{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:33:07Z","timestamp":1791109987041,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Genetics and Cytogenetics"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.cancergencyto.2004.09.020","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T11:41:22Z","timestamp":1114602082000},"page":"1-9","source":"Crossref","is-referenced-by-count":38,"title":["A combination of molecular cytogenetic analyses reveals complex genetic alterations in conventional renal cell carcinoma"],"prefix":"10.1016","volume":"159","author":[{"given":"Jon C.","family":"Strefford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Stasevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim M.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan D.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cancergencyto.2004.09.020_bib1","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1056\/NEJM199609193351207","article-title":"Renal-cell carcinoma","volume":"335","author":"Motzer","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/(SICI)1096-9896(199710)183:2<131::AID-PATH931>3.0.CO;2-G","article-title":"The Heidelberg classification of renal cell tumours","volume":"183","author":"Kovacs","year":"1997","journal-title":"J Pathol"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib3","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.8493574","article-title":"Identification of the von Hippel-Lindau disease tumor suppressor gene","volume":"260","author":"Latif","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib4","first-page":"2946","article-title":"Absence or reduction of Fhit expression in most clear cell renal carcinomas","volume":"58","author":"Hadaczek","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib5","doi-asserted-by":"crossref","first-page":"7504","DOI":"10.1073\/pnas.131216298","article-title":"The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis","volume":"98","author":"Dreijerink","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib6","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/327721a0","article-title":"Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma","volume":"327","author":"Zbar","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib7","first-page":"1071","article-title":"Molecular analysis of genetic changes in the origin and development of renal cell carcinoma","volume":"51","author":"Anglard","year":"1991","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1098-2264(200001)27:1<1::AID-GCC1>3.0.CO;2-6","article-title":"Loss of expression of the DRR 1 gene at chromosomal segment 3p21.1 in renal cell carcinoma","volume":"27","author":"Wang","year":"2000","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib9","first-page":"651","article-title":"Clonal chromosome abnormalities in tumor cells from patients with sporadic renal cell carcinomas","volume":"49","author":"Kovacs","year":"1989","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib10","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1073\/pnas.88.1.194","article-title":"Nonhomologous chromatid exchange in hereditary and sporadic renal cell carcinomas","volume":"88","author":"Kovacs","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/372143a0","article-title":"Chromosomal translocations in human cancer","volume":"372","author":"Rabbitts","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib12","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/sj.onc.1200915","article-title":"Duplication of an approximately 1.5 Mb DNA segment at chromosome 5q22 indicates the locus of a new tumour gene in nonpapillary renal cell carcinomas","volume":"14","author":"Kenck","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/(SICI)1098-2264(199705)19:1<29::AID-GCC5>3.0.CO;2-2","article-title":"Significance of chromosome arm 14q loss in nonpapillary renal cell carcinomas","volume":"19","author":"Herbers","year":"1997","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib14","first-page":"5780","article-title":"Allelic deletions in renal tumours: histopathological correlations","volume":"53","author":"Presti","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib15","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/(SICI)1097-0142(19960315)77:6<1154::AID-CNCR23>3.0.CO;2-#","article-title":"The correlation between the loss of chromosome 14q with histologic grade, pathologic stage, and outcome of patients with nonpapillary renal cell carcinoma","volume":"77","author":"Wu","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib16","first-page":"820","article-title":"Allelotype of renal cell carcinoma","volume":"51","author":"Morita","year":"1991","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib17","first-page":"5817","article-title":"Common regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma","volume":"51","author":"Morita","year":"1991","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib18","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1073\/pnas.92.7.2854","article-title":"Comprehensive allelotyping of human renal cell carcinomas using microsatellite DNA probes","volume":"92","author":"Thrash-Bingham","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/(SICI)1096-9896(199710)183:2<151::AID-PATH928>3.0.CO;2-R","article-title":"Loss of heterozygosity at chromosomes 8p, 9p, and 14q is associated with stage and grade of non-papillary renal cell carcinomas","volume":"183","author":"Schullerus","year":"1997","journal-title":"J