{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:13:31Z","timestamp":1790691211931,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Epidemiology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.canep.2025.102831","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T19:44:16Z","timestamp":1745610256000},"page":"102831","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Exposure to per- and poly-fluoroalkyl substances and hematological cancer: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3158-1827","authenticated-orcid":false,"given":"Michele","family":"Sassano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Maria","family":"Kappil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongzhang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monireh Sadat","family":"Seyyedsalehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.canep.2025.102831_bib1","first-page":"13","article-title":"Global burden of hematologic malignancies and evolution patterns over the past 30 years","volume":"13","author":"Zhang","year":"2023","journal-title":"Blood Cancer J. 2023"},{"key":"10.1016\/j.canep.2025.102831_bib2","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1039\/D0EM00291G","article-title":"An overview of the uses of per- and polyfluoroalkyl substances (PFAS)","volume":"22","author":"Gl\u00fcge","year":"2020","journal-title":"Environ. Sci. Process Impacts"},{"key":"10.1016\/j.canep.2025.102831_bib3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S1470-2045(23)00622-8","article-title":"Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid","volume":"25","author":"Zahm","year":"2024","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canep.2025.102831_bib4","article-title":"Per- and poly-fluoroalkyl substances (PFAS) exposure and risk of kidney, liver, and testicular cancers: a systematic review and meta-analysis","volume":"114","author":"Seyyedsalehi","year":"2023","journal-title":"La Med. Del. Lav. | Work, Environ. Health"},{"key":"10.1016\/j.canep.2025.102831_bib5","doi-asserted-by":"crossref","first-page":"86540","DOI":"10.1007\/s11356-023-28592-9","article-title":"Systematic review and meta-analysis of breast cancer risks in relation to 2,3,7,8-tetrachlorodibenzo-p-dioxin and per- and polyfluoroalkyl substances","volume":"30","author":"Cong","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.canep.2025.102831_bib6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1080\/10962247.2021.1909668","article-title":"Critical review on PFOA, kidney cancer, and testicular cancer","volume":"71","author":"Bartell","year":"2021","journal-title":"J. Air Waste Manag. Assoc."},{"key":"10.1016\/j.canep.2025.102831_bib7","doi-asserted-by":"crossref","DOI":"10.1093\/aje\/kwae010","article-title":"Exposure to per- and polyfluoroalkyl substances and breast cancer risk: a systematic review and meta-analysis of epidemiologic studies","author":"Chang","year":"2024","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.canep.2025.102831_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxlet.2024.07.910","article-title":"Per- and polyfluoroalkyl substances (PFAS) exposure and thyroid cancer: systematic review and meta-analysis","author":"van Gerwen","year":"2024","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.canep.2025.102831_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002742","article-title":"COSMOS-E: guidance on conducting systematic reviews and meta-analyses of observational studies of etiology","volume":"16","author":"Dekkers","year":"2019","journal-title":"PLoS Med."},{"key":"10.1016\/j.canep.2025.102831_bib10","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","author":"Page","year":"2021","journal-title":"BMJ 372"},{"key":"10.1016\/j.canep.2025.102831_bib11","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.envint.2018.07.015","article-title":"Identifying the PECO: a framework for formulating good questions to explore the association of environmental and other exposures with health outcomes","volume":"121","author":"Morgan","year":"2018","journal-title":"Environ. Int"},{"key":"10.1016\/j.canep.2025.102831_bib12","unstructured":"International Agency for Research on Cancer, Some Chemicals Used as Solvents and in Polymer Manufacture - IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 110, 2017. \u3008https:\/\/publications.iarc.fr\/Book-And-Report-Series\/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans\/Some-Chemicals-Used-As-Solvents-And-In-Polymer-Manufacture-2016\u3009 (accessed July 26, 2024)."},{"key":"10.1016\/j.canep.2025.102831_bib13","unstructured":"Agency for Toxic Substances and Disease Registry, Toxicological Profile for Perfluoroalkyls, 2021. \u3008https:\/\/wwwn.cdc.gov\/TSP\/ToxProfiles\/ToxProfiles.aspx?id=\u20091117&tid=\u2009237\u3009 (accessed July 26, 2024)."},{"issue":"n.d","key":"10.1016\/j.canep.2025.102831_bib14","article-title":"The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses","author":"Wells","year":"2019","journal-title":"Last Access."},{"key":"10.1016\/j.canep.2025.102831_bib15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jrsm.1316","article-title":"A comparison of heterogeneity variance estimators in simulated random-effects meta-analyses","volume":"10","author":"Langan","year":"2019","journal-title":"Res Synth. Methods"},{"key":"10.1016\/j.canep.2025.102831_bib16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.canep.2025.102831_bib17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jclinepi.2015.09.005","article-title":"High statistical heterogeneity is more frequent in meta-analysis of continuous than binary outcomes","volume":"70","author":"Alba","year":"2016","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.canep.2025.102831_bib18","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2019"},{"key":"10.1016\/j.canep.2025.102831_bib19","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jclinepi.2007.11.010","article-title":"Contour-enhanced meta-analysis funnel plots help distinguish publication bias from other causes of asymmetry","volume":"61","author":"Peters","year":"2008","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.canep.2025.102831_bib20","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test measures of funnel plot asymmetry","volume":"315","author":"Egger","year":"1997","journal-title":"Bmj"},{"key":"10.1016\/j.canep.2025.102831_bib21","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1097\/00043764-199309000-00020","article-title":"Mortality among employees of a perfluorooctanoic acid production plant","volume":"35","author":"Gilliland","year":"1993","journal-title":"J. Occup. Med"},{"key":"10.1016\/j.canep.2025.102831_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.annepidem.2007.06.011","article-title":"Retrospective cohort mortality study of workers in a polymer production plant including a reference population of regional