{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:15:16Z","timestamp":1788048916966,"version":"build-2784847793"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015406","name":"Tianjin Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017964","name":"Tianjin Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017964","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273019"],"award-info":[{"award-number":["82273019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Epidemiology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.canep.2026.103197","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:27:07Z","timestamp":1786451227000},"page":"103197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Stage shift, histological differentiation, and survival patterns of lung squamous cell carcinoma versus adenocarcinoma in low-dose CT screening"],"prefix":"10.1016","volume":"104","author":[{"given":"Yaguang","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-9654","authenticated-orcid":false,"given":"Heng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1892-1196","authenticated-orcid":false,"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-4429","authenticated-orcid":false,"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-0871","authenticated-orcid":false,"given":"Youlin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.canep.2026.103197_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"11","key":"10.1016\/j.canep.2026.103197_bib2","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S1470-2045(23)00444-8","article-title":"Global variations in lung cancer incidence by histological subtype in 2020: a population-based study","volume":"24","author":"Zhang","year":"2023","journal-title":"Lancet Oncol."},{"issue":"7417","key":"10.1016\/j.canep.2026.103197_bib3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature11404","article-title":"Comprehensive genomic characterization of squamous cell lung cancers","volume":"489","author":"N. Cancer Genome Atlas Research","year":"2012","journal-title":"Nature"},{"issue":"7511","key":"10.1016\/j.canep.2026.103197_bib4","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature13385","article-title":"Comprehensive molecular profiling of lung adenocarcinoma","volume":"511","author":"N. Cancer Genome Atlas Research","year":"2014","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.canep.2026.103197_bib5","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/ijc.27339","article-title":"Cigarette smoking and lung cancer--relative risk estimates for the major histological types from a pooled analysis of case-control studies","volume":"131","author":"Pesch","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canep.2026.103197_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2022.944032","article-title":"Squamous cell carcinoma predicts worse prognosis than adenocarcinoma in stage IA lung cancer patients: a population-based propensity score matching analysis","volume":"9","author":"Hao","year":"2022","journal-title":"Front. Surg."},{"issue":"5","key":"10.1016\/j.canep.2026.103197_bib7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJMoa1102873","article-title":"Reduced lung-cancer mortality with low-dose computed tomographic screening","volume":"365","author":"Aberle","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.canep.2026.103197_bib8","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa1911793","article-title":"Reduced lung-cancer mortality with volume CT screening in a randomized trial","volume":"382","author":"de Koning","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.canep.2026.103197_bib9","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1093\/annonc\/mdz117","article-title":"Prolonged lung cancer screening reduced 10-year mortality in the MILD trial: new confirmation of lung cancer screening efficacy","volume":"30","author":"Pastorino","year":"2019","journal-title":"Ann. Oncol."},{"issue":"22","key":"10.1016\/j.canep.2026.103197_bib10","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1002\/cncr.28326","article-title":"The National lung screening trial: results stratified by demographics, smoking history, and lung cancer histology","volume":"119","author":"Pinsky","year":"2013","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.canep.2026.103197_bib11","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.chest.2018.07.029","article-title":"Characteristics and outcomes of small cell lung cancer detected by CT screening","volume":"154","author":"Thomas","year":"2018","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.canep.2026.103197_bib12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.lungcan.2009.04.016","article-title":"The adenocarcinoma-specific stage shift in the anti-lung cancer association project: significance of repeated screening for lung cancer for more than 5 years with low-dose helical computed tomography in a high-risk cohort","volume":"67","author":"Seki","year":"2010","journal-title":"Lung Cancer"},{"issue":"12","key":"10.1016\/j.canep.2026.103197_bib13","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.37508","article-title":"Association of stage shift and population mortality among patients with non-small cell lung cancer","volume":"4","author":"Flores","year":"2021","journal-title":"JAMA Netw. Open."},{"issue":"1","key":"10.1016\/j.canep.2026.103197_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1148\/radiol.10091808","article-title":"The National lung screening trial: overview and study design","volume":"258","author":"Lung","year":"2011","journal-title":"Radiology"},{"issue":"12","key":"10.1016\/j.canep.2026.103197_bib15","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/S1470-2045(14)70387-0","article-title":"Detection of lung cancer through low-dose CT screening (NELSON): a prespecified analysis of screening test performance and interval cancers","volume":"15","author":"Horeweg","year":"2014","journal-title":"Lancet Oncol."