{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T05:29:22Z","timestamp":1761802162738,"version":"build-2065373602"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009945","name":"Merck KGaA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Epidemiology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.canep.2021.102081","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T05:40:02Z","timestamp":1639546802000},"page":"102081","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Clinical and pathological features of Merkel cell carcinoma: A 4-year follow-up observational retrospective study in Spain"],"prefix":"10.1016","volume":"76","author":[{"given":"Juan Jos\u00e9","family":"R\u00edos-Mart\u00edn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Rodriguez-Salas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"V\u00e1zquez-Doval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Llombart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nohelia","family":"Rojas-Ferrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Carmen","family":"Gonz\u00e1lez-Vela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Zulueta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Monteagudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Aneiros-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Beato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Carrillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Yohana","family":"Silva-Carmona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Ayala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Gallego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Rodr\u00edguez-Peralto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Fraga-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Teresa","family":"Fern\u00e1ndez-Figueras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Barranco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"C\u00f3rdoba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Sanz-Zorrilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berta","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"F\u00fanez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Santonja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Saus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Angel","family":"Idoate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Santos-Briz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Onrubia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Pinedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"de las Pe\u00f1as","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canep.2021.102081_bib1","first-page":"31","article-title":"Update on merkel cell carcinoma, head and neck","volume":"12","author":"Tetzlaff","year":"2018","journal-title":"Pathology"},{"key":"10.1016\/j.canep.2021.102081_bib2","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1245\/s10434-016-5266-4","article-title":"Analysis of prognostic factors from 9387 merkel cell carcinoma cases forms the basis for the new 8th edition AJCC staging system","volume":"23","author":"Harms","year":"2016","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.canep.2021.102081_bib3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejca.2016.10.022","article-title":"Merkel cell carcinoma: epidemiology, prognosis, therapy and unmet medical needs","volume":"71","author":"Schadendorf","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.canep.2021.102081_bib4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11864-016-0409-1","article-title":"Merkel cell carcinoma therapeutic update","volume":"17","author":"Cassler","year":"2016","journal-title":"Curr. Treat Opt. Oncol."},{"key":"10.1016\/j.canep.2021.102081_bib5","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1634\/theoncologist.2018-0718","article-title":"Recent therapeutic advances and change in treatment paradigm of patients with merkel cell carcinoma","volume":"24","author":"Garcia-Carbonero","year":"2019","journal-title":"The Oncologist"},{"key":"10.1016\/j.canep.2021.102081_bib6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jaad.2007.11.020","article-title":"Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features","volume":"58","author":"Heath","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.canep.2021.102081_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.hoc.2018.08.002","article-title":"Merkel cell carcinoma review","volume":"33","author":"Xue","year":"2019","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"10.1016\/j.canep.2021.102081_bib8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/jid.2008.229","article-title":"Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors","volume":"129","author":"Garneski","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.canep.2021.102081_bib9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.canep.2016.09.001","article-title":"Trends in incidence and survival analysis in non-melanoma skin cancer from 1994 to 2012 in Girona, Spain: a population-based study","volume":"45","author":"Rubi\u00f3-Casadevall","year":"2016","journal-title":"Cancer epidemiol."},{"key":"10.1016\/j.canep.2021.102081_bib10","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ad.2015.12.008","article-title":"Incidencia y mortalidad del c\u00e1ncer cut\u00e1neo en Espana: revisi\u00f3n sistem\u00e1tica y metaan\u00e1lisis","volume":"107","author":"Tejera-Vaquerizo","year":"2016","journal-title":"Actas Dermosifiliogr"},{"key":"10.1016\/j.canep.2021.102081_bib11","doi-asserted-by":"crossref","first-page":"17077","DOI":"10.1038\/nrdp.2017.77","article-title":"Merkel cell carcinoma","volume":"3","author":"Becker","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.canep.2021.102081_bib12","doi-asserted-by":"crossref","first-page":"2565e78","DOI":"10.1016\/j.ejca.2013.02.029","article-title":"Rare neuroendocrine tumours: results of the surveillance of rare cancers in Europe project","volume":"49","author":"van der Zwan","year":"2013","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.canep.2021.102081_bib13","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1038\/s41375-020-0987-6","article-title":"Second cancer incidence in CLL patients receiving BTK inhibitors","volume":"34","author":"Bond","year":"2020","journal-title":"Leukemia."},{"key":"10.1016\/j.canep.2021.102081_bib14","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jaad.2012.09.036","article-title":"Prognostic factors in Merkel cell carcinoma: analysis of 240 cases","volume":"68","author":"Tarantola","year":"2013","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.canep.2021.102081_bib15","first-page":"113","article-title":"A meta-analysis of the prognostic significance of sentinel lymph node status in Merkel cell carcinoma","volume":"28","author":"Mehrany","year":"2002","journal-title":"Dermatol. Surg."},{"key":"10.1016\/j.canep.2021.102081_bib16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/00000637-199008000-00012","article-title":"Merkel cell carcinoma: the clinical course","volume":"25","author":"Mercer","year":"1990","journal-title":"Ann. Plast Surg."},{"key":"10.1016\/j.canep.2021.102081_bib17","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s10434-001-0204-4","article-title":"Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases","volume":"8","author":"Medina-Franco","year":"2001","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.canep.2021.102081_bib18","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.ijrobp.2010.04.061","article-title":"Merkel cell carcinoma: 27-year experience at the Peter MacCallum Cancer Centre","volume":"80","author":"Hui","year":"2011","journal-title":"Int. J. Radiat Oncol. Biol. Phys."},{"key":"10.1016\/j.canep.2021.102081_bib19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.6004\/jnccn.2009.0025","article-title":"Merkel cell carcinoma: a review of current advances","volume":"1","author":"Zhan","year":"2009","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"10.1016\/j.canep.2021.102081_bib20","series-title":"Management of Non-melanoma Skin Cancers: Merkel Cell Carcinoma","first-page":"623","author":"Prieto","year":"2018"}],"container-title":["Cancer Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782121001983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782121001983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T05:27:45Z","timestamp":1761802065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877782121001983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":20,"alternative-id":["S1877782121001983"],"URL":"https:\/\/doi.org\/10.1016\/j.canep.2021.102081","relation":{},"ISSN":["1877-7821"],"issn-type":[{"type":"print","value":"1877-7821"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and pathological features of Merkel cell carcinoma: A 4-year follow-up observational retrospective study in Spain","name":"articletitle","label":"Article Title"},{"value":"Cancer Epidemiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canep.2021.102081","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102081"}}