{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:09:34Z","timestamp":1793329774632,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Epidemiology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.canep.2022.102209","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:33:51Z","timestamp":1658190831000},"page":"102209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Late effects of childhood cancer treatment in long-term survivors diagnosed before the age of 3 years \u2013 A multicenter, nationwide study"],"prefix":"10.1016","volume":"80","author":[{"given":"Eryk","family":"Latoch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Zubowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"M\u0142ynarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Stachowicz-Stencel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Stefanowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"S\u0142awi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Kowalczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Skalska-Sadowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Wachowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Badowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Czaj\u0144ska-Deptu\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u017cenna","family":"Dembowska-Bagi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Garus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szymon","family":"Skocze\u0144","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Pobudejska-Pieni\u0105\u017cek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Szczepa\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Machnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Panasiuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"S\u0119ga-Pondel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Malesza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Raciborska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Zielezi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Urasi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Mizia-Malarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wawrze\u0144czyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u017cyna","family":"Karolczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Ko\u0142tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Wysocki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Wo\u0142owiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Matysiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryna","family":"Krawczuk-Rybak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canep.2022.102209_bib1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.clp.2020.11.009","article-title":"Late effects in survivors of neonatal cancer","volume":"48","author":"Janardan","year":"2021","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.canep.2022.102209_bib2","doi-asserted-by":"crossref","first-page":"e286","DOI":"10.1097\/MPH.0000000000001692","article-title":"Neonatal cancer epidemiology and outcome: a retrospective study","volume":"42","author":"Geurten","year":"2020","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.canep.2022.102209_bib3","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1200\/JCO.2013.51.1055","article-title":"Aging and risk of severe, disabling, life-threatening, and fatal events in the childhood cancer survivor study","volume":"32","author":"Armstrong","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canep.2022.102209_bib4","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1159\/000484936","article-title":"Late effects and long-term follow-up after cancer in childhood","volume":"40","author":"Langer","year":"2017","journal-title":"Oncol. Res. Treat."},{"issue":"Pt. B","key":"10.1016\/j.canep.2022.102209_bib5","article-title":"Childhood cancer: survival, treatment modalities, late effects and improvements over time","volume":"71","author":"Erdmann","year":"2021","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.canep.2022.102209_bib6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00431-017-3066-x","article-title":"Health status of Polish children and adolescents after cancer treatment","volume":"177","author":"Krawczuk-Rybak","year":"2018","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.canep.2022.102209_bib7","first-page":"S92","article-title":"Late effects of early childhood cancer therapy","volume":"18","author":"Meadows","year":"1992","journal-title":"Br. J. Cancer Suppl."},{"key":"10.1016\/j.canep.2022.102209_bib8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00383-002-0760-0","article-title":"Long-term follow-up of cancer in neonates and infants: a national survey of 142 patients","volume":"19","author":"Pinter","year":"2003","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.canep.2022.102209_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.27747","article-title":"Unintended consequences of evolution of the common terminology criteria for adverse events","volume":"66","author":"Miller","year":"2019","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.canep.2022.102209_bib10","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0140-6736(81)91216-2","article-title":"Declines in IQ scores and cognitive dysfunctions in children with acute lymphocytic leukaemia treated with cranial irradiation","volume":"2","author":"Meadows","year":"1981","journal-title":"Lancet"},{"key":"10.1016\/j.canep.2022.102209_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/bcj.2014.17","article-title":"The evolution