{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:28:53Z","timestamp":1788470933270,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-21-CE17-0023-01"],"award-info":[{"award-number":["ANR-21-CE17-0023-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-23-CE17-0045"],"award-info":[{"award-number":["ANR-23-CE17-0045"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-18-RHUS-0001"],"award-info":[{"award-number":["ANR-18-RHUS-0001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Vessels, Thrombosis &amp; Hemostasis"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bvth.2026.100191","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:11:59Z","timestamp":1783959119000},"page":"100191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelets mediate fibrin-induced thromboinflammation and NETosis through a GPVI-polyphosphate-FXIIa procoagulant axis"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8955-214X","authenticated-orcid":false,"given":"Astride","family":"Perrot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Ollivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Delbosc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Zemali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmina","family":"Rogozarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0911-8999","authenticated-orcid":false,"given":"Mikael","family":"Mazighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Camerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9637-3682","authenticated-orcid":false,"given":"Nathalie","family":"Kubis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8450-9247","authenticated-orcid":false,"given":"Martine","family":"Jandrot-Perrus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7428-1760","authenticated-orcid":false,"given":"Benoit","family":"Ho-Tin-No\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bvth.2026.100191_bib1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1084\/jem.187.6.903","article-title":"Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP","volume":"187","author":"Feng","year":"1998","journal-title":"J Exp Med"},{"issue":"5","key":"10.1016\/j.bvth.2026.100191_bib2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007804","article-title":"Downstream microvascular thrombosis in cortical venules is an early response to proximal cerebral arterial occlusion","volume":"7","author":"Desilles","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"10.1016\/j.bvth.2026.100191_bib3","doi-asserted-by":"crossref","first-page":"C951","DOI":"10.1152\/ajpcell.00252.2022","article-title":"Procoagulant platelets: novel players in thromboinflammation","volume":"323","author":"Denorme","year":"2022","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"10.1016\/j.bvth.2026.100191_bib4","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/09537104.2020.1817360","article-title":"Immunothrombosis and thromboinflammation in host defense and disease","volume":"32","author":"Martinod","year":"2021","journal-title":"Platelets"},{"issue":"12","key":"10.1016\/j.bvth.2026.100191_bib5","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1055\/a-2523-1821","article-title":"Recent advances in immunothrombosis and thromboinflammation","volume":"125","author":"Kaiser","year":"2025","journal-title":"Thromb Haemost"},{"issue":"8031","key":"10.1016\/j.bvth.2026.100191_bib6","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/s41586-024-07873-4","article-title":"Fibrin drives thromboinflammation and neuropathology in COVID-19","volume":"633","author":"Ryu","year":"2024","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.bvth.2026.100191_bib7","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1161\/01.STR.25.9.1847","article-title":"Fibrin contributes to microvascular obstructions and parenchymal changes during early focal cerebral ischemia and reperfusion","volume":"25","author":"Okada","year":"1994","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.bvth.2026.100191_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1748-1716.2009.02037.x","article-title":"Mechanisms of fibrinogen-induced microvascular dysfunction during cardiovascular disease","volume":"198","author":"Lominadze","year":"2010","journal-title":"Acta Physiol"},{"issue":"1","key":"10.1016\/j.bvth.2026.100191_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-026-70717-4","article-title":"CD177+ neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis","volume":"17","author":"Lan","year":"2026","journal-title":"Nat Commun"},{"issue":"6575","key":"10.1016\/j.bvth.2026.100191_bib10","article-title":"Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier","volume":"374","author":"Silva","year":"2021","journal-title":"Science (1979)"},{"issue":"7","key":"10.1016\/j.bvth.2026.100191_bib11","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1161\/STROKEAHA.117.017080","article-title":"Exacerbation of thromboinflammation by hyperglycemia precipitates cerebral infarct growth and hemorrhagic transformation","volume":"48","author":"Desilles","year":"2017","journal-title":"Stroke"},{"issue":"7","key":"10.1016\/j.bvth.2026.100191_bib12","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nm.3887","article-title":"Diabetes primes neutrophils to undergo NETosis, which impairs wound