{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:44:01Z","timestamp":1790199841598,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T00:00:00Z","timestamp":1691884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1121151"],"award-info":[{"award-number":["APP1121151"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1173346"],"award-info":[{"award-number":["GNT1173346"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1185416"],"award-info":[{"award-number":["APP1185416"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Epidemiology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.canep.2023.102444","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T17:37:21Z","timestamp":1692207441000},"page":"102444","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Association between antihypertensive medicine use and risk of ovarian cancer in women aged 50 years and older"],"prefix":"10.1016","volume":"86","author":[{"given":"Karen M.","family":"Tuesley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7434-2957","authenticated-orcid":false,"given":"Katrina","family":"Spilsbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope M.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda M.","family":"Protani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Dixon-Suen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-6855","authenticated-orcid":false,"given":"Sallie-Anne","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-601X","authenticated-orcid":false,"given":"Peter","family":"Donovan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Coory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Steer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise M.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmala","family":"Pandeya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canep.2023.102444_bib1","series-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay","year":"2018"},{"issue":"5","key":"10.1016\/j.canep.2023.102444_bib2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/1753-6405.12471","article-title":"Cancers in Australia in 2010 attributable to modifiable factors: summary and conclusions","volume":"39","author":"Whiteman","year":"2015","journal-title":"Aust. N. Z. J. Public Health"},{"issue":"19","key":"10.1016\/j.canep.2023.102444_bib3","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.2174\/1568026616666160216154946","article-title":"Repurposing drugs for cancer prevention","volume":"16","author":"Lee","year":"2016","journal-title":"Curr. Top. Med Chem."},{"issue":"12","key":"10.1016\/j.canep.2023.102444_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/S1470-2045(20)30610-0","article-title":"Drug repurposing in oncology","volume":"21","author":"Frantzi","year":"2020","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canep.2023.102444_bib5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.phrs.2017.07.026","article-title":"Antihypertensive drugs","volume":"124","author":"Laurent","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.canep.2023.102444_bib6","article-title":"Adrenergic beta2-receptors mediates visceral hypersensitivity induced by heterotypic intermittent stress in rats","volume":"9","author":"Zhang","year":"2014","journal-title":"PLOS One"},{"issue":"12","key":"10.1016\/j.canep.2023.102444_bib7","first-page":"4514","article-title":"Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines","volume":"9","author":"Lutgendorf","year":"2003","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.canep.2023.102444_bib8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ygyno.2019.05.030","article-title":"Post-diagnosis use of antihypertensive medications and the risk of death from ovarian cancer","volume":"154","author":"Harding","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.canep.2023.102444_bib9","article-title":"Perioperative beta-blocker supply and survival in women with epithelial ovarian cancer and a history of cardiovascular conditions","author":"Spilsbury","year":"2022","journal-title":"J. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.canep.2023.102444_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072327","article-title":"Calcium channels as novel therapeutic targets for ovarian cancer stem cells","volume":"21","author":"Lee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.canep.2023.102444_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13040668","article-title":"Emerging roles for ion channels in ovarian cancer: pathomechanisms and pharmacological treatment","volume":"13","author":"Altamura","year":"2021","journal-title":"Cancers"},{"issue":"2","key":"10.1016\/j.canep.2023.102444_bib12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/ijc.30066","article-title":"Hypertension, use of antihypertensive medications, and risk of epithelial ovarian cancer","volume":"139","author":"Huang","year":"2016","journal-title":"Int. J. Cancer"},{"issue":"6","key":"10.1016\/j.canep.2023.102444_bib13","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/jnci\/djac050","article-title":"Nitrogen-based bisphosphonate use and ovarian cancer risk in women aged 50 years and older","volume":"114","author":"Tuesley","year":"2022","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.canep.2023.102444_bib14","unstructured":"Australian Government Department of Health and Aged Care, The Pharmaceutical Benefits Scheme, Fees, Patient Contributions and Safety Net Thresholds 2022 [Available from: https:\/\/www.pbs.gov.au\/info\/healthpro\/explanatory-notes\/front\/fee."