{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T07:47:51Z","timestamp":1781164071854,"version":"3.54.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Epidemiology"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.canep.2009.07.003","type":"journal-article","created":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T13:23:12Z","timestamp":1248873792000},"page":"242-248","source":"Crossref","is-referenced-by-count":2,"title":["Obesity is associated with atypia in breast ductal lavage of women with proliferative breast disease"],"prefix":"10.1016","volume":"33","author":[{"given":"Zora","family":"Djuric","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi","family":"Madan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Darga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassann","family":"Blake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Koletsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance K.","family":"Heilbrun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canep.2009.07.003_bib1","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/1097-0142(19930215)71:4<1258::AID-CNCR2820710415>3.0.CO;2-I","article-title":"Breast cancer risk associated with proliferative breast disease and atypical hyperplasia","volume":"71","author":"Dupont","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.canep.2009.07.003_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jcb.240531108","article-title":"Clinical and histologic aspects of proliferative and non-proliferative benign breast disease","volume":"17G","author":"Connolly","year":"1993","journal-title":"J Cell Biochem\u2013Suppl"},{"key":"10.1016\/j.canep.2009.07.003_bib3","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1002\/1097-0142(19930615)71:12<3896::AID-CNCR2820711217>3.0.CO;2-I","article-title":"Prognostic significance of benign proliferative breast disease","volume":"71","author":"Bodian","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.canep.2009.07.003_bib4","first-page":"289","article-title":"Risk factors for breast cancer from benign breast disease in a diverse population","volume":"111","author":"Worsham","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.canep.2009.07.003_bib5","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/00000478-199107000-00010","article-title":"Is cystic disease related to breast cancer?","volume":"15","author":"Haagensen","year":"1991","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.canep.2009.07.003_bib6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0165-4608(98)00088-0","article-title":"Cytogenetic changes in benign proliferative and nonproliferative lesions of the breast","volume":"107","author":"Lundin","year":"1998","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.canep.2009.07.003_bib7","first-page":"313","article-title":"MCF10AT: a model for the evolution of cancer from proliferative breast disease","volume":"148","author":"Dawson","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.canep.2009.07.003_bib8","first-page":"873","article-title":"Association of age and reproductive factors with benign breast tissue composition","volume":"8","author":"Gertig","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.canep.2009.07.003_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/(SICI)1097-0142(20000225)90:1<33::AID-CNCR5>3.0.CO;2-5","article-title":"Cytologic features of proliferative breast disease: a study designed to minimize sampling error","volume":"90","author":"Frost","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.canep.2009.07.003_bib10","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/ajcp\/64.6.728","article-title":"Cellular composition of the nipple aspirate specimen of breast fluid. I. The benign cells","volume":"64","author":"King","year":"1975","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.canep.2009.07.003_bib11","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1126\/science.2270486","article-title":"Inheritance of proliferative breast disease in breast cancer kindreds","volume":"250","author":"Skolnick","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.canep.2009.07.003_bib12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/jnci\/djn075","article-title":"Conjugated equine estrogen and risk of benign proliferative breast disease: a randomized controlled trial","volume":"100","author":"Rohan","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.canep.2009.07.003_bib13","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1002\/1097-0142(19850601)55:11<2698::AID-CNCR2820551127>3.0.CO;2-A","article-title":"Atypical hyperplastic lesions of the female breast. A long-term follow-up study","volume":"55","author":"Page","year":"1985","journal-title":"Cancer"},{"key":"10.1016\/j.canep.2009.07.003_bib14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/cncr.22408","article-title":"Magnitude and laterality of breast cancer risk according to histologic type of atypical hyperplasia: results from the Nurses\u2019 Health Study","volume":"109","author":"Collins","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.canep.2009.07.003_bib15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1207\/S15327914NC432_3","article-title":"Dietary and reproductive factors associated with benign breast disease in Mexican women","volume":"43","author":"Galvan-Portillo","year":"2002","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.canep.2009.07.003_bib16","first-page":"1369","article-title":"Alcohol consumption and incidence of benign breast