healing","volume":"21","author":"Wong","year":"2015","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.bvth.2026.100191_bib13","doi-asserted-by":"crossref","first-page":"R65","DOI":"10.1530\/JME-20-0128","article-title":"Netosis contributes to the pathogenesis of diabetes and its complications","volume":"65","author":"Njeim","year":"2020","journal-title":"J Mol Endocrinol"},{"issue":"1","key":"10.1016\/j.bvth.2026.100191_bib14","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-022-01655-w","article-title":"Diabetes mellitus duration and mortality in patients hospitalized with acute myocardial infarction","volume":"21","author":"Baviera","year":"2022","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.bvth.2026.100191_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev-med-042220-011857","article-title":"COVID-19 and diabetes","volume":"73","author":"Singh","year":"2022","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.bvth.2026.100191_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2020.108382","article-title":"Hyperglycemia without diabetes and new-onset diabetes are both associated with poorer outcomes in COVID-19","volume":"167","author":"Singh","year":"2020","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"10.1016\/j.bvth.2026.100191_bib17","article-title":"GLUT1-mediated HMGB1 O-GlcNAcylation drives hyperglycemia-induced neutrophil extracellular trap networks formation via TLR4 signaling and exacerbates fibroblast inflammation","volume":"15","author":"Sun","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.bvth.2026.100191_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2026.178860","article-title":"Acute hyperglycemia induces NETosis and futile recanalization after ischemic stroke via RAGE\/DIAPH1 pathway","volume":"1023","author":"Li","year":"2026","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"10.1016\/j.bvth.2026.100191_bib19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/23969873241247400","article-title":"Stress hyperglycemia is associated with futile recanalization in patients with anterior large vessel occlusion undergoing mechanical thrombectomy","volume":"9","author":"Merlino","year":"2024","journal-title":"Eur Stroke J"},{"issue":"11","key":"10.1016\/j.bvth.2026.100191_bib20","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1161\/STROKEAHA.120.029944","article-title":"High admission glucose is associated with poor outcome after endovascular treatment for ischemic stroke","volume":"51","author":"Rinkel","year":"2020","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.bvth.2026.100191_bib21","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/jth.13907","article-title":"Hemodynamic force triggers rapid NETosis within sterile thrombotic occlusions","volume":"16","author":"Yu","year":"2018","journal-title":"J Thromb Haemost"},{"issue":"4","key":"10.1016\/j.bvth.2026.100191_bib22","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1055\/s-0039-1678529","article-title":"Fibrin modulates shear-induced NETosis in sterile occlusive thrombi formed under haemodynamic flow","volume":"119","author":"Yu","year":"2019","journal-title":"Thromb Haemost"},{"issue":"11","key":"10.1016\/j.bvth.2026.100191_bib23","doi-asserted-by":"crossref","DOI":"10.1128\/jb.00189-25","article-title":"The PA2803-encoded PcrP exhibits a novel non-catalytic function and contributes to polymyxin B resistance in P. aeruginosa","volume":"207","author":"Salpadoru","year":"2025","journal-title":"J Bacteriol"},{"issue":"4","key":"10.1016\/j.bvth.2026.100191_bib24","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0167-4889(82)90094-5","article-title":"Localization of polyphosphates in Saccharomyces fragilis, as revealed by 4\u2032,6-diamidino-2-phenylindole fluorescence","volume":"721","author":"Tijssen","year":"1982","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"10.1016\/j.bvth.2026.100191_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-17648-w","article-title":"Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs","volume":"11","author":"Wilbs","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.bvth.2026.100191_bib26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s12933-023-01990-6","article-title":"Diabetes- versus smoking-related thrombo-inflammation in peripheral artery disease","volume":"22","author":"Alnima","year":"2023","journal-title":"Cardiovasc Diabetol"},{"issue":"3","key":"10.1016\/j.bvth.2026.100191_bib27","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0167-4838(86)90279-7","article-title":"Gly-Pro-Arg-Pro modifies the glutamine residues in the \u03b1- and \u03b3-chains of fibrinogen: inhibition of transglutaminase cross-linking","volume":"872","author":"Achyuthan","year":"1986","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"10.1016\/j.bvth.2026.100191_bib28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1182\/blood-2011-10-389247","article-title":"Granule exocytosis is required for platelet spreading: differential sorting of \u03b1-granules expressing VAMP-7","volume":"120","author":"Peters","year":"2012","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.bvth.2026.100191_bib29","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1182\/blood-2015-02-629717","article-title":"Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation","volume":"126","author":"Mammadova-Bach","year":"2015","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.bvth.2026.100191_bib30","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1182\/blood.V76.2.345.345","article-title":"Glycoprotein