{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:38:09Z","timestamp":1791499089274,"version":"4.3.4"},"reference-count":100,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23PRE1014240"],"award-info":[{"award-number":["23PRE1014240"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008907","name":"Oklahoma Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008907","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001563","name":"Otago Medical Research Foundation","doi-asserted-by":"publisher","award":["3-6"],"award-info":[{"award-number":["3-6"]}],"id":[{"id":"10.13039\/501100001563","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Vessels, Thrombosis &amp; Hemostasis"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bvth.2025.100123","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T19:12:43Z","timestamp":1761678763000},"page":"100123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["From oversight to insight: the curious case of the endothelial insulin receptor"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4501-349X","authenticated-orcid":false,"given":"Rahul","family":"Rajala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bvth.2025.100123_bib1","doi-asserted-by":"crossref","DOI":"10.2174\/1573399819666230413094200","article-title":"Prevalence of diabetes in India: a review of IDF Diabetes Atlas 10th edition","volume":"20","author":"Kumar","year":"2024","journal-title":"Curr Diabetes Rev"},{"issue":"1","key":"10.1016\/j.bvth.2025.100123_bib2","doi-asserted-by":"crossref","first-page":"17275","DOI":"10.1038\/s41598-025-01564-4","article-title":"Obesity-induced adipocytes promote diabetes mellitus by regulating \u03b2 islet cell function through exosome miR-138-5p","volume":"15","author":"Fan","year":"2025","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.bvth.2025.100123_bib3","first-page":"237","article-title":"The barrier within: endothelial transport of hormones","volume":"27","author":"Kolka","year":"2012","journal-title":"Physiology (Bethesda)"},{"issue":"1","key":"10.1016\/j.bvth.2025.100123_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-65397-z","article-title":"Enhanced skeletal muscle insulin sensitivity after acute resistance-type exercise is upregulated by rapamycin-sensitive mTOR complex 1 inhibition","volume":"10","author":"Kido","year":"2020","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.bvth.2025.100123_bib5","first-page":"336","article-title":"Endothelial transcytosis of insulin: does it contribute to insulin resistance?","volume":"31","author":"Lee","year":"2016","journal-title":"Physiology (Bethesda)"},{"issue":"10","key":"10.1016\/j.bvth.2025.100123_bib6","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1111\/jth.15469","article-title":"How big is the endothelium? Comment on \u201cSpatial and temporal dynamics of the endothelium\u201d","volume":"19","author":"Rajala","year":"2021","journal-title":"J Thromb Haemost"},{"issue":"5512","key":"10.1016\/j.bvth.2025.100123_bib7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/bmj.2.5512.487","article-title":"The endothelial cell","volume":"2","year":"1966","journal-title":"Br Med J"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib8","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1001\/archinte.1987.00370030173034","article-title":"Endothelial cells. Not just a cellophane wrapper","volume":"147","author":"Kaiser","year":"1987","journal-title":"Arch Intern Med"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib9","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1172\/JCI62589","article-title":"Endothelium: from cellophane to orchestral maestro","volume":"122","author":"Nachman","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bvth.2025.100123_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1439419","article-title":"Editorial: unconventional roles of endothelial cells","volume":"12","author":"Iovino","year":"2024","journal-title":"Front Cell Dev Biol"},{"issue":"12","key":"10.1016\/j.bvth.2025.100123_bib11","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.2337\/db13-0627","article-title":"Nitric oxide directly promotes vascular endothelial insulin transport","volume":"62","author":"Wang","year":"2013","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.bvth.2025.100123_bib12","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1172\/JCI15211","article-title":"The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance","volume":"111","author":"Vicent","year":"2003","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.bvth.2025.100123_bib13","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/tra.12645","article-title":"Endothelial cell barriers: transport of molecules between blood and tissues","volume":"20","author":"Yazdani","year":"2019","journal-title":"Traffic"},{"issue":"6734","key":"10.1016\/j.bvth.2025.100123_bib14","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.adr4731","article-title":"Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes","volume":"387","author":"Cho","year":"2025","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.bvth.2025.100123_bib15","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1161\/ATVBAHA.125.323140","article-title":"Novel