{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:47:33Z","timestamp":1777290453472,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Epidemiology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.canep.2022.102121","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T18:06:57Z","timestamp":1645121217000},"page":"102121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Non-aspirin NSAIDs and head and neck cancer mortality in a Danish nationwide cohort study"],"prefix":"10.1016","volume":"77","author":[{"given":"Cecilie D.","family":"de la Cour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Dehlendorff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"von Buchwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Garset-Zamani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Gr\u00f8nh\u00f8j","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda-Louise F.","family":"Carlander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Friis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne K.","family":"Kjaer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canep.2022.102121_bib1","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.canep.2022.102121_bib2","first-page":"1","article-title":"Increasing incidence and survival of head and neck cancers in Denmark: a nation-wide study from 1980 to 2014","author":"Jakobsen","year":"2018","journal-title":"Acta Oncol."},{"key":"10.1016\/j.canep.2022.102121_bib3","first-page":"f3195","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs). BMJ","volume":"346","author":"Day","year":"2013","journal-title":"Br. Med. J."},{"key":"10.1016\/j.canep.2022.102121_bib4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrclinonc.2011.199","article-title":"The role of aspirin in cancer prevention","volume":"9","author":"Thun","year":"2012","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.canep.2022.102121_bib5","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1002\/jcp.27411","article-title":"Cyclooxygenase-2 in cancer: a review","volume":"234","author":"Hashemi Goradel","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.canep.2022.102121_bib6","first-page":"991","article-title":"Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck","volume":"59","author":"Chan","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.canep.2022.102121_bib7","doi-asserted-by":"crossref","first-page":"9246","DOI":"10.3390\/ijms21239246","article-title":"Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis","volume":"21","author":"Frejborg","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canep.2022.102121_bib8","doi-asserted-by":"crossref","first-page":"47265","DOI":"10.18632\/oncotarget.10059","article-title":"Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: a meta-analysis","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.canep.2022.102121_bib9","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/aps.2012.18","article-title":"Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation","volume":"33","author":"Liu","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.canep.2022.102121_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034988","article-title":"Tolfenamic acid induces apoptosis and growth inhibition in head and neck cancer: involvement of NAG-1 expression","volume":"7","author":"Kang","year":"2012","journal-title":"PLOS One"},{"key":"10.1016\/j.canep.2022.102121_bib11","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.1038\/s41598-017-06673-3","article-title":"Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma","volume":"7","author":"Chiang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canep.2022.102121_bib12","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.2147\/IJN.S109199","article-title":"Increased survival rate by local release of diclofenac in a murine model of recurrent oral carcinoma","volume":"11","author":"Will","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.canep.2022.102121_bib13","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1002\/ijc.32544","article-title":"Use of nonaspirin nonsteroidal anti-inflammatory drugs and risk of head and neck cancer: a nationwide case-control study","volume":"146","author":"de la Cour","year":"2020","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canep.2022.102121_bib14","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s10147-017-1165-3","article-title":"Aspirin use and head and neck cancer survival: an observational study of 11,623 person-years follow-up","volume":"23","author":"Kim","year":"2018","journal-title":"Int. J. Clin. Oncol."