{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:23:12Z","timestamp":1793193792650,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["105863"],"award-info":[{"award-number":["105863"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["2022SF176"],"award-info":[{"award-number":["2022SF176"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100025520","name":"Medical Research Future Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100025520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["APP2017914"],"award-info":[{"award-number":["APP2017914"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["MRF2023977"],"award-info":[{"award-number":["MRF2023977"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Vessels, Thrombosis & Hemostasis"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bvth.2025.100096","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T22:06:28Z","timestamp":1752876388000},"page":"100096","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endo-chip laser-induced thrombus formation: a vessel-on-chip model for in vitro testing of antithrombotic agents"],"prefix":"10.1016","volume":"2","author":[{"given":"Alexander","family":"Dupuy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3753-8268","authenticated-orcid":false,"given":"Jemma C. L.","family":"Fenwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7566-1653","authenticated-orcid":false,"given":"Daisie M.","family":"Yates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-9964","authenticated-orcid":false,"given":"Jennifer R.","family":"Gamble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-0864","authenticated-orcid":false,"given":"Lining Arnold","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4584-2044","authenticated-orcid":false,"given":"Freda H.","family":"Passam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.bvth.2025.100096_bib1","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/nm782","article-title":"Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse","volume":"8","author":"Falati","year":"2002","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.bvth.2025.100096_bib2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1172\/JCI58969","article-title":"Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin","volume":"122","author":"Owens","year":"2012","journal-title":"J Clin Invest"},{"issue":"10","key":"10.1016\/j.bvth.2025.100096_bib3","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1182\/blood-2012-06-437772","article-title":"Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation","volume":"120","author":"Darbousset","year":"2012","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bvth.2025.100096_bib4","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1172\/JCI30537","article-title":"Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model","volume":"117","author":"Dubois","year":"2007","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.bvth.2025.100096_bib5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1182\/blood-2008-02-142943","article-title":"Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa","volume":"112","author":"Marx","year":"2008","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.bvth.2025.100096_bib6","first-page":"1123","article-title":"A critical role for extracellular protein disulfide isomerase during thrombus formation in mice","volume":"118","author":"Cho","year":"2008","journal-title":"J Clin Invest"},{"issue":"11","key":"10.1016\/j.bvth.2025.100096_bib7","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1111\/jth.12709","article-title":"The disulfide isomerase ERp57 is required for fibrin deposition in vivo","volume":"12","author":"Zhou","year":"2014","journal-title":"J Thromb Haemost"},{"issue":"2","key":"10.1016\/j.bvth.2025.100096_bib8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/jth.13878","article-title":"A humanized monoclonal antibody that inhibits platelet-surface ERp72 reveals a role for ERp72 in thrombosis","volume":"16","author":"Holbrook","year":"2018","journal-title":"J Thromb Haemost"},{"issue":"6","key":"10.1016\/j.bvth.2025.100096_bib9","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1182\/blood-2016-12-755587","article-title":"The disulfide isomerase ERp72 supports arterial thrombosis in mice","volume":"130","author":"Zhou","year":"2017","journal-title":"Blood"},{"issue":"14","key":"10.1016\/j.bvth.2025.100096_bib10","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1182\/blood-2013-12-547208","article-title":"Both platelet- and endothelial cell-derived ERp5 support thrombus formation in a laser-induced mouse model of thrombosis","volume":"125","author":"Passam","year":"2015","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.bvth.2025.100096_bib11","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1182\/bloodadvances.2022008457","article-title":"Endoplasmic reticulum protein 5 