{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:30:01Z","timestamp":1773660601060,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Genetics and Cytogenetics"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.cancergencyto.2005.07.016","type":"journal-article","created":{"date-parts":[[2006,2,19]],"date-time":"2006-02-19T12:15:17Z","timestamp":1140351317000},"page":"25-35","source":"Crossref","is-referenced-by-count":43,"title":["Cytogenetic aberrations in immortalization of esophageal epithelial cells"],"prefix":"10.1016","volume":"165","author":[{"given":"Hao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuesheng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Law","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai-Wah","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yok-Lam","family":"Kwong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cancergencyto.2005.07.016_bib1","first-page":"403","article-title":"Esophageal cancer trends and risk factors","volume":"21","author":"Blot","year":"1994","journal-title":"Semin Oncol"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib2","first-page":"459","article-title":"Pathology of esophageal cancers: local experience and current insights","volume":"110","author":"Lam","year":"1997","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/jnci\/dji024","article-title":"The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence","volume":"97","author":"Pohl","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib4","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/S0140-6736(04)16868-2","article-title":"Oesophageal cancer: a view over overviews","volume":"364","author":"Munro","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib5","unstructured":"Mitelman F, Johansson B, Mertens F. Mitelman Database of Chromosome Aberrations in Cancer. Available at: http:\/\/www.cgap.nci.nih.gov\/Chromosomes\/Mitelman. Accessed in May 2005."},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib6","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0165-4608(99)00193-4","article-title":"Establishment and characterization of HKESC-1, a new cancer cell line from human esophageal squamous cell carcinoma","volume":"118","author":"Hu","year":"2000","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0165-4608(01)00580-5","article-title":"Establishment, characterization, karyotyping, and comparative genomic hybridization analysis of HKESC-2 and HKESC-3: two newly established human esophageal squamous cell carcinoma cell lines","volume":"135","author":"Hu","year":"2002","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/1097-0142(19920115)69:2<277::AID-CNCR2820690202>3.0.CO;2-C","article-title":"Characterization of 21 newly established esophageal cancer cell lines","volume":"69","author":"Shimada","year":"1992","journal-title":"Cancer"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0165-4608(00)00317-4","article-title":"Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line SLMT-1 of Chinese origin","volume":"124","author":"Tang","year":"2001","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jcv.2004.04.004","article-title":"Physical status of HPV-16 in esophageal squamous cell carcinoma","volume":"32","author":"Si","year":"2005","journal-title":"J Clin Virol"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib11","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/(SICI)1097-0142(19980815)83:4<652::AID-CNCR4>3.0.CO;2-M","article-title":"In situ hybridization for the detection of telomerase RNA in the progression from Barrett's esophagus to esophageal adenocarcinoma","volume":"83","author":"Morales","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0958-1669(99)00011-7","article-title":"Constructing immortalized human cell lines","volume":"10","author":"Yeager","year":"1999","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib13","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0167-4889(02)00208-2","article-title":"Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6\/E7 viral oncogenes","volume":"1590","author":"Tsao","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib14","series-title":"ISCN. An international system for human cytogenetic nomenclature","year":"1995"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/sj.ejhg.5200265","article-title":"New strategy for multi-colour fluorescence in situ hybridization.: COBRA (COmbined Binary RAtio labelling)","volume":"7","author":"Tanke","year":"1999","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0165-4608(03)00213-9","article-title":"Cytogenetic and fluorescence in situ hybridization characterization of clonal chromosomal aberrations and CCND1 amplification in esophageal carcinomas","volume":"148","author":"Jin","year":"2004","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib17","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cancergencyto.2003.09.007","article-title":"Sequential cytogenetic and molecular cytogenetic characterization of an SV40T-immortalized nasopharyngeal cell line transformed by Epstein-Barr virus latent membrane protein-1 gene","volume":"150","author":"Zhang","year":"2004","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ygyno.2003.09.007","article-title":"Cytogenetic and molecular genetic characterization of immortalized human ovarian surface epithelial cell lines: consistent loss of chromosome 13 and amplification of chromosome 20","volume":"92","author":"Jin","year":"2004","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1006\/excr.1997.3670","article-title":"Genomic instability and telomerase activity in human bronchial epithelial cells during immortalization by human papillomavirus-16 E6 and E7 genes","volume":"235","author":"Coursen","year":"1997","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib20","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/sj.onc.1200868","article-title":"20q gain associates with immortalization: 20q13.2 amplification correlates with genome instability in human papillomavirus 16 E7 transformed human uroepithelial cells","volume":"14","author":"Savelieva","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib21","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/sj.onc.1206296","article-title":"Amplification of chromosome 5p correlates with increased expression of Skp2 in HPV-immortalized keratinocytes","volume":"22","author":"Dowen","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib22","first-page":"526","article-title":"Gain of 5p15 detected by comparative genomic hybridization as an independent marker of poor prognosis in patients with esophageal squamous cell carcinoma","volume":"8","author":"Ueno","year":"2002","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00001622-200401000-00006","article-title":"Chromosomal instability","volume":"16","author":"Gollin","year":"2004","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.cancergencyto.2005.07.016_bib24","doi-asserted-by":"crossref","first-page":"12683","DOI":"10.1073\/pnas.211357798","article-title":"Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors","volume":"98","author":"Gisselsson","year":"2001","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Cancer Genetics and Cytogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165460805004073?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165460805004073?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T12:23:01Z","timestamp":1547814181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165460805004073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0165460805004073"],"URL":"https:\/\/doi.org\/10.1016\/j.cancergencyto.2005.07.016","relation":{},"ISSN":["0165-4608"],"issn-type":[{"value":"0165-4608","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}