{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:41:13Z","timestamp":1783514473301,"version":"3.55.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/20\/12\/34982"],"award-info":[{"award-number":["PG\/20\/12\/34982"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Vessels, Thrombosis & Hemostasis"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.bvth.2024.100007","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T06:10:28Z","timestamp":1714457428000},"page":"100007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["A multicellular vessel-on-a-chip model reveals context-dependent roles for platelets in inflammation and inflammatory hemostasis"],"prefix":"10.1016","volume":"1","author":[{"given":"Rebecca B.","family":"Riddle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1254-5158","authenticated-orcid":false,"given":"Karin","family":"Jennbacken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny M.","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4740-637X","authenticated-orcid":false,"given":"Matthew T.","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bvth.2024.100007_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-pathol-020712-164023","article-title":"The multifaceted functions of neutrophils","volume":"9","author":"Mayadas","year":"2014","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.bvth.2024.100007_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.666732","article-title":"Phagocytosis, degranulation and extracellular traps release by neutrophils\u2014the current knowledge, pharmacological modulation and future prospects","volume":"12","author":"Gierlikowska","year":"2021","journal-title":"Front Pharmacol"},{"issue":"6","key":"10.1016\/j.bvth.2024.100007_bib3","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.bvth.2024.100007_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-05800-6","article-title":"Resolution of chronic inflammatory disease: universal and tissue-specific concepts","volume":"9","author":"Schett","year":"2018","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.bvth.2024.100007_bib5","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J\u00a0Immunol"},{"issue":"5","key":"10.1016\/j.bvth.2024.100007_bib6","first-page":"433","article-title":"Differences in innate immune response between man and mouse","volume":"34","author":"Zschaler","year":"2014","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.bvth.2024.100007_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2020.00033","article-title":"Is it time to start transitioning from 2D to 3D cell culture?","volume":"7","author":"Jensen","year":"2020","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.bvth.2024.100007_bib8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41573-020-0079-3","article-title":"Tagle DA Organs-on-chips: into the next decade","volume":"20","author":"Low","year":"2020","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"10.1016\/j.bvth.2024.100007_bib9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.tips.2020.11.009","article-title":"Organ-on-a-chip: a new paradigm for drug development","volume":"42","author":"Ma","year":"2021","journal-title":"Trends Pharmacol Sci"},{"issue":"5986","key":"10.1016\/j.bvth.2024.100007_bib10","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1126\/science.1188302","article-title":"Reconstituting organ-level lung functions on a chip","volume":"328","author":"Huh","year":"2010","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bvth.2024.100007_bib11","doi-asserted-by":"crossref","first-page":"6855","DOI":"10.1038\/s41598-022-10849-x","article-title":"Endothelial inflammation and neutrophil transmigration are modulated by extracellular matrix composition in an inflammation-on-a-chip model","volume":"12","author":"Riddle","year":"2022","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.bvth.2024.100007_bib12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/09537104.2016.1240766","article-title":"Platelet secretion in inflammatory and infectious diseases","volume":"28","author":"Manne","year":"2017","journal-title":"Platelets"},{"issue":"1","key":"10.1016\/j.bvth.2024.100007_bib13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2353\/ajpath.2010.081117","article-title":"Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction","volume":"176","author":"Hara","year":"2010","journal-title":"Am J Pathol"},{"issue":"4","key":"10.1016\/j.bvth.2024.100007_bib14","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1097\/CCM.0b013e31819ceb71","article-title":"Platelets support pulmonary recruitment of neutrophils in abdominal