{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:00:03Z","timestamp":1786370403801,"version":"build-2736575974"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024370","name":"Governo Italiano Ministero dell&apos;Istruzione dell&apos;Universita e della Ricerca","doi-asserted-by":"publisher","award":["PRIN 2017-Z5LR5Z"],"award-info":[{"award-number":["PRIN 2017-Z5LR5Z"]}],"id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024370","name":"Governo Italiano Ministero dell&apos;Istruzione dell&apos;Universita e della Ricerca","doi-asserted-by":"publisher","award":["PRIN 2022-2022P9RM9M"],"award-info":[{"award-number":["PRIN 2022-2022P9RM9M"]}],"id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell&apos;Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Fondazione Italiana per la Ricerca sul Cancro Airc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018703","name":"European Innovation Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Vessels, Thrombosis &amp; Hemostasis"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.bvth.2025.100060","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T06:16:09Z","timestamp":1738822569000},"page":"100060","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dose-dependent effects of eltrombopag iron chelation on platelet formation"],"prefix":"10.1016","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0934-4398","authenticated-orcid":false,"given":"Elisabetta","family":"Bassi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8066-9895","authenticated-orcid":false,"given":"Vittorio","family":"Abbonante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8846-5299","authenticated-orcid":false,"given":"Hana","family":"Raslova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Bussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6472-2008","authenticated-orcid":false,"given":"Christian Andrea","family":"Di Buduo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-3693","authenticated-orcid":false,"given":"Alessandro","family":"Malara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3145-1245","authenticated-orcid":false,"given":"Alessandra","family":"Balduini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bvth.2025.100060_bib1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1136\/gut.2010.214312","article-title":"Iron sensing and signalling","volume":"61","author":"Evstatiev","year":"2012","journal-title":"Gut"},{"issue":"18","key":"10.1016\/j.bvth.2025.100060_bib2","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1182\/blood.2019002039","article-title":"Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice","volume":"134","author":"Xavier-Ferrucio","year":"2019","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.bvth.2025.100060_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1586\/17474086.2015.1010504","article-title":"Iron-induced thrombocytopenia in severe iron-deficiency anemia","volume":"8","author":"Cunha","year":"2015","journal-title":"Expert Rev Hematol"},{"issue":"1","key":"10.1016\/j.bvth.2025.100060_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/vox.12454","article-title":"Iron deficiency and thrombocytosis","volume":"112","author":"Holbro","year":"2017","journal-title":"Vox Sang"},{"issue":"17","key":"10.1016\/j.bvth.2025.100060_bib5","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1182\/blood-2016-10-740241","article-title":"Eltrombopag: a powerful chelator of cellular or extracellular iron(III) alone or combined with a second chelator","volume":"130","author":"Vlachodimitropoulou","year":"2017","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.bvth.2025.100060_bib6","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3324\/haematol.2016.146746","article-title":"Revealing eltrombopag's promotion of human megakaryopoiesis through AKT\/ERK-dependent pathway activation","volume":"101","author":"Di Buduo","year":"2016","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.bvth.2025.100060_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1182\/bloodadvances.2021004207","article-title":"Iron status influences the response of cord blood megakaryocyte progenitors to eltrombopag in vitro","volume":"6","author":"Liu","year":"2022","journal-title":"Blood Adv"},{"issue":"18","key":"10.1016\/j.bvth.2025.100060_bib8","article-title":"Bioprinting soft 3D models of hematopoiesis using natural silk fibroin-based bioink efficiently supports platelet differentiation","volume":"11","author":"Di Buduo","year":"2024","journal-title":"Adv Sci"},{"issue":"8","key":"10.1016\/j.bvth.2025.100060_bib9","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1074\/jbc.M116.751693","article-title":"The plant hormone abscisic acid is a prosurvival factor in human and murine megakaryocytes","volume":"292","author":"Malara","year":"2017","journal-title":"J Biol Chem"},{"issue":"20","key":"10.1016\/j.bvth.2025.100060_bib10","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1182\/blood-2009-05-224188","article-title":"Specific iron chelators determine the route of ferritin degradation","volume":"114","author":"De Domenico","year":"2009","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.bvth.2025.100060_bib11","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1124\/dmd.111.040170","article-title":"Metabolism and disposition of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist, in healthy human subjects","volume":"39","author":"Deng","year":"2011","journal-title":"Drug Metab Dispos"},{"issue":"6","key":"10.1016\/j.bvth.2025.100060_bib12","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1182\/blood.2020010567","article-title":"CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag","volume":"138","author":"Basso-Valentina","year":"2021","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bvth.2025.100060_bib13","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1083\/jcb.201006102","article-title":"Cytoskeletal mechanics of proplatelet maturation and platelet release","volume":"191","author":"Thon","year":"2010","journal-title":"J Cell Biol"},{"issue":"1","key":"10.1016\/j.bvth.2025.100060_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054723","article-title":"High doses of romiplostim induce proliferation and reduce proplatelet formation by human megakaryocytes","volume":"8","author":"Currao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bvth.2025.100060_bib15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3389\/fncel.2015.00381","article-title":"Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking","volume":"9","author":"Wilson","year":"2015","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"10.1016\/j.bvth.2025.100060_bib16","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.bbrc.2003.12.126","article-title":"Modulation of the redox state of tubulin by the glutathione\/glutaredoxin reductase system","volume":"314","author":"Landino","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bvth.2025.100060_bib17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2091-8-26","article-title":"Glutathionylation of beta-actin via a cysteinyl sulfenic acid intermediary","volume":"8","author":"Johansson","year":"2007","journal-title":"BMC Biochem"},{"issue":"6","key":"10.1016\/j.bvth.2025.100060_bib18","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.immuni.2012.08.017","article-title":"Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils","volume":"37","author":"Sakai","year":"2012","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.bvth.2025.100060_bib19","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1073\/pnas.0914351107","article-title":"Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis","volume":"107","author":"Hattori","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.bvth.2025.100060_bib20","doi-asserted-by":"crossref","DOI":"10.1172\/JCI149856","article-title":"Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia","volume":"132","author":"Guan","year":"2022","journal-title":"J Clin Investig"},{"issue":"22","key":"10.1016\/j.bvth.2025.100060_bib21","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1056\/NEJMoa073275","article-title":"Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura","volume":"357","author":"Bussel","year":"2007","journal-title":"N Engl J Med"},{"issue":"9664","key":"10.1016\/j.bvth.2025.100060_bib22","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0140-6736(09)60402-5","article-title":"Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial","volume":"373","author":"Bussel","year":"2009","journal-title":"Lancet"},{"issue":"458","key":"10.1016\/j.bvth.2025.100060_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aas9563","article-title":"Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag","volume":"10","author":"Kao","year":"2018","journal-title":"Sci Transl Med"}],"container-title":["Blood Vessels, Thrombosis &amp; Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327225000178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327225000178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T02:55:18Z","timestamp":1762656918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950327225000178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2950327225000178"],"URL":"https:\/\/doi.org\/10.1016\/j.bvth.2025.100060","relation":{},"ISSN":["2950-3272"],"issn-type":[{"value":"2950-3272","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dose-dependent effects of eltrombopag iron chelation on platelet formation","name":"articletitle","label":"Article Title"},{"value":"Blood Vessels, Thrombosis & Hemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bvth.2025.100060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100060"}}