{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:58:30Z","timestamp":1770220710515,"version":"3.49.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Epidemiology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.canep.2011.09.001","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T04:53:20Z","timestamp":1318308800000},"page":"190-197","source":"Crossref","is-referenced-by-count":23,"title":["Contribution of epigenetic alteration of BRCA1 and BRCA2 genes in breast carcinomas in Tunisian patients"],"prefix":"10.1016","volume":"36","author":[{"given":"R.","family":"Ben Gacem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hachana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ziadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Amara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Ksia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mokni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Trimeche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canep.2011.09.001_bib0005","series-title":"GLOBOCAN 2002. Cancer incidence, mortality and prevalence worldwide, IARC CancerBase No. 5, version 2.0","author":"Ferlay","year":"2000"},{"key":"10.1016\/j.canep.2011.09.001_bib0010","series-title":"Cancer in Africa: epidemiology and prevention","author":"Parkin","year":"2003"},{"key":"10.1016\/j.canep.2011.09.001_bib0015","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1006\/scbi.2000.0325","article-title":"Hereditary breast cancer: a review","volume":"10","author":"Arver","year":"2000","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.canep.2011.09.001_bib0020","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.7545954","article-title":"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1","volume":"266","author":"Miki","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.canep.2011.09.001_bib0025","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng1294-399","article-title":"Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families","volume":"8","author":"Friedman","year":"1994","journal-title":"Nat Genet"},{"key":"10.1016\/j.canep.2011.09.001_bib0030","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/378789a0","article-title":"Identification of the breast cancer susceptibility gene BRCA2","volume":"378","author":"Wooster","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.canep.2011.09.001_bib0035","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00109-005-0696-7","article-title":"Hereditary breast and ovarian cancer: review and future perspectives","volume":"84","author":"Lux","year":"2006","journal-title":"J Mol Med"},{"key":"10.1016\/j.canep.2011.09.001_bib0040","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1126\/science.7939630","article-title":"BRCA1 mutations in primary breast and ovarian carcinomas","volume":"266","author":"Futreal","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.canep.2011.09.001_bib0045","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1038\/sj.onc.1202847","article-title":"Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer","volume":"18","author":"Khoo","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.canep.2011.09.001_bib0050","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/bjc.1995.493","article-title":"Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13","volume":"72","author":"Cleton-Jansen","year":"1995","journal-title":"Br J Cancer"},{"key":"10.1016\/j.canep.2011.09.001_bib0055","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/(SICI)1097-0215(19970620)74:3<322::AID-IJC15>3.0.CO;2-D","article-title":"Genomic deletions in the BRCA1, BRCA2 and TP53 regions associate with low expression of the estrogen receptor in sporadic breast carcinoma","volume":"74","author":"Schmutzler","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1016\/j.canep.2011.09.001_bib0060","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0168-9525(99)01971-X","article-title":"DNA hypermethylation in tumorigenesis: epigenetics joins genetics","volume":"16","author":"Baylin","year":"2000","journal-title":"Trends Genet"},{"key":"10.1016\/j.canep.2011.09.001_bib0065","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg816","article-title":"The fundamental role of epigenetic events in cancer","volume":"3","author":"Jones","year":"2002","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.canep.2011.09.001_bib0070","doi-asserted-by":"crossref","first-page":"5427","DOI":"10.1038\/sj.onc.1205600","article-title":"CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future","volume":"21","author":"Esteller","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.canep.2011.09.001_bib0075","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1044-579X(02)00056-1","article-title":"BRCA1 methylation: a significant role in tumor development?","volume":"12","author":"Catteau","year":"2002","journal-title":"Cancer Biol"},{"key":"10.1016\/j.canep.2011.09.001_bib0080","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/sj.onc.1202086","article-title":"Aberrant methylation of BRCA1 CpG island is associated with decreased BRCA1 mRNA in sporadic breast cancer cells","volume":"17","author":"Rice","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.canep.2011.09.001_bib0085","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/jnci\/92.7.564","article-title":"Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors","volume":"92","author":"Esteller","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.canep.2011.09.001_bib0090","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1093\/jnci\/94.18.1396","article-title":"Inactivation of BRCA1 and BRCA2 in ovarian cancer","volume":"94","author":"Hilton","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.canep.2011.09.001_bib0095","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/bjc.1997.526","article-title":"Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers","volume":"76","author":"Collins","year":"1997","journal-title":"Br J Cancer"},{"key":"10.1016\/j.canep.2011.09.001_bib0100","first-page":"302","article-title":"Breast cancer in Tunisia: clinical and epidemiological study","volume":"86","author":"Maalej","year":"1999","journal-title":"Bull