function for endothelial protease-activated receptors in modulating insulin receptor activity with implications for diabetes","volume":"45","author":"Rajala","year":"2025","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib16","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1210\/jcem-47-3-699","article-title":"Insulin receptors in human endothelial cells: identification and characterization","volume":"47","author":"Bar","year":"1978","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.bvth.2025.100123_bib17","doi-asserted-by":"crossref","first-page":"794","DOI":"10.2337\/diab.33.8.794","article-title":"Processing of insulin by bovine endothelial cells in culture. Internalization without degradation","volume":"33","author":"Jialal","year":"1984","journal-title":"Diabetes"},{"issue":"2 pt 1","key":"10.1016\/j.bvth.2025.100123_bib18","first-page":"E244","article-title":"Processing of cell-bound insulin by capillary and macrovascular endothelial cells in culture","volume":"248","author":"Dernovsek","year":"1985","journal-title":"Am J Physiol"},{"issue":"5","key":"10.1016\/j.bvth.2025.100123_bib19","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1172\/JCI114339","article-title":"Insulin transport across capillaries is rate limiting for insulin action in dogs","volume":"84","author":"Yang","year":"1989","journal-title":"J Clin Invest"},{"issue":"1 pt 1","key":"10.1016\/j.bvth.2025.100123_bib20","first-page":"E17","article-title":"Importance of transcapillary insulin transport to dynamics of insulin action after intravenous glucose","volume":"266","author":"Yang","year":"1994","journal-title":"Am J Physiol"},{"issue":"4","key":"10.1016\/j.bvth.2025.100123_bib21","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1172\/JCI113439","article-title":"Vascular transport of insulin to rat cardiac muscle. Central role of the capillary endothelium","volume":"81","author":"Bar","year":"1988","journal-title":"J Clin Invest"},{"issue":"pt 7","key":"10.1016\/j.bvth.2025.100123_bib22","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1242\/jcs.109.7.1857","article-title":"Transport of insulin and albumin by the microvascular endothelium of the rete mirabile","volume":"109","author":"Bendayan","year":"1996","journal-title":"J Cell Sci"},{"issue":"40","key":"10.1016\/j.bvth.2025.100123_bib23","doi-asserted-by":"crossref","first-page":"E8478","DOI":"10.1073\/pnas.1710625114","article-title":"Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice","volume":"114","author":"Konishi","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.bvth.2025.100123_bib24","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.cell.2020.01.015","article-title":"Single-cell transcriptome atlas of murine endothelial cells","volume":"180","author":"Kalucka","year":"2020","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bvth.2025.100123_bib25","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab252","article-title":"Capillary endothelial insulin transport: the rate limiting step for insulin-stimulated glucose uptake","volume":"163","author":"Williams","year":"2022","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib26","doi-asserted-by":"crossref","first-page":"364","DOI":"10.4239\/wjd.v5.i3.364","article-title":"Adrenomedullin and diabetes","volume":"5","author":"Wong","year":"2014","journal-title":"World J Diabetes"},{"issue":"4","key":"10.1016\/j.bvth.2025.100123_bib27","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3390\/biom11040602","article-title":"Regulation of phosphoinositide levels in the retina by protein tyrosine phosphatase 1B and growth factor receptor-bound protein 14","volume":"11","author":"Rajala","year":"2021","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib28","doi-asserted-by":"crossref","first-page":"540","DOI":"10.2337\/db07-0967","article-title":"Insulin signaling stimulates insulin transport by bovine aortic endothelial cells","volume":"57","author":"Wang","year":"2008","journal-title":"Diabetes"},{"issue":"24","key":"10.1016\/j.bvth.2025.100123_bib29","doi-asserted-by":"crossref","first-page":"21938","DOI":"10.1074\/jbc.C100109200","article-title":"Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade","volume":"276","author":"Mahadev","year":"2001","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.bvth.2025.100123_bib30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2337\/diabetes.54.2.311","article-title":"Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets","volume":"54","author":"Goldstein","year":"2005","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib31","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.jtha.2024.11.022","article-title":"Intercellular synergy between protease-activated receptors in mouse development","volume":"23","author":"Rajala","year":"2025","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.bvth.2025.100123_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcvm.2025.1541879","article-title":"Endothelial protease-activated receptor 4: impotent or important?","volume":"12","author":"Rajala","year":"2025","journal-title":"Front Cardiovasc