{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:55:57Z","timestamp":1782888957126,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cancerepidemiology.net","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Epidemiology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.canep.2015.10.025","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T14:03:45Z","timestamp":1447077825000},"page":"978-985","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Polymorphisms in lncRNA HOTAIR and susceptibility to breast cancer in a Chinese population"],"prefix":"10.1016","volume":"39","author":[{"given":"Rui","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6028-5923","authenticated-orcid":false,"given":"Chunhua","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canep.2015.10.025_bib0005","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.canep.2015.10.025_bib0010","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3322\/caac.21203","article-title":"Breast cancer statistics, 2013","volume":"64","author":"DeSantis","year":"2014","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.canep.2015.10.025_bib0015","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1073\/pnas.1200010109","article-title":"Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA","volume":"109","author":"Volinia","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canep.2015.10.025_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064896","article-title":"Assessing SNP\u2013SNP interactions among DNA repair, modification and metabolism related pathway genes in breast cancer susceptibility","volume":"8","author":"Sapkota","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.canep.2015.10.025_bib0025","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/aje\/kws238","article-title":"Gene\u2013environment interactions for breast cancer risk among chinese women: a report from the shanghai breast cancer genetics study","volume":"177","author":"Li","year":"2013","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.canep.2015.10.025_bib0030","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1126\/science.1103388","article-title":"Global identification of human transcribed sequences with genome tiling arrays","volume":"306","author":"Bertone","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.canep.2015.10.025_bib0035","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1101\/gr.132159.111","article-title":"The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression","volume":"22","author":"Derrien","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.canep.2015.10.025_bib0040","doi-asserted-by":"crossref","first-page":"U148","DOI":"10.1038\/nature08975","article-title":"Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis","volume":"464","author":"Gupta","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.canep.2015.10.025_bib0045","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1038\/sj.onc.1206928","article-title":"MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer","volume":"22","author":"Ji","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.canep.2015.10.025_bib0050","doi-asserted-by":"crossref","first-page":"e1583","DOI":"10.1038\/cddis.2014.541","article-title":"Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p","volume":"6","author":"Ma","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canep.2015.10.025_bib0055","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1158\/1535-7163.MCT-14-0492","article-title":"ANRIL promotes non-small cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and P21 Expression","volume":"14","author":"Nie","year":"2015","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.canep.2015.10.025_bib0060","article-title":"A Polymorphism rs12325489C>T in the LincRNA-ENST00000515084 exon was found to modulate breast cancer risk via GWAS-based association analyses","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.canep.2015.10.025_bib0065","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1093\/carcin\/bgt252","article-title":"A genetic polymorphism in lincRNA-uc003opf.1 is associated with susceptibility to esophageal squamous cell carcinoma in Chinese populations","volume":"34","author":"Wu","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canep.2015.10.025_bib0070","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2007.05.022","article-title":"Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs","volume":"129","author":"Rinn","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.canep.2015.10.025_bib0075","doi-asserted-by":"crossref","first-page":"11667","DOI":"10.1073\/pnas.0904715106","article-title":"Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression","volume":"106","author":"Khalil","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canep.2015.10.025_bib0080","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.1192002","article-title":"Long noncoding RNA as modular scaffold of histone modification complexes","volume":"329","author":"Tsai","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.canep.2015.10.025_bib0085","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1007\/s12032-011-0004-z","article-title":"Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation","volume":"29","author":"Lai","year":"2012","journal-title":"Med. Oncol."},{"key":"10.1016\/j.canep.2015.10.025_bib0090","doi-asserted-by":"crossref","DOI":"10.1007\/s12032-013-0670-0","article-title":"Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues","volume":"30","author":"Hajjari","year":"2013","journal-title":"Med. Oncol."