},{"key":"10.1016\/j.canep.2022.102121_bib15","first-page":"4235","article-title":"Effect of celecoxib on survival of mobile tongue cancer","volume":"35","author":"Lee","year":"2015","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canep.2022.102121_bib16","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.canep.2015.10.030","article-title":"Aspirin and other non-steroidal anti-inflammatory drug prescriptions and survival after the diagnosis of head and neck and oesophageal cancer","volume":"39","author":"Macfarlane","year":"2015","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.canep.2022.102121_bib17","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10654-014-9930-3","article-title":"The Danish civil registration system as a tool in epidemiology","volume":"29","author":"Schmidt","year":"2014","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.canep.2022.102121_bib18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejca.2020.04.027","article-title":"The current epidemic of HPV-associated oropharyngeal cancer: an 18-year Danish population-based study with 2,169 patients","volume":"134","author":"Zamani","year":"2020","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.canep.2022.102121_bib19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejca.2016.10.015","article-title":"Continuing rise in oropharyngeal cancer in a high HPV prevalence area: a Danish population-based study from 2011 to 2014","volume":"70","author":"Carlander","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.canep.2022.102121_bib20","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/ijc.29254","article-title":"A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, 2000-2010: the largest registry-based study to date","volume":"136","author":"Garnaes","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canep.2022.102121_bib21","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"61","author":"von Elm","year":"2008","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.canep.2022.102121_bib22","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/1403494810393562","article-title":"The Danish cancer registry","volume":"39","author":"Gjerstorff","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"10.1016\/j.canep.2022.102121_bib23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/bcpt.13472","article-title":"How patients in Denmark acquire their medicines: overview, data sources and implications for pharmacoepidemiology","volume":"128","author":"Jensen","year":"2021","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"3","key":"10.1016\/j.canep.2022.102121_bib24","article-title":"Data resource profile: the Danish national prescription registry","volume":"46","author":"Pottegard","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.canep.2022.102121_bib25","unstructured":"Methodology WCCfDS. ATC classification index with DDDs. Oslo, Norway 2021."},{"key":"10.1016\/j.canep.2022.102121_bib26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/1403494811399958","article-title":"The Danish register of causes of death","volume":"39","author":"Helweg-Larsen","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"10.1016\/j.canep.2022.102121_bib27","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","article-title":"The American joint committee on cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM","volume":"17","author":"Edge","year":"2010","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.canep.2022.102121_bib28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2147\/CLEP.S91125","article-title":"The Danish national patient registry: a review of content, data quality, and research potential","volume":"7","author":"Schmidt","year":"2015","journal-title":"Clin. Epidemiol."},{"key":"10.1016\/j.canep.2022.102121_bib29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/1403494811405098","article-title":"Danish registers on personal income and transfer payments","volume":"39","author":"Baadsgaard","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"10.1016\/j.canep.2022.102121_bib30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/1403494810394715","article-title":"Danish education registers","volume":"39","author":"Jensen","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"10.1016\/j.canep.2022.102121_bib31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11864-017-0484-y","article-title":"Overview of the 8th edition TNM classification for head and neck cancer","volume":"18","author":"Huang","year":"2017","journal-title":"Curr. Treat. Options Oncol."},{"key":"10.1016\/j.canep.2022.102121_bib32","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1038\/s41416-018-0107-9","article-title":"Development and external validation of nomograms in oropharyngeal cancer patients with known HPV-DNA status: a European multicentre study (OroGrams)","volume":"118","author":"Gr\u00f8nh\u00f8j","year":"2018","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canep.2022.102121_bib33","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1177\/0962280214521348","article-title":"Multiple imputation of covariates by fully conditional specification: accommodating the substantive model","volume":"24","author":"Bartlett","year":"2015","journal-title":"Stat. Methods Med. Res."},{"key":"10.1016\/j.canep.2022.102121_bib34","unstructured":"R: A language and environment for statistical computing.Vienna, Austria: R Foundation for Statistical Computing, 2020. \u3008https:\/\/www.R-project.org\/\u3009."},{"key":"10.1016\/j.canep.2022.102121_bib35","unstructured":"A Package for Survival Analysis in R: R package version 3.1\u201312, 2020. \u3008https:\/\/CRAN.R-project.org\/package=survival\u3009."},{"key":"10.1016\/j.canep.2022.102121_bib36","unstructured":"smcfcs: Multiple Imputation of Covariates by Substantive Model Compatible Fully Conditional Specification: R package version 1.4.2, 2020. \u3008https:\/\/CRAN.R-project.org\/package=smcfcs\u3009."