},{"issue":"11","key":"10.1016\/j.canep.2026.103197_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju284","article-title":"Projected outcomes using different nodule sizes to define a positive CT lung cancer screening examination","volume":"106","author":"Gierada","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"issue":"2","key":"10.1016\/j.canep.2026.103197_bib17","first-page":"186","article-title":"[Statistical methods for comparing survival rates at a fixed time point]","volume":"36","author":"Chen","year":"2015","journal-title":"Zhonghua Liu Xing Bing. Xue Za Zhi"},{"issue":"6","key":"10.1016\/j.canep.2026.103197_bib18","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/ijc.32486","article-title":"Lung cancer mortality reduction by LDCT screening-results from the randomized German LUSI trial","volume":"146","author":"Becker","year":"2020","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.canep.2026.103197_bib19","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.lungcan.2011.05.007","article-title":"Different efficacy of CT screening for lung cancer according to histological type: analysis of Japanese-smoker cases detected using a low-dose CT screen","volume":"74","author":"Kondo","year":"2011","journal-title":"Lung Cancer"},{"issue":"1","key":"10.1016\/j.canep.2026.103197_bib20","doi-asserted-by":"crossref","first-page":"8060","DOI":"10.1038\/s41467-025-63471-6","article-title":"N.t. consortium, A comparative analysis of heterogeneity in lung cancer screening effectiveness in two randomised controlled trials","volume":"16","author":"Welz","year":"2025","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.canep.2026.103197_bib21","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jtho.2025.09.1761","article-title":"I.P.C. members, a grading system for resected invasive squamous cell carcinoma of the lung: a multi-institutional study by the iaslc pathology committee","volume":"21","author":"Mino-Kenudson","year":"2026","journal-title":"J. Thorac. Oncol."},{"issue":"6","key":"10.1016\/j.canep.2026.103197_bib22","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/ng.3564","article-title":"Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas","volume":"48","author":"Campbell","year":"2016","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.canep.2026.103197_bib23","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1038\/s41467-019-11452-x","article-title":"Proteogenomic landscape of squamous cell lung cancer","volume":"10","author":"Stewart","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.canep.2026.103197_bib24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1164\/rccm.201107-1223OC","article-title":"Doubling times and CT screen-detected lung cancers in the pittsburgh lung screening study","volume":"185","author":"Wilson","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.canep.2026.103197_bib25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.lungcan.2009.01.018","article-title":"Doubling time of lung cancer determined using three-dimensional volumetric software: comparison of squamous cell carcinoma and adenocarcinoma","volume":"66","author":"Honda","year":"2009","journal-title":"Lung Cancer"},{"key":"10.1016\/j.canep.2026.103197_bib26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.lungcan.2020.09.013","article-title":"I.E. Investigators, Lung cancer screening intervals based on cancer risk","volume":"149","author":"Zhang","year":"2020","journal-title":"Lung Cancer"},{"key":"10.1016\/j.canep.2026.103197_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejca.2024.114339","article-title":"Lung cancer volume doubling time by computed tomography: a systematic review and meta-analysis","volume":"212","author":"Jiang","year":"2024","journal-title":"Eur. J. Cancer"},{"issue":"1","key":"10.1016\/j.canep.2026.103197_bib28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12890-020-01385-3","article-title":"Duration of lead time in screening for lung cancer","volume":"21","author":"Benbassat","year":"2021","journal-title":"BMC Pulm. Med."},{"issue":"8","key":"10.1016\/j.canep.2026.103197_bib29","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1513\/AnnalsATS.201412-577OC","article-title":"Indolent, potentially inconsequential lung cancers in the pittsburgh lung screening study","volume":"12","author":"Thalanayar","year":"2015","journal-title":"Ann. Am. Thorac. Soc."},{"issue":"3","key":"10.1016\/j.canep.2026.103197_bib30","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s00330-017-5029-z","article-title":"I. International early lung cancer action program, baseline and annual repeat rounds of screening: implications for optimal regimens of screening","volume":"28","author":"Henschke","year":"2018","journal-title":"Eur. Radiol."},{"issue":"11","key":"10.1016\/j.canep.2026.103197_bib31","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.21037\/tlcr-21-658","article-title":"Differences in detection patterns, characteristics, and outcomes of central and peripheral lung cancers in low-dose computed tomography screening","volume":"10","author":"Kim","year":"2021","journal-title":"Transl. Lung Cancer Res."},{"issue":"8","key":"10.1016\/j.canep.2026.103197_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159880","article-title":"Differences in patient outcomes of prevalence, interval, and screen-detected lung cancers in the ct arm of the national lung screening trial","volume":"11","author":"Schabath","year":"2016","journal-title":"PLoS. One"}],"container-title":["Cancer Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782126002134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877782126002134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T23:21:25Z","timestamp":1788045685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877782126002134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":32,"alternative-id":["S1877782126002134"],"URL":"https:\/\/doi.org\/10.1016\/j.canep.2026.103197","relation":{},"ISSN":["1877-7821"],"issn-type":[{"value":"1877-7821","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stage shift, histological differentiation, and survival patterns of lung squamous cell carcinoma versus adenocarcinoma in low-dose CT screening","name":"articletitle","label":"Article Title"},{"value":"Cancer Epidemiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canep.2026.103197","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103197"}}