{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:13:52Z","timestamp":1761707632407},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/j.canlet.2003.09.023","type":"journal-article","created":{"date-parts":[[2003,12,4]],"date-time":"2003-12-04T11:59:03Z","timestamp":1070539143000},"page":"15-21","source":"Crossref","is-referenced-by-count":18,"title":["Effects of Schistosoma haematobium infection on drug-metabolizing enzymes in human bladder cancer tissues"],"prefix":"10.1016","volume":"205","author":[{"given":"S.A","family":"Sheweita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.G","family":"El-Shahat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A","family":"Bazeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.R","family":"Abu El-Maati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2003.09.023_BIB1","unstructured":"World Health Organization, The control of schistosomiasis, Report of a WHO Expert committee, Technical Report Series No 728, WHO, Geneva (1985)."},{"key":"10.1016\/j.canlet.2003.09.023_BIB2","first-page":"45","article-title":"World health organization evaluation of carcinogenic risk to humans. Schistosome, liver flukes and Helicobacter pylori","volume":"61","year":"1994","journal-title":"IARC Monogr."},{"key":"10.1016\/j.canlet.2003.09.023_BIB3","series-title":"Cancer prevention in developing countries","article-title":"Site distribution of cancer in Egypt: twelve-years experience (1970\u20131981)","author":"Ibrahim","year":"1986"},{"key":"10.1016\/j.canlet.2003.09.023_BIB4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3109\/02841869709001327","article-title":"Cancer patterns in the Middle East. Special report from the Middle East cancer society","volume":"36","author":"Kahan","year":"1997","journal-title":"Acta Oncol."},{"key":"10.1016\/j.canlet.2003.09.023_BIB5","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3322\/canjclin.27.2.100","article-title":"Parasites in the etiology of cancer: bilharziasis and bladder cancer","volume":"27","author":"El-Sebai","year":"1977","journal-title":"CA-Cancer J. Clin."},{"key":"10.1016\/j.canlet.2003.09.023_BIB6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF00262625","article-title":"Cancer of the bilharzial bladder","volume":"6","author":"El-Sebai","year":"1978","journal-title":"Urol. Res."},{"key":"10.1016\/j.canlet.2003.09.023_BIB7","series-title":"Cancer Occurrence in developing countries. International Agency for Research on Cancer. Scientific publication No. 75, Lyon","first-page":"37","article-title":"Egypt: Cairo metropolitan cancer registry, 1978\u20131979","author":"Aboul-Nasr","year":"1986"},{"key":"10.1016\/j.canlet.2003.09.023_BIB8","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/ijc.2910440513","article-title":"Urinary excretion of N-nitrosamino acids and nitrate by inhibitants in low- and high-risk areas for stomach cancer in Poland","volume":"44","author":"Zatonski","year":"1989","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2003.09.023_BIB9","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/carcin\/10.3.547","article-title":"Urinary excretion of nitrate, nitrite and N-nitroso compounds in schistosomiasis and bilharzial bladder cancer patients","volume":"10","author":"Tricker","year":"1989","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2003.09.023_BIB10","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/carcin\/15.4.619","article-title":"Nitrate, nitrite and volatile N-nitroso compounds in the urine of Schistosoma mansoni infected patients","volume":"15","author":"Mostafa","year":"1994","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2003.09.023_BIB11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF00308517","article-title":"Repressible and inducible enzymatic forms of DMN-demethylase","volume":"89","author":"Arcos","year":"1977","journal-title":"Z. Krebsforsch."},{"key":"10.1016\/j.canlet.2003.09.023_BIB12","first-page":"155","article-title":"Recovery of the hepatic carcinogen-metabolizing capacity in schistosome-infected mice after treatment with the antischistosomal praziquantel","volume":"2","author":"Sheweita","year":"1995","journal-title":"Oncol.Rep."},{"key":"10.1016\/j.canlet.2003.09.023_BIB13","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/carcin\/14.4.653","article-title":"Promutagenic methylation damage in liver DNA of mice infected with Schistosoma mansoni","volume":"14","author":"Badawi","year":"1993","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2003.09.023_BIB14","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1152\/physrev.1980.60.4.1107","article-title":"Benzo(a)pyrene metabolism, activation, and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes","volume":"60","author":"Gelboin","year":"1980","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.canlet.2003.09.023_BIB15","doi-asserted-by":"crossref","first-page":"10019","DOI":"10.1016\/S0021-9258(18)99177-5","article-title":"Reactions and significance of cytochrome P-450","volume":"226","author":"Guengerich","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2003.09.023_BIB16","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/0006-2952(78)90280-0","article-title":"Time course of the induction of aryl hydrocarbon hydroxylase in rat liver nuclei and microsomes by phenobarbital, 3-methylcholantherene, 2, 3, 7, 8-tetrachloro-dibenzo-p-dioxin, dielrin and other inducers","volume":"27","author":"Viviani","year":"1978","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.canlet.2003.09.023_BIB17","first-page":"4875","article-title":"Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G.H.A Clowes, memorial lecture","volume":"42","author":"Conney","year":"1982","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2003.09.023_BIB18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/01480549209014160","article-title":"Relationship between activities of cytochrome P450 monooxygenases in human placental microsomes and binding of benzo(a)pyrene metabolites to calf thymus DNA","volume":"15","author":"Kim","year":"1992","journal-title":"Drug. Chem. Toxicol."