attenuates platelet endoplasmic reticulum stress and secretion in a mouse model","volume":"7","author":"Lay","year":"2023","journal-title":"Blood Adv"},{"issue":"4","key":"10.1016\/j.bvth.2025.100096_bib12","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1182\/blood-2014-02-554980","article-title":"Platelets are required for enhanced activation of the endothelium and fibrinogen in a mouse thrombosis model of APS","volume":"124","author":"Proulle","year":"2014","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.bvth.2025.100096_bib13","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1172\/JCI90958","article-title":"Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia","volume":"127","author":"Hayes","year":"2017","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.bvth.2025.100096_bib14","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1172\/JCI61228","article-title":"Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents","volume":"122","author":"Jasuja","year":"2012","journal-title":"J Clin Invest"},{"issue":"15","key":"10.1016\/j.bvth.2025.100096_bib15","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.99329","article-title":"Platelet-targeted dual pathway antithrombotic inhibits thrombosis with preserved hemostasis","volume":"3","author":"Hanjaya-Putra","year":"2018","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.bvth.2025.100096_bib16","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1038\/s41467-023-37709-0","article-title":"Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design","volume":"14","author":"La","year":"2023","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.bvth.2025.100096_bib17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3390\/diagnostics11020203","article-title":"Thromboinflammation model-on-a-chip by whole blood microfluidics on fixed human endothelium","volume":"11","author":"Dupuy","year":"2021","journal-title":"Diagnostics (Basel)"},{"issue":"10","key":"10.1016\/j.bvth.2025.100096_bib18","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/s41589-020-0584-z","article-title":"Pharmacologic IRE1\/XBP1s activation confers targeted ER proteostasis reprogramming","volume":"16","author":"Grandjean","year":"2020","journal-title":"Nat Chem Biol"},{"issue":"2","key":"10.1016\/j.bvth.2025.100096_bib19","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/jth.15174","article-title":"Wall shear rates in human and mouse arteries: standardization of hemodynamics for in vitro blood flow assays: communication from the ISTH SSC subcommittee on biorheology","volume":"19","author":"Panteleev","year":"2021","journal-title":"J Thromb Haemost"},{"issue":"12","key":"10.1016\/j.bvth.2025.100096_bib20","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1182\/bloodadvances.2024014165","article-title":"Endothelial cell activation enhances thromboinflammation in vaccine-induced immune thrombotic thrombocytopenia","volume":"9","author":"Dupuy","year":"2025","journal-title":"Blood Adv"},{"key":"10.1016\/j.bvth.2025.100096_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2021.102747","article-title":"\u0392eta-2-glycoprotein I exerts antithrombotic function through its domain V in mice","volume":"126","author":"Passam","year":"2022","journal-title":"J Autoimmun"},{"issue":"11","key":"10.1016\/j.bvth.2025.100096_bib22","doi-asserted-by":"crossref","DOI":"10.1172\/JCI163808","article-title":"TMEM16E regulates endothelial cell procoagulant activity and thrombosis","volume":"133","author":"Schmaier","year":"2023","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bvth.2025.100096_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.953062","article-title":"Flow-induced glycocalyx formation and cell alignment of HUVECs compared to iPSC-derived ECs for tissue engineering applications","volume":"10","author":"Lindner","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"10.1016\/j.bvth.2025.100096_bib24","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1038\/s41598-022-07892-z","article-title":"Scanning laser-induced endothelial injury: a standardized and reproducible thrombosis model for intravital microscopy","volume":"12","author":"Larsson","year":"2022","journal-title":"Sci Rep"},{"issue":"9330","key":"10.1016\/j.bvth.2025.100096_bib25","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0140-6736(02)09605-8","article-title":"Outcomes at 6 months for the direct comparison of tirofiban and abciximab during percutaneous coronary revascularisation with stent placement: the TARGET follow-up study","volume":"360","author":"Moliterno","year":"2002","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.bvth.2025.100096_bib26","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1111\/jth.12637","article-title":"Reappraisal of the clinical pharmacology of low-dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action","volume":"12","author":"Patrignani","year":"2014","journal-title":"Thromb