workers","volume":"18","author":"Leonard","year":"2008","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.canep.2025.102831_bib23","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/aje\/kws171","article-title":"Cohort mortality study of workers exposed to perfluorooctanoic acid","volume":"176","author":"Steenland","year":"2012","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.canep.2025.102831_bib24","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1289\/ehp.1306615","article-title":"Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant","volume":"121","author":"Barry","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.canep.2025.102831_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108743","article-title":"A mortality study on male subjects exposed to polyfluoroalkyl acids with high internal dose of perfluorooctanoic acid","volume":"179","author":"Girardi","year":"2019","journal-title":"Environ. Res"},{"key":"10.1016\/j.canep.2025.102831_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112217","article-title":"Cancer incidence in a Swedish cohort with high exposure to perfluoroalkyl substances in drinking water","volume":"204","author":"Li","year":"2022","journal-title":"Environ. Res"},{"key":"10.1016\/j.canep.2025.102831_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.canep.2022.102296","article-title":"Relative rates of cancers and deaths in Australian communities with PFAS environmental contamination associated with firefighting foams: a cohort study using linked data","volume":"82","author":"Law","year":"2023","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.canep.2025.102831_bib28","doi-asserted-by":"crossref","DOI":"10.1289\/EHP13174","article-title":"Case-Cohort Study of the Association between PFAS and Selected Cancers among Participants in the American Cancer Society\u2019s cancer prevention Study II LifeLink Cohort","volume":"131","author":"Winquist","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.canep.2025.102831_bib29","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1289\/ehp.1205829","article-title":"Perfluorooctanoic acid exposure and cancer outcomes in a contaminated community: a geographic analysis","volume":"121","author":"Vieira","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.canep.2025.102831_bib30","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/eurpub\/ckx066","article-title":"Drinking water contamination from perfluoroalkyl substances (PFAS): an ecological mortality study in the Veneto Region, Italy","volume":"28","author":"Mastrantonio","year":"2018","journal-title":"Eur. J. Public Health"},{"key":"10.1016\/j.canep.2025.102831_bib31","article-title":"Risk of cancer in a community exposed to per- and poly-fluoroalkyl substances","volume":"16","author":"Messmer","year":"2022","journal-title":"Environ. Health Insights"},{"key":"10.1016\/j.canep.2025.102831_bib32","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/EDE.0b013e3181b5f395","article-title":"Ammonium perfluorooctanoate production and occupational mortality","volume":"20","author":"Lundin","year":"2009","journal-title":"Epidemiology"},{"key":"10.1016\/j.canep.2025.102831_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109058","article-title":"Serum concentrations of per- and polyfluorinated substances and risk of B-cell non-Hodgkin lymphoma","volume":"192","author":"Rhee","year":"2024","journal-title":"Environ. Int"},{"key":"10.1016\/j.canep.2025.102831_bib34","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/ajim.23568","article-title":"Mortality and cancer incidence in perfluorooctanesulfonyl fluoride production workers","volume":"67","author":"Alexander","year":"2024","journal-title":"Am. J. Ind. Med."},{"issue":"5","key":"10.1016\/j.canep.2025.102831_bib35","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s00204-024-03685-7","article-title":"Involvement of per- and polyfluoroalkyl compounds in tumor development","volume":"98","author":"Pesonen","year":"2024","journal-title":"Arch. Toxicol. 2024"},{"key":"10.1016\/j.canep.2025.102831_bib36","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","article-title":"Perfluoroalkyl acids: a review of monitoring and toxicological findings","volume":"99","author":"Lau","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.canep.2025.102831_bib37","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.envint.2013.06.004","article-title":"Accumulation of perfluoroalkyl substances in human tissues","volume":"59","author":"P\u00e9rez","year":"2013","journal-title":"Environ. Int"},{"key":"10.1016\/j.canep.2025.102831_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.115188","article-title":"A systematic evidence map of chronic inflammation and immunosuppression related to per- and polyfluoroalkyl substance (PFAS) exposure","volume":"220","author":"Zhang","year":"2023","journal-title":"Environ. Res"},{"issue":"1","key":"10.1016\/j.canep.2025.102831_bib39","first-page":"8","article-title":"Comprehensive analysis of PFAS presence from environment to plate","volume":"8","author":"Dimitrakopoulou","year":"2024","journal-title":"Npj Sci. Food 2024"},{"key":"10.1016\/j.canep.2025.102831_bib40","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/etc.4890","article-title":"Per- and polyfluoroalkyl substance toxicity and human health review: current state of knowledge and strategies for informing future research","volume":"40","author":"Fenton","year":"2021","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.canep.2025.102831_bib41","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1001\/archpediatrics.2009.31","article-title":"The relative merits of risk ratios and odds ratios","volume":"163","author":"Cummings","year":"2009","journal-title":"Arch. Pedia Adolesc. Med"},{"key":"10.1016\/j.canep.2025.102831_bib42","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00043764-198106000-00013","article-title":"Practical considerations for approximating relative risk by the standardized mortality ratio","volume":"23","author":"Symons","year":"1981","journal-title":"J. Occup. Med."}],"container-title":["Cancer Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782125000918?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782125000918?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:22:51Z","timestamp":1769588571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877782125000918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":42,"alternative-id":["S1877782125000918"],"URL":"https:\/\/doi.org\/10.1016\/j.canep.2025.102831","relation":{},"ISSN":["1877-7821"],"issn-type":[{"value":"1877-7821","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to per- and poly-fluoroalkyl substances and hematological cancer: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Cancer Epidemiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canep.2025.102831","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102831"}}