Cancer"},{"key":"10.1016\/j.canep.2011.09.001_bib0105","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3917\/spub.023.0231","article-title":"Breast cancer prognosis in Tunisian women: analysis of a hospital series of 729 patients","volume":"14","author":"Ben Ahmed","year":"2004","journal-title":"Sante Publique"},{"key":"10.1016\/j.canep.2011.09.001_bib0110","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10549-008-9901-z","article-title":"Evidence for a role of the Simian Virus 40 in human breast carcinomas","volume":"113","author":"Hachana","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.canep.2011.09.001_bib0115","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.canlet.2004.11.001","article-title":"Loss of heterozygosity at the BRCA1 locus in Tunisian women with sporadic breast cancer","volume":"224","author":"Charef-Hamza","year":"2005","journal-title":"Cancer Lett"},{"key":"10.1016\/j.canep.2011.09.001_bib0120","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/324163a0","article-title":"Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes","volume":"324","author":"Saiki","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.canep.2011.09.001_bib0125","first-page":"631","article-title":"Methylation of multiple genes in prostate cancer and the relationship with clinicopathological features of disease","volume":"12","author":"Singal","year":"2004","journal-title":"Oncol Rep"},{"key":"10.1016\/j.canep.2011.09.001_bib0130","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/1097-0142(20010815)92:4<787::AID-CNCR1384>3.0.CO;2-4","article-title":"Loss of heterozygosity on chromosome 13q12-q14, BRCA-2 mutations and lack of BRCA-2 promoter hypermethylation in sporadic epithelial ovarian tumors","volume":"92","author":"Gras","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.canep.2011.09.001_bib0135","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1073\/pnas.93.18.9821","article-title":"Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands","volume":"93","author":"Herman","year":"1996","journal-title":"PNAS"},{"key":"10.1016\/j.canep.2011.09.001_bib0140","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/jjco\/hyf020","article-title":"Promoter hypermethylation and post-transcriptional mechanisms for reduced BRCA1 immunoreactivity in sporadic human breast cancers","volume":"32","author":"Miyamoto","year":"2002","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.canep.2011.09.001_bib0145","doi-asserted-by":"crossref","first-page":"17163","DOI":"10.1074\/jbc.M501375200","article-title":"Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells","volume":"280","author":"Tripathi","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.canep.2011.09.001_bib0150","doi-asserted-by":"crossref","first-page":"15107","DOI":"10.1073\/pnas.251234498","article-title":"Functional significance of concomitant inactivation of hMLH1 and hMSH6 in tumor cells of the microsatellite mutator phenotype","volume":"98","author":"Baranovskaya","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.canep.2011.09.001_bib0155","first-page":"3347","article-title":"Methylation of the BRCA1 gene in sporadic breast cancer","volume":"57","author":"Dobrovic","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.canep.2011.09.001_bib0160","doi-asserted-by":"crossref","first-page":"10692","DOI":"10.1158\/0008-5472.CAN-05-1277","article-title":"BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy","volume":"65","author":"Wei","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.canep.2011.09.001_bib0165","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1111\/j.1349-7006.2009.01225.x","article-title":"BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer","volume":"100","author":"Chen","year":"2009","journal-title":"Cancer Sci"},{"key":"10.1016\/j.canep.2011.09.001_bib0170","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.lfs.2007.05.012","article-title":"Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients","volume":"81","author":"Mirza","year":"2007","journal-title":"Life Sci"},{"key":"10.1016\/j.canep.2011.09.001_bib0175","first-page":"436","article-title":"Diagnostic value of BRCA1 and p16 gene methylation in sporadic breast cancer","volume":"28","author":"Feng","year":"2009","journal-title":"Ai Zheng"},{"key":"10.1016\/j.canep.2011.09.001_bib0180","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10549-004-7603-8","article-title":"BRCA1 promoter methylation in sporadic breast tumors: relationship to gene expression profiles","volume":"91","author":"Matros","year":"2005","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.canep.2011.09.001_bib0185","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nrc1457","article-title":"Hallmarks of \u2018BRCAness\u2019 in sporadic cancers","volume":"4","author":"Turner","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.canep.2011.09.001_bib0190","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ejca.2006.09.002","article-title":"Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumors","volume":"43","author":"Butcher Darci","year":"2007","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.canep.2011.09.001_bib0195","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/sj.onc.1201630","article-title":"CpG methylation within the 5\u2032 regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site","volume":"16","author":"Mancini","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.canep.2011.09.001_bib0200","doi-asserted-by":"crossref","first-page":"R38","DOI":"10.1186\/bcr1522","article-title":"Epigenetic silencing and deletion of the BRCA1 gene in sporadic breast cancer","volume":"8","author":"Birgisdottir","year":"2006","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.canep.2011.09.001_bib0205","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/annonc\/mdn409","article-title":"Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer","volume":"19","author":"Suijkerbuijk","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1016\/j.canep.2011.09.001_bib0210","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3233\/CBM-2008-4102","article-title":"Complete mutation screening and haplotype characterization