of clinical trials for infant acute lymphoblastic leukemia","volume":"4","author":"Kotecha","year":"2014","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.canep.2022.102209_bib12","doi-asserted-by":"crossref","first-page":"e938","DOI":"10.1542\/peds.2009-1597","article-title":"Auditory late effects of childhood cancer therapy: a report from the children\u2019s oncology group","volume":"125","author":"Grewal","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.canep.2022.102209_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejca.2016.09.023","article-title":"DCOG-LATER The Netherlands, determinants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer: a DCOG late-effects study","volume":"69","author":"Clemens","year":"2016","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.canep.2022.102209_bib14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11845-016-1473-z","article-title":"Late effects of chemotherapeutic agents on renal function in childhood cancer survivors: a review of the literature","volume":"186","author":"O\u2019Sullivan","year":"2017","journal-title":"Ir. J. Med. Sci."},{"key":"10.1016\/j.canep.2022.102209_bib15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00467-017-3662-z","article-title":"Late renal toxicity of treatment for childhood malignancy: risk factors, long-term outcomes, and surveillance","volume":"33","author":"Skinner","year":"2018","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.canep.2022.102209_bib16","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/bmt.2013.218","article-title":"Late effects in children treated with intensive multimodal therapy for high-risk neuroblastoma: high incidence of endocrine and growth problems","volume":"49","author":"Cohen","year":"2014","journal-title":"Bone Marrow Transpl."},{"key":"10.1016\/j.canep.2022.102209_bib17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/pbc.20067","article-title":"4S neuroblastoma: the long-term outcome","volume":"43","author":"Levitt","year":"2004","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.canep.2022.102209_bib18","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/pbc.20331","article-title":"Long-term complications in survivors of advanced stage neuroblastoma","volume":"45","author":"Laverdi\u00e8re","year":"2005","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.canep.2022.102209_bib19","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/0284186X.2019.1672892","article-title":"Neurologic disorders in long-term survivors of neuroblastoma - a population-based cohort study within the adult life after childhood cancer in Scandinavia (ALiCCS) research program","volume":"59","author":"Norsker","year":"2020","journal-title":"Acta Oncol."},{"key":"10.1016\/j.canep.2022.102209_bib20","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1002\/ijc.31631","article-title":"Somatic late effects in 5-year survivors of neuroblastoma: a population-based cohort study within the adult life after childhood cancer in Scandinavia study","volume":"143","author":"Norsker","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canep.2022.102209_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/MPH.0000000000000848","article-title":"Late effects in pediatric high-risk neuroblastoma survivors after intensive induction chemotherapy followed by myeloablative consolidation chemotherapy and triple autologous stem cell transplants","volume":"40","author":"Armstrong","year":"2018","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.canep.2022.102209_bib22","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1515\/jpem-2018-0273","article-title":"Endocrine consequences of neuroblastoma treatment in children: 20 years\u2019 experience of a single center","volume":"32","author":"Geurten","year":"2019","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.canep.2022.102209_bib23","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3389\/fendo.2019.00555","article-title":"Gonadal failure is common in long-term survivors of childhood high-risk neuroblastoma treated with high-dose chemotherapy and autologous stem cell rescue","volume":"10","author":"Utriainen","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.canep.2022.102209_bib24","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/pbc.23090","article-title":"Twenty-five year follow-up of childhood Wilms tumor: a report from the childhood cancer survivor study","volume":"57","author":"Termuhlen","year":"2011","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.canep.2022.102209_bib25","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3109\/08880010903019344","article-title":"Late effects of treatment for wilms tumor","volume":"26","author":"Karen","year":"2009","journal-title":"Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.canep.2022.102209_bib26","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1007\/s00467-017-3673-9","article-title":"Prospective analysis of long-term renal function in survivors of childhood Wilms tumor","volume":"32","author":"Neu","year":"2017","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.canep.2022.102209_bib27","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/pbc.22518","article-title":"Increased prevalence of risk factors for cardiovascular disease in long-term survivors of acute lymphoblastic leukemia and Wilms tumor treated with radiotherapy","volume":"55","author":"Geenen","year":"2010","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.canep.2022.102209_bib28","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0360-3016(99)00534-9","article-title":"Late effects in children treated with radiation therapy for Wilms\u2019 tumor","volume":"46","author":"Paulino","year":"2000","journal-title":"Int. J. Radiat. Biol. Phys."