Med"},{"issue":"5","key":"10.1016\/j.bvth.2025.100123_bib33","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1002\/j.1460-2075.1993.tb05843.x","article-title":"Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation","volume":"12","author":"Flint","year":"1993","journal-title":"EMBO J"},{"issue":"5","key":"10.1016\/j.bvth.2025.100123_bib34","doi-asserted-by":"crossref","first-page":"F63","DOI":"10.1530\/ERC-12-0026","article-title":"Insulin and its analogues and their affinities for the IGF1 receptor","volume":"19","author":"Varewijck","year":"2012","journal-title":"Endocr Relat Cancer"},{"issue":"2","key":"10.1016\/j.bvth.2025.100123_bib35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/1359-6101(96)00015-9","article-title":"Signaling via the insulin-like growth factor-I receptor: does it differ from insulin receptor signaling?","volume":"7","author":"Blakesley","year":"1996","journal-title":"Cytokine Growth Factor Rev"},{"issue":"6","key":"10.1016\/j.bvth.2025.100123_bib36","doi-asserted-by":"crossref","first-page":"E896","DOI":"10.1152\/ajpendo.00327.2003","article-title":"Insulin-like growth factor I receptors are more abundant than insulin receptors in human micro- and macrovascular endothelial cells","volume":"286","author":"Chisalita","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.bvth.2025.100123_bib37","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.2337\/db12-0654","article-title":"Endothelial insulin and IGF-1 receptors: when yes means no","volume":"61","author":"Muniyappa","year":"2012","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.bvth.2025.100123_bib38","doi-asserted-by":"crossref","first-page":"E323","DOI":"10.1152\/ajpendo.00047.2006","article-title":"The vascular endothelial cell mediates insulin transport into skeletal muscle","volume":"291","author":"Wang","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib39","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.cmet.2011.01.018","article-title":"Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle","volume":"13","author":"Kubota","year":"2011","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.bvth.2025.100123_bib40","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1161\/ATVBAHA.120.315310","article-title":"Endothelial TFEB (transcription factor EB) improves glucose tolerance via upregulation of IRS (insulin receptor substrate) 1 and IRS2","volume":"41","author":"Sun","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"11","key":"10.1016\/j.bvth.2025.100123_bib41","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.4161\/cc.10.11.15824","article-title":"The insulin receptor substrate (IRS) proteins: at the intersection of metabolism and cancer","volume":"10","author":"Shaw","year":"2011","journal-title":"Cell Cycle"},{"issue":"8","key":"10.1016\/j.bvth.2025.100123_bib42","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.2337\/db11-0197","article-title":"The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium","volume":"60","author":"Abbas","year":"2011","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.bvth.2025.100123_bib43","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.2337\/db11-1494","article-title":"Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice","volume":"61","author":"Imrie","year":"2012","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.bvth.2025.100123_bib44","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1128\/MCB.01110-06","article-title":"Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function","volume":"27","author":"Laustsen","year":"2007","journal-title":"Mol Cell Biol"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib45","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41684-025-01519-2","article-title":"Rapid protein degradation systems to determine gene function in vivo","volume":"54","author":"Scott","year":"2025","journal-title":"Lab Anim (NY)"},{"issue":"47","key":"10.1016\/j.bvth.2025.100123_bib46","doi-asserted-by":"crossref","first-page":"23618","DOI":"10.1073\/pnas.1912409116","article-title":"The in vivo endothelial cell translatome is highly heterogeneous across vascular beds","volume":"116","author":"Cleuren","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.bvth.2025.100123_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2022.100321","article-title":"A two-stage digestion of whole murine knee joints for single-cell RNA sequencing","volume":"4","author":"Leale","year":"2022","journal-title":"Osteoarthr Cartil Open"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib48","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgad063","article-title":"Atlas of phosphoinositide signatures in the retina identifies heterogeneity between cell types","volume":"2","author":"Rajala","year":"2023","journal-title":"PNAS Nexus"},{"issue":"1","key":"10.1016\/j.bvth.2025.100123_bib49","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1161\/ATVBAHA.124.321353","article-title":"Acetaminophen overdose reveals PAR4 as a low-expressing but potent receptor on the hepatic endothelium in mice","volume":"45","author":"Rajala","year":"2025","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8","key":"10.1016\/j.bvth.2025.100123_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-024-06924-y","article-title":"Age-related