},{"key":"10.1016\/j.canlet.2003.09.023_BIB19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1017\/S0022149X00001012","article-title":"Different levels of Schistosoma mansoni induce changes in drug-metabolizing enzymes","volume":"72","author":"Sheweita","year":"1998","journal-title":"J. Helminthol."},{"key":"10.1016\/j.canlet.2003.09.023_BIB20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1079\/JOH200186","article-title":"Changes in the expression of cytochrome P450 isozymes and related carcinogen metabolizing enzyme activities in Schistosoma mansoni infected mice","volume":"76","author":"Sheweita","year":"2002","journal-title":"J. Helminthol."},{"issue":"2","key":"10.1016\/j.canlet.2003.09.023_BIB21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2174\/1389200003339117","article-title":"Drug-metabolizing enzymes: mechanisms and functions","volume":"1","author":"Sheweita","year":"2000","journal-title":"Current. Drug. Metab."},{"key":"10.1016\/j.canlet.2003.09.023_BIB22","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/S0021-9258(20)82245-5","article-title":"The carbon monoxide-binding pigments of liver microsomes. II. Solubilization, purification and properties","volume":"239","author":"Omura","year":"1964","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2003.09.023_BIB23","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/0006-2952(75)90028-3","article-title":"Aryl hydrocarbon (benzo[a]pyrene) hydroxylases in liver from rats of different age, sex and nutritional status. Distinction of two types by 7,8-benzoflavone","volume":"24","author":"Wiebel","year":"1975","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.canlet.2003.09.023_BIB24","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0024-3205(68)90217-8","article-title":"Differential effects of polycyclic hydrocarbons on the demethylation of the carcinogen dimethylnitrosamine by rat tissues","volume":"7","author":"Venkatesan","year":"1968","journal-title":"Life Sci."},{"key":"10.1016\/j.canlet.2003.09.023_BIB25","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1042\/bj0550416","article-title":"The calorimetric estimation of formaldehyde by means of Hantzsch reactions","volume":"55","author":"Nash","year":"1953","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2003.09.023_BIB26","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/0006-2952(74)90291-3","article-title":"The use of new methods to measure: the effect of diet and inducers of microsomal enzyme synthesis on cytochrome P-450 in liver homogenates, and on metabolism of dimethyl nitrosamine","volume":"23","author":"McLean","year":"1974","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.canlet.2003.09.023_BIB27","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2003.09.023_BIB28","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0003-9861(59)90259-0","article-title":"Inhibition of lipid peroxidation in mitochondria by vitamin E","volume":"80","author":"Tappel","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.canlet.2003.09.023_BIB29","first-page":"185","article-title":"Acetaminophen -induced hepatic necrosis. I. Role of drug metabolism","volume":"187","author":"Mitchell","year":"1973","journal-title":"J. Pharmacol. Exper. Therap."},{"key":"10.1016\/j.canlet.2003.09.023_BIB30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2003.09.023_BIB31","first-page":"2983","article-title":"Microsomal metabolism of dimethylnitrosamine and the cytochrome P-450 dependency of its activation to a mutagen","volume":"33","author":"Czygan","year":"1973","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2003.09.023_BIB32","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/0003-9861(75)90256-8","article-title":"Isolation by high pressure liquid chromatography and characterization of benzo(a)pyrene-4,5-epoxide as a metabolite of benzo(a)pyrene","volume":"168","author":"Selkirk","year":"1975","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.canlet.2003.09.023_BIB33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0300-483X(76)90049-4","article-title":"Studies on the in vitro metabolism of dimethylnitrosamine by rat liver","volume":"5","author":"Lake","year":"1976","journal-title":"Toxicol."},{"key":"10.1016\/j.canlet.2003.09.023_BIB34","first-page":"1499","article-title":"Metabolism of N-nitrosodialkylamines by human liver microsomes","volume":"88","author":"Yoo","year":"1980","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2003.09.023_BIB35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1128\/CMR.12.1.97","article-title":"The relationship between schistosomiasis and bladder cancer. A review","volume":"12","author":"Mostafa","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.canlet.2003.09.023_BIB36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1021\/tx00005a001","article-title":"Mammalian synthesis of nitrite, nitrate, nitric oxide and N-nitrosating agents","volume":"1","author":"Marlleta","year":"1988","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.canlet.2003.09.023_BIB37","first-page":"65","article-title":"DNA methylation in individuals at high risk for stomach cancer","volume":"13","author":"Cooper","year":"1991","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2003.09.023_BIB38","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/carcin\/13.5.877","article-title":"Promutagenic methylation damage in bladder DNA from patients with bladder cancer associated with schistosomiasis and from normal individuals","volume":"13","author":"Badawi","year":"1992","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2003.09.023_BIB39","first-page":"80","article-title":"Effects of various metals on hepatic biological responses in rat","volume":"10","author":"Arizono","year":"1993","journal-title":"Trace Elem. Med."