{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:39:54Z","timestamp":1792060794626,"version":"4.4.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Genetics and Cytogenetics"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.cancergencyto.2006.04.008","type":"journal-article","created":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T16:16:58Z","timestamp":1156954618000},"page":"143-149","source":"Crossref","is-referenced-by-count":15,"title":["Identification of recurrent chromosomal breakpoints in multiple myeloma with complex karyotypes by combined G-banding, spectral karyotyping, and fluorescence in situ hybridization analyses"],"prefix":"10.1016","volume":"169","author":[{"given":"Borja","family":"S\u00e1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 I.","family":"Mart\u00edn-Subero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Largo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda C.","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda D.","family":"Odero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Prosper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"Calasanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Cigudosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cancergencyto.2006.04.008_bib1","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1182\/blood-2002-10-3017","article-title":"Clinical and biologic implications of recurrent genomic aberrations in myeloma","volume":"101","author":"Fonseca","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib2","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1182\/blood-2005-04-1411","article-title":"Clinical implications of t(11;14)(q13;q32), t(4;14)(p16.3;q32), and \u201317p13 in myeloma patients treated with high-dose therapy","volume":"106","author":"Gertz","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib3","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1182\/blood-2004-04-1363","article-title":"p53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation","volume":"105","author":"Chang","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib4","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/sj.leu.2403256","article-title":"Chromosomal abnormalities clustering in multiple myeloma reveals cytogenetic subgroups with nonrandom acquisition of chromosomal changes","volume":"18","author":"Saez","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib5","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/sj.leu.2402797","article-title":"Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma","volume":"17","author":"Debes-Marun","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib6","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1126\/science.273.5274.494","article-title":"Multicolor spectral karyotyping of human chromosomes","volume":"273","author":"Schr\u00f6ck","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib7","first-page":"1743","article-title":"Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma","volume":"92","author":"Rao","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib8","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1182\/blood.V92.11.4269","article-title":"Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping","volume":"92","author":"Sawyer","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib9","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/(SICI)1098-2264(199702)18:2<84::AID-GCC2>3.0.CO;2-X","article-title":"Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations","volume":"18","author":"Calasanz","year":"1997","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib10","unstructured":"ISCN. An international system for human cytogenetic nomenclature. Mitelman F, editor. Basel: S. Karger, 1995."},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib11","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/ijc.10169","article-title":"Interphase FISH assays for the detection of translocations with breakpoints in immunoglobulin light chain loci","volume":"98","author":"Martin-Subero","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/mc.10159","article-title":"TP53 is frequently altered by methylation, mutation, and\/or deletion in acute lymphoblastic leukaemia","volume":"38","author":"Agirre","year":"2003","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib13","first-page":"1139","article-title":"Interphase cytogenetics of hematological neoplasms under the perspective of the novel WHO classification","volume":"23","author":"Martin-Subero","year":"2003","journal-title":"Anticancer Res"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib14","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1182\/blood-2002-11-3502","article-title":"Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma","volume":"102","author":"Ye","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib15","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1182\/blood-2004-10-3907","article-title":"Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome","volume":"105","author":"Rubio-Moscardo","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib16","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1046\/j.1365-2141.2003.04221.x","article-title":"A pooled analysis of karyotypic patterns, breakpoints and imbalances in 783 cytogenetically abnormal multiple myelomas reveals frequently involved chromosome segments as well as significant age- and sex-related differences","volume":"120","author":"Nilsson","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.cancergencyto.2006.04.008_bib17","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1046\/j.1365-2141.1997.2443061.x","article-title":"Hypodiploidy and 22q11 rearrangements at diagnosis are associated with poor prognosis in patients with multiple myeloma","volume":"98","author":"Calasanz","year":"1997","journal-title":"Br J Haematol"}],"container-title":["Cancer Genetics and Cytogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165460806002585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165460806002585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T03:10:53Z","timestamp":1587179453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165460806002585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0165460806002585"],"URL":"https:\/\/doi.org\/10.1016\/j.cancergencyto.2006.04.008","relation":{},"ISSN":["0165-4608"],"issn-type":[{"value":"0165-4608","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}