sepsis","volume":"37","author":"Asaduzzaman","year":"2009","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.bvth.2024.100007_bib15","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1182\/blood-2012-02-413047","article-title":"Platelets can enhance vascular permeability","volume":"120","author":"Cloutier","year":"2012","journal-title":"Blood"},{"issue":"39","key":"10.1016\/j.bvth.2024.100007_bib16","doi-asserted-by":"crossref","first-page":"24316","DOI":"10.1073\/pnas.2007642117","article-title":"Hemostasis vs. homeostasis: platelets are essential for preserving vascular barrier function in the absence of injury or inflammation","volume":"117","author":"Gupta","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.bvth.2024.100007_bib17","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1084\/jem.20142076","article-title":"Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia","volume":"212","author":"Hillgruber","year":"2015","journal-title":"J\u00a0Exp Med"},{"issue":"16","key":"10.1016\/j.bvth.2024.100007_bib18","doi-asserted-by":"crossref","first-page":"6851","DOI":"10.1158\/0008-5472.CAN-08-0718","article-title":"Platelet granule secretion continuously prevents intratumor hemorrhage","volume":"68","author":"Ho-Tin-No\u00e9","year":"2008","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.bvth.2024.100007_bib19","first-page":"908","article-title":"Platelet ITAM signaling is critical for vascular integrity in inflammation","volume":"123","author":"Boulaftali","year":"2013","journal-title":"J\u00a0Clin Invest"},{"issue":"4","key":"10.1016\/j.bvth.2024.100007_bib20","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.2353\/ajpath.2009.090460","article-title":"Innate immune cells induce hemorrhage in tumors during thrombocytopenia","volume":"175","author":"Ho-Tin-No\u00e9","year":"2009","journal-title":"Am J Pathol"},{"issue":"6","key":"10.1016\/j.bvth.2024.100007_bib21","doi-asserted-by":"crossref","first-page":"e256","DOI":"10.3324\/haematol.2017.182162","article-title":"The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent","volume":"103","author":"Rayes","year":"2018","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.bvth.2024.100007_bib22","doi-asserted-by":"crossref","first-page":"4958","DOI":"10.1182\/blood-2007-11-123620","article-title":"Inflammation induces hemorrhage in thrombocytopenia","volume":"111","author":"Goerge","year":"2008","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.bvth.2024.100007_bib23","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1182\/blood-2014-12-617159","article-title":"Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice","volume":"126","author":"Gros","year":"2015","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.bvth.2024.100007_bib24","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1182\/blood-2016-12-750711","article-title":"Platelet secretion is crucial to prevent bleeding in the ischemic brain but not in the inflamed skin or lung in mice","volume":"129","author":"Deppermann","year":"2017","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bvth.2024.100007_bib25","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1038\/srep01932","article-title":"Intravital analysis of vascular permeability in mice using two-photon microscopy","volume":"3","author":"Egawa","year":"2013","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.bvth.2024.100007_bib26","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1182\/blood-2011-08-376822","article-title":"Platelets support a protective immune response to LCMV by preventing splenic necrosis","volume":"121","author":"Loria","year":"2013","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.bvth.2024.100007_bib27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/ajh.21321","article-title":"Petechial bleeding after sunburn in a patient with mild thrombocytopenia","volume":"84","author":"Carbo","year":"2009","journal-title":"Am J Hematol"},{"issue":"2","key":"10.1016\/j.bvth.2024.100007_bib28","first-page":"197","article-title":"Significance of periodontal health in primary immune thrombocytopenia- a case report and review of literature","volume":"10","author":"Sangwan","year":"2013","journal-title":"J\u00a0Dent"},{"issue":"4","key":"10.1016\/j.bvth.2024.100007_bib29","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1073\/pnas.0510412103","article-title":"Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage","volume":"103","author":"Kisucka","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.bvth.2024.100007_bib30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/1471-2407-14-167","article-title":"Presence of intratumoral platelets is associated with tumor vessel structure and