{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:09:31Z","timestamp":1773673771863,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.canlet.2004.04.014","type":"journal-article","created":{"date-parts":[[2004,7,8]],"date-time":"2004-07-08T00:34:31Z","timestamp":1089246871000},"page":"35-41","source":"Crossref","is-referenced-by-count":19,"title":["Skin and salivary gland carcinogenicity of 7,12-dimethylbenz[a]anthracene is equivalent in the presence or absence of aryl hydrocarbon receptor"],"prefix":"10.1016","volume":"214","author":[{"given":"Fumio","family":"Ide","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Suka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munenori","family":"Kitada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Sakashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Kusama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takatoshi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2004.04.014_BIB1","series-title":"Polynuclear Aromatic Hydrocarbons. Part 1: Chemical, Environmental and Experimental Data","author":"IARC","year":"1983"},{"key":"10.1016\/j.canlet.2004.04.014_BIB2","first-page":"201","article-title":"Reduction of p53 dosage renders mice hypersensitive to 7,12-dimethylbenz[a]anthracene-induced salivary gland tumorigenesis","volume":"22","author":"Ide","year":"2003","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2004.04.014_BIB3","first-page":"1194","article-title":"The aryl hydrocarbon receptor. Studies using the AHR-null mice","volume":"26","author":"Gonzalez","year":"1998","journal-title":"Drug. Metab. Dispos."},{"key":"10.1016\/j.canlet.2004.04.014_BIB4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0006-2952(99)00310-X","article-title":"Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis","volume":"59","author":"Nebert","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.canlet.2004.04.014_BIB5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0003-9861(02)00364-8","article-title":"Study of P450 function using gene knockout and transgenic mice","volume":"409","author":"Gonzalez","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.canlet.2004.04.014_BIB6","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1046\/j.1365-2443.1997.1490345.x","article-title":"Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor","volume":"2","author":"Mimura","year":"1997","journal-title":"Genes Cells"},{"key":"10.1016\/j.canlet.2004.04.014_BIB7","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1073\/pnas.97.2.779","article-title":"Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor","volume":"97","author":"Shimizu","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2004.04.014_BIB8","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.20365","article-title":"Dibenzo[a,l]pyrene-induced genotoxic and carcinogenic responses are dramatically suppressed in aryl hydrocarbon receptor-deficient mice","author":"Nakatsuru","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2004.04.014_BIB9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/toxsci\/68.1.24","article-title":"Expression and activity of microsomal epoxide hydrolase in follicles isolated from mouse ovaries","volume":"68","author":"Cannady","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.canlet.2004.04.014_BIB10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00008571-199602000-00002","article-title":"P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature","volume":"6","author":"Nelson","year":"1996","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.canlet.2004.04.014_BIB11","doi-asserted-by":"crossref","first-page":"23963","DOI":"10.1074\/jbc.274.34.23963","article-title":"Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene","volume":"274","author":"Miyata","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.04.014_BIB12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1349-7006.2004.tb03162.x","article-title":"Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochrome P450 1A1 and 1B1","volume":"95","author":"Shimada","year":"2004","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2004.04.014_BIB13","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1126\/science.6800033","article-title":"A 7-hydroxymethyl sulfate ester as an active metabolite of 7,12-dimethylbenz[a]anthracene","volume":"215","author":"Watabe","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.canlet.2004.04.014_BIB14","first-page":"684","article-title":"Sulfate esters of hydroxymethyl-methyl-benz[a]anthracenes as active metabolites of 7,12-dimethylbenz[a]anthracene","volume":"76","author":"Watabe","year":"1985","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1016\/j.canlet.2004.04.014_BIB15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/carcin\/24.2.327","article-title":"CYP1B1 determines susceptibility to low doses of 7,12-dimethylbenz[a]anthracene-induced ovarian cancers in mice: correlation of CYP1B1-mediated DNA adducts with carcinogenicity","volume":"24","author":"Buters","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2004.04.014_BIB16","doi-asserted-by":"crossref","first-page":"13092","DOI":"10.1016\/S0021-9258(17)36803-5","article-title":"Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2","volume":"269","author":"Sutter","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.04.014_BIB17","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.96.5.1977","article-title":"Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz[a]anthracene-induced