{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T01:49:31Z","timestamp":1760320171896},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81071765","81372379"],"award-info":[{"award-number":["81071765","81372379"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["08143047"],"award-info":[{"award-number":["08143047"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["cancerepidemiology.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Epidemiology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.canep.2014.07.002","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T21:32:06Z","timestamp":1406583126000},"page":"471-478","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Methylenetetrahydrofolate reductase gene polymorphisms contribute to acute myeloid leukemia and chronic myeloid leukemia susceptibilities: Evidence from meta-analyses"],"prefix":"10.1016","volume":"38","author":[{"given":"Hairong","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonghao","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taotao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangxia","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.canep.2014.07.002_bib0005","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/09723757.2012.11886176","article-title":"Investigation of GSTP1 (Ile105Val) gene polymorphism in chronic myeloid leukaemia patients","volume":"12","author":"Karkucak","year":"2012","journal-title":"Int J Hum Genet"},{"issue":"6","key":"10.1016\/j.canep.2014.07.002_bib0010","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.7314\/APJCP.2013.14.6.3861","article-title":"Risk effects of GST gene polymorphisms in patients with acute myeloid leukemia: a prospective study","volume":"14","author":"Zhou","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"issue":"12","key":"10.1016\/j.canep.2014.07.002_bib0015","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1038\/sj.leu.2403135","article-title":"Standardization and quality control studies of \u2018real-time\u2019 quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia \u2013 a Europe Against Cancer program","volume":"17","author":"Gabert","year":"2003","journal-title":"Leukemia"},{"issue":"22","key":"10.1016\/j.canep.2014.07.002_bib0020","doi-asserted-by":"crossref","first-page":"12810","DOI":"10.1073\/pnas.96.22.12810","article-title":"Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults","volume":"96","author":"Skibola","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8 Suppl.","key":"10.1016\/j.canep.2014.07.002_bib0025","doi-asserted-by":"crossref","first-page":"2444S","DOI":"10.1093\/jn\/132.8.2444S","article-title":"Impact of folate deficiency on DNA stability","volume":"132","author":"Duthie","year":"2002","journal-title":"J Nutr"},{"issue":"26","key":"10.1016\/j.canep.2014.07.002_bib0030","doi-asserted-by":"crossref","first-page":"14853","DOI":"10.1073\/pnas.261469998","article-title":"Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase","volume":"98","author":"Yamada","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.canep.2014.07.002_bib0035","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1073\/pnas.94.7.3290","article-title":"Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage","volume":"94","author":"Blount","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"22","key":"10.1016\/j.canep.2014.07.002_bib0040","doi-asserted-by":"crossref","first-page":"7592","DOI":"10.1158\/1078-0432.CCR-04-1057","article-title":"Methylenetetrahydrofolate reductase genotype affects risk of relapse after hematopoietic cell transplantation for chronic myelogenous leukemia","volume":"10","author":"Robien","year":"2004","journal-title":"Clin Cancer Res"},{"issue":"4","key":"10.1016\/j.canep.2014.07.002_bib0045","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.clon.2011.03.005","article-title":"Methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C and G1793A polymorphisms: association with risk for clear cell renal cell carcinoma and tumour behaviour in men","volume":"24","author":"Safarinejad","year":"2012","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"1","key":"10.1016\/j.canep.2014.07.002_bib0050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.canep.2014.07.002_bib0055","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0021-9150(00)00671-7","article-title":"The 1298A\u2192C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine","volume":"156","author":"Weisberg","year":"2001","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.canep.2014.07.002_bib0060","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/tpj.2012.44","article-title":"A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia","volume":"13","author":"Lopez-Lopez","year":"2012","journal-title":"Pharmacogenomics J"},{"issue":"1","key":"10.1016\/j.canep.2014.07.002_bib0065","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3324\/haematol.2012.063172","article-title":"Has the time for first-line treatment with second generation tyrosine kinase inhibitors in patients with chronic myelogenous leukemia already come? Systematic review and meta-analysis","volume":"98","author":"Gurion","year":"2013","journal-title":"Haematologica"},{"issue":"7109","key":"10.1016\/j.canep.2014.07.002_bib0070","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.canep.2014.07.002_bib0075","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1365-2257.2006.00769.x","article-title":"Methylenetetrahydrofolate reductase A1298C genotypes are associated with the risks of acute lymphoblastic leukaemia and chronic myelogenous leukaemia in the Korean population","volume":"28","author":"Hur","year":"2006","journal-title":"Clin Lab Haematol"},{"issue":"4","key":"10.1016\/j.canep.2014.07.002_bib0080","first-page":"451","article-title":"Association of single nucleotide polymorphism of methylenetetrahydrofolate reductase gene with susceptibility to acute leukemia","volume":"30","author":"Zheng","year":"2013","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"issue":"2","key":"10.1016\/j.canep.2014.07.002_bib0085","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4238\/2012.April.19.6","article-title":"Association between methylene tetrahydrofolate reductase and glutathione S-transferase M1 gene polymorphisms and chronic myeloid leukemia in a Brazilian population","volume":"11","author":"Lordelo","year":"2012","journal-title":"Genet Mol Res"},{"issue":"8","key":"10.1016\/j.canep.2014.07.002_bib0090","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1309\/LMA6H9RW9CKNLNDV","article-title":"Methylenetetrahydrofolate reductase gene polymorphisms and risk of myeloid leukemia","volume":"41","author":"Vahid","year":"2010","journal-title":"Lab Med"},{"issue":"1","key":"10.1016\/j.canep.2014.07.002_bib0095","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/S1415-47572008000100005","article-title":"Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil","volume":"31","author":"Barbosa","year":"2008","journal-title":"Genet