disease","volume":"11","author":"Byrne","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.canep.2009.07.003_bib17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S1047-2797(02)00256-9","article-title":"Polybrominated biphenyl exposure and benign breast disease in a cohort of US women","volume":"13","author":"Kaiser","year":"2003","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.canep.2009.07.003_bib18","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1158\/1055-9965.EPI-07-0368","article-title":"Plasma isoflavones and fibrocystic breast conditions and breast cancer among women in Shanghai, China","volume":"16","author":"Lampe","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.canep.2009.07.003_bib19","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/ijc.20964","article-title":"Dietary and other risk factors in women having fibrocystic breast conditions with and without concurrent breast cancer: a nested case\u2013control study in Shanghai, China","volume":"115","author":"Li","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1016\/j.canep.2009.07.003_bib20","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/1097-0215(20010920)95:5<282::AID-IJC1048>3.0.CO;2-X","article-title":"Prognostic value of morphometry in patients with normal breast tissue or usual ductal hyperplasia of the breast","volume":"95","author":"Mommers","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.canep.2009.07.003_bib21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1207\/s15327914nc5501_6","article-title":"Women participating in a dietary intervention trial maintain dietary changes without much effect on household members","volume":"55","author":"Radakovich","year":"2006","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.canep.2009.07.003_bib22","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/0895-4356(90)90099-B","article-title":"Validation of a self-administered diet history questionnaire using multiple diet records","volume":"43","author":"Block","year":"1990","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.canep.2009.07.003_bib23","unstructured":"National Cancer Institute. Breast Cancer Risk Assessment Tool; 2008."},{"issue":"3","key":"10.1016\/j.canep.2009.07.003_bib24","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/07315724.2006.10719530","article-title":"Effects of high fruit-vegetable and\/or low-fat intervention on plasma micronutrient levels","volume":"25","author":"Djuric","year":"2006","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.canep.2009.07.003_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0009-8981(91)90336-B","article-title":"A simplified analysis of fatty acids in serum phospholipids using Sep-Pak cartridges","volume":"200","author":"Ellin","year":"1991","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.canep.2009.07.003_bib26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0378-4347(95)00142-6","article-title":"Gas chromatographic analysis of fatty acid methyl esters","volume":"671","author":"Eder","year":"1995","journal-title":"J Chromatogr B"},{"key":"10.1016\/j.canep.2009.07.003_bib27","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand J Stat"},{"key":"10.1016\/j.canep.2009.07.003_bib28","series-title":"Center for Nutrition Policy and Promotion","article-title":"The Healthy Eating Index 1994\u201396","author":"Bowman","year":"1998"},{"key":"10.1016\/j.canep.2009.07.003_bib29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1471-2407-8-75","article-title":"Epithelial cells in nipple aspirate fluid and subsequent breast cancer risk: a historic prospective study","volume":"8","author":"Baltzell","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canep.2009.07.003_bib30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10549-005-9132-5","article-title":"Presence of epithelial cells in nipple aspirate fluid is associated with subsequent breast cancer: a 25-year prospective study","volume":"98","author":"Buehring","year":"2006","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.canep.2009.07.003_bib31","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1093\/jnci\/93.21.1624","article-title":"Ductal lavage for detection of cellular atypia in women at high risk for breast cancer","volume":"93","author":"Dooley","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.canep.2009.07.003_bib32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.amjsurg.2005.10.004","article-title":"Correlation of nipple aspiration and ductal lavage cytology with histopathologic findings for patients before scheduled breast biopsy examination","volume":"191","author":"West","year":"2006","journal-title":"Am J Surg"},{"key":"10.1016\/j.canep.2009.07.003_bib33","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10549-005-9111-x","article-title":"Comparison of cytomorphology in specimens obtained by random periareolar fine needle aspiration and ductal lavage from women at high risk for development of breast cancer","volume":"97","author":"Zalles","year":"2006","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.canep.2009.07.003_bib34","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1158\/1055-9965.EPI-05-0302","article-title":"Endocrine biomarkers in ductal lavage samples from women at high risk for breast cancer","volume":"14","author":"Bhandare","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.canep.2009.07.003_bib35","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10549-007-9861-8","article-title":"Reproducibility of ductal lavage cytology and cellularity over a six month interval in high risk