Haemost"},{"issue":"3","key":"10.1016\/j.bvth.2025.100096_bib27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/svn-2022-002267","article-title":"Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy?","volume":"9","author":"Ingleton","year":"2024","journal-title":"Stroke Vasc Neurol"},{"issue":"15","key":"10.1016\/j.bvth.2025.100096_bib28","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1039\/C9LC00469F","article-title":"Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips","volume":"19","author":"Mathur","year":"2019","journal-title":"Lab Chip"},{"issue":"14","key":"10.1016\/j.bvth.2025.100096_bib29","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1039\/D4LC00216D","article-title":"Site-specific thrombus formation: advancements in photothrombosis-on-a-chip technology","volume":"24","author":"Liu","year":"2024","journal-title":"Lab Chip"},{"issue":"23","key":"10.1016\/j.bvth.2025.100096_bib30","doi-asserted-by":"crossref","first-page":"2214179","DOI":"10.1002\/adfm.202214179","article-title":"Novel movable typing for personalized Vein-chips in large scale: recapitulate patient-specific Virchow\u2019s triad and its contribution to cerebral venous sinus thrombosis","volume":"33","author":"Zhao","year":"2023","journal-title":"Adv Funct Mater"},{"issue":"8065","key":"10.1016\/j.bvth.2025.100096_bib31","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/s41586-025-08804-7","article-title":"Clinically relevant clot resolution via a thromboinflammation-on-a-chip","volume":"641","author":"Qiu","year":"2025","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.bvth.2025.100096_bib32","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1182\/blood-2010-05-283986","article-title":"Laser-induced endothelial cell activation supports fibrin formation","volume":"116","author":"Atkinson","year":"2010","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bvth.2025.100096_bib33","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/s41467-019-09150-9","article-title":"Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk","volume":"10","author":"Ting","year":"2019","journal-title":"Nat Commun"},{"issue":"18","key":"10.1016\/j.bvth.2025.100096_bib34","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1182\/bloodadvances.2017013995","article-title":"The endothelial glycocalyx anchors von Willebrand factor fibers to the vascular endothelium","volume":"2","author":"Kalagara","year":"2018","journal-title":"Blood Adv"},{"issue":"9","key":"10.1016\/j.bvth.2025.100096_bib35","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1182\/blood-2005-02-0618","article-title":"Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress","volume":"107","author":"Reininger","year":"2006","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bvth.2025.100096_bib36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1182\/blood.V99.1.159","article-title":"Shear-dependent tether formation during platelet translocation on von Willebrand factor","volume":"99","author":"Dopheide","year":"2002","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.bvth.2025.100096_bib37","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1182\/blood-2006-04-011551","article-title":"Activation-independent platelet adhesion and aggregation under elevated shear stress","volume":"108","author":"Ruggeri","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bvth.2025.100096_bib38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3389\/fcvm.2019.00141","article-title":"Shear-dependent platelet aggregation: mechanisms and therapeutic opportunities","volume":"6","author":"Rana","year":"2019","journal-title":"Front Cardiovasc Med"},{"issue":"4","key":"10.1016\/j.bvth.2025.100096_bib39","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1073\/pnas.1209905110","article-title":"Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner","volume":"110","author":"Westein","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bvth.2025.100096_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.111394","article-title":"Endothelialization of PDMS-based microfluidic devices under high shear stress conditions","volume":"197","author":"Siddique","year":"2021","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"4","key":"10.1016\/j.bvth.2025.100096_bib41","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1182\/blood-2010-05-287623","article-title":"von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models","volume":"117","author":"Brill","year":"2011","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.bvth.2025.100096_bib42","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1161\/ATVBAHA.117.309885","article-title":"Stasis promotes erythrocyte adhesion to von Willebrand factor","volume":"37","author":"Smeets","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7","key":"10.1016\/j.bvth.2025.100096_bib43","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1161\/ATVBAHA.113.303016","article-title":"von