{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:16:08Z","timestamp":1788297368515,"version":"build-2803163510"},"reference-count":82,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005384","name":"American Physiological Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005384","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL151735"],"award-info":[{"award-number":["R01HL151735"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Vessels, Thrombosis &amp; Hemostasis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bvth.2026.100184","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:33:48Z","timestamp":1783010028000},"page":"100184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Augmenting hemopexin-mediated heme scavenging mitigates sepsis-induced acute kidney injury in humanized sickle cell mice"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3387-2097","authenticated-orcid":false,"given":"Olufunke O.","family":"Falayi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1991-4844","authenticated-orcid":false,"given":"Jada D.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-257X","authenticated-orcid":false,"given":"Ravi","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6830-0996","authenticated-orcid":false,"given":"Olufunke O.","family":"Arishe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-5603","authenticated-orcid":false,"given":"Jeremiah M.","family":"Afolabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7033-1871","authenticated-orcid":false,"given":"Adebowale","family":"Adebiyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9757","key":"10.1016\/j.bvth.2026.100184_bib1","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(10)61029-X","article-title":"Sickle-cell disease","volume":"376","author":"Rees","year":"2010","journal-title":"Lancet"},{"issue":"9442","key":"10.1016\/j.bvth.2026.100184_bib2","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0140-6736(04)17192-4","article-title":"Sickle-cell disease","volume":"364","author":"Stuart","year":"2004","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bvth.2026.100184_bib3","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1016\/j.ijid.2009.03.010","article-title":"Infection in sickle cell disease: a review","volume":"14","author":"Booth","year":"2010","journal-title":"Int J Infect Dis"},{"issue":"3","key":"10.1016\/j.bvth.2026.100184_bib4","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/jmri.21490","article-title":"Magnetic resonance detection of kidney iron deposition in sickle cell disease: a marker of chronic hemolysis","volume":"28","author":"Schein","year":"2008","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.bvth.2026.100184_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fphar.2014.00061","article-title":"Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes","volume":"5","author":"Chiabrando","year":"2014","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.bvth.2026.100184_bib6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.semnephrol.2016.01.003","article-title":"Targeting iron homeostasis in acute kidney injury","volume":"36","author":"Walker","year":"2016","journal-title":"Semin Nephrol"},{"issue":"2","key":"10.1016\/j.bvth.2026.100184_bib7","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1681\/ASN.2006080894","article-title":"Physiology and pathophysiology of heme: implications for kidney disease","volume":"18","author":"Tracz","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.bvth.2026.100184_bib8","article-title":"The worst things in life are free: the role of free heme in sickle cell disease","volume":"11","author":"Gbotosho","year":"2020","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.bvth.2026.100184_bib9","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41581-019-0181-0","article-title":"Mechanisms of haemolysis-induced kidney injury","volume":"15","author":"Van Avondt","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.bvth.2026.100184_bib10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fped.2020.00038","article-title":"Life-threatening infectious complications in sickle cell disease: a concise narrative review","volume":"8","author":"Ochocinski","year":"2020","journal-title":"Front Pediatr"},{"issue":"1","key":"10.1016\/j.bvth.2026.100184_bib11","doi-asserted-by":"crossref","DOI":"10.4084\/mjhid.2019.042","article-title":"Sickle cell disease and infections in high- and low-income countries","volume":"11","author":"Cannas","year":"2019","journal-title":"Mediterr J Hematol Infect Dis"},{"issue":"8348","key":"10.1016\/j.bvth.2026.100184_bib12","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0140-6736(83)90524-X","article-title":"Sickle-cell anaemia: an explanation for the ancient myth of reincarnation in Nigeria","volume":"2","author":"Onwubalili","year":"1983","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.bvth.2026.100184_bib13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41581-023-00683-3","article-title":"Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup","volume":"19","author":"Zarbock","year":"2023","journal-title":"Nat Rev Nephrol"},{"issue":"5","key":"10.1016\/j.bvth.2026.100184_bib14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1086\/506356","article-title":"Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta \/bone morphogenetic protein pathway with bacteremia in sickle cell anemia","volume":"43","author":"Adewoye","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"10","key":"10.1016\/j.bvth.2026.100184_bib15","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/ajh.20692","article-title":"Bloodstream infections in hospitalized adults with sickle cell disease: a retrospective analysis","volume":"81","author":"Chulamokha","year":"2006","journal-title":"Am J Hematol"},{"issue":"5","key":"10.1016\/j.bvth.2026.100184_bib16","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s10753-018-0810-y","article-title":"Mechanisms of hemolysis during sepsis","volume":"41","author":"Effenberger-Neidnicht","year":"2018","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.bvth.2026.100184_bib17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40560-019-0387-z","article-title":"Sepsis-associated disseminated intravascular coagulation and its differential diagnoses","volume":"7","author":"Iba","year":"2019","journal-title":"J Intensive Care"},{"key":"10.1016\/j.bvth.2026.100184_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40560-016-0149-0","article-title":"Sepsis and disseminated intravascular coagulation","volume":"4","author":"Okamoto","year":"2016","journal-title":"J Intensive Care"},{"issue":"2","key":"10.1016\/j.bvth.2026.100184_bib19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.semnephrol.2020.01.006","article-title":"The role of circulating cell-free hemoglobin in sepsis-associated acute kidney injury","volume":"40","author":"Kerchberger","year":"2020","journal-title":"Semin Nephrol"},{"issue":"5","key":"10.1016\/j.bvth.2026.100184_bib20","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1177\/0310057X1003800522","article-title":"Intravascular haemolysis and septicaemia due to Clostridium perfringens liver abscess","volume":"38","author":"Rajendran","year":"2010","journal-title":"Anaesth Intensive Care"},{"issue":"7","key":"10.1016\/j.bvth.2026.100184_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/toxins8070207","article-title":"Regulation of toxin production in Clostridium perfringens","volume":"8","author":"Ohtani","year":"2016","journal-title":"Toxins (Basel)"},{"issue":"5","key":"10.1016\/j.bvth.2026.100184_bib22","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.kint.2019.05.026","article-title":"Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment","volume":"96","author":"Peerapornratana","year":"2019","journal-title":"Kidney Int"},{"issue":"6","key":"10.1016\/j.bvth.2026.100184_bib23","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1681\/ASN.2006121402","article-title":"Evidence for the role of reactive nitrogen species in polymicrobial sepsis-induced renal peritubular capillary dysfunction and tubular injury","volume":"18","author":"Wu","year":"2007","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.bvth.2026.100184_bib24","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1056\/NEJMra1214243","article-title":"Acute kidney injury and chronic kidney disease as interconnected syndromes","volume":"371","author":"Chawla","year":"2014","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.bvth.2026.100184_bib25","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1053\/j.ajkd.2010.03.025","article-title":"Hemolysis and acute kidney failure","volume":"56","author":"Qian","year":"2010","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"10.1016\/j.bvth.2026.100184_bib26","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.kint.2019.08.026","article-title":"Hemolysis-associated hemoglobin cast nephropathy results from a range of clinicopathologic disorders","volume":"96","author":"Dvanajscak","year":"2019","journal-title":"Kidney Int"},{"issue":"9","key":"10.1016\/j.bvth.2026.100184_bib27","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.ekir.2020.06.019","article-title":"Hemoglobin cast nephropathy","volume":"5","author":"Mahmud","year":"2020","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.bvth.2026.100184_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.88","article-title":"Chronic kidney disease","volume":"3","author":"Romagnani","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"10.1016\/j.bvth.2026.100184_bib29","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/03630269.2016.1224766","article-title":"Renal failure in sickle cell disease: prevalence, predictors of disease, mortality and effect on length of hospital stay","volume":"40","author":"Yeruva","year":"2016","journal-title":"Hemoglobin"},{"issue":"3","key":"10.1016\/j.bvth.2026.100184_bib30","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/bjh.12024","article-title":"High one year mortality in adults with sickle cell disease and end-stage renal disease","volume":"159","author":"McClellan","year":"2012","journal-title":"Br J Haematol"},{"issue":"8","key":"10.1016\/j.bvth.2026.100184_bib31","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1007\/s00467-017-3623-6","article-title":"Acute kidney injury during a pediatric sickle cell vaso-occlusive pain crisis","volume":"32","author":"Baddam","year":"2017","journal-title":"Pediatr