Ib, von Willebrand factor, and glycoprotein IIb:IIIa are all involved in platelet adhesion to fibrin in flowing whole blood","volume":"76","author":"Hantgan","year":"1990","journal-title":"Blood"},{"issue":"25","key":"10.1016\/j.bvth.2026.100191_bib31","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1021\/bi025770x","article-title":"Interaction of fibrin(ogen) with fibronectin: further characterization and localization of the fibronectin-binding site","volume":"41","author":"Makogonenko","year":"2002","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.bvth.2026.100191_bib32","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1182\/blood-2003-12-4293","article-title":"Fibrin-incorporated vitronectin is involved in platelet adhesion and thrombus formation through homotypic interactions with platelet-associated vitronectin","volume":"104","author":"Wu","year":"2004","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.bvth.2026.100191_bib33","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1182\/blood-2005-10-4168","article-title":"Enhancement of thrombogenesis by plasma fibronectin cross-linked to fibrin and assembled in platelet thrombi","volume":"107","author":"Cho","year":"2006","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.bvth.2026.100191_bib34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1182\/blood.2021014914","article-title":"Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI","volume":"140","author":"Kaiser","year":"2022","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.bvth.2026.100191_bib35","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.cell.2009.11.001","article-title":"Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo","volume":"139","author":"M\u00fcller","year":"2009","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.bvth.2026.100191_bib36","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1182\/blood-2013-05-499384","article-title":"Putting polyphosphates to the test: evidence against platelet-induced activation of factor XII","volume":"122","author":"Fax\u00e4lv","year":"2013","journal-title":"Blood"},{"issue":"23","key":"10.1016\/j.bvth.2026.100191_bib37","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1182\/blood-2013-09-525840","article-title":"Time-dependent degradation and tissue factor addition mask the ability of platelet polyphosphates in activating factor XII\u2013mediated coagulation","volume":"122","author":"Nickel","year":"2013","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.bvth.2026.100191_bib38","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1182\/blood-2015-01-620245","article-title":"Platelet binding sites for factor VIII in relation to fibrin and phosphatidylserine","volume":"126","author":"Gilbert","year":"2015","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.bvth.2026.100191_bib39","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1111\/j.1538-7836.2008.03104.x","article-title":"Polyphosphate as a general procoagulant agent","volume":"6","author":"Smith","year":"2008","journal-title":"J Thromb Haemost"},{"issue":"1","key":"10.1016\/j.bvth.2026.100191_bib40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s42003-020-1002-5","article-title":"Single platelet variability governs population sensitivity and initiates intrinsic heterotypic responses","volume":"3","author":"Jongen","year":"2020","journal-title":"Commun Biol"},{"issue":"21","key":"10.1016\/j.bvth.2026.100191_bib41","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1182\/blood.V122.21.197.197","article-title":"Platelet cytoskeletal force transmission through the GPIb-IX-V complex","volume":"122","author":"Feghhi","year":"2013","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.bvth.2026.100191_bib42","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1182\/blood-2010-01-262683","article-title":"Key role of glycoprotein Ib\/V\/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow","volume":"117","author":"Cosemans","year":"2011","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bvth.2026.100191_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2022.100006","article-title":"Discriminating young platelets on human leukocyte antigen-I expression highlights their extremely high reactivity potential","volume":"7","author":"Ang\u00e9nieux","year":"2023","journal-title":"Res Pract Thromb Haemost"},{"issue":"14","key":"10.1016\/j.bvth.2026.100191_bib44","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1182\/blood.2024024901","article-title":"Aging platelets shift their hemostatic properties to inflammatory functions","volume":"145","author":"Anjum","year":"2025","journal-title":"Blood"},{"issue":"14","key":"10.1016\/j.bvth.2026.100191_bib45","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1182\/bloodadvances.2021006904","article-title":"GPVI expression is linked to platelet size, age, and reactivity","volume":"6","author":"Veninga","year":"2022","journal-title":"Blood