retinal degeneration resulting from the deletion of Shp2 tyrosine phosphatase in photoreceptor neurons","volume":"15","author":"Rajala","year":"2024","journal-title":"Cell Death Dis"},{"issue":"4","key":"10.1016\/j.bvth.2025.100123_bib51","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00315583","article-title":"Insulin-induced increase in heart rate and its prevention by propranolol","volume":"38","author":"Siani","year":"1990","journal-title":"Eur J Clin Pharmacol"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib52","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ecl.2008.06.001","article-title":"An integrated view of insulin resistance and endothelial dysfunction","volume":"37","author":"Muniyappa","year":"2008","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib53","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1172\/JCI117433","article-title":"Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release","volume":"94","author":"Steinberg","year":"1994","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.bvth.2025.100123_bib54","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1091\/mbc.E14-08-1307","article-title":"Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells","volume":"26","author":"Azizi","year":"2015","journal-title":"Mol Biol Cell"},{"issue":"1","key":"10.1016\/j.bvth.2025.100123_bib55","doi-asserted-by":"crossref","first-page":"E134","DOI":"10.1152\/ajpendo.00498.2010","article-title":"Caveolin-1 is required for vascular endothelial insulin uptake","volume":"300","author":"Wang","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.bvth.2025.100123_bib56","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1083\/jcb.127.5.1217","article-title":"Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules","volume":"127","author":"Schnitzer","year":"1994","journal-title":"J Cell Biol"},{"issue":"19","key":"10.1016\/j.bvth.2025.100123_bib57","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1021\/bi00134a008","article-title":"Distinct alpha-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities","volume":"31","author":"Kellerer","year":"1992","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/j.bvth.2025.100123_bib58","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1210\/mend-5-5-734","article-title":"Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action","volume":"5","author":"McClain","year":"1991","journal-title":"Mol Endocrinol"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib59","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1091\/mbc.e05-09-0899","article-title":"An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-Hrs-and Tsg101-independent functions of sorting nexins","volume":"17","author":"Gullapalli","year":"2006","journal-title":"Mol Biol Cell"},{"issue":"6","key":"10.1016\/j.bvth.2025.100123_bib60","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrm3351","article-title":"Regulation of glucose transport by insulin: traffic control of GLUT4","volume":"13","author":"Leto","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"suppl 2","key":"10.1016\/j.bvth.2025.100123_bib61","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.2337\/dc11-s225","article-title":"Insulin: potential negative consequences of early routine use in patients with type 2 diabetes","volume":"34","author":"Lebovitz","year":"2011","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.bvth.2025.100123_bib62","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/dmr.5610030202","article-title":"The kinetics of insulin in man. II. Role of the liver","volume":"3","author":"Ferrannini","year":"1987","journal-title":"Diabetes Metab Rev"},{"issue":"1","key":"10.1016\/j.bvth.2025.100123_bib63","doi-asserted-by":"crossref","first-page":"9","DOI":"10.29252\/ibj.23.1.9","article-title":"Bioprinting in vascularization strategies","volume":"23","author":"Jafarkhani","year":"2019","journal-title":"Iran Biomed J"},{"issue":"21","key":"10.1016\/j.bvth.2025.100123_bib64","doi-asserted-by":"crossref","first-page":"14230","DOI":"10.1074\/jbc.M800061200","article-title":"Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo","volume":"283","author":"Zabolotny","year":"2008","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.bvth.2025.100123_bib65","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00125-010-1707-y","article-title":"Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes","volume":"53","author":"Igoillo-Esteve","year":"2010","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.bvth.2025.100123_bib66","doi-asserted-by":"crossref","first-page":"E35","DOI":"10.1152\/ajpendo.00611.2014","article-title":"Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis","volume":"309","author":"Pillon","year":"2015","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"10","key":"10.1016\/j.bvth.2025.100123_bib67","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/j.cellsig.2012.04.019","article-title":"Palmitate-induced PTP1B expression is mediated by ceramide-JNK and nuclear factor \u03baB (NF-\u03baB) activation","volume":"24","author":"MohammadTaghvaei","year":"2012","journal-title":"Cell