Nephrol"},{"issue":"1","key":"10.1016\/j.bvth.2026.100184_bib32","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12882-022-02731-9","article-title":"Acute kidney injury in hospitalized children with sickle cell anemia","volume":"23","author":"Batte","year":"2022","journal-title":"BMC Nephrol"},{"issue":"6","key":"10.1016\/j.bvth.2026.100184_bib33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41581-022-00540-9","article-title":"The nephropathy of sickle cell trait and sickle cell disease","volume":"18","author":"Ataga","year":"2022","journal-title":"Nat Rev Nephrol"},{"issue":"3","key":"10.1016\/j.bvth.2026.100184_bib34","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrneph.2015.8","article-title":"Sickle cell disease: renal manifestations and mechanisms","volume":"11","author":"Nath","year":"2015","journal-title":"Nat Rev Nephrol"},{"issue":"2","key":"10.1016\/j.bvth.2026.100184_bib35","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1089\/ars.2009.2787","article-title":"Heme scavenging and the other facets of hemopexin","volume":"12","author":"Tolosano","year":"2010","journal-title":"Antioxid Redox Signal"},{"issue":"4","key":"10.1016\/j.bvth.2026.100184_bib36","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1089\/104454902753759717","article-title":"Hemopexin: structure, function, and regulation","volume":"21","author":"Tolosano","year":"2002","journal-title":"DNA Cell Biol"},{"issue":"5","key":"10.1016\/j.bvth.2026.100184_bib37","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/MOL.0000000000000208","article-title":"Role of hemoglobin\/heme scavenger protein hemopexin in atherosclerosis and inflammatory diseases","volume":"26","author":"Mehta","year":"2015","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.bvth.2026.100184_bib38","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3389\/fphys.2014.00415","article-title":"Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development","volume":"5","author":"Schaer","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.bvth.2026.100184_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jss.2016.12.020","article-title":"Protective effect of hemopexin on systemic inflammation and acute lung injury in an endotoxemia model","volume":"212","author":"Jung","year":"2017","journal-title":"J Surg Res"},{"issue":"13","key":"10.1016\/j.bvth.2026.100184_bib40","first-page":"1044","article-title":"Hemopexin deficiency promotes acute kidney injury in sickle cell disease","volume":"135","author":"Ofori-Acquah","year":"2020","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.bvth.2026.100184_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126408","article-title":"Critical role of hemopexin mediated cytoprotection in the pathophysiology of sickle cell disease","volume":"22","author":"Ashouri","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"5339","key":"10.1016\/j.bvth.2026.100184_bib42","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1126\/science.278.5339.873","article-title":"Knockout-transgenic mouse model of sickle cell disease","volume":"278","author":"Ryan","year":"1997","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.bvth.2026.100184_bib43","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1182\/blood-2006-02-004812","article-title":"Correction of sickle cell disease by homologous recombination in embryonic stem cells","volume":"108","author":"Wu","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bvth.2026.100184_bib44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-1-62703-481-4_15","article-title":"Sepsis induced by cecal ligation and puncture","volume":"1031","author":"Wen","year":"2013","journal-title":"Methods Mol Biol"},{"issue":"1","key":"10.1016\/j.bvth.2026.100184_bib45","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40635-016-0096-z","article-title":"Sepsis modeling in mice: ligation length is a major severity factor in cecal ligation and puncture","volume":"4","author":"Ruiz","year":"2016","journal-title":"Intensive Care Med Exp"},{"issue":"12","key":"10.1016\/j.bvth.2026.100184_bib46","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.1128\/IAI.67.12.6603-6610.1999","article-title":"Immunopathologic alterations in murine models of sepsis of increasing severity","volume":"67","author":"Ebong","year":"1999","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.bvth.2026.100184_bib47","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat Protoc"},{"issue":"1","key":"10.1016\/j.bvth.2026.100184_bib48","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jss.2008.02.016","article-title":"Evaluation of gene promoters for liver expression by hydrodynamic gene transfer","volume":"148","author":"Nguyen","year":"2008","journal-title":"J Surg Res"},{"key":"10.1016\/j.bvth.2026.100184_bib49","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-1-61779-370-7_6","article-title":"AAV-mediated liver-directed gene therapy","volume":"807","author":"Sands","year":"2011","journal-title":"Methods Mol Biol"},{"issue":"1","key":"10.1016\/j.bvth.2026.100184_bib50","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1128\/JVI.79.1.214-224.2005","article-title":"Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice","volume":"79","author":"Nakai","year":"2005","journal-title":"J