Mol Biol"},{"issue":"3","key":"10.1016\/j.canep.2014.07.002_bib0100","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3324\/haematol.10752","article-title":"The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia","volume":"92","author":"Bolufer","year":"2007","journal-title":"Haematologica"},{"issue":"6","key":"10.1016\/j.canep.2014.07.002_bib0105","first-page":"1069","article-title":"A new method for 5, 10-methylenetetrahydrofolate reductase single nucleotide polymorphisms genotyping used to study susceptibility of hematological malignancy","volume":"14","author":"Chen","year":"2006","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"issue":"10","key":"10.1016\/j.canep.2014.07.002_bib0110","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1080\/10428190600800132","article-title":"Association between the MTHFR A1298C polymorphism and increased risk of acute myeloid leukemia in Brazilian children","volume":"47","author":"Da Costa Ramos","year":"2006","journal-title":"Leuk Lymphoma"},{"issue":"3\u20134","key":"10.1016\/j.canep.2014.07.002_bib0115","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF03260036","article-title":"Genotyping of the MTHFR gene polymorphism, C677T in patients with leukemia by melting curve analysis","volume":"7","author":"Deligezer","year":"2003","journal-title":"Mol Diagn"},{"issue":"4","key":"10.1016\/j.canep.2014.07.002_bib0120","doi-asserted-by":"crossref","first-page":"e227","DOI":"10.1016\/j.canep.2012.02.008","article-title":"Methylenetetrahydrofolate reductase C677T genetic polymorphisms and risk of leukaemia among the North Indian population","volume":"36","author":"Hussain","year":"2012","journal-title":"Cancer Epidemiol"},{"issue":"19","key":"10.1016\/j.canep.2014.07.002_bib0125","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1182\/blood-2009-10-249722","article-title":"Genetic variation in the folate metabolic pathway and risk of childhood leukemia","volume":"115","author":"Lightfoot","year":"2010","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.canep.2014.07.002_bib0130","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.leukres.2006.10.016","article-title":"MTHFR 677CC\/1298CC genotypes are highly associated with chronic myelogenous leukemia: a case-control study in Korea","volume":"31","author":"Moon","year":"2007","journal-title":"Leuk Res"},{"issue":"1","key":"10.1016\/j.canep.2014.07.002_bib0135","first-page":"8","article-title":"Methylenetetrahydrofolate reductase (MTHFR) genotype association with the risk of chronic myelogenous leukemia","volume":"43","author":"Ismail","year":"2009","journal-title":"Jordan Med J"},{"issue":"7","key":"10.1016\/j.canep.2014.07.002_bib0140","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3109\/10428194.2011.645210","article-title":"Association between methylenetetrahydrofolate reductase polymorphism C677T and risk of chronic myeloid leukemia in Serbian population","volume":"53","author":"Jakovljevic","year":"2012","journal-title":"Leuk Lymphoma"},{"issue":"15","key":"10.1016\/j.canep.2014.07.002_bib0145","article-title":"Relation of methylenetetrahydrofolate reductase C677T polymorphism to chronic myeloid leukemia in Serbia","volume":"29","author":"Jankovic","year":"2011","journal-title":"J Clin Oncol"},{"issue":"12","key":"10.1016\/j.canep.2014.07.002_bib0150","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.leukres.2010.03.034","article-title":"MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: a meta-analysis","volume":"34","author":"Wang","year":"2010","journal-title":"Leuk Res"},{"issue":"9297","key":"10.1016\/j.canep.2014.07.002_bib0155","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1016\/S0140-6736(01)06959-8","article-title":"Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study","volume":"358","author":"Thompson","year":"2001","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.canep.2014.07.002_bib0160","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1182\/blood-2008-07-165928","article-title":"Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia","volume":"113","author":"de Jonge","year":"2009","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.canep.2014.07.002_bib0165","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1056\/NEJM198702193160806","article-title":"Meta-analyses of randomized controlled trials","volume":"316","author":"Sacks","year":"1987","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.canep.2014.07.002_bib0170","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s11033-013-2873-z","article-title":"Association between polymorphism of MTHFR c.677C>T and risk of cardiovascular disease in Turkish population: a meta-analysis for 2.780 cases and 3.022 controls","volume":"41","author":"Bozok","year":"2013","journal-title":"Mol Biol Rep"},{"issue":"7","key":"10.1016\/j.canep.2014.07.002_bib0175","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s12094-013-1126-x","article-title":"Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects","volume":"16","author":"Guo","year":"2013","journal-title":"Clin Transl Oncol"},{"issue":"1","key":"10.1016\/j.canep.2014.07.002_bib0180","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1182\/blood-2003-06-1794","article-title":"Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia","volume":"103","author":"Krajinovic","year":"2004","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.canep.2014.07.002_bib0185","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1158\/1055-9965.EPI-03-0273","article-title":"MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study","volume":"13","author":"Shrubsole","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"4","key":"10.1016\/j.canep.2014.07.002_bib0190","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1158\/0008-5472.CAN-04-2630","article-title":"One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer","volume":"65","author":"Chen","year":"2005","journal-title":"Cancer Res"}],"container-title":["Cancer Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782114001283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782114001283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T03:22:14Z","timestamp":1589253734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877782114001283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S1877782114001283"],"URL":"https:\/\/doi.org\/10.1016\/j.canep.2014.07.002","relation":{},"ISSN":["1877-7821"],"issn-type":[{"value":"1877-7821","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methylenetetrahydrofolate reductase gene polymorphisms contribute to acute myeloid leukemia and chronic myeloid leukemia susceptibilities: Evidence from meta-analyses","name":"articletitle","label":"Article Title"},{"value":"Cancer Epidemiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canep.2014.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}