns.2026.108188_bib22","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.neuroimage.2017.10.034","article-title":"Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank","volume":"166","author":"Alfaro-Almagro","year":"2018","journal-title":"Neuroimage"},{"key":"10.1016\/j.burns.2026.108188_bib23","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/nn.4393","article-title":"Multimodal population brain imaging in the UK Biobank prospective epidemiological study","volume":"19","author":"Miller","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.burns.2026.108188_bib24","doi-asserted-by":"crossref","first-page":"tkad007","DOI":"10.1093\/burnst\/tkad007","article-title":"Current understanding of the chronic stress response to burn injury from human studies","volume":"11","author":"Osborne","year":"2023","journal-title":"Burns Trauma"},{"key":"10.1016\/j.burns.2026.108188_bib25","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1021\/acs.jproteome.3c00516","article-title":"Nonsevere burn induces a prolonged systemic metabolic phenotype indicative of a persistent inflammatory response postinjury","volume":"23","author":"Ryan","year":"2023","journal-title":"J Proteome Res"},{"key":"10.1016\/j.burns.2026.108188_bib26","doi-asserted-by":"crossref","DOI":"10.1186\/cc13999","article-title":"Use of 1H-nuclear magnetic resonance to screen a set of biomarkers for monitoring metabolic disturbances in severe burn patients","volume":"18","author":"Zhang","year":"2014","journal-title":"Crit care"},{"key":"10.1016\/j.burns.2026.108188_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1105163","article-title":"Cardiometabolic disease risk markers are increased following burn injury in children","volume":"11","author":"Begum","year":"2023","journal-title":"Front Public Health"},{"key":"10.1016\/j.burns.2026.108188_bib28","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1016\/j.bbadis.2017.02.019","article-title":"The biochemical alterations underlying post-burn hypermetabolism","volume":"1863","author":"Auger","year":"2017","journal-title":"Biochim Et Biophys Acta (bba)-Mol basis Dis"},{"key":"10.1016\/j.burns.2026.108188_bib29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/cc7794","article-title":"Bench-to-bedside review: burn-induced cerebral inflammation\u2013a neglected entity?","volume":"13","author":"Flierl","year":"2009","journal-title":"Crit care"},{"key":"10.1016\/j.burns.2026.108188_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/ams2.976","article-title":"Systemic immune response of burns from the acute to chronic phase","volume":"11","author":"Osuka","year":"2024","journal-title":"Acute Med Surg"},{"key":"10.1016\/j.burns.2026.108188_bib31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrcardio.2015.124","article-title":"Dysfunctional HDL and atherosclerotic cardiovascular disease","volume":"13","author":"Rosenson","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.burns.2026.108188_bib32","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.addr.2020.01.004","article-title":"Fatty acid metabolism in the progression and resolution of CNS disorders","volume":"159","author":"Bogie","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.burns.2026.108188_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2022.111975","article-title":"Cutaneous burn injury induces neuroinflammation and reactive astrocyte activation in the hippocampus of aged mice","volume":"169","author":"Walrath","year":"2022","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.burns.2026.108188_bib34","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.3390\/ijms19082195","article-title":"Early hyperbaric oxygen treatment attenuates burn-induced neuroinflammation by inhibiting the galectin-3-dependent toll-like receptor-4 pathway in a rat model","volume":"19","author":"Wu","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.burns.2026.108188_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1368905","article-title":"Non-severe thermal burn injuries induce long-lasting downregulation of gene expression in cortical excitatory neurons and microglia","volume":"17","author":"Ong","year":"2024","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.burns.2026.108188_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/jcsm.13755","article-title":"Activated Microglia Mediate the Motor Neuron-, Synaptic Denervation-and Muscle Wasting-Changes in Burn Injured Mice","volume":"16","author":"Chen","year":"2025","journal-title":"J Cachex-- Sarcopenia Muscle"},{"key":"10.1016\/j.burns.2026.108188_bib37","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/SHK.0000000000002202","article-title":"Remote burn injury in aged mice induces colonic lymphoid aggregate expansion and dysbiosis of the fecal microbiome which correlates with neuroinflammation","volume":"60","author":"Walrath","year":"2023","journal-title":"Shock"},{"key":"10.1016\/j.burns.2026.108188_bib38","unstructured":"Allahham A. The Effect of Burn Injuries on The Brain: The University of Western Australia; 2024."