},{"issue":"2","key":"10.1016\/j.canep.2023.102444_bib15","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ygyno.2016.11.019","article-title":"Worldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2)","volume":"144","author":"Matz","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.canep.2023.102444_bib16","unstructured":"SEIFA 2011: Australian Bureau of Statistics; 2011 [updated 19 September 2013. Available from: http:\/\/www.abs.gov.au\/websitedbs\/censushome.nsf\/home\/seifa2011?opendocument&navpos=260."},{"key":"10.1016\/j.canep.2023.102444_bib17","unstructured":"ABS Geography Publications: Australian Bureau of Statistics; 2017 [updated 21 April 2017. Available from: http:\/\/www.abs.gov.au\/websitedbs\/D3310114.nsf\/home\/ABS+Geography+Publications."},{"key":"10.1016\/j.canep.2023.102444_bib18","unstructured":"Ware V., Gronda H., Vitis L. Vicki-Ann Ware, Hellene Gronda and Laura Vitis, 2010. Addressing locational disadvantage effectively (international evidence). Melbourne: AHURI Research Synthesis Service, Australian Housing and Urban Research Institute. 2010."},{"issue":"2","key":"10.1016\/j.canep.2023.102444_bib19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jclinepi.2010.02.015","article-title":"Charlson and Rx-Risk comorbidity indices were predictive of mortality in the Australian health care setting","volume":"64","author":"Lu","year":"2011","journal-title":"J. Clin. Epidemiol."},{"issue":"4","key":"10.1016\/j.canep.2023.102444_bib20","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-021122","article-title":"The validity of the Rx-Risk Comorbidity Index using medicines mapped to the anatomical therapeutic chemical (ATC) classification system","volume":"8","author":"Pratt","year":"2018","journal-title":"BMJ Open"},{"issue":"4","key":"10.1016\/j.canep.2023.102444_bib21","doi-asserted-by":"crossref","first-page":"268","DOI":"10.7326\/M16-2607","article-title":"Sensitivity analysis in observational research: introducing the E-value","volume":"167","author":"VanderWeele","year":"2017","journal-title":"Ann. Intern Med"},{"issue":"529","key":"10.1016\/j.canep.2023.102444_bib22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/01621459.2018.1529598","article-title":"Sensitivity analysis for unmeasured confounding in meta-analyses","volume":"115","author":"Mathur","year":"2020","journal-title":"J. Am. Stat. Assoc."},{"issue":"1","key":"10.1016\/j.canep.2023.102444_bib23","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-020-01891-5","article-title":"A systematic assessment of the association between frequently prescribed medicines and the risk of common cancers: a series of nested case-control studies","volume":"19","author":"McDowell","year":"2021","journal-title":"BMC Med."},{"issue":"5","key":"10.1016\/j.canep.2023.102444_bib24","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1158\/1055-9965.EPI-08-0936","article-title":"Risk of endometrial cancer in relation to medical conditions and medication use","volume":"18","author":"Fortuny","year":"2009","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"7","key":"10.1016\/j.canep.2023.102444_bib25","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/cncr.11663","article-title":"Relation between use of antihypertensive medications and risk of breast carcinoma among women ages 65-79 years","volume":"98","author":"Li","year":"2003","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.canep.2023.102444_bib26","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S1470-2045(21)00033-4","article-title":"Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis","volume":"22","author":"Copland","year":"2021","journal-title":"Lancet Oncol."},{"issue":"6","key":"10.1016\/j.canep.2023.102444_bib27","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1161\/CIRCRESAHA.116.305697","article-title":"Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms","volume":"116","author":"Hall","year":"2015","journal-title":"Circ. Res"},{"issue":"24","key":"10.1016\/j.canep.2023.102444_bib28","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1200\/JCO.2016.66.8178","article-title":"Ovarian cancer risk factors by histologic subtype: an analysis from the ovarian cancer cohort consortium","volume":"34","author":"Wentzensen","year":"2016","journal-title":"J. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.canep.2023.102444_bib29","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00595.2018","article-title":"Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension","volume":"316","author":"Dikalov","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Cancer Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782123001248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782123001248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:39:14Z","timestamp":1778830754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877782123001248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":29,"alternative-id":["S1877782123001248"],"URL":"https:\/\/doi.org\/10.1016\/j.canep.2023.102444","relation":{},"ISSN":["1877-7821"],"issn-type":[{"value":"1877-7821","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between antihypertensive medicine use and risk of ovarian cancer in women aged 50 years and older","name":"articletitle","label":"Article Title"},{"value":"Cancer Epidemiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canep.2023.102444","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102444"}}