Willebrand factor directly interacts with DNA from neutrophil extracellular traps","volume":"34","author":"Gr\u00e4ssle","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"10.1016\/j.bvth.2025.100096_bib44","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3324\/haematol.2019.241042","article-title":"The von Willebrand factor A1 domain mediates thromboinflammation, aggravating ischemic stroke outcome in mice","volume":"106","author":"Denorme","year":"2021","journal-title":"Haematologica"},{"issue":"5","key":"10.1016\/j.bvth.2025.100096_bib45","article-title":"In vitro recapitulation of functional microvessels for the study of endothelial shear response, nitric oxide and [Ca2+]i","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"issue":"16","key":"10.1016\/j.bvth.2025.100096_bib46","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1001\/jama.2022.18331","article-title":"Hypercalcemia: a review","volume":"328","author":"Walker","year":"2022","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.bvth.2025.100096_bib47","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1111\/jth.15059","article-title":"Injury measurements improve interpretation of thrombus formation data in the cremaster arteriole laser-induced injury model of thrombosis","volume":"18","author":"Grover","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"4","key":"10.1016\/j.bvth.2025.100096_bib48","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/09537104.2020.1748589","article-title":"Mouse laser injury models: variations on a theme","volume":"31","author":"Stalker","year":"2020","journal-title":"Platelets"},{"issue":"7","key":"10.1016\/j.bvth.2025.100096_bib49","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41569-021-00511-w","article-title":"Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases","volume":"18","author":"Ren","year":"2021","journal-title":"Nat Rev Cardiol"},{"issue":"4","key":"10.1016\/j.bvth.2025.100096_bib50","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1161\/CIRCRESAHA.121.320530","article-title":"Unfolded protein response differentially modulates the platelet phenotype","volume":"131","author":"Jain","year":"2022","journal-title":"Circ Res"},{"issue":"5","key":"10.1016\/j.bvth.2025.100096_bib51","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1055\/s-0038-1646454","article-title":"An anti-tissue factor monoclonal antibody which inhibits TF.VIIa complex is a potent anticoagulant in plasma","volume":"66","author":"Ruf","year":"1991","journal-title":"Thromb Haemost"},{"issue":"6","key":"10.1016\/j.bvth.2025.100096_bib52","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1002\/cpt.1054","article-title":"Organ-on-chip recapitulates thrombosis induced by an anti-CD154 monoclonal antibody: translational potential of advanced microengineered systems","volume":"104","author":"Barrile","year":"2018","journal-title":"Clin Pharmacol Ther"},{"issue":"10","key":"10.1016\/j.bvth.2025.100096_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.582","article-title":"Vascular transcriptomics: investigating endothelial activation and vascular dysfunction using blood outgrowth endothelial cells, organ-chips, and RNA sequencing","volume":"2","author":"Mathur","year":"2022","journal-title":"Curr Protoc"},{"issue":"9","key":"10.1016\/j.bvth.2025.100096_bib54","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.stemcr.2021.08.003","article-title":"Engineered 3D vessel-on-chip using hiPSC-derived endothelial- and vascular smooth muscle cells","volume":"16","author":"Vila Cuenca","year":"2021","journal-title":"Stem Cell Rep"},{"issue":"11","key":"10.1016\/j.bvth.2025.100096_bib55","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.3324\/haematol.2020.250761","article-title":"Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation in vitro","volume":"106","author":"Hoefer","year":"2021","journal-title":"Haematologica"}],"container-title":["Blood Vessels, Thrombosis & Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327225000531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327225000531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T22:40:54Z","timestamp":1772923254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950327225000531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2950327225000531"],"URL":"https:\/\/doi.org\/10.1016\/j.bvth.2025.100096","relation":{},"ISSN":["2950-3272"],"issn-type":[{"value":"2950-3272","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endo-chip laser-induced thrombus formation: a vessel-on-chip model for in vitro testing of antithrombotic agents","name":"articletitle","label":"Article Title"},{"value":"Blood Vessels, Thrombosis & Hemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bvth.2025.100096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100096"}}