{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T02:56:39Z","timestamp":1762656999646,"version":"build-2065373602"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000241","name":"Physicians' Services Incorporated Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022104","name":"University of Western Ontario Schulich School of Medicine & Dentistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Vessels, Thrombosis & Hemostasis"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.bvth.2024.100016","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T12:19:32Z","timestamp":1719231572000},"page":"100016","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterizing the association between complement-mediated TMA\u00a0and cognitive dysfunction using MRI and neurocognitive assessment"],"prefix":"10.1016","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-4407","authenticated-orcid":false,"given":"Pauline K.","family":"Kosalka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8321-683X","authenticated-orcid":false,"given":"Fahad","family":"Hannan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2089-8650","authenticated-orcid":false,"given":"Christopher J.","family":"Patriquin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Pavenski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Jurkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro","family":"Tristao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5738-3765","authenticated-orcid":false,"given":"Adrian M.","family":"Owen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean C. L.","family":"Deoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-4469","authenticated-orcid":false,"given":"Jean","family":"Th\u00e9berge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Mandzia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6132-3020","authenticated-orcid":false,"given":"Jonathan D.","family":"Thiessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyn S.","family":"Garland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan B.","family":"McGrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Han Susan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bvth.2024.100016_bib1","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1182\/blood-2014-02-558296","article-title":"Dynamics of complement activation in aHUS and how to monitor eculizumab therapy","volume":"124","author":"Noris","year":"2014","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bvth.2024.100016_bib2","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1182\/blood-2005-10-007252","article-title":"Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome","volume":"108","author":"Caprioli","year":"2006","journal-title":"Blood"},{"issue":"23","key":"10.1016\/j.bvth.2024.100016_bib3","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1056\/NEJMoa1208981","article-title":"Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome","volume":"368","author":"Legendre","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.bvth.2024.100016_bib4","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.kint.2015.11.026","article-title":"Eculizumab is a safe and effective treatment in pediatric patients with atypical hemolytic uremic syndrome","volume":"89","author":"Greenbaum","year":"2016","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.bvth.2024.100016_bib5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1053\/j.ajkd.2015.12.034","article-title":"Terminal complement inhibitor eculizumab in adult patients with atypical hemolytic uremic syndrome: a single-arm, open-label trial","volume":"68","author":"Fakhouri","year":"2016","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"10.1016\/j.bvth.2024.100016_bib6","doi-asserted-by":"crossref","first-page":"554","DOI":"10.2215\/CJN.04760512","article-title":"Genetics and outcome of atypical hemolytic uremic syndrome: a nationwide French series comparing children and adults","volume":"8","author":"Fremeaux-Bacchi","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"issue":"6","key":"10.1016\/j.bvth.2024.100016_bib7","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/j.1537-2995.2009.02101.x","article-title":"Cognitive deficits after recovery from thrombotic thrombocytopenic purpura","volume":"49","author":"Kennedy","year":"2009","journal-title":"Transfusion"},{"issue":"8","key":"10.1016\/j.bvth.2024.100016_bib8","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ajh.24060","article-title":"Depression and cognitive impairment following recovery from thrombotic thrombocytopenic purpura","volume":"90","author":"Han","year":"2015","journal-title":"Am J Hematol"},{"issue":"1","key":"10.1016\/j.bvth.2024.100016_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00467-015-3076-8","article-title":"An international consensus approach to the management of atypical hemolytic uremic syndrome in children","volume":"31","author":"Loirat","year":"2016","journal-title":"Pediatr Nephrol"},{"issue":"6","key":"10.1016\/j.bvth.2024.100016_bib10","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/mrm.21704","article-title":"Gleaning multicomponent T1 and T2 information from steady-state imaging data","volume":"60","author":"Deoni","year":"2008","journal-title":"Magn Reson Med"},{"issue":"6","key":"10.1016\/j.bvth.2024.100016_bib11","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.neuron.2012.06.022","article-title":"Fractionating human intelligence","volume":"76","author":"Hampshire","year":"2012","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/j.bvth.2024.100016_bib12","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsy182","article-title":"Dissociable effects of self-reported daily sleep duration on high-level cognitive abilities","volume":"41","author":"Wild","year":"2018","journal-title":"Sleep"},{"key":"10.1016\/j.bvth.2024.100016_bib13","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A\u00a0new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br J Psychiatry"},{"issue":"6","key":"10.1016\/j.bvth.2024.100016_bib15","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s11910-001-0060-4","article-title":"Frontal lobe functions","volume":"1","author":"Chayer","year":"2001","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"1","key":"10.1016\/j.bvth.2024.100016_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/ENEURO.0214-18.2018","article-title":"Human verbal memory encoding is hierarchically distributed in a continuous processing stream","volume":"6","author":"Kucewicz","year":"2019","journal-title":"eNeuro"},{"year":"2020","series-title":"Chronic Neurological Impairment in Patients with Thrombotic Thrombocytopenic Purpura: Findings in Quantitative MRI. Electronic Thesis and Dissertation Repository","author":"Hamilton","key":"10.1016\/j.bvth.2024.100016_bib17"},{"issue":"5","key":"10.1016\/j.bvth.2024.100016_bib18","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/bjh.17126","article-title":"Cerebral MRI findings predict the risk of cognitive impairment in thrombotic thrombocytopenic purpura","volume":"191","author":"Alwan","year":"2020","journal-title":"Br