metastasis","volume":"14","author":"Li","year":"2014","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.bvth.2024.100007_bib31","doi-asserted-by":"crossref","first-page":"9987","DOI":"10.1038\/s41598-018-28363-4","article-title":"Lipid rafts are essential for release of phosphatidylserine-exposing extracellular vesicles from platelets","volume":"8","author":"Wei","year":"2018","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.bvth.2024.100007_bib32","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"4","key":"10.1016\/j.bvth.2024.100007_bib33","doi-asserted-by":"crossref","first-page":"C848","DOI":"10.1152\/ajpcell.00520.2008","article-title":"Dynamics of neutrophil extravasation and vascular permeability are uncoupled during aseptic cutaneous wounding","volume":"296","author":"Kim","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"issue":"9","key":"10.1016\/j.bvth.2024.100007_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025109","article-title":"The use of spinning-disk confocal microscopy for the intravital analysis of platelet dynamics in response to systemic and local inflammation","volume":"6","author":"Jenne","year":"2011","journal-title":"PLoS One"},{"issue":"4 pt 2","key":"10.1016\/j.bvth.2024.100007_bib35","first-page":"H763","article-title":"Role of platelets in maintenance of pulmonary vascular permeability to protein","volume":"254","author":"Lo","year":"1988","journal-title":"Am J Physiol"},{"issue":"4","key":"10.1016\/j.bvth.2024.100007_bib36","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1182\/blood.V46.4.567.567","article-title":"Ultrastructural changes of endothelium associated with thrombocytopenia","volume":"46","author":"Kitchens","year":"1975","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.bvth.2024.100007_bib37","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/s41374-021-00593-7","article-title":"Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice","volume":"101","author":"Retamal","year":"2021","journal-title":"Lab Invest"},{"issue":"4","key":"10.1016\/j.bvth.2024.100007_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202002228","article-title":"ICAM-1 activates platelets and promotes endothelial permeability through VE-cadherin after insufficient radiofrequency ablation","volume":"8","author":"Kong","year":"2021","journal-title":"Adv Sci"},{"issue":"7","key":"10.1016\/j.bvth.2024.100007_bib39","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1084\/jem.20132413","article-title":"Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF","volume":"211","author":"Finsterbusch","year":"2014","journal-title":"J Exp Med"},{"issue":"11","key":"10.1016\/j.bvth.2024.100007_bib40","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.it.2009.07.012","article-title":"Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability","volume":"30","author":"DiStasi","year":"2009","journal-title":"Trends Immunol"},{"issue":"2","key":"10.1016\/j.bvth.2024.100007_bib41","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1096\/fj.201801329R","article-title":"Neutrophils engage the kallikrein-kinin system to open up the endothelial barrier in acute inflammation","volume":"33","author":"Kenne","year":"2019","journal-title":"FASEB J"},{"issue":"112","key":"10.1016\/j.bvth.2024.100007_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002761","article-title":"Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration","volume":"3","author":"Huynh","year":"2011","journal-title":"Sci Transl Med"},{"issue":"5","key":"10.1016\/j.bvth.2024.100007_bib43","doi-asserted-by":"crossref","DOI":"10.1063\/5.0061997","article-title":"Microfluidic model of monocyte extravasation reveals the role of hemodynamics and subendothelial matrix mechanics in regulating endothelial integrity","volume":"15","author":"P\u00e9rez-Rodr\u00edguez","year":"2021","journal-title":"Biomicrofluidics"},{"issue":"19","key":"10.1016\/j.bvth.2024.100007_bib44","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1039\/D0BM01349H","article-title":"Substrate stiffness induced mechanotransduction regulates temporal evolution of human fetal neural progenitor cell phenotype, differentiation, and biomechanics","volume":"8","author":"Kothapalli","year":"2020","journal-title":"Biomater Sci"},{"issue":"3","key":"10.1016\/j.bvth.2024.100007_bib45","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ccr.2005.08.010","article-title":"Tensional homeostasis and the malignant phenotype","volume":"8","author":"Paszek","year":"2005","journal-title":"Cancer Cell"},{"issue":"15","key":"10.1016\/j.bvth.2024.100007_bib46","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1111\/bph.14711","article-title":"Histidine-rich glycoprotein ameliorates endothelial barrier dysfunction through regulation