of BRCA1 gene in Tunisian patients with familial breast cancer","volume":"4","author":"Troudi","year":"2008","journal-title":"Cancer Biomark"},{"key":"10.1016\/j.canep.2011.09.001_bib0215","doi-asserted-by":"crossref","first-page":"R12","DOI":"10.1186\/bcr1858","article-title":"BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype","volume":"10","author":"Snell","year":"2008","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.canep.2011.09.001_bib0220","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s10549-009-0628-2","article-title":"Gene promoter methylation is associated with increased mortality among women with breast cancer","volume":"121","author":"Xu","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.canep.2011.09.001_bib0225","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1038\/sj.onc.1208190","article-title":"Structural determinants of the BRCA1: estrogen receptor interaction","volume":"24","author":"Ma","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.canep.2011.09.001_bib0230","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1210\/me.2004-0488","article-title":"The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells","volume":"20","author":"Ma","year":"2006","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.canep.2011.09.001_bib0235","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.coph.2005.03.006","article-title":"Targeting the DNA repair defect of BRCA tumours","volume":"5","author":"Turner","year":"2005","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.canep.2011.09.001_bib0240","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.coph.2008.06.016","article-title":"A targeted therapy for cancer using PARP inhibitors","volume":"8","author":"Lord Ashworth","year":"2008","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.canep.2011.09.001_bib0245","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature03445","article-title":"Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy","volume":"434","author":"Farmer","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.canep.2011.09.001_bib0250","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng0696-245","article-title":"Mutation analysis in the BRCA2 gene in primary breast cancers","volume":"13","author":"Miki","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.canep.2011.09.001_bib0255","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/ng0696-238","article-title":"BRCA2 mutations in primary breast and ovarian cancers","volume":"13","author":"Lancaster","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.canep.2011.09.001_bib0260","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1038\/bjc.1997.572","article-title":"Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma","volume":"76","author":"Bi\u00e8che","year":"1997","journal-title":"Br J Cancer"},{"key":"10.1016\/j.canep.2011.09.001_bib0265","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/bjc.1996.597","article-title":"Allelic loss at chromosome 13q12-q13 is associated with poor prognosis in familial and sporadic breast cancer","volume":"74","author":"van den Berg","year":"1996","journal-title":"Br J Cancer"},{"key":"10.1016\/j.canep.2011.09.001_bib0270","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.1038\/sj.onc.1202903","article-title":"Overexpression of BRCA2 gene in sporadic breast tumours","volume":"18","author":"Bi\u00e8che","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.canep.2011.09.001_bib0275","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/bjc.1997.526","article-title":"Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers","volume":"9","author":"Collins","year":"1997","journal-title":"Br J Cancer"},{"key":"10.1016\/j.canep.2011.09.001_bib0280","doi-asserted-by":"crossref","first-page":"13078","DOI":"10.1073\/pnas.93.23.13078","article-title":"BRCA2 is co-ordinately regulated with BRCA1 during proliferation and differentiation in mammary epithelial cells","volume":"93","author":"Rajan","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.canep.2011.09.001_bib0285","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10549-008-0075-5","article-title":"BRCA1 promoter methylation is associated with increased mortality among women with breast cancer","volume":"115","author":"Xu","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.canep.2011.09.001_bib0290","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10689-005-2832-5","article-title":"BRCA1 BRCA2: chemosensitivity, treatment outcomes and prognosis","volume":"5","author":"Foulkes","year":"2006","journal-title":"Fam Cancer"},{"key":"10.1016\/j.canep.2011.09.001_bib0295","first-page":"E101","article-title":"Usefulness of predictive tests for cancer treatment","volume":"93","author":"Rosell","year":"2006","journal-title":"Bull Cancer"},{"key":"10.1016\/j.canep.2011.09.001_bib0300","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1476-4598-8-48","article-title":"Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas","volume":"8","author":"Swisher","year":"2009","journal-title":"Mol Cancer"},{"key":"10.1016\/j.canep.2011.09.001_bib0305","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1399-0004.2009.01207.x","article-title":"BRCA2 alteration is important in clear cell carcinoma of the ovary","volume":"76","author":"Goodheart","year":"2009","journal-title":"Clin Genet"},{"key":"10.1016\/j.canep.2011.09.001_bib0310","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1200\/JCO.2009.22.4725","article-title":"Efficacy of neoadjuvant cisplatin in triple-negative breast cancer","volume":"28","author":"Silver","year":"2010","journal-title":"J Clin Oncol"}],"container-title":["Cancer Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782111001299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782111001299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T05:23:35Z","timestamp":1560749015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877782111001299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S1877782111001299"],"URL":"https:\/\/doi.org\/10.1016\/j.canep.2011.09.001","relation":{},"ISSN":["1877-7821"],"issn-type":[{"value":"1877-7821","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}