Signal"},{"issue":"2","key":"10.1016\/j.bvth.2025.100123_bib68","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.bbrc.2010.04.118","article-title":"Palmitate and inflammatory state additively induce the expression of PTP1B in muscle cells","volume":"396","author":"Parvaneh","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"30","key":"10.1016\/j.bvth.2025.100123_bib69","doi-asserted-by":"crossref","first-page":"28430","DOI":"10.1074\/jbc.M103382200","article-title":"Insulin-induced adipocyte differentiation. Activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation","volume":"276","author":"Klemm","year":"2001","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.bvth.2025.100123_bib70","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.febslet.2007.11.057","article-title":"Inflammation and insulin resistance","volume":"582","author":"de Luca","year":"2008","journal-title":"FEBS Lett"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib71","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cell.2013.06.037","article-title":"Role of PFKFB3-driven glycolysis in vessel sprouting","volume":"154","author":"De Bock","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bvth.2025.100123_bib72","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev-physiol-020518-114731","article-title":"Metabolic pathways fueling the endothelial cell drive","volume":"81","author":"Li","year":"2019","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.bvth.2025.100123_bib73","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.atherosclerosis.2020.06.004","article-title":"Actin remodelling of the endothelium during transendothelial migration of leukocytes","volume":"315","author":"van Steen","year":"2020","journal-title":"Atherosclerosis"},{"issue":"8","key":"10.1016\/j.bvth.2025.100123_bib74","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1083\/jcb.201706041","article-title":"Vav3-induced cytoskeletal dynamics contribute to heterotypic properties of endothelial barriers","volume":"217","author":"Hilfenhaus","year":"2018","journal-title":"J Cell Biol"},{"issue":"6","key":"10.1016\/j.bvth.2025.100123_bib75","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.4049\/jimmunol.179.6.4053","article-title":"ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration","volume":"179","author":"Allingham","year":"2007","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib76","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ajpath.2019.11.004","article-title":"Endothelial cell calcium signaling during barrier function and inflammation","volume":"190","author":"Dalal","year":"2020","journal-title":"Am J Pathol"},{"issue":"18","key":"10.1016\/j.bvth.2025.100123_bib77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms20184411","article-title":"Vascular endothelial cell biology: an update","volume":"20","author":"Kr\u00fcger-Genge","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib78","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2019.08.011","article-title":"Hallmarks of endothelial cell metabolism in health and disease","volume":"30","author":"Li","year":"2019","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.bvth.2025.100123_bib79","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1091\/mbc.11.2.419","article-title":"Reconstitution of ATP-dependent movement of endocytic vesicles along microtubules in vitro: an oscillatory bidirectional process","volume":"11","author":"Murray","year":"2000","journal-title":"Mol Biol Cell"},{"issue":"37","key":"10.1016\/j.bvth.2025.100123_bib80","doi-asserted-by":"crossref","first-page":"22325","DOI":"10.1074\/jbc.M115.656405","article-title":"The role of mitochondrially derived ATP in synaptic vesicle recycling","volume":"290","author":"Pathak","year":"2015","journal-title":"J Biol Chem"},{"issue":"17","key":"10.1016\/j.bvth.2025.100123_bib81","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.1523\/JNEUROSCI.21-17-06467.2001","article-title":"ATP is required at an early step in compensatory endocytosis in synaptic terminals","volume":"21","author":"Heidelberger","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.bvth.2025.100123_bib82","first-page":"1","article-title":"Presynaptic boutons that contain mitochondria are more stable","volume":"11","author":"Lees","year":"2019","journal-title":"Front Synaptic Neurosci"},{"issue":"1","key":"10.1016\/j.bvth.2025.100123_bib83","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/ijms21010022","article-title":"How to make anticancer drugs cross the blood-brain barrier to treat brain metastases","volume":"21","author":"Angeli","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.bvth.2025.100123_bib84","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41589-021-00926-z","article-title":"The evolution of synthetic receptor systems","volume":"18","author":"Manhas","year":"2022","journal-title":"Nat Chem Biol"},{"issue":"1","key":"10.1016\/j.bvth.2025.100123_bib85","first-page":"1","article-title":"Programmable synthetic receptors: the next-generation of cell and gene therapies","volume":"9","author":"Teng","year":"2024","journal-title":"Signal Transduct Target Ther"},{"issue":"12","key":"10.1016\/j.bvth.2025.100123_bib86","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1021\/acs.bioconjchem.2c00096","article-title":"Applications