Pathol"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib20","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1349-7006.1995.tb03087.x","article-title":"Contribution of chromosome 9p21-22 deletion to the progression of human renal cell carcinoma","volume":"86","author":"Kinoshita","year":"1995","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/(SICI)1097-0215(19990105)80:1<22::AID-IJC5>3.0.CO;2-S","article-title":"Microsatellite analysis reveals deletion of a large region at chromosome 8p in conventional renal cell carcinoma","volume":"80","author":"Schullerus","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib22","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0165-4608(95)00024-J","article-title":"Renal cell carcinoma: cytogenetic analysis of tumors and cell lines","volume":"82","author":"Zhao","year":"1995","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/gcc.1111","article-title":"Molecular cytogenetic characterization of early and late renal cell carcinomas in von Hippel-Lindau disease","volume":"31","author":"Phillips","year":"2001","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib24","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/ng0496-368","article-title":"Karyotyping human chromosomes by combinatorial multi-fluor FISH","volume":"12","author":"Speicher","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib25","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.1359641","article-title":"Comparative genomic hybridization for molecular genetic analysis of solid tumors","volume":"258","author":"Kallioniemi","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/2524","article-title":"High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays","volume":"20","author":"Pinkel","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib27","first-page":"5531","article-title":"Establishment and characterization of human renal cancer and normal kidney cell lines","volume":"50","author":"Ebert","year":"1990","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib28","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/gcc.10184","article-title":"Genetic alterations in primary cutaneous CD30+ anaplastic large cell lymphoma","volume":"37","author":"Mao","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0165-4608(00)00339-3","article-title":"The use of multicolor fluorescence technologies in the characterization of prostate carcinoma cell lines: a comparison of multiplex fluorescence in situ hybridization and spectral karyotyping data","volume":"124","author":"Strefford","year":"2001","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000048774","article-title":"The characterization of the lymphoma cell line U937, using comparative genomic hybridisation and multi-plex FISH","volume":"94","author":"Strefford","year":"2001","journal-title":"Cytogenet Cell Genet"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib31","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1054\/bjoc.2000.1458","article-title":"Molecular cytogenetic analysis of breast cancer cell lines","volume":"83","author":"Davidson","year":"2000","journal-title":"Br J Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib32","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1073\/pnas.041603298","article-title":"Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement","volume":"98","author":"Abdel-Rahman","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/1098-2264(200007)28:3<308::AID-GCC9>3.0.CO;2-B","article-title":"Chromosomal alterations in 15 breast cancer cell lines by comparative genomic hybridization and spectral karyotyping","volume":"28","author":"Kytola","year":"2000","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib34","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/gcc.1174","article-title":"Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines","volume":"32","author":"Van Roy","year":"2001","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ijc.2910400208","article-title":"Specific chromosome aberration in human renal cell carcinoma","volume":"40","author":"Kovacs","year":"1987","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib36","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/ijc.2910430313","article-title":"Tissue-specific expression of a constitutional 3;6 translocation: development of multiple bilateral renal-cell carcinoma","volume":"43","author":"Kovacs","year":"1989","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib37","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/25292","article-title":"Genetic instabilities in human cancers","volume":"396","author":"Lengauer","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib38","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/351453a0","article-title":"The p53 tumour suppressor gene","volume":"351","author":"Levine","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib39","first-page":"3092","article-title":"Chromosome 17p deletions and p53 mutations in renal cell carcinoma","volume":"53","author":"Reiter","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib40","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/(SICI)1096-9896(199702)181:2<136::AID-PATH766>3.0.CO;2-2","article-title":"Mutation of the p53 tumour suppressor gene occurs preferentially in the chromophobe type of renal cell tumour","volume":"181","author":"Contractor","year":"1997","journal-title":"J Pathol"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib41","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/S0022-5347(17)35760-9","article-title":"Tumor suppressor gene allelic loss in human renal