lymphomas","volume":"96","author":"Buters","year":"1999","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2004.04.014_BIB18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0027-5107(02)00333-0","article-title":"Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies","volume":"523\u2013524","author":"Guengerich","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2004.04.014_BIB19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.pharmtox.41.1.297","article-title":"Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1","volume":"41","author":"Murray","year":"2001","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.canlet.2004.04.014_BIB20","first-page":"4498","article-title":"Ah receptor regulation of CYP1B1 expression in primary mouse embryo-derived cells","volume":"57","author":"Alexander","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.04.014_BIB21","doi-asserted-by":"crossref","first-page":"11595","DOI":"10.1074\/jbc.270.19.11595","article-title":"Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation","volume":"270","author":"Bhattacharyya","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.04.014_BIB22","doi-asserted-by":"crossref","first-page":"14905","DOI":"10.1016\/S0021-9258(17)36551-1","article-title":"Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression","volume":"269","author":"Savas","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.04.014_BIB23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0003-9861(03)00174-7","article-title":"Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues","volume":"414","author":"Choudhary","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.canlet.2004.04.014_BIB24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0041-008X(03)00338-7","article-title":"Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver","volume":"193","author":"Galvan","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.canlet.2004.04.014_BIB25","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1124\/mol.54.6.1000","article-title":"Bone marrow stromal cells constitutively express high levels of cytochrome P4501B1 that metabolize 7,12-dimethylbenz[a]anthracene","volume":"54","author":"Heidel","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.canlet.2004.04.014_BIB26","doi-asserted-by":"crossref","first-page":"5174","DOI":"10.1074\/jbc.273.9.5174","article-title":"Characterization of the mouse Cyp1B1 gene. Identification of an enhancer region that directs aryl hydrocarbon receptor-mediated constitutive and induced expression","volume":"273","author":"Zhang","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.04.014_BIB27","first-page":"825","article-title":"Aryl hydrocarbon receptor regulation of cytochrome P4501B1 in rat mammary fibroblasts: evidence for transcriptional repression by glucocorticoids","volume":"54","author":"Brake","year":"1998","journal-title":"Mol. Phamacol."},{"key":"10.1016\/j.canlet.2004.04.014_BIB28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0303-7207(95)03668-W","article-title":"Cytochrome CYP1A1 and CYP1B1 in the rat mammary gland: cell-specific expression and regulation by polycyclic aromatic hydrocarbons and hormones","volume":"15","author":"Christou","year":"1995","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.canlet.2004.04.014_BIB29","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/carcin\/19.8.1437","article-title":"Expression of CYP1B1 but not CYP1A1 by primary cultured human mammary stromal fibroblasts constitutively and in response to dioxin exposure: role of the Ah receptor","volume":"19","author":"Eltom","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2004.04.014_BIB30","first-page":"2366","article-title":"Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism","volume":"58","author":"Larsen","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.04.014_BIB31","doi-asserted-by":"crossref","first-page":"6770","DOI":"10.1074\/jbc.275.10.6770","article-title":"Transcriptional regulation of the human CYP1B1 gene. Evidence for involvement of aryl hydrocarbon receptor response element in constitutive expression","volume":"275","author":"Shehin","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.04.014_BIB32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/carcin\/18.2.391","article-title":"Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells","volume":"18","author":"Hakkola","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2004.04.014_BIB33","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/carcin\/19.2.291","article-title":"Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells","volume":"19","author":"Spink","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2004.04.014_BIB34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1023\/A:1006443104670","article-title":"Expression of the aryl hydrocarbon receptor\/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis","volume":"63","author":"Trombino","year":"2000","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.canlet.2004.04.014_BIB35","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/carcin\/18.3.553","article-title":"Induction of mammary cancer and lymphoma by multiple, low oral doses of 7,12-dimethylbenz[a]anthracene in SENCAR mice","volume":"18","author":"Qing","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2004.04.014_BIB36","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0006-2952(03)00111-4","article-title":"Quantitative analysis of the Ah receptor\/cytochrome P450 CYP1B1\/CYP1A1 signaling pathway","volume":"65","author":"McFadyen","year":"2003","journal-title":"Biochem. Pharmacol."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383504003428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383504003428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T02:23:31Z","timestamp":1624501411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383504003428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S0304383504003428"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2004.04.014","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}