Virol"},{"issue":"18","key":"10.1016\/j.bvth.2026.100184_bib51","doi-asserted-by":"crossref","first-page":"11854","DOI":"10.1073\/pnas.182412299","article-title":"Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy","volume":"99","author":"Gao","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"140","key":"10.1016\/j.bvth.2026.100184_bib52","doi-asserted-by":"crossref","DOI":"10.3791\/58520","article-title":"Transdermal measurement of glomerular filtration rate in mice","author":"Scarfe","year":"2018","journal-title":"J Vis Exp"},{"issue":"6-12","key":"10.1016\/j.bvth.2026.100184_bib53","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1080\/10715762.2023.2269313","article-title":"Rhabdomyolysis aggravates renal iron accumulation and acute kidney injury in a humanized mouse model of sickle cell disease","volume":"57","author":"Williams","year":"2023","journal-title":"Free Radic Res"},{"issue":"187","key":"10.1016\/j.bvth.2026.100184_bib54","doi-asserted-by":"crossref","DOI":"10.3791\/64413","article-title":"Transdermal measurement of glomerular filtration rate in mechanically ventilated piglets","author":"Fanous","year":"2022","journal-title":"J Vis Exp"},{"issue":"1","key":"10.1016\/j.bvth.2026.100184_bib55","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/0886022X.2018.1456938","article-title":"Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding","volume":"40","author":"Soni","year":"2018","journal-title":"Ren Fail"},{"issue":"6","key":"10.1016\/j.bvth.2026.100184_bib56","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/76299","article-title":"Assessing tumors in living animals through measurement of urinary beta-human chorionic gonadotropin","volume":"6","author":"Shih","year":"2000","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.bvth.2026.100184_bib57","article-title":"Post-injury inhibition of endothelin-1 dependent renal vasoregulation mitigates rhabdomyolysis-induced acute kidney injury","volume":"4","author":"Afolabi","year":"2023","journal-title":"Function (Oxf)"},{"issue":"5","key":"10.1016\/j.bvth.2026.100184_bib58","doi-asserted-by":"crossref","first-page":"756","DOI":"10.2215\/CJN.08511109","article-title":"Glomerular hyperfiltration in adult sickle cell anemia: a frequent hemolysis associated feature","volume":"5","author":"Haymann","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"issue":"12","key":"10.1016\/j.bvth.2026.100184_bib59","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1002\/ajh.23817","article-title":"Hyperfiltration is associated with the development of microalbuminuria in patients with sickle cell anemia","volume":"89","author":"Vazquez","year":"2014","journal-title":"Am J Hematol"},{"issue":"9","key":"10.1016\/j.bvth.2026.100184_bib60","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1182\/bloodadvances.2018028878","article-title":"Hyperfiltration predicts long-term renal outcomes in humanized sickle cell mice","volume":"3","author":"Kasztan","year":"2019","journal-title":"Blood Adv"},{"issue":"4","key":"10.1016\/j.bvth.2026.100184_bib61","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tim.2011.01.001","article-title":"Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?","volume":"19","author":"Dejager","year":"2011","journal-title":"Trends Microbiol"},{"issue":"10","key":"10.1016\/j.bvth.2026.100184_bib62","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1172\/JCI39421","article-title":"Animal models of sepsis and sepsis-induced kidney injury","volume":"119","author":"Doi","year":"2009","journal-title":"J Clin Invest"},{"issue":"20","key":"10.1016\/j.bvth.2026.100184_bib63","doi-asserted-by":"crossref","first-page":"9954","DOI":"10.3390\/ijms26209954","article-title":"Precision profiling of disease progression in murine models of sepsis and septic shock","volume":"26","author":"Ramsay","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.bvth.2026.100184_bib64","first-page":"546","article-title":"Infections in sickle cell disease","volume":"110","author":"Scourfield","year":"2025","journal-title":"Haematologica"},{"issue":"22","key":"10.1016\/j.bvth.2026.100184_bib65","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1182\/blood.V128.22.3649.3649","article-title":"Serum haptoglobin and hemopexin levels in pediatric SS and SC disease patients: biomarker of hemolysis and inflammation","volume":"128","author":"Santiago","year":"2016","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.bvth.2026.100184_bib66","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1182\/blood.V32.5.811.811","article-title":"Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases","volume":"32","author":"Muller-Eberhard","year":"1968","journal-title":"Blood"},{"key":"10.1016\/j.bvth.2026.100184_bib67","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bcmd.2018.07.002","article-title":"Serum haptoglobin and hemopexin levels are depleted in pediatric sickle cell disease patients","volume":"72","author":"Santiago","year":"2018","journal-title":"Blood Cells Mol Dis"},{"issue":"4","key":"10.1016\/j.bvth.2026.100184_bib68","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0891-5849(99)00264-6","article-title":"Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo","volume":"28","author":"Roberts","year":"2000","journal-title":"Free