{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:34:35Z","timestamp":1765888475051,"version":"build-2065373602"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Epidemiology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.canep.2020.101850","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T21:21:08Z","timestamp":1605734468000},"page":"101850","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Survival and prognostic factors for childhood malignant liver tumors: analysis of harmonized clinical data"],"prefix":"10.1016","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3022-4382","authenticated-orcid":false,"given":"Maria A.","family":"Karalexi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Servitzoglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Moschovi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Moiseenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiota","family":"Bouka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-4181","authenticated-orcid":false,"given":"Evangelia","family":"Ntzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3704-8783","authenticated-orcid":false,"given":"Denis","family":"Kachanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3695-3439","authenticated-orcid":false,"given":"Eleni Th.","family":"Petridou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kondilia","family":"Antoniadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Baka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Dana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gavra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Hatzipantelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kourti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astero","family":"Malama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgenia","family":"Papaconstantinou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iordanis","family":"Pelagiadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Polychronopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalliopi","family":"Stefanaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eftichia","family":"Steiakaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Strantzia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Akhaladze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Filin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Varfolomeeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.canep.2020.101850_bib0005","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1053\/jhep.2003.50375","article-title":"Epidemiology of primary hepatic malignancies in U.S. children","volume":"38","author":"Darbari","year":"2003","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.canep.2020.101850_bib0010","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1634\/theoncologist.2008-0011","article-title":"Liver tumors in children","volume":"13","author":"Litten","year":"2008","journal-title":"Oncologist"},{"issue":"5","key":"10.1016\/j.canep.2020.101850_bib0015","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/pbc.24215","article-title":"The epidemiology of hepatoblastoma","volume":"59","author":"Spector","year":"2012","journal-title":"Pediatr Blood Cancer"},{"issue":"2","key":"10.1016\/j.canep.2020.101850_bib0020","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cld.2011.03.011","article-title":"Liver neoplasia in children","volume":"15","author":"Hadzic","year":"2011","journal-title":"Clin Liver Dis"},{"issue":"11","key":"10.1016\/j.canep.2020.101850_bib0025","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/lt.21654","article-title":"Liver tumors: pediatric population","volume":"14","author":"Finegold","year":"2008","journal-title":"Liver Transpl"},{"issue":"1","key":"10.1016\/j.canep.2020.101850_bib0030","article-title":"Hepatoblastoma-The Evolution of Biology, Surgery, and Transplantation","volume":"6","author":"Lim","year":"2018","journal-title":"Children (Basel)"},{"issue":"11","key":"10.1016\/j.canep.2020.101850_bib0035","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1002\/pbc.25128","article-title":"Neonatal medical exposures and characteristics of low birth weight hepatoblastoma cases: a report from the Children\u2019s Oncology Group","volume":"61","author":"Turcotte","year":"2014","journal-title":"Pediatr Blood Cancer"},{"issue":"12","key":"10.1016\/j.canep.2020.101850_bib0040","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1200\/JCO.2002.06.102","article-title":"Hepatocellular carcinoma in children: results of the first prospective study of the International Society of Pediatric Oncology group","volume":"20","author":"Czauderna","year":"2002","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.canep.2020.101850_bib0045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/MOP.0000000000000046","article-title":"Hepatoblastoma state of the art: pathology, genetics, risk stratification, and chemotherapy","volume":"26","author":"Czauderna","year":"2014","journal-title":"Curr