J Haematol"},{"issue":"3","key":"10.1016\/j.bvth.2024.100016_bib19","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/bjh.19246","article-title":"Cognitive decline in survivors of immune-mediated thrombotic thrombocytopenic purpura: the role of white matter health as assessed by myelin water imaging","volume":"204","author":"Hannan","year":"2024","journal-title":"Br J Haematol"},{"issue":"2","key":"10.1016\/j.bvth.2024.100016_bib20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/mrm.1910170212","article-title":"In\u00a0vivo brain water determination by T1 measurements: effect of total water content, hydration fraction, and field strength","volume":"17","author":"Fatouros","year":"1991","journal-title":"Magn Reson Med"},{"issue":"pt 2","key":"10.1016\/j.bvth.2024.100016_bib21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.neuroimage.2013.06.005","article-title":"Using high-resolution quantitative mapping of R1 as an index of cortical myelination","volume":"93","author":"Lutti","year":"2014","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.bvth.2024.100016_bib22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/RMR.0b013e31821e56d8","article-title":"Quantitative relaxometry of the brain","volume":"21","author":"Deoni","year":"2010","journal-title":"Top Magn Reson Imaging"},{"issue":"5","key":"10.1016\/j.bvth.2024.100016_bib23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/nbm.951","article-title":"MR properties of excised neural tissue following experimentally induced demyelination","volume":"18","author":"Odrobina","year":"2005","journal-title":"NMR Biomed"},{"issue":"3","key":"10.1016\/j.bvth.2024.100016_bib24","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/mrm.20008","article-title":"MR properties of excised neural tissue following experimentally induced inflammation","volume":"51","author":"Stanisz","year":"2004","journal-title":"Magn Reson Med"},{"issue":"5","key":"10.1016\/j.bvth.2024.100016_bib25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S1076-6332(05)80335-6","article-title":"In\u00a0vivo characterization of cytotoxic intracellular edema by multicomponent analysis of transverse magnetization decay curves","volume":"2","author":"Kleine","year":"1995","journal-title":"Acad Radiol"},{"issue":"8","key":"10.1016\/j.bvth.2024.100016_bib26","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/dmcn.12161","article-title":"Brain magnetic resonance imaging pattern and outcome in children with haemolytic-uraemic syndrome and neurological impairment treated with eculizumab","volume":"55","author":"Gitiaux","year":"2013","journal-title":"Dev Med Child Neurol"},{"issue":"1","key":"10.1016\/j.bvth.2024.100016_bib27","first-page":"32","article-title":"Chronic neurological complications in hemolytic uremic syndrome in children","volume":"13","author":"Tavasoli","year":"2019","journal-title":"Iran J Kidney Dis"},{"issue":"5","key":"10.1016\/j.bvth.2024.100016_bib28","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3174\/ajnr.A3336","article-title":"Central nervous system involvement in adults with epidemic hemolytic uremic syndrome","volume":"34","author":"Wengenroth","year":"2013","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.bvth.2024.100016_bib29","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neubiorev.2016.07.024","article-title":"Adolescent brain development and depression: a case for the importance of connectivity of the anterior cingulate cortex","volume":"70","author":"Lichenstein","year":"2016","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bvth.2024.100016_bib30","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fnhum.2012.00323","article-title":"Major depressive disorder and alterations in insular cortical activity: a review of current functional magnetic imaging research","volume":"6","author":"Sliz","year":"2012","journal-title":"Front Hum Neurosci"},{"key":"10.1016\/j.bvth.2024.100016_bib31","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1471-2377-12-126","article-title":"The association between cognitive function and white matter lesion location in older adults: a systematic review","volume":"12","author":"Bolandzadeh","year":"2012","journal-title":"BMC Neurol"},{"key":"10.1016\/j.bvth.2024.100016_bib32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2377-11-29","article-title":"Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol","volume":"11","author":"van Norden","year":"2011","journal-title":"BMC Neurol"},{"issue":"7","key":"10.1016\/j.bvth.2024.100016_bib33","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/ndt\/gfx314","article-title":"Prevalence and patterns of cognitive impairment in adult hemodialysis patients: the COGNITIVE-HD study","volume":"33","author":"van Zwieten","year":"2018","journal-title":"Nephrol Dial Transplant"},{"issue":"6","key":"10.1016\/j.bvth.2024.100016_bib34","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/ki.2015.62","article-title":"Ischemic brain injury in hemodialysis patients: which is more dangerous, hypertension or intradialytic hypotension?","volume":"87","author":"McIntyre","year":"2015","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.bvth.2024.100016_bib35","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s12974-020-02024-8","article-title":"The good, the bad, and the opportunities of the complement system in neurodegenerative disease","volume":"17","author":"Schartz","year":"2020","journal-title":"J\u00a0Neuroinflammation"},{"issue":"11","key":"10.1016\/j.bvth.2024.100016_bib36","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41582-020-0400-0","article-title":"Complement in neurological disorders and emerging complement-targeted therapeutics","volume":"16","author":"Dalakas","year":"2020","journal-title":"Nat Rev Neurol"},{"issue":"20","key":"10.1016\/j.bvth.2024.100016_bib37","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1182\/bloodadvances.2021005317","article-title":"Blood-brain barrier permeability in survivors of immune-mediated thrombotic thrombocytopenic purpura: a pilot study","volume":"5","author":"Huang","year":"2021","journal-title":"Blood Adv"}],"container-title":["Blood Vessels, Thrombosis & Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327224000160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327224000160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T02:54:32Z","timestamp":1762656872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950327224000160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S2950327224000160"],"URL":"https:\/\/doi.org\/10.1016\/j.bvth.2024.100016","relation":{},"ISSN":["2950-3272"],"issn-type":[{"type":"print","value":"2950-3272"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterizing the association between complement-mediated TMA\u00a0and cognitive dysfunction using MRI and neurocognitive assessment","name":"articletitle","label":"Article Title"},{"value":"Blood Vessels, Thrombosis & Hemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bvth.2024.100016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100016"}}