},{"key":"10.1016\/j.canep.2015.10.025_bib0095","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/onc.2012.193","article-title":"HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer","volume":"32","author":"Kim","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.canep.2015.10.025_bib0100","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s10549-012-2314-z","article-title":"Association of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancer","volume":"136","author":"Lu","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.canep.2015.10.025_bib0105","doi-asserted-by":"crossref","first-page":"18985","DOI":"10.3390\/ijms151018985","article-title":"Large intervening non-coding RNA HOTAIR is an indicator of poor prognosis and a therapeutic target in human cancers","volume":"15","author":"Yao","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canep.2015.10.025_bib0110","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1093\/carcin\/bgu103","article-title":"The identification of an ESCC susceptibility SNP rs920778 that regulates the expression of lncRNA HOTAIR via a novel intronic enhancer","volume":"35","author":"Zhang","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canep.2015.10.025_bib0115","article-title":"Genetic variants in lncRNA HOTAIR are associated with risk of colorectal cancer","author":"Xue","year":"2014","journal-title":"Mutagenesis"},{"key":"10.1016\/j.canep.2015.10.025_bib0120","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1007\/s13277-014-2912-y","article-title":"Associations between polymorphisms of HOTAIR and risk of gastric cardia adenocarcinoma in a population of north China","volume":"36","author":"Guo","year":"2015","journal-title":"Tumor Biol."},{"key":"10.1016\/j.canep.2015.10.025_bib0125","doi-asserted-by":"crossref","DOI":"10.1007\/s13277-014-3028-0","article-title":"Effect of HOTAIR rs920778 polymorphism on breast cancer susceptibility and clinicopathologic features in a Turkish population","author":"Bayram","year":"2015","journal-title":"Tumour Biol."},{"key":"10.1016\/j.canep.2015.10.025_bib0130","doi-asserted-by":"crossref","DOI":"10.1007\/s10689-015-9813-0","article-title":"A functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case-control study","author":"Bayram","year":"2015","journal-title":"Fam. Cancer"},{"key":"10.1016\/j.canep.2015.10.025_bib0135","article-title":"A functional lncRNA HOTAIR genetic variant contributes to gastric cancer susceptibility","author":"Pan","year":"2015","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.canep.2015.10.025_bib0140","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10549-007-9756-8","article-title":"Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients","volume":"111","author":"Tan","year":"2008","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.canep.2015.10.025_bib0145","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1158\/0008-5472.CAN-11-1021","article-title":"HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers","volume":"71","author":"Kogo","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.canep.2015.10.025_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077070","article-title":"Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer","volume":"8","author":"Endo","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.canep.2015.10.025_bib0155","doi-asserted-by":"crossref","first-page":"946","DOI":"10.3892\/or.2012.2219","article-title":"Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma","volume":"29","author":"Ishibashi","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.canep.2015.10.025_bib0160","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s10549-013-2776-7","article-title":"Long non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer","volume":"142","author":"Sorensen","year":"2013","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.canep.2015.10.025_bib0165","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0140-6736(03)12715-8","article-title":"Problems of reporting genetic associations with complex outcomes","volume":"361","author":"Colhoun","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.canep.2015.10.025_bib0170","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ng749","article-title":"Replication validity of genetic association studies","volume":"29","author":"Ioannidis","year":"2001","journal-title":"Nat Genet."},{"key":"10.1016\/j.canep.2015.10.025_bib0175","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/bmj.322.7280.226","article-title":"Sifting the evidence-what\u2019s wrong with significance tests?","volume":"322","author":"Sterne","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.canep.2015.10.025_bib0180","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1016\/S0140-6736(10)60636-8","article-title":"Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study","volume":"375","author":"Travis","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.canep.2015.10.025_bib0185","doi-asserted-by":"crossref","DOI":"10.1186\/bcr2797","article-title":"Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case\u2013control study","volume":"12","author":"Milne","year":"2010","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.canep.2015.10.025_bib0190","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1093\/jnci\/djr265","article-title":"Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium","volume":"103","author":"Campa","year":"2011","journal-title":"J. Natl. Cancer Inst."}],"container-title":["Cancer Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782115002362?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782115002362?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T06:54:56Z","timestamp":1567320896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877782115002362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S1877782115002362"],"URL":"https:\/\/doi.org\/10.1016\/j.canep.2015.10.025","relation":{},"ISSN":["1877-7821"],"issn-type":[{"value":"1877-7821","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polymorphisms in lncRNA HOTAIR and susceptibility to breast cancer in a Chinese population","name":"articletitle","label":"Article Title"},{"value":"Cancer Epidemiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canep.2015.10.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}