Adv"},{"issue":"5","key":"10.1016\/j.bvth.2026.100191_bib46","doi-asserted-by":"crossref","first-page":"932","DOI":"10.2337\/db18-0981","article-title":"Glucose metabolism is required for platelet hyperactivation in a murine model of type 1 diabetes","volume":"68","author":"Fidler","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.bvth.2026.100191_bib47","article-title":"Hyperglycemia induces neutrophil extracellular traps formation through an NADPH oxidase-dependent pathway in diabetic retinopathy","volume":"9","author":"Wang","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.bvth.2026.100191_bib48","article-title":"Blood glucose level affects prognosis of patients who received intravenous thrombolysis after acute ischemic stroke? A meta-analysis","volume":"14","author":"Wang","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"10.1016\/j.bvth.2026.100191_bib49","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1182\/blood-2015-01-624023","article-title":"P-selectin promotes neutrophil extracellular trap formation in mice","volume":"126","author":"Etulain","year":"2015","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bvth.2026.100191_bib50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41419-025-07428-z","article-title":"Non-classical neutrophil extracellular traps induced by PAR2-signaling proteases","volume":"16","author":"Bryzek","year":"2025","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.bvth.2026.100191_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.thromres.2023.12.005","article-title":"White blood cell subtypes and neutrophil extracellular traps content as biomarkers for stroke etiology in acute ischemic stroke clots retrieved by mechanical thrombectomy","volume":"234","author":"Jabrah","year":"2024","journal-title":"Thromb Res"},{"issue":"3","key":"10.1016\/j.bvth.2026.100191_bib52","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/STROKEAHA.117.019896","article-title":"Thrombus neutrophil extracellular traps content impair tPA-induced thrombolysis in acute ischemic stroke","volume":"49","author":"Ducroux","year":"2018","journal-title":"Stroke"},{"issue":"18","key":"10.1016\/j.bvth.2026.100191_bib53","doi-asserted-by":"crossref","first-page":"E1686","DOI":"10.1212\/WNL.0000000000008395","article-title":"Acute ischemic stroke thrombi have an outer shell that impairs fibrinolysis","volume":"93","author":"Di Meglio","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.bvth.2026.100191_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.548631","article-title":"Platelets as mediators of neuroinflammation and thrombosis","volume":"11","author":"Rawish","year":"2020","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.bvth.2026.100191_bib55","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/STROKEAHA.122.038733","article-title":"Thromboinflammation in brain ischemia: recent updates and future perspectives","volume":"53","author":"De Meyer","year":"2022","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.bvth.2026.100191_bib56","first-page":"787","article-title":"Tissue factor in crescentic glomerulonephritis","volume":"150","author":"McCluskey","year":"1997","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.bvth.2026.100191_bib57","first-page":"873","article-title":"Tissue factor initiates glomerular fibrin deposition and promotes major histocompatibility complex class II expression in crescentic glomerulonephritis","volume":"150","author":"Erlich","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1016\/j.bvth.2026.100191_bib58","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.atherosclerosis.2018.12.023","article-title":"GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity","volume":"281","author":"Barrachina","year":"2019","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.bvth.2026.100191_bib59","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1161\/ATVBAHA.120.314485","article-title":"Phosphoproteomic analysis of platelets in severe obesity uncovers platelet reactivity and signaling pathways alterations","volume":"41","author":"Barrachina","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"10.1016\/j.bvth.2026.100191_bib60","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.3324\/haematol.2022.281726","article-title":"Age- and gender-matched controls needed for platelet-based biomarker studies","volume":"108","author":"Sabrkhany","year":"2023","journal-title":"Haematologica"}],"container-title":["Blood Vessels, Thrombosis &amp; Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327226000562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950327226000562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:11:18Z","timestamp":1788469878000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950327226000562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2950327226000562"],"URL":"https:\/\/doi.org\/10.1016\/j.bvth.2026.100191","relation":{},"ISSN":["2950-3272"],"issn-type":[{"value":"2950-3272","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelets mediate fibrin-induced thromboinflammation and NETosis through a GPVI-polyphosphate-FXIIa procoagulant axis","name":"articletitle","label":"Article Title"},{"value":"Blood Vessels, Thrombosis & Hemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bvth.2026.100191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100191"}}