Opin Pediatr"},{"issue":"5","key":"10.1016\/j.canep.2020.101850_bib0050","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00383-009-2349-3","article-title":"Survival trends in children with hepatoblastoma","volume":"25","author":"Horton","year":"2009","journal-title":"Pediatr Surg Int"},{"issue":"15","key":"10.1016\/j.canep.2020.101850_bib0055","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1200\/JCO.2009.22.4857","article-title":"Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study","volume":"28","author":"Zsiros","year":"2010","journal-title":"J Clin Oncol"},{"issue":"8","key":"10.1016\/j.canep.2020.101850_bib0060","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/petr.12144","article-title":"Surgical treatment of primary liver tumors in children: outcomes analysis of resection and transplantation in the SEER database","volume":"17","author":"McAteer","year":"2013","journal-title":"Pediatr Transplant"},{"issue":"5","key":"10.1016\/j.canep.2020.101850_bib0065","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1470-2045(18)30895-7","article-title":"Minimal adjuvant chemotherapy for children with hepatoblastoma resected at diagnosis (AHEP0731): a Children\u2019s Oncology Group, multicentre, phase 3 trial","volume":"20","author":"Katzenstein","year":"2019","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1016\/j.canep.2020.101850_bib0070","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00247-006-0361-5","article-title":"2005 PRETEXT: a revised staging system for primary malignant liver tumours of childhood developed by the SIOPEL group","volume":"37","author":"Roebuck","year":"2007","journal-title":"Pediatr Radiol"},{"issue":"4","key":"10.1016\/j.canep.2020.101850_bib0075","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s00247-018-4078-z","article-title":"2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT)","volume":"48","author":"Towbin","year":"2018","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.canep.2020.101850_bib0080","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejca.2015.09.023","article-title":"The Children\u2019s Hepatic tumors International Collaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model","volume":"52","author":"Czauderna","year":"2016","journal-title":"Eur J Cancer"},{"issue":"5","key":"10.1016\/j.canep.2020.101850_bib0085","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/pbc.24217","article-title":"Hepatoblastoma clinical research: lessons learned and future challenges","volume":"59","author":"Perilongo","year":"2012","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"10.1016\/j.canep.2020.101850_bib0090","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S1470-2045(16)30598-8","article-title":"Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children\u2019s Hepatic tumors International Collaboration","volume":"18","author":"Meyers","year":"2017","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.canep.2020.101850_bib0095","doi-asserted-by":"crossref","DOI":"10.7189\/jogh.10.010801","article-title":"The disease burden of childhood asthma in China: a systematic review and meta-analysis","volume":"10","author":"Li","year":"2020","journal-title":"J Glob Health."},{"issue":"3","key":"10.1016\/j.canep.2020.101850_bib0100","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/modpathol.2013.80","article-title":"Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium","volume":"27","author":"Lopez-Terrada","year":"2014","journal-title":"Mod Pathol"},{"issue":"282","key":"10.1016\/j.canep.2020.101850_bib0105","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric Estimation from Incomplete Observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"Journal of the American Statistical Association"},{"issue":"10","key":"10.1016\/j.canep.2020.101850_bib0110","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/hpb.12112","article-title":"Predictors of survival and incidence of hepatoblastoma in the paediatric population","volume":"15","author":"Allan","year":"2013","journal-title":"HPB (Oxford)"},{"issue":"1","key":"10.1016\/j.canep.2020.101850_bib0115","first-page":"62","article-title":"Incidence trends and survival prediction of hepatoblastoma in children: a population-based study","volume":"39","author":"Feng","year":"2019","journal-title":"Cancer Commun (Lond)"},{"issue":"5","key":"10.1016\/j.canep.2020.101850_bib0120","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/CEJ.0000000000000006","article-title":"Childhood cancer survival in France, 2000-2008","volume":"23","author":"Lacour","year":"2014","journal-title":"Eur J Cancer Prev"},{"issue":"20","key":"10.1016\/j.canep.2020.101850_bib0125","doi-asserted-by":"crossref","first-page":"555","DOI":"10.21037\/atm.2019.09.76","article-title":"Survival and analysis of prognostic factors for hepatoblastoma: based on SEER database","volume":"7","author":"Feng","year":"2019","journal-title":"Ann Transl