{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:53:17Z","timestamp":1786985597716,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Epidemiology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.canep.2024.102642","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T21:37:18Z","timestamp":1723153038000},"page":"102642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Evaluation of a multigenomic liquid biopsy (PROSTest) for prostate cancer detection and follow-up in a Caribbean population"],"prefix":"10.1016","volume":"92","author":[{"given":"R. David","family":"Rosin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1525-5167","authenticated-orcid":false,"given":"Mark","family":"Kidd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignat","family":"Drozdov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irvin","family":"Modlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel","family":"Halim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.canep.2024.102642_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.canep.2024.102642_bib2","doi-asserted-by":"crossref","DOI":"10.1177\/10732748221082372","article-title":"Prostate cancer in the Caribbean: a baseline assessment of current practices and potential needs","volume":"29","author":"Khandwala","year":"2022","journal-title":"Cancer Control"},{"issue":"19","key":"10.1016\/j.canep.2024.102642_bib3","article-title":"Recent global patterns in prostate cancer incidence and mortality rates","volume":"4","author":"Culp","year":"2019","journal-title":"Eur. Urol."},{"key":"10.1016\/j.canep.2024.102642_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/565230","article-title":"Prostate cancer incidence and mortality in barbados, west indies","volume":"2011","author":"Hennis","year":"2011","journal-title":"Prostate Cancer"},{"key":"10.1016\/j.canep.2024.102642_bib5","first-page":"27","article-title":"Cancer in Barbados REPORT 2022, the Barbados national registry for non-communicable disease (BNR) George alleyne chronic disease research centre","author":"Sobers","year":"2022","journal-title":"Barbados"},{"key":"10.1016\/j.canep.2024.102642_bib6","doi-asserted-by":"crossref","unstructured":"J.J. Fenton, M.S. Weyrich, S. Durbin, Y. Liu, H. Bang, J. Melnikow, U.S. Preventive Services Task Force Evidence Syntheses, formerly Systematic Evidence Reviews, Prostate-Specific Antigen-Based Screening for Prostate Cancer: A Systematic Evidence Review for the U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality (US), Rockville (MD), 2018.","DOI":"10.1001\/jama.2018.3712"},{"issue":"17","key":"10.1016\/j.canep.2024.102642_bib7","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1002\/cncr.27379","article-title":"Explaining racial differences in prostate cancer mortality","volume":"118","author":"Taksler","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.canep.2024.102642_bib8","unstructured":"C.H. Bunker, A.L. Patrick, B.R. Konety, R. Dhir, A.M. Brufsky, C.A. Vivas, M.J. Becich, D.L. Trump, L.H. Kuller, High prevalence of screening-detected prostate cancer among Afro-Caribbeans: the Tobago Prostate Cancer Survey, Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 11(8) (2002) 726-9."},{"issue":"4","key":"10.1016\/j.canep.2024.102642_bib9","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.urology.2003.10.064","article-title":"Prostate cancer screening parameters in a high-risk African-Caribbean population","volume":"63","author":"Bunker","year":"2004","journal-title":"Urology"},{"issue":"1","key":"10.1016\/j.canep.2024.102642_bib10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10552-017-0963-2","article-title":"Prostate cancer screening by prostate-specific antigen (PSA); a relevant approach for the small population of the Cayman Islands","volume":"29","author":"Jyoti","year":"2018","journal-title":"Cancer causes Control.: CCC"},{"issue":"11","key":"10.1016\/j.canep.2024.102642_bib11","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s10552-017-0972-1","article-title":"The prostate cancer screening clinic in the Bahamas: a model for low- and middle-income countries","volume":"28","author":"Roberts","year":"2017","journal-title":"Cancer causes Control.: CCC"},{"issue":"4","key":"10.1016\/j.canep.2024.102642_bib12","first-page":"504","article-title":"Unique features of prostate cancer in African American and West Indian patients including diagnosis of high grade cancers using only elevated serum levels of prostate specific antigen","volume":"50","author":"Seydafkan","year":"2020","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"19","key":"10.1016\/j.canep.2024.102642_bib13","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1056\/NEJMoa043739","article-title":"Radical prostatectomy versus watchful waiting in early prostate cancer","volume":"352","author":"Bill-Axelson","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canep.2024.102642_bib14","doi-asserted-by":"crossref","unstructured":"A. Maeda-Minami, T. Nishikawa, H. Ishikawa, M. Mutoh, K. Akimoto, Y. Matsuyama, Y. Mano, H. Uemura, Association of PSA variability with prostate cancer development using large-scale medical information data: a retrospective cohort study, Genes and environment: the official journal of the Japanese Environmental Mutagen Society 45(1) (2023) 25.","DOI":"10.1186\/s41021-023-00280-7"},{"issue":"18","key":"10.1016\/j.canep.2024.102642_bib15","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1001\/jama.2018.3712","article-title":"Prostate-specific antigen-based screening for prostate cancer: evidence report and systematic review for the US preventive services task force","volume":"319","author":"Fenton","year":"2018","journal-title":"Jama"},{"key":"10.1016\/j.canep.2024.102642_bib16","article-title":"Diagnostic accuracy of liquid biomarkers for clinically significant prostate cancer detection: a systematic review and diagnostic meta-analysis of multiple thresholds","author":"Kawada","year":"2023","journal-title":"Eur. Urol. Oncol."