of NF-\u03baB and MAPK signal pathway","volume":"176","author":"Gao","year":"2019","journal-title":"Br J Pharmacol"},{"issue":"10","key":"10.1016\/j.bvth.2024.100007_bib47","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00018-022-04560-3","article-title":"p73 is required for vessel integrity controlling endothelial junctional dynamics through Angiomotin","volume":"79","author":"Maeso-Alonso","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.bvth.2024.100007_bib48","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jcis.2021.03.053","article-title":"A\u00a0permeable on-chip microvasculature for assessing the transport of macromolecules and polymeric nanoconstructs","volume":"594","author":"Barbato","year":"2021","journal-title":"J\u00a0Colloid Interface Sci"},{"issue":"6","key":"10.1016\/j.bvth.2024.100007_bib49","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.2353\/ajpath.2007.060881","article-title":"The role of platelets in leukocyte recruitment in chronic contact hypersensitivity induced by repeated elicitation","volume":"170","author":"Tamagawa-Mineoka","year":"2007","journal-title":"Am J Pathol"},{"issue":"12","key":"10.1016\/j.bvth.2024.100007_bib50","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1172\/JCI29499","article-title":"Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation","volume":"116","author":"Zarbock","year":"2006","journal-title":"J\u00a0Clin Invest"},{"issue":"11","key":"10.1016\/j.bvth.2024.100007_bib51","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.4049\/jimmunol.176.11.6991","article-title":"Leukocyte recruitment to the inflamed glomerulus: a critical role for platelet-derived P-selectin in the absence of rolling","volume":"176","author":"Kuligowski","year":"2006","journal-title":"J\u00a0Immunol"},{"issue":"5","key":"10.1016\/j.bvth.2024.100007_bib52","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1002\/hep.28003","article-title":"Imaging the dynamic platelet-neutrophil response in sterile liver injury and repair in mice","volume":"62","author":"Slaba","year":"2015","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.bvth.2024.100007_bib53","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nm.1939","article-title":"Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury","volume":"154","author":"Hidalgo","year":"2009","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.bvth.2024.100007_bib54","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/1523-1747.ep12286444","article-title":"Platelets play a role in the pathogenesis of the irritant reaction in mice","volume":"108","author":"Senaldi","year":"1997","journal-title":"J\u00a0Invest Dermatol"},{"issue":"5","key":"10.1016\/j.bvth.2024.100007_bib55","doi-asserted-by":"crossref","first-page":"G1054","DOI":"10.1152\/ajpgi.00350.2007","article-title":"Mechanisms of platelet and leukocyte recruitment in experimental colitis","volume":"293","author":"Vowinkel","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"25","key":"10.1016\/j.bvth.2024.100007_bib56","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1182\/blood.2018877043","article-title":"Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice","volume":"133","author":"Volz","year":"2019","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bvth.2024.100007_bib57","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/jth.14620","article-title":"P2X1 ion channel deficiency causes massive bleeding in inflamed intestine and increases thrombosis","volume":"18","author":"W\u00e9ra","year":"2020","journal-title":"J\u00a0Thromb Haemost"},{"issue":"3","key":"10.1016\/j.bvth.2024.100007_bib58","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1182\/bloodadvances.2018026286","article-title":"Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury","volume":"3","author":"Bain","year":"2019","journal-title":"Blood Adv"},{"issue":"8","key":"10.1016\/j.bvth.2024.100007_bib59","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1182\/blood-2017-06-788067","article-title":"Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria","volume":"131","author":"Claushuis","year":"2018","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bvth.2024.100007_bib60","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41467-018-02990-x","article-title":"A microengineered vascularized bleeding model that integrates the principal components of hemostasis","volume":"9","author":"Sakurai","year":"2018","journal-title":"Nat Commun"},{"issue":"15","key":"10.1016\/j.bvth.2024.100007_bib61","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202004889","article-title":"A human vascular injury-on-a-chip model of