},{"key":"10.1016\/j.canlet.2003.09.023_BIB40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/1389200033336919","article-title":"Cancer and phase II drug-metabolizing enzymes","volume":"4","author":"Sheweita","year":"2003","journal-title":"Curr.Drug Metab."},{"key":"10.1016\/j.canlet.2003.09.023_BIB41","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0304-3835(80)90118-4","article-title":"Inhibition of microsomes mediated binding of aflatoxin B1 to DNA by glutathione S-transferase","volume":"9","author":"Lotlikar","year":"1980","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.canlet.2003.09.023_BIB42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0027-5107(81)90067-1","article-title":"Effect of glutathione and uridine 5(-diphosphoglucuronic acid on mutagenesis by benzo(a)pyrene and aflatoxin B1 in the Salmonella\/microsome assay","volume":"83","author":"Malaveille","year":"1981","journal-title":"Mut. Res."},{"key":"10.1016\/j.canlet.2003.09.023_BIB43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0304-3835(92)90047-Y","article-title":"Glutathione conjugation of microsomes-mediated and synthetic aflatoxin B1-8,9-oxide by purified glutathione S-transferases from rats","volume":"64","author":"Gopalan","year":"1992","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2003.09.023_BIB44","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/carcin\/11.3.451","article-title":"Glutathione S-transferase and glutathione peroxidase expression in normal and tumor human tissues","volume":"11","author":"Howie","year":"1990","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2003.09.023_BIB45","first-page":"527","article-title":"Identification of an anionic form of glutathione transferase present in many human tumors and human tumor cell lines","volume":"48","author":"Shea","year":"1988","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2003.09.023_BIB46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0304-3835(95)04034-X","article-title":"N-nitroso compounds and their effects on the hepatic level of glutathione, glutathione reductase and glutathione S-transferase activities in the liver of male mice","volume":"99","author":"Sheweita","year":"1996","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2003.09.023_BIB47","first-page":"119","article-title":"Schistosomiasis induced changes in glutathione levels and glutathione reductase\/glutathione S-transferase activities in human liver","volume":"56","author":"Sheweita","year":"1997","journal-title":"Biomed. Lett."},{"key":"10.1016\/j.canlet.2003.09.023_BIB48","doi-asserted-by":"crossref","first-page":"13704","DOI":"10.1016\/S0021-9258(18)33504-X","article-title":"Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologies, potent inhibitors of glutathione synthesis","volume":"257","author":"Griffin","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2003.09.023_BIB49","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0076-6879(85)13050-8","article-title":"Glutathione biosynthesis; \u03b3-glutamylcysteine synthetase from rat kidney","volume":"113","author":"Seelig","year":"1985","journal-title":"Meth. Enzymol."},{"key":"10.1016\/j.canlet.2003.09.023_BIB50","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0014-5793(92)80911-Y","article-title":"Biological relevant metal ion-dependent hydroxyl radical generation","volume":"307","author":"Halliwell","year":"1992","journal-title":"Fed. Eur. Biochem. Sci. Lett."},{"key":"10.1016\/j.canlet.2003.09.023_BIB51","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1749-6632.1992.tb38654.x","article-title":"Protein oxidation in aging brain","volume":"663","author":"Smith","year":"1992","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.canlet.2003.09.023_BIB52","first-page":"45","article-title":"Melatonin, Hydroxyl radical-mediated oxidative damage: a hypothesis","volume":"32","author":"Poeggeler","year":"1993","journal-title":"J. Pineal. Res."},{"key":"10.1016\/j.canlet.2003.09.023_BIB53","first-page":"277","article-title":"Biochemistry of Schistosoma mansoni involvement of siderosomes in hepatic inflammatory processes","volume":"23","author":"Rodrigues","year":"1990","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.canlet.2003.09.023_BIB54","first-page":"2199","article-title":"Changes in unsaturated fatty acids in serum lipids of hamsters infected with schistosomes (S. mansoni)","volume":"2919","author":"Allan","year":"1987","journal-title":"Biochem., Biophys. Acta"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383503006669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383503006669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T10:12:16Z","timestamp":1623579136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383503006669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0304383503006669"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2003.09.023","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}