{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T19:36:33Z","timestamp":1760729793240},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Genetics and Cytogenetics"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.cancergencyto.2006.03.007","type":"journal-article","created":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T08:45:21Z","timestamp":1154421921000},"page":"33-38","source":"Crossref","is-referenced-by-count":16,"title":["The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer: clinical and pathologic features"],"prefix":"10.1016","volume":"169","author":[{"given":"Gershon Y.","family":"Locker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Kaul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Gatalica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Peterman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Klatzco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olufunmilayo I.","family":"Olopade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Bomzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Newlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Keenan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Tajuddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Knezetic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Coronel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry T.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cancergencyto.2006.03.007_bib1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3322\/canjclin.55.1.10","article-title":"Cancer Statistics 2005","volume":"55","author":"Jemal","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib2","unstructured":"Ries LAG, Eisner MP, Kosary CL, Hankery BF, Miller BA, Clegg L, Marrioto A, Fueur EJ, Edwards BK, editors. SEER Cancer Statistics Review, 1975\u20132002. Bethesda, MD: National Cancer Institute. Available at: http:\/\/seer.cancer.gov\/csr\/1975_2002. Accessed June 23, 2005."},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib3","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1002\/1097-0142(19860901)58:5<1167::AID-CNCR2820580532>3.0.CO;2-R","article-title":"Colorectal adenomatous polyps and carcinoma in Ashkenazi and non-Ashkenazi Jews in Israel","volume":"58","author":"Bat","year":"1986","journal-title":"Cancer"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib4","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1002\/1097-0142(19871101)60:9<2355::AID-CNCR2820600940>3.0.CO;2-R","article-title":"Familial colon cancer in the Tel-Aviv area and the influence of ethnic origin","volume":"60","author":"Rozen","year":"1987","journal-title":"Cancer"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib5","first-page":"2755","article-title":"Colorectal cancer in Russian-speaking Jewish emigr\u00e9s: community-based screening","volume":"96","author":"Vadlamani","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0002-8703(80)90324-5","article-title":"Excessive proneness of Jews to ischemic heart and bowel diseases","volume":"99","author":"Walker","year":"1980","journal-title":"Am Heart J"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib7","first-page":"341","article-title":"Do Ashkenazi Jews have a higher than expected cancer burden? Implications for cancer control prioritization efforts","volume":"3","author":"Feldman","year":"2001","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib8","first-page":"301","article-title":"Patterns of gastrointestinal neoplasia in Israel","volume":"14","author":"Modan","year":"1979","journal-title":"Isr J Med Sci"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib9","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.1651562","article-title":"Identification of the FAP locus genes from chromosome 5q21","volume":"253","author":"Kinzler","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/ng0997-79","article-title":"Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC","volume":"17","author":"Laken","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)81333-1","article-title":"Lessons from hereditary colorectal cancer","volume":"87","author":"Kinzler","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0016-5085(99)70229-5","article-title":"The I1307K polymorphism of the APC gene in colorectal cancer","volume":"116","author":"Prior","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib13","first-page":"4040","article-title":"Somatic instability of the APC I1307K allele in colorectal neoplasia","volume":"58","author":"Gryfe","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib14","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/1722","article-title":"The APC I1307K allele and cancer risk in a community-based study of Ashkenazi Jews","volume":"20","author":"Woodage","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib15","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/(SICI)1097-0142(20000215)88:4<755::AID-CNCR4>3.0.CO;2-7","article-title":"Adenomatous polyposis coli I1307K mutation in Jewish patients of different ethnicities","volume":"88","author":"Drucker","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/109065701753145628","article-title":"Theodor l. The I307K APC polymorphism: prevalence in non-Ashkenazi Jews and evidence for a founder effect","volume":"5","author":"Shtoyerman-Chen","year":"2001","journal-title":"Genet Test"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib17","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1002\/cncr.10529","article-title":"Clinical and screening implications of the I1307K Adenomatous Polposis Coli gene variant in Israeli Ashkenazi Jews with familial colorectal neoplasia","volume":"94","author":"Rozen","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib18","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1086\/302262","article-title":"Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism","volume":"64","author":"Gryfe","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib19","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1054\/bjoc.2001.2093","article-title":"Phenotypic characteristics of colorectal cancer in I1307K APC germline mutation carriers compared with sporadic cases","volume":"85","author":"Figer","year":"2001","journal-title":"Br J Cancer"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib20","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/cncr.21230","article-title":"Clinical and genetic findings in an Ashkenazi Jewish population with colorectal