},{"key":"10.1016\/j.canep.2022.102209_bib29","first-page":"227","article-title":"Late effects of abdominal irradiation in children: a review of the literature","volume":"30","author":"Bolling","year":"2010","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canep.2022.102209_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/bcj.2016.129","article-title":"Late effects in survivors of infantile acute leukemia: a study of the L.E.A program","volume":"7","author":"Gandemer","year":"2017","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.canep.2022.102209_bib31","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/sj.leu.2401818","article-title":"Late effects in survivors of infant leukemia","volume":"14","author":"Leung","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.canep.2022.102209_bib32","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1182\/blood-2019-123881","article-title":"Late effects in survivors of infant acute lymphoblastic leukemia from the 3 consecutive Japanese nationwide clinical trials","volume":"134","author":"Aoki","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.canep.2022.102209_bib33","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S1470-2045(14)70265-7","article-title":"Risk of late effects of treatment in children newly diagnosed with standard-risk acute lymphoblastic leukaemia: a report from the childhood cancer survivor study cohort","volume":"15","author":"Essig","year":"2014","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canep.2022.102209_bib34","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/pbc.26061","article-title":"Late toxicities of intensity-modulated radiation therapy for head and neck rhabdomyosarcoma","volume":"63","author":"Lockney","year":"2016","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.canep.2022.102209_bib35","doi-asserted-by":"crossref","first-page":"e306","DOI":"10.1016\/S2352-3026(19)30050-X","article-title":"The changing burden of long-term health outcomes in survivors of childhood acute lymphoblastic leukaemia: a retrospective analysis of the St Jude Lifetime Cohort Study","volume":"6","author":"Mulrooney","year":"2019","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.canep.2022.102209_bib36","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s11864-016-0426-0","article-title":"Long-term effect of cranial radiotherapy on pituitary-hypothalamus area in childhood acute lymphoblastic leukemia survivors","volume":"17","author":"Follin","year":"2016","journal-title":"Curr. Treat. Options Oncol."},{"key":"10.1016\/j.canep.2022.102209_bib37","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1203\/00006450-199511000-00027","article-title":"Late effects among long-term survivors of childhood acute leukemia in The Netherlands: a Dutch childhood leukemia study group report","volume":"38","author":"van der Does-van den Berg","year":"1995","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.canep.2022.102209_bib38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/bjh.16337","article-title":"Long-term outcome evaluation of medium\/high risk acute lymphoblastic leukaemia children treated with or without cranial radiotherapy in the EORTC 58832 randomized study","volume":"189","author":"Piette","year":"2020","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.canep.2022.102209_bib39","first-page":"CD008205","article-title":"Hepatic late adverse effects after antineoplastic treatment for childhood cancer","volume":"4","author":"Mulder","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.canep.2022.102209_bib40","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1055\/s-0033-1349854","article-title":"The progressive reduction in the ovarian reserve in young women after anticancer treatment","volume":"45","author":"Krawczuk-Rybak","year":"2013","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.canep.2022.102209_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.29200","article-title":"Late adverse effects of childhood acute lymphoblastic leukemia treatment on developing dentition","volume":"68","author":"Immonen","year":"2021","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.canep.2022.102209_bib42","first-page":"2009","article-title":"Oral and dental late effects in survivors of childhood cancer: a Children\u2019s Oncology Group report","volume":"22","author":"Effinger","year":"2014","journal-title":"Support. Care Cancer"}],"container-title":["Cancer Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187778212200114X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187778212200114X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T05:29:58Z","timestamp":1761802198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187778212200114X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":42,"alternative-id":["S187778212200114X"],"URL":"https:\/\/doi.org\/10.1016\/j.canep.2022.102209","relation":{},"ISSN":["1877-7821"],"issn-type":[{"value":"1877-7821","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Late effects of childhood cancer treatment in long-term survivors diagnosed before the age of 3 years \u2013 A multicenter, nationwide study","name":"articletitle","label":"Article Title"},{"value":"Cancer Epidemiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canep.2022.102209","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102209"}}