{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T21:22:13Z","timestamp":1773955333100,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["5T32HL110841"],"award-info":[{"award-number":["5T32HL110841"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017551","name":"Children&apos;s National Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Vessels, Thrombosis &amp; Hemostasis"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bvth.2025.100121","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T19:12:39Z","timestamp":1761678759000},"page":"100121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute pain in pediatric patients with SCD without chronic pain is associated with elevated VCAM-1 and P-selectin adhesion"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7723-8936","authenticated-orcid":false,"given":"Olufunke Y.","family":"Martin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasa","family":"Borhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-6637","authenticated-orcid":false,"given":"Aliya U.","family":"Zaidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiufeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9945-5271","authenticated-orcid":false,"given":"Kaleab","family":"Ribbiso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika S.","family":"Darbari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick C.","family":"Hines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8829-0043","authenticated-orcid":false,"given":"Andrew D.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bvth.2025.100121_bib1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/jama.2022.10233","article-title":"Sickle cell disease: a review","volume":"328","author":"Kavanagh","year":"2022","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.bvth.2025.100121_bib2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/ejh.13430","article-title":"The vaso-occlusive pain crisis in sickle cell disease: definition, pathophysiology, and management","volume":"105","author":"Darbari","year":"2020","journal-title":"Eur J Haematol"},{"issue":"10091","key":"10.1016\/j.bvth.2025.100121_bib3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0140-6736(17)30193-9","article-title":"Sickle cell disease","volume":"390","author":"Ware","year":"2017","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.bvth.2025.100121_bib4","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion--from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.bvth.2025.100121_bib5","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/pbc.24838","article-title":"Neuropathic pain in patients with sickle cell disease","volume":"61","author":"Brandow","year":"2014","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.bvth.2025.100121_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134445","article-title":"Neuropathic pain in individuals with sickle cell disease","volume":"714","author":"Sharma","year":"2020","journal-title":"Neurosci Lett"},{"issue":"5","key":"10.1016\/j.bvth.2025.100121_bib7","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jpain.2016.12.016","article-title":"AAPT diagnostic criteria for chronic sickle cell disease pain","volume":"18","author":"Dampier","year":"2017","journal-title":"J Pain"},{"issue":"7","key":"10.1016\/j.bvth.2025.100121_bib8","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.jpain.2018.12.003","article-title":"AAAPT diagnostic criteria for acute sickle cell disease pain","volume":"20","author":"Field","year":"2019","journal-title":"J Pain"},{"issue":"1","key":"10.1016\/j.bvth.2025.100121_bib9","first-page":"1","article-title":"Correlation between soluble endothelial adhesion molecules and nitric oxide metabolites in sickle cell disease","volume":"7","author":"Antwi-Boasiako","year":"2018","journal-title":"Med Sci (Basel)"},{"issue":"2","key":"10.1016\/j.bvth.2025.100121_bib10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/diseases6020029","article-title":"Levels of soluble endothelium adhesion molecules and complications among sickle cell disease patients in Ghana","volume":"6","author":"Antwi-Boasiako","year":"2018","journal-title":"Diseases"},{"issue":"1","key":"10.1016\/j.bvth.2025.100121_bib11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/clin.1996.0163","article-title":"Enhanced levels of soluble VCAM-1 in sickle cell patients and their specific increment during vasoocclusive crisis","volume":"81","author":"Duits","year":"1996","journal-title":"Clin Immunol Immunopathol"},{"issue":"5","key":"10.1016\/j.bvth.2025.100121_bib12","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/acr.20140","article-title":"The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity","volume":"62","author":"Wolfe","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.bvth.2025.100121_bib13","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2147\/JPR.S151198","article-title":"Pain catastrophizing is associated with poorer health-related quality of life in pediatric patients with sickle cell disease","volume":"11","author":"Bakshi","year":"2018","journal-title":"J Pain Res"},{"issue":"9","key":"10.1016\/j.bvth.2025.100121_bib14","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.jpain.2016.05.008","article-title":"Pediatric sickle cell disease and parent and child catastrophizing","volume":"17","author":"Sil","year":"2016","journal-title":"J Pain"},{"issue":"1-3","key":"10.1016\/j.bvth.2025.100121_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pain.2007.02.008","article-title":"The role of catastrophizing in sickle cell disease \u2013 the PiSCES project","volume":"133","author":"Citero","year":"2007","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.bvth.2025.100121_bib16","doi-asserted-by":"crossref","first-page":"e29583","DOI":"10.1002\/pbc.29583","article-title":"Prevalence of neuropathic pain in adolescents with sickle cell disease: a single-center experience","volume":"69","author":"Cregan","year":"2022","journal-title":"Pediatr Blood Cancer"},{"issue":"26","key":"10.1016\/j.bvth.2025.100121_bib18","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1056\/NEJMp1802313","article-title":"Making neighborhood-disadvantage metrics accessible - the neighborhood atlas","volume":"378","author":"Kind","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bvth.2025.100121_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: Building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J Biomed Inform"},{"issue":"2","key":"10.1016\/j.bvth.2025.100121_bib20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"10.1016\/j.bvth.2025.100121_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcmd.2019.102397","article-title":"Cross-sectional analysis of adhesion in individuals with sickle cell disease using a standardized whole blood adhesion bioassay to VCAM-1","volume":"81","author":"White","year":"2020","journal-title":"Blood Cells Mol Dis"},{"issue":"6","key":"10.1016\/j.bvth.2025.100121_bib22","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1111\/bjh.17643","article-title":"Flow adhesion of whole blood to P-selectin: a prognostic biomarker for vaso-occlusive crisis in sickle cell disease","volume":"194","author":"Hines","year":"2021","journal-title":"Br J Haematol"},{"issue":"5","key":"10.1016\/j.bvth.2025.100121_bib23","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-3083.2008.02029.x","article-title":"Soluble ICAM-1 and VCAM-1 as markers of endothelial activation","volume":"67","author":"Videm","year":"2008","journal-title":"Scand J Immunol"},{"issue":"12","key":"10.1016\/j.bvth.2025.100121_bib24","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2967\/jnumed.118.225169","article-title":"Targeting P-selectin adhesion molecule in molecular imaging: P-selectin expression as a valuable imaging biomarker of inflammation in cardiovascular disease","volume":"60","author":"Perkins","year":"2019","journal-title":"J Nucl Med"}],"container-title":["Blood Vessels, Thrombosis &amp; Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327225000786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327225000786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:48:39Z","timestamp":1773938919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950327225000786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2950327225000786"],"URL":"https:\/\/doi.org\/10.1016\/j.bvth.2025.100121","relation":{},"ISSN":["2950-3272"],"issn-type":[{"value":"2950-3272","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute pain in pediatric patients with SCD without chronic pain is associated with elevated VCAM-1 and P-selectin adhesion","name":"articletitle","label":"Article Title"},{"value":"Blood Vessels, Thrombosis & Hemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bvth.2025.100121","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100121"}}