Radic Biol Med"},{"issue":"2-3","key":"10.1016\/j.bvth.2026.100184_bib69","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0014-5793(97)00469-9","article-title":"What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?","volume":"411","author":"Halliwell","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bvth.2026.100184_bib70","article-title":"Role of ROS-induced NLRP3 inflammasome activation in the formation of calcium oxalate nephrolithiasis","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol"},{"issue":"9","key":"10.1016\/j.bvth.2026.100184_bib71","doi-asserted-by":"crossref","first-page":"e897","DOI":"10.1097\/CCM.0000000000001735","article-title":"Histopathology of septic acute kidney injury: a systematic review of experimental data","volume":"44","author":"Kosaka","year":"2016","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.bvth.2026.100184_bib72","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1097\/CCM.0b013e3182a639da","article-title":"Renal histopathology during experimental septic acute kidney injury and recovery","volume":"42","author":"Langenberg","year":"2014","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1016\/j.bvth.2026.100184_bib73","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1164\/rccm.201211-1983OC","article-title":"Mechanisms of cardiac and renal dysfunction in patients dying of sepsis","volume":"187","author":"Takasu","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.bvth.2026.100184_bib74","doi-asserted-by":"crossref","DOI":"10.1186\/cc7164","article-title":"Renal haemodynamic, microcirculatory, metabolic and histopathological responses to peritonitis-induced septic shock in pigs","volume":"12","author":"Chvojka","year":"2008","journal-title":"Crit Care"},{"issue":"4","key":"10.1016\/j.bvth.2026.100184_bib75","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.semnephrol.2016.05.005","article-title":"The role of acute kidney injury in chronic kidney disease","volume":"36","author":"Hsu","year":"2016","journal-title":"Semin Nephrol"},{"issue":"13","key":"10.1016\/j.bvth.2026.100184_bib76","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1177\/15353702231182199","article-title":"Safety and feasibility of the gene transfer of hemopexin for conditions with increased free heme","volume":"248","author":"de Lima","year":"2023","journal-title":"Exp Biol Med (Maywood)"},{"issue":"1","key":"10.1016\/j.bvth.2026.100184_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.bvth.2025.100115","article-title":"Sustained expression of hemopexin in an animal model of sickle cell anemia","volume":"3","author":"De Lima","year":"2026","journal-title":"Blood Vessel Thromb Hemost"},{"issue":"suppl 1","key":"10.1016\/j.bvth.2026.100184_bib78","article-title":"Phase 1 study of the safety and pharmacokinetics of CSL889 (hemopexin) in adults with SCD","volume":"1","author":"Shore","year":"2024","journal-title":"J Sick Cell Dis"},{"issue":"S1","key":"10.1016\/j.bvth.2026.100184_bib79","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/01.HS9.0000928236.70320.48","article-title":"5610845 a phase 1 study of CSL888 (hemopexin) in adult patients with sickle cell disease","volume":"7","author":"Biemond","year":"2023","journal-title":"Hemasphere"},{"issue":"suppl 1","key":"10.1016\/j.bvth.2026.100184_bib80","article-title":"Design of the RHEMEDY study: a phase 2\/3 safety, efficacy and pharmacokinetics study of CSL889 in adults and adolescents with sickle cell disease during vaso-occlusive crisis","volume":"2","author":"Gordeuk","year":"2025","journal-title":"J Sick Cell Dis"},{"issue":"3","key":"10.1016\/j.bvth.2026.100184_bib81","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11030630","article-title":"Plasma-derived hemopexin as a candidate therapeutic agent for acute vaso-occlusion in sickle cell disease: preclinical evidence","volume":"11","author":"Gentinetta","year":"2022","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.bvth.2026.100184_bib82","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00277-025-06216-1","article-title":"A review on disease modifying pharmacologic therapies for sickle cell disease","volume":"104","author":"Mahadevia","year":"2025","journal-title":"Ann Hematol"}],"container-title":["Blood Vessels, Thrombosis &amp; Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327226000495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327226000495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:40:58Z","timestamp":1788295258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950327226000495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":82,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2950327226000495"],"URL":"https:\/\/doi.org\/10.1016\/j.bvth.2026.100184","relation":{},"ISSN":["2950-3272"],"issn-type":[{"value":"2950-3272","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Augmenting hemopexin-mediated heme scavenging mitigates sepsis-induced acute kidney injury in humanized sickle cell mice","name":"articletitle","label":"Article Title"},{"value":"Blood Vessels, Thrombosis & Hemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bvth.2026.100184","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100184"}}