of synthetic receptors in bioanalysis and drug transport","volume":"33","author":"Chen","year":"2022","journal-title":"Bioconjug Chem"},{"issue":"6","key":"10.1016\/j.bvth.2025.100123_bib87","doi-asserted-by":"crossref","first-page":"e15199","DOI":"10.15252\/emmm.202115199","article-title":"Liver gene therapy with intein-mediated F8 trans-splicing corrects mouse haemophilia A","volume":"14","author":"Esposito","year":"2022","journal-title":"EMBO Mol Med"},{"issue":"8023","key":"10.1016\/j.bvth.2025.100123_bib88","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41586-024-07710-8","article-title":"Split intein-mediated protein trans-splicing to express large dystrophins","volume":"632","author":"Tasfaout","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bvth.2025.100123_bib89","doi-asserted-by":"crossref","DOI":"10.1194\/jlr.TR120000806","article-title":"Signaling roles of phosphoinositides in the retina","volume":"62","author":"Rajala","year":"2021","journal-title":"J Lipid Res"},{"issue":"28","key":"10.1016\/j.bvth.2025.100123_bib90","doi-asserted-by":"crossref","first-page":"19781","DOI":"10.1074\/jbc.M802374200","article-title":"Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells","volume":"283","author":"Rajala","year":"2008","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.bvth.2025.100123_bib91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-022-05074-3","article-title":"Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection","volume":"13","author":"Rajala","year":"2022","journal-title":"Cell Death Dis"},{"issue":"12","key":"10.1016\/j.bvth.2025.100123_bib92","doi-asserted-by":"crossref","first-page":"107469","DOI":"10.1016\/j.vph.2025.107469","article-title":"Kinome profiling: a veritable Rosetta stone for protease-activated receptor 1 biased signaling","volume":"158","author":"Rajala","year":"2025","journal-title":"Vascul Pharmacol"},{"issue":"9","key":"10.1016\/j.bvth.2025.100123_bib93","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.1073\/pnas.1917295117","article-title":"Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function","volume":"117","author":"Lin","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"10.1016\/j.bvth.2025.100123_bib94","doi-asserted-by":"crossref","first-page":"e2037","DOI":"10.1038\/cddis.2015.381","article-title":"Obesity and cancer, a case for insulin signaling","volume":"6","author":"Poloz","year":"2015","journal-title":"Cell Death Dis"},{"issue":"4","key":"10.1016\/j.bvth.2025.100123_bib95","doi-asserted-by":"crossref","first-page":"E729","DOI":"10.1152\/ajpendo.00003.2006","article-title":"Mechanism of insulin's anabolic effect on muscle: measurements of muscle protein synthesis and breakdown using aminoacyl-tRNA and other surrogate measures","volume":"291","author":"Chow","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.bvth.2025.100123_bib96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcell.2018.00100","article-title":"The Warburg effect in endothelial cells and its potential as an anti-angiogenic target in cancer","volume":"6","author":"Fitzgerald","year":"2018","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.bvth.2025.100123_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcell.2020.00266","article-title":"Aerobic glycolysis in the retina: functional roles of pyruvate kinase isoforms","volume":"8","author":"Rajala","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"11","key":"10.1016\/j.bvth.2025.100123_bib98","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.tcb.2020.08.005","article-title":"Photoreceptor discs: built like ectosomes","volume":"30","author":"Spencer","year":"2020","journal-title":"Trends Cell Biol"},{"issue":"1","key":"10.1016\/j.bvth.2025.100123_bib99","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1152\/physrev.00001.2017","article-title":"Endothelial cell metabolism","volume":"98","author":"Eelen","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bvth.2025.100123_bib100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1874120701007010001","article-title":"Role of endothelial cells in myocardial ischemia-reperfusion injury","volume":"7","author":"Singhal","year":"2010","journal-title":"Vasc Dis Prev"}],"container-title":["Blood Vessels, Thrombosis &amp; Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327225000804?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327225000804?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:11:59Z","timestamp":1772032319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950327225000804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":100,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2950327225000804"],"URL":"https:\/\/doi.org\/10.1016\/j.bvth.2025.100123","relation":{},"ISSN":["2950-3272"],"issn-type":[{"value":"2950-3272","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From oversight to insight: the curious case of the endothelial insulin receptor","name":"articletitle","label":"Article Title"},{"value":"Blood Vessels, Thrombosis & Hemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bvth.2025.100123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100123"}}