Med"},{"issue":"29","key":"10.1016\/j.canep.2020.101850_bib0130","doi-asserted-by":"crossref","first-page":"10137","DOI":"10.3748\/wjg.v20.i29.10137","article-title":"Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas: 10 year single-center experience and literature review","volume":"20","author":"Ayllon Teran","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"6","key":"10.1016\/j.canep.2020.101850_bib0135","doi-asserted-by":"crossref","first-page":"387","DOI":"10.6061\/clinics\/2015(06)01","article-title":"New concepts and outcomes for children with hepatoblastoma based on the experience of a tertiary center over the last 21 years","volume":"70","author":"Tannuri","year":"2015","journal-title":"Clinics (Sao Paulo)"},{"issue":"24","key":"10.1016\/j.canep.2020.101850_bib0140","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1200\/JCO.2010.29.3837","article-title":"Complete surgical resection is curative for children with hepatoblastoma with pure fetal histology: a report from the Children\u2019s Oncology Group","volume":"29","author":"Malogolowkin","year":"2011","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.canep.2020.101850_bib0145","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/MOP.0000000000000042","article-title":"Hepatoblastoma state of the art: pre-treatment extent of disease, surgical resection guidelines and the role of liver transplantation","volume":"26","author":"Meyers","year":"2014","journal-title":"Curr Opin Pediatr"},{"issue":"2","key":"10.1016\/j.canep.2020.101850_bib0150","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3727\/105221616X693639","article-title":"Novel Advances in Understanding of Molecular Pathogenesis of Hepatoblastoma: A Wnt\/beta-Catenin Perspective","volume":"17","author":"Bell","year":"2017","journal-title":"Gene Expr"},{"issue":"4","key":"10.1016\/j.canep.2020.101850_bib0155","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cld.2018.06.008","article-title":"Pediatric Liver Tumors","volume":"22","author":"Ng","year":"2018","journal-title":"Clin Liver Dis"},{"issue":"11","key":"10.1016\/j.canep.2020.101850_bib0160","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1007\/s00247-019-04402-8","article-title":"Rare malignant liver tumors in children","volume":"49","author":"Chavhan","year":"2019","journal-title":"Pediatr Radiol"},{"issue":"8","key":"10.1016\/j.canep.2020.101850_bib0165","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.28350","article-title":"The importance of age as prognostic factor for the outcome of patients with hepatoblastoma: Analysis from the Children\u2019s Hepatic tumors International Collaboration (CHIC) database","volume":"67","author":"Haeberle","year":"2020","journal-title":"Pediatr Blood Cancer"},{"issue":"4","key":"10.1016\/j.canep.2020.101850_bib0170","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ejca.2007.11.022","article-title":"Hepatoblastoma with a low serum alpha-fetoprotein level at diagnosis: the SIOPEL group experience","volume":"44","author":"De Ioris","year":"2008","journal-title":"Eur J Cancer"},{"issue":"4","key":"10.1016\/j.canep.2020.101850_bib0175","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/pbc.23069","article-title":"Prognostic implications of serum alpha-fetoprotein response during treatment of hepatoblastoma","volume":"57","author":"Koh","year":"2011","journal-title":"Pediatr Blood Cancer"},{"issue":"12","key":"10.1016\/j.canep.2020.101850_bib0180","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1002\/1097-0142(20011215)92:12<3130::AID-CNCR10115>3.0.CO;2-#","article-title":"Small cell undifferentiated histology in hepatoblastoma may be unfavorable","volume":"92","author":"Haas","year":"2001","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.canep.2020.101850_bib0185","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11091387","article-title":"Prognostic Factors for Event-Free Survival in Pediatric Patients with Hepatoblastoma Based on the 2017 PRETEXT and CHIC-HS Systems","volume":"11","author":"Yoon","year":"2019","journal-title":"Cancers (Basel)"}],"container-title":["Cancer Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782120301843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782120301843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T05:27:44Z","timestamp":1761802064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877782120301843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":37,"alternative-id":["S1877782120301843"],"URL":"https:\/\/doi.org\/10.1016\/j.canep.2020.101850","relation":{},"ISSN":["1877-7821"],"issn-type":[{"type":"print","value":"1877-7821"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Survival and prognostic factors for childhood malignant liver tumors: analysis of harmonized clinical data","name":"articletitle","label":"Article Title"},{"value":"Cancer Epidemiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canep.2020.101850","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101850"}}