},{"key":"10.1016\/j.canep.2024.102642_bib17","doi-asserted-by":"crossref","unstructured":"P.M. Bossuyt, L. Irwig, J. Craig, P. Glasziou, Comparative accuracy: assessing new tests against existing diagnostic pathways, BMJ (Clinical research ed.) 332(7549) (2006) 1089-92.","DOI":"10.1136\/bmj.332.7549.1089"},{"issue":"5","key":"10.1016\/j.canep.2024.102642_bib18","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.125529","article-title":"Multiparametric liquid biopsy analysis in metastatic prostate cancer","volume":"4","author":"Hodara","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.canep.2024.102642_bib19","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.critrevonc.2017.11.007","article-title":"Biomarkers in prostate cancer - Current clinical utility and future perspectives","volume":"120","author":"Kretschmer","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.canep.2024.102642_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/pros.24704","article-title":"Development of a multigenomic liquid biopsy (PROSTest) for prostate cancer in whole blood","author":"Modlin","year":"2024","journal-title":"Prostate"},{"issue":"9596","key":"10.1016\/j.canep.2024.102642_bib21","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.canep.2024.102642_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218592","article-title":"Utility of a ready-to-use PCR system for neuroendocrine tumor diagnosis","volume":"14","author":"Kidd","year":"2019","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.canep.2024.102642_bib23","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1148\/radiology.148.3.6878708","article-title":"A method of comparing the areas under receiver operating characteristic curves derived from the same cases","volume":"148","author":"Hanley","year":"1983","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.canep.2024.102642_bib24","first-page":"37","article-title":"Evaluation: from precision, recall and F-measure to ROC, informedness, markedness and correlation","volume":"2","author":"Powers","year":"2011","journal-title":"Int. J. Mach. Learn. Technol."},{"issue":"Suppl","key":"10.1016\/j.canep.2024.102642_bib25","first-page":"14","article-title":"Benign prostatic hyperplasia and lower urinary tract symptoms: evidence and approaches for best case management","volume":"18","author":"Barkin","year":"2011","journal-title":"Can. J. Urol."},{"key":"10.1016\/j.canep.2024.102642_bib26","doi-asserted-by":"crossref","first-page":"k3519","DOI":"10.1136\/bmj.k3519","article-title":"Prostate cancer screening with prostate-specific antigen (PSA) test: a systematic review and meta-analysis","volume":"362","author":"Ilic","year":"2018","journal-title":"BMJ (Clin. Res. Ed.)"},{"issue":"3","key":"10.1016\/j.canep.2024.102642_bib27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s40615-015-0085-z","article-title":"Race and ethnic group differences in comorbid major depressive disorder, generalized anxiety disorder, and chronic medical conditions","volume":"2","author":"Watkins","year":"2015","journal-title":"J. Racial Ethn. Health disparities"},{"issue":"2","key":"10.1016\/j.canep.2024.102642_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrurol.2015.298","article-title":"Prostate cancer in men of African origin","volume":"13","author":"McGinley","year":"2016","journal-title":"Nat. Rev. Urol."},{"issue":"10071","key":"10.1016\/j.canep.2024.102642_bib29","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(16)32401-1","article-title":"Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study","volume":"389","author":"Ahmed","year":"2017","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.canep.2024.102642_bib30","doi-asserted-by":"crossref","DOI":"10.1001\/jamahealthforum.2022.1116","article-title":"Evaluation of prostate cancer screening strategies in a low-resource, high-risk population in the bahamas","volume":"3","author":"Heijnsdijk","year":"2022","journal-title":"JAMA Health Forum"},{"issue":"1","key":"10.1016\/j.canep.2024.102642_bib31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1001\/jama.2015.6036","article-title":"Trends in management for patients with localized prostate cancer, 1990-2013","volume":"314","author":"Cooperberg","year":"2015","journal-title":"Jama"}],"container-title":["Cancer Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782124001218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782124001218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T21:53:01Z","timestamp":1738446781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877782124001218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":31,"alternative-id":["S1877782124001218"],"URL":"https:\/\/doi.org\/10.1016\/j.canep.2024.102642","relation":{},"ISSN":["1877-7821"],"issn-type":[{"value":"1877-7821","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of a multigenomic liquid biopsy (PROSTest) for prostate cancer detection and follow-up in a Caribbean population","name":"articletitle","label":"Article Title"},{"value":"Cancer Epidemiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canep.2024.102642","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102642"}}