},{"key":"10.1016\/j.canep.2022.102121_bib37","unstructured":"mitools: Tools for Multiple Imputation of Missing Data: R package version 2.4, 2019. \u3008https:\/\/CRAN.R-project.org\/package=mitools\u3009."},{"key":"10.1016\/j.canep.2022.102121_bib38","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1084\/jem.20181936","article-title":"Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer","volume":"216","author":"Hedberg","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canep.2022.102121_bib39","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.7199","article-title":"Association of nonsteroidal anti-inflammatory drug use with survival in patients with squamous cell carcinoma of the head and neck treated with chemoradiation therapy","volume":"3","author":"Iovoli","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.canep.2022.102121_bib40","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/jnci\/djk200","article-title":"Association of aspirin and nonaspirin nonsteroidal anti-inflammatory drugs with cancer incidence and mortality","volume":"99","author":"Bardia","year":"2007","journal-title":"J. Natl. Cancer Inst."},{"issue":"7","key":"10.1016\/j.canep.2022.102121_bib41","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/jnci\/djab008","article-title":"Associations of aspirin and non-aspirin non-steroidal anti-inflammatory drugs with colorectal cancer mortality after diagnosis","volume":"113","author":"Figueiredo","year":"2021","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.canep.2022.102121_bib42","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ygyno.2018.06.018","article-title":"Non-aspirin NSAID use and ovarian cancer mortality","volume":"150","author":"Verdoodt","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.canep.2022.102121_bib43","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10549-006-9277-x","article-title":"NSAID use and survival after breast cancer diagnosis in post-menopausal women","volume":"101","author":"Blair","year":"2007","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.canep.2022.102121_bib44","first-page":"109","article-title":"Nonsteroidal anti-inflammatory drugs and endometrial carcinoma mortality and recurrence","author":"Brasky","year":"2016","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.canep.2022.102121_bib45","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/jnci\/djaa114","article-title":"Effect of aspirin on cancer incidence and mortality in older adults","volume":"113","author":"McNeil","year":"2020","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.canep.2022.102121_bib46","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1200\/JCO.2015.61.1509","article-title":"Immunology and immunotherapy of head and neck cancer","volume":"33","author":"Ferris","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canep.2022.102121_bib47","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/rheumatology\/kez320","article-title":"Methodological considerations when analysing and interpreting real-world data","volume":"59","author":"St\u00fcrmer","year":"2019","journal-title":"Rheumatology"},{"key":"10.1016\/j.canep.2022.102121_bib48","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1093\/jnci\/djt211","article-title":"Threats to validity of nonrandomized studies of postdiagnosis exposures on cancer recurrence and survival","volume":"105","author":"Chubak","year":"2013","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.canep.2022.102121_bib49","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/phar.2217","article-title":"Nonaspirin nonsteroidal antiinflammatory drug use in the nordic countries from a cardiovascular risk perspective, 2000-2016: a drug utilization study","volume":"39","author":"Kristensen","year":"2019","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.canep.2022.102121_bib50","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0140-6736(13)60900-9","article-title":"Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials","volume":"382","author":"Bhala","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.canep.2022.102121_bib51","doi-asserted-by":"crossref","first-page":"c7086","DOI":"10.1136\/bmj.c7086","article-title":"Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis","volume":"342","author":"Trelle","year":"2011","journal-title":"BMJ"}],"container-title":["Cancer Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782122000261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782122000261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T05:29:59Z","timestamp":1761802199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877782122000261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":51,"alternative-id":["S1877782122000261"],"URL":"https:\/\/doi.org\/10.1016\/j.canep.2022.102121","relation":{},"ISSN":["1877-7821"],"issn-type":[{"value":"1877-7821","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-aspirin NSAIDs and head and neck cancer mortality in a Danish nationwide cohort study","name":"articletitle","label":"Article Title"},{"value":"Cancer Epidemiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canep.2022.102121","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102121"}}