{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:57:20Z","timestamp":1792223840520,"version":"4.4.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008653","name":"Canadian Society for Vascular Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Vessels, Thrombosis & Hemostasis"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.bvth.2024.100023","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T12:06:27Z","timestamp":1722600387000},"page":"100023","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy of vitamin C with Fe supplementation in patients with iron deficiency anemia: a systematic review and meta-analysis"],"prefix":"10.1016","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7087-3965","authenticated-orcid":false,"given":"Joanna","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0798-0219","authenticated-orcid":false,"given":"Luca","family":"Ramelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3625-1154","authenticated-orcid":false,"given":"Pei Ye","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7827-5827","authenticated-orcid":false,"given":"Ali","family":"Eshaghpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6615-7295","authenticated-orcid":false,"given":"Allen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Schuenemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Crowther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bvth.2024.100023_bib1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1017\/S1368980008002401","article-title":"Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005","volume":"12","author":"McLean","year":"2009","journal-title":"Publ Health Nutr"},{"issue":"1","key":"10.1016\/j.bvth.2024.100023_bib2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1182\/blood-2018-05-815944","article-title":"Iron deficiency","volume":"133","author":"Camaschella","year":"2019","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.bvth.2024.100023_bib3","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1182\/blood-2013-06-508325","article-title":"A\u00a0systematic analysis of global anemia burden from 1990 to 2010","volume":"123","author":"Kassebaum","year":"2014","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.bvth.2024.100023_bib4","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011866","article-title":"Iron deficiency anemia: a common and curable disease","volume":"3","author":"Miller","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.bvth.2024.100023_bib5","series-title":"Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity","year":"2011"},{"issue":"3","key":"10.1016\/j.bvth.2024.100023_bib6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/1756283X11398736","article-title":"Diagnosis and management of iron deficiency anemia in the 21st century","volume":"4","author":"Johnson-Wimbley","year":"2011","journal-title":"Therap Adv Gastroenterol"},{"issue":"6","key":"10.1016\/j.bvth.2024.100023_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.18773\/austprescr.2016.069","article-title":"Correcting iron deficiency","volume":"39","author":"Baird-Gunning","year":"2016","journal-title":"Aust Prescr"},{"key":"10.1016\/j.bvth.2024.100023_bib8","series-title":"Iron Supplementation","author":"Nguyen","year":"2024"},{"issue":"3","key":"10.1016\/j.bvth.2024.100023_bib9","doi-asserted-by":"crossref","first-page":"604","DOI":"10.12669\/pjms.323.9799","article-title":"Medication adherence to oral iron therapy in patients with iron deficiency anemia","volume":"32","author":"Gereklioglu","year":"2016","journal-title":"Pak J Med Sci"},{"issue":"11","key":"10.1016\/j.bvth.2024.100023_bib10","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.23644","article-title":"The efficacy and safety of vitamin C for iron supplementation in adult patients with iron deficiency anemia","volume":"3","author":"Li","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"2","key":"10.1016\/j.bvth.2024.100023_bib11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/ajcn\/30.2.235","article-title":"Vitamin C, the common cold, and iron absorption","volume":"30","author":"Cook","year":"1977","journal-title":"Am J Clin Nutr"},{"issue":"12","key":"10.1016\/j.bvth.2024.100023_bib12","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1007\/s12098-019-03068-2","article-title":"Comparison of therapeutic efficacy of ferrous ascorbate and iron polymaltose complex in iron deficiency anemia in children: a randomized controlled trial","volume":"86","author":"Patil","year":"2019","journal-title":"Indian J Pediatr"},{"issue":"10","key":"10.1016\/j.bvth.2024.100023_bib13","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1136\/gut.2010.228874","article-title":"Guidelines for the management of iron deficiency anaemia","volume":"60","author":"Goddard","year":"2011","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.bvth.2024.100023_bib14","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1136\/gutjnl-2021-325210","article-title":"British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults","volume":"70","author":"Snook","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.bvth.2024.100023_bib15","series-title":"Wiley StatsRef: Statistics Reference Online [Internet]","article-title":"Mantel\u2013Haenszel methods","author":"Landis","year":"2014"},{"issue":"71","key":"10.1016\/j.bvth.2024.100023_bib16","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Br Med J"},{"issue":"3","key":"10.1016\/j.bvth.2024.100023_bib17","first-page":"332","article-title":"The role of addition of vitamin C in iron supplementation on ferritin serum levels in anemia adolescent females","volume":"2","author":"Astuti","year":"2018","journal-title":"Health Notions"},{"issue":"1","key":"10.1016\/j.bvth.2024.100023_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.15379\/2408-9877.2015.02.01.04","article-title":"Ferrous sulfate versus ferrous fumarate plus zinc sulfate and vitamin C for treatment of iron deficiency anemia in children","volume":"2","author":"Aycicek","year":"2015","journal-title":"G\u00a0J Hematol Blood Trans"},{"issue":"1","key":"10.1016\/j.bvth.2024.100023_bib19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4103\/ijmr.IJMR_1753_18","article-title":"Comparison of efficacy & safety of iron polymaltose complex & ferrous ascorbate with ferrous sulphate in pregnant women with iron-deficiency anaemia","volume":"154","author":"Chavan","year":"2021","journal-title":"Indian J Med Res"},{"issue":"11","key":"10.1016\/j.bvth.2024.100023_bib20","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1111\/jog.14999","article-title":"A\u00a0randomized controlled trial comparing the efficacy, tolerability, and cost of oral iron preparations in iron-deficiency anemia in pregnancy","volume":"47","author":"Gamad","year":"2021","journal-title":"J\u00a0Obstet Gynaecol Res"},{"issue":"2","key":"10.1016\/j.bvth.2024.100023_bib21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.9734\/BJMMR\/2012\/900","article-title":"Comparison between ferrous ascorbate and colloidal iron in the treatment of iron deficiency anemia in children from Kolkata, India","volume":"2","author":"Ganguly","year":"2012","journal-title":"Br J Med Med Res"},{"issue":"3","key":"10.1016\/j.bvth.2024.100023_bib22","doi-asserted-by":"crossref","first-page":"066","DOI":"10.7324\/JAPS.2015.50311","article-title":"Evaluation of efficacy, safety and cost of oral and parenteral iron preparations in patients with iron deficiency anemia","volume":"5","author":"Panchal","year":"2015","journal-title":"J\u00a0Appl Pharm Sci"},{"issue":"1","key":"10.1016\/j.bvth.2024.100023_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1475-2891-9-40","article-title":"Efficacy of different strategies to treat anemia in children: a randomized clinical trial","volume":"9","author":"Rosado","year":"2010","journal-title":"Nutr J"},{"issue":"3","key":"10.1016\/j.bvth.2024.100023_bib24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5958\/2394-2754.2015.00005.3","article-title":"Comparison of various oral iron salts in the treatment of iron deficiency anemia in pregnancy","volume":"2","author":"Singhal","year":"2015","journal-title":"Ind Jour of Obstet and Gyn Res"},{"issue":"6","key":"10.1016\/j.bvth.2024.100023_bib25","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/ajcn\/74.6.791","article-title":"Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods","volume":"74","author":"Zlotkin","year":"2001","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1016\/j.bvth.2024.100023_bib26","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"355","key":"10.1016\/j.bvth.2024.100023_bib27","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.bvth.2024.100023_bib28","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1152\/japplphysiol.00505.2005","article-title":"Errors of measurement for blood volume parameters: a meta-analysis","volume":"99","author":"Gore","year":"2005","journal-title":"J\u00a0Appl Physiol"},{"issue":"1","key":"10.1016\/j.bvth.2024.100023_bib30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1749-6632.1980.tb21325.x","article-title":"Interaction of vitamin C and iron","volume":"355","author":"Lynch","year":"1980","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.bvth.2024.100023_bib31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.clnesp.2023.07.081","article-title":"Treatment efficacy of vitamin C or ascorbate given as co-intervention with iron for anemia - a systematic review and meta-analysis of experimental studies","volume":"57","author":"Loganathan","year":"2023","journal-title":"Clin Nutr ESPEN"}],"container-title":["Blood Vessels, Thrombosis & Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327224000238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327224000238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T03:21:52Z","timestamp":1755746512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950327224000238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S2950327224000238"],"URL":"https:\/\/doi.org\/10.1016\/j.bvth.2024.100023","relation":{},"ISSN":["2950-3272"],"issn-type":[{"value":"2950-3272","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of vitamin C with Fe supplementation in patients with iron deficiency anemia: a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Blood Vessels, Thrombosis & Hemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bvth.2024.100023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100023"}}