cancers","volume":"150","author":"Brooks","year":"1993","journal-title":"J Urol"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib42","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0046-8177(97)90178-7","article-title":"Loss of retinoblastoma gene function and heterozygosity at the RB locus in renal cortical neoplasms","volume":"28","author":"Lai","year":"1997","journal-title":"Hum Pathol"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib43","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0022-5347(01)69132-8","article-title":"Biallelic inactivation of the von Hippel-Lindau tumor suppressor gene in sporadic renal cell carcinoma","volume":"167","author":"Hamano","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib44","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/(SICI)1098-2264(199706)19:2<59::AID-GCC1>3.0.CO;2-Z","article-title":"Involvement of multiple loci on chromosome 3 in renal cell cancer development","volume":"19","author":"van den Berg","year":"1997","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib45","first-page":"455","article-title":"Deletion of chromosome 3p14.2-p25 involving the VHL and FHIT genes in conventional renal cell carcinoma","volume":"63","author":"Sukosd","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib46","first-page":"7277","article-title":"Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma","volume":"61","author":"Morrissey","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib47","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1080\/1042819031000119299","article-title":"Aberrant expression of HOXA9, DEK, CBL and CSF1R in acute myeloid leukemia","volume":"44","author":"Casas","year":"2003","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib48","doi-asserted-by":"crossref","first-page":"38524","DOI":"10.1074\/jbc.M005220200","article-title":"EGR1 target genes in prostate carcinoma cells identified by microarray analysis","volume":"275","author":"Svaren","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib49","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/gcc.10209","article-title":"Patterns of aneuploidy in stage IV clear cell renal cell carcinoma revealed by comparative genomic hybridization and spectral karyotyping","volume":"37","author":"Pavlovich","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib50","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/gcc.2870030403","article-title":"Cytogenetics of papillary renal cell tumors","volume":"3","author":"Kovacs","year":"1991","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib51","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/ng0597-68","article-title":"Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas","volume":"16","author":"Schmidt","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib52","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/sj.bjc.6601208","article-title":"LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT\u2013PCR and immunohistochemical analysis","volume":"89","author":"Thomasson","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib53","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/(SICI)1096-9896(199804)184:4<424::AID-PATH1223>3.0.CO;2-A","article-title":"EGF-r gene copy number changes in renal cell carcinoma detected by fluorescence in situ hybridization","volume":"184","author":"Moch","year":"1998","journal-title":"J Pathol"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib54","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/(SICI)1097-0215(20000501)86:3<318::AID-IJC3>3.0.CO;2-B","article-title":"Mutation analysis of replicative genes encoding the large subunits of DNA polymerase \u03b1 and replication factors A and C in human sporadic colorectal cancers","volume":"86","author":"Popanda","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib55","first-page":"3460","article-title":"Expression of nuclear receptor interacting proteins TIF-1, SUG-1, receptor interacting protein 140, and corepressor SMRT in tamoxifen-resistant breast cancer","volume":"5","author":"Chan","year":"1999","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib56","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000056987","article-title":"Genomic imbalances in 61 renal cancers from the proximal tubulus detected by comparative genomic hybridization","volume":"93","author":"Reutzel","year":"2001","journal-title":"Cytogenet Cell Genet"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib57","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1158\/0008-5472.CAN-03-2756","article-title":"Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss","volume":"64","author":"Iacobuzio-Donahue","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2004.09.020_bib58","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/cncr.11482","article-title":"Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosis","volume":"98","author":"Zhao","year":"2003","journal-title":"Cancer"}],"container-title":["Cancer Genetics and Cytogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165460804004741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165460804004741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T15:26:59Z","timestamp":1550244419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165460804004741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S0165460804004741"],"URL":"https:\/\/doi.org\/10.1016\/j.cancergencyto.2004.09.020","relation":{},"ISSN":["0165-4608"],"issn-type":[{"value":"0165-4608","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}