neoplasia","volume":"104","author":"Zauber","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib21","first-page":"801","article-title":"Genetic susceptibility to non-polyposis colorectal cancer","volume":"36","author":"Lynch","year":"1999","journal-title":"J Med Genet"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10689-004-9547-x","article-title":"Genetic factors and colorectal cancer in Ashkenazi Jews","volume":"3","author":"Locker","year":"2004","journal-title":"Fam Cancer"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib23","first-page":"2923","article-title":"The APC I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer","volume":"58","author":"Lothe","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib24","doi-asserted-by":"crossref","first-page":"10722","DOI":"10.1073\/pnas.95.18.10722","article-title":"The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always a family history","volume":"95","author":"Frayling","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib25","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/1097-0142(20010715)92:2<440::AID-CNCR1340>3.0.CO;2-O","article-title":"The frequency of founder mutations in the BRCA1, BRCA2, and APC genes in Australian Ashkenazi Jews: implications for the generality of U.S. population data","volume":"92","author":"Bahar","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib26","first-page":"1012","article-title":"The I1307K adenomatous polyposis coli gene variant does not contribute in the assessment of the risk for colorectal cancer in Ashkenazi Jews","volume":"12","author":"Strul","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib27","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/humu.9123","article-title":"Genetic analysis of familial colorectal cancer in Israeli Arabs","volume":"21","author":"Chen-Shtoyerman","year":"2003","journal-title":"Hum Mutat"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib28","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1086\/345075","article-title":"The founder mutation MSH2\u22171906G\u2192C is an important cause of hereditary non-polyposis colorectal cancer in the Ashkenazi Jewish population","volume":"71","author":"Foulkes","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib29","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S1072-7515(02)01808-2","article-title":"A636P is associated with early-onset colon cancer in Ashkenazi Jews","volume":"196","author":"Guillem","year":"2003","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1053\/gast.1997.v112.pm9024286","article-title":"Clinical and molecular features of the hereditary mixed polyposis syndrome","volume":"112","author":"Whitelaw","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib31","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0016-5085(99)70061-2","article-title":"Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22","volume":"116","author":"Tomlinson","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib32","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1086\/375144","article-title":"An ancestral Ashkenazi haplotype at the HMPS\/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome","volume":"72","author":"Jaeger","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib33","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1001\/jama.284.7.857","article-title":"Phenotypic characteristics associated with the APC I1307K mutation in Ashkenazi Jewish patients with colorectal polyps","volume":"284","author":"Syngal","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib34","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1053\/gast.2001.21170","article-title":"APC 1307K increases the risk of transition from polyp to colorectal carcinoma in Ashkenazi Jews","volume":"120","author":"Stern","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib35","unstructured":"Locker GY, Lynch H, Kaul K, Watson P, Coronel S, Weinberg D, Peterman A, Tajuddin M, Klatzco L. The I1307k APC polymorphism in Ashkenazi Jews: association with familial colorectal cancer [Abstract]. In: ASCO 2004 Gastrointestinal Cancers Symposium, San Francisco, American Society of Clinical Oncology, 2004. Available at: http:\/\/www.asco.org."},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1054\/bjoc.2000.1248","article-title":"Association of the I1307K APC mutation with hereditary and sporadic breast\/ovarian cancer: more questions than answers","volume":"83","author":"Gershoni-Baruch","year":"2000","journal-title":"Br J Cancer"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib37","first-page":"5480","article-title":"The I1307K APC mutation does not predispose to colorectal cancer in Jewish Ashkenazi breast and breast-ovarian cancer kindreds","volume":"57","author":"Petrukhin","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/1666","article-title":"The APC I1307K allele and breast cancer risk","volume":"20","author":"Redston","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib39","first-page":"2919","article-title":"No association of the I1307K APC allele with ovarian cancer risk in Ashkenazi Jews","volume":"58","author":"Abrahamson","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib40","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1086\/302345","article-title":"The APC I1307K allele and BrCA-associated ovarian cancer risk","volume":"64","author":"Maresco","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib41","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1200\/JCO.1997.15.7.2744","article-title":"Brain tumor-polyposis syndromes: two genetic diseases?","volume":"155","author":"Paraf","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.cancergencyto.2006.03.007_bib42","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1038\/35101031","article-title":"Two genetic hits (more or less) to cancer","volume":"1","author":"Knudson","year":"2001","journal-title":"Nat Rev Cancer"}],"container-title":["Cancer Genetics and Cytogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165460806001968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165460806001968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T08:24:14Z","timestamp":1555748654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165460806001968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0165460806001968"],"URL":"https:\/\/doi.org\/10.1016\/j.cancergencyto.2006.03.007","relation":{},"ISSN":["0165-4608"],"issn-type":[{"value":"0165-4608","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}