hemostasis","volume":"17","author":"Poventud-Fuentes","year":"2021","journal-title":"Small"},{"issue":"24","key":"10.1016\/j.bvth.2024.100007_bib62","doi-asserted-by":"crossref","first-page":"9342","DOI":"10.1073\/pnas.1201240109","article-title":"In\u00a0vitro microvessels for the study of angiogenesis and thrombosis","volume":"109","author":"Zheng","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bvth.2024.100007_bib63","doi-asserted-by":"crossref","first-page":"127170","DOI":"10.1155\/2013\/127170","article-title":"Angiogenesis and its therapeutic opportunities","volume":"2013","author":"Yoo","year":"2013","journal-title":"Mediators Inflamm"},{"issue":"2","key":"10.1016\/j.bvth.2024.100007_bib64","doi-asserted-by":"crossref","first-page":"265","DOI":"10.21037\/apm.2017.11.01","article-title":"Bleeding in cancer patients and its treatment: a review","volume":"7","author":"Johnstone","year":"2018","journal-title":"Ann Palliat Med"},{"issue":"5","key":"10.1016\/j.bvth.2024.100007_bib65","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1158\/0008-5472.CAN-10-2038","article-title":"Increased efficacy of breast cancer chemotherapy in thrombocytopenic mice","volume":"71","author":"Demers","year":"2011","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.bvth.2024.100007_bib66","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/jmi.12017","article-title":"Mammary ductal elongation and myoepithelial migration are regulated by the composition of the extracellular matrix","volume":"251","author":"Nguyen-Ngoc","year":"2013","journal-title":"J\u00a0Microsc"},{"issue":"1","key":"10.1016\/j.bvth.2024.100007_bib67","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1741-7015-4-38","article-title":"Collagen reorganization at the tumor-stromal interface facilitates local invasion","volume":"4","author":"Provenzano","year":"2006","journal-title":"BMC Med"},{"issue":"8","key":"10.1016\/j.bvth.2024.100007_bib68","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1039\/c3lc41320a","article-title":"Engineering of functional, perfusable 3D microvascular networks on a chip","volume":"13","author":"Kim","year":"2013","journal-title":"Lab Chip"},{"issue":"134","key":"10.1016\/j.bvth.2024.100007_bib69","article-title":"Perfusable vascular network with a tissue model in a microfluidic device","volume":"2018","author":"Nashimoto","year":"2018","journal-title":"J\u00a0Vis Exp"},{"issue":"7","key":"10.1016\/j.bvth.2024.100007_bib70","doi-asserted-by":"crossref","first-page":"7627","DOI":"10.1021\/acsnano.9b00686","article-title":"Microphysiological engineering of self-assembled and perfusable microvascular beds for the production of vascularized three-dimensional human microtissues","volume":"13","author":"Paek","year":"2019","journal-title":"ACS Nano"},{"issue":"17","key":"10.1016\/j.bvth.2024.100007_bib71","doi-asserted-by":"crossref","first-page":"6712","DOI":"10.1073\/pnas.1221526110","article-title":"Biomimetic model to reconstitute angiogenic sprouting morphogenesis in\u00a0vitro","volume":"110","author":"Nguyen","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.bvth.2024.100007_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-03597-w","article-title":"A\u00a0microengineered model of RBC transfusion-induced pulmonary vascular injury","volume":"7","author":"Seo","year":"2017","journal-title":"Sci Rep"},{"issue":"16","key":"10.1016\/j.bvth.2024.100007_bib73","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1039\/c2lc40131b","article-title":"In\u00a0vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devices","volume":"12","author":"Yeon","year":"2012","journal-title":"Lab Chip"}],"container-title":["Blood Vessels, Thrombosis & Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S295032722400007X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S295032722400007X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T03:20:10Z","timestamp":1755746410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S295032722400007X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":73,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S295032722400007X"],"URL":"https:\/\/doi.org\/10.1016\/j.bvth.2024.100007","relation":{},"ISSN":["2950-3272"],"issn-type":[{"value":"2950-3272","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A multicellular vessel-on-a-chip model reveals context-dependent roles for platelets in inflammation and inflammatory hemostasis","name":"articletitle","label":"Article Title"},{"value":"Blood Vessels, Thrombosis & Hemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bvth.2024.100007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by The American Society of Hematology.","name":"copyright","label":"Copyright"}],"article-number":"100007"}}