women","volume":"112","author":"Patil","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.canep.2009.07.003_bib36","doi-asserted-by":"crossref","first-page":"R1122","DOI":"10.1186\/bcr1348","article-title":"Nipple aspiration and ductal lavage in women with a germline BRCA1 or BRCA2 mutation","volume":"7","author":"Mitchell","year":"2005","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.canep.2009.07.003_bib37","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1158\/1055-9965.EPI-05-0810","article-title":"Atypia and Ki-67 expression from ductal lavage in women at different risk for breast cancer","volume":"15","author":"Cazzaniga","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.canep.2009.07.003_bib38","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1158\/1055-9965.EPI-06-0578","article-title":"The importance of cytologic intrarater and interrater reproducibility: the case of ductal lavage","volume":"15","author":"Visvanathan","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.canep.2009.07.003_bib39","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1158\/1055-9965.EPI-06-0878","article-title":"Overweight and obese perimenopausal and postmenopausal women exhibit increased abnormal mammary epithelial cytology","volume":"16","author":"Seewaldt","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.canep.2009.07.003_bib40","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1001\/archinte.167.19.2091","article-title":"Adiposity, adult weight change, and postmenopausal breast cancer risk","volume":"167","author":"Ahn","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.canep.2009.07.003_bib41","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/j.1471-0528.2006.01021.x","article-title":"Obesity as a risk factor for development and poor prognosis of breast cancer","volume":"113","author":"Carmichael","year":"2006","journal-title":"BJOG"},{"key":"10.1016\/j.canep.2009.07.003_bib42","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/cncr.22538","article-title":"Patient variables that predict atypical cytology by nipple duct lavage","volume":"109","author":"Bushnaq","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.canep.2009.07.003_bib43","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s11883-004-0082-x","article-title":"Inflammation, insulin resistance, and obesity","volume":"6","author":"Ferroni","year":"2004","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.canep.2009.07.003_bib44","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/00006199-200611000-00006","article-title":"C-reactive protein in nipple aspirate fluid: relation to women's health factors","volume":"55","author":"Lithgow","year":"2006","journal-title":"Nurs Res"},{"key":"10.1016\/j.canep.2009.07.003_bib45","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1177\/1099800407306426","article-title":"C-reactive protein in nipple aspirate fluid associated with Gail model factors","volume":"9","author":"Lithgow","year":"2007","journal-title":"Biol Res Nurs"},{"key":"10.1016\/j.canep.2009.07.003_bib46","first-page":"1087","article-title":"Image morphometric nuclear grading of intraepithelial neoplastic lesions with applications to cancer chemoprevention trials","volume":"8","author":"Bacus","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.canep.2009.07.003_bib47","first-page":"63","article-title":"Karyometry of breast epithelial cells acquired by random periareolar fine needle aspiration in women at high risk for breast cancer","volume":"29","author":"Bartels","year":"2007","journal-title":"Anal Quant Cytol Histol"},{"key":"10.1016\/j.canep.2009.07.003_bib48","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1002\/ijc.22861","article-title":"Alcohol and folate consumption and risk of benign proliferative epithelial disorders of the breast","volume":"121","author":"Cui","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1016\/j.canep.2009.07.003_bib49","first-page":"99","article-title":"Effect of quantitative nuclear image features on recurrence of ductal carcinoma in situ (DCIS) of the breast","volume":"6","author":"Axelrod","year":"2008","journal-title":"Cancer Inf"},{"key":"10.1016\/j.canep.2009.07.003_bib50","first-page":"157","article-title":"Cytologic identification of clinically occult proliferative breast disease in women with a family history of breast cancer","volume":"95","author":"Marshall","year":"1991","journal-title":"Anat Pathol"},{"key":"10.1016\/j.canep.2009.07.003_bib51","first-page":"291","article-title":"Characterization by image cytometry of duct epithelial proliferative disease of the breast","volume":"4","author":"King","year":"1991","journal-title":"Mod Pathol"},{"key":"10.1016\/j.canep.2009.07.003_bib52","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/dc.20003","article-title":"Cytology of ductal lavage fluid of the breast","volume":"30","author":"Ljung","year":"2004","journal-title":"Diagn Cytopathol"}],"container-title":["Cancer Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782109000782?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782109000782?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T03:29:12Z","timestamp":1545103752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877782109000782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":52,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S1877782109000782"],"URL":"https:\/\/doi.org\/10.1016\/j.canep.2009.07.003","relation":{},"ISSN":["1877-7821"],"issn-type":[{"value":"1877-7821","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}