},{"key":"10.1016\/j.burns.2026.108188_bib39","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/340936","article-title":"Association between peripheral oxidative stress and white matter damage in acute traumatic brain injury","volume":"2014","author":"Lin","year":"2014","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.burns.2026.108188_bib40","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1089\/neu.2019.6890","article-title":"Damage mechanisms to oligodendrocytes and white matter in central nervous system injury: the Australian context","volume":"37","author":"Warnock","year":"2020","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.burns.2026.108188_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114444","article-title":"Ebselen alleviates white matter lesions and improves cognitive deficits by attenuating oxidative stress via Keap1\/Nrf2 pathway in chronic cerebral hypoperfusion mice","volume":"448","author":"Dong","year":"2023","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.burns.2026.108188_bib42","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.neuroimage.2014.09.042","article-title":"Regional brain shrinkage over two years: individual differences and effects of pro-inflammatory genetic polymorphisms","volume":"103","author":"Persson","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.burns.2026.108188_bib43","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jad.2023.12.071","article-title":"The effect of inflammation markers on cortical thinning in major depressive disorder: A possible mediator of depression and cortical changes","volume":"348","author":"Kang","year":"2024","journal-title":"J Affect Disord"},{"key":"10.1016\/j.burns.2026.108188_bib44","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/j.burns.2024.05.008","article-title":"Perioperative research into memory (PRiMe), part 2: Adult burns intensive care patients show altered structure and function of the default mode network","volume":"50","author":"O\u2019Connor","year":"2024","journal-title":"Burns"},{"key":"10.1016\/j.burns.2026.108188_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.burns.2024.107305","article-title":"Altered resting-state functional brain activity in patients with chronic post-burn pruritus","volume":"51","author":"Lu","year":"2025","journal-title":"Burns"},{"key":"10.1016\/j.burns.2026.108188_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2025.1629878","article-title":"Gray matter volume microstructural alterations in chronic post-burn pruritus: a voxel-based morphometry analysis using 3D T1-weighted imaging","volume":"19","author":"Lu","year":"2025","journal-title":"Front Neurosci"},{"key":"10.1016\/j.burns.2026.108188_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurad.2025.101323","article-title":"Experimental study on the mechanism of cerebral edema development and MM-MRI manifestation in burned rats","volume":"52","author":"Usman","year":"2025","journal-title":"J Neuroradiol"},{"key":"10.1016\/j.burns.2026.108188_bib48","article-title":"Posterior reversible encephalopathy syndrome in a child after burns: A case report and literature review","volume":"11","author":"He","year":"2023","journal-title":"SAGE Open Med Case Rep"},{"key":"10.1016\/j.burns.2026.108188_bib49","article-title":"Posterior Reversible Encephalopathy Syndrome in a Pediatric Burn Patient: A Case Report","volume":"17","author":"Shouri","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.burns.2026.108188_bib50","article-title":"Frontal Lobe Thermal Injury Mimicking Cerebritis On Imaging","author":"Leon","year":"2025","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.burns.2026.108188_bib51","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1093\/jbcr\/irad111","article-title":"Fungal brain abscess in a severely burned patient","volume":"44","author":"Stevens","year":"2023","journal-title":"J Burn Care Res"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417926003402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417926003402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:28:00Z","timestamp":1792081680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417926003402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S0305417926003402"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2026.108188","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term neurological outcomes of burn injury and the potential mediating role of plasma metabolite profiles and brain structural alterations: A prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2026.108188","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd and ISBI. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108188"}}