{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:04:24Z","timestamp":1791191064263,"version":"4.1.0"},"reference-count":125,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1016\/j.canlet.2004.08.007","type":"journal-article","created":{"date-parts":[[2004,10,5]],"date-time":"2004-10-05T15:09:06Z","timestamp":1096988946000},"page":"1-14","source":"Crossref","is-referenced-by-count":113,"title":["Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors"],"prefix":"10.1016","volume":"218","author":[{"given":"Sophie","family":"North","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Moenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Bikfalvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2004.08.007_bib1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1161\/01.RES.0000026654.65882.55","article-title":"Hypoxia and HIF-1alpha stability: another stress-sensing mechanism for Shc","volume":"91","author":"Abe","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib2","doi-asserted-by":"crossref","first-page":"6104","DOI":"10.1038\/sj.onc.1203128","article-title":"Role of redox potential and reactive oxygen species in stress signaling","volume":"18","author":"Adler","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2004.08.007_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0960-9822(98)70061-2","article-title":"ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage","volume":"8","author":"Aladjem","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.canlet.2004.08.007_bib4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0891-5849(99)00242-7","article-title":"Oxidative stress and gene regulation","volume":"28","author":"Allen","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.canlet.2004.08.007_bib5","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1038\/sj.onc.1204636","article-title":"The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor","volume":"20","author":"Ambartsumian","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2004.08.007_bib6","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/32925","article-title":"Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha","volume":"392","author":"An","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2004.08.007_bib7","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1073\/pnas.022630199","article-title":"Reactive oxygen generated by Nox1 triggers the angiogenic switch","volume":"99","author":"Arbiser","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2004.08.007_bib8","first-page":"5881","article-title":"High expression of inducible 6-phosphofructo-2-kinase\/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers","volume":"62","author":"Atsumi","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib9","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1128\/MCB.24.7.2905-2914.2004","article-title":"Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression","volume":"24","author":"Bardos","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.canlet.2004.08.007_bib10","doi-asserted-by":"crossref","first-page":"6330","DOI":"10.1128\/MCB.17.11.6330","article-title":"Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter","volume":"17","author":"Bian","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.canlet.2004.08.007_bib11","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0165-6147(02)02109-0","article-title":"Recent advances in angiogenesis, anti-angiogenesis and vascular targeting","volume":"23","author":"Bikfalvi","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.canlet.2004.08.007_bib12","doi-asserted-by":"crossref","first-page":"11995","DOI":"10.1074\/jbc.273.20.11995","article-title":"p53 inhibits hypoxia-inducible factor-stimulated transcription","volume":"273","author":"Blagosklonny","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1535-6108(03)00194-6","article-title":"The hypoxic response of tumors is dependent on their microenvironment","volume":"4","author":"Blouw","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2004.08.007_bib14","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1042\/bj2360595","article-title":"Expression of the v-src or v-fps oncogene increases fructose 2,6-bisphosphate in chick-embryo fibroblasts. Novel mechanism for the stimulation of glycolysis by retroviruses","volume":"236","author":"Bosca","year":"1986","journal-title":"Biochem J."},{"key":"10.1016\/j.canlet.2004.08.007_bib15","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.1038\/sj.onc.1205679","article-title":"Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo","volume":"21","author":"Brantley","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2004.08.007_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00709-002-0059-y","article-title":"Redox signaling of NF-kappaB by membrane NAD(P)H oxidases in normal and malignant cells","volume":"221","author":"Brar","year":"2003","journal-title":"Protoplasma"},{"key":"10.1016\/j.canlet.2004.08.007_bib17","doi-asserted-by":"crossref","first-page":"39192","DOI":"10.1074\/jbc.C100428200","article-title":"Hypoxia-inducible factor-2alpha (HIF-2alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia","volume":"276","author":"Brusselmans","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/10715769009109669","article-title":"Oxidative stress and tumour cell proliferation","volume":"11","author":"Burdon","year":"1990","journal-title":"Free Radic. Res. Commun."},{"key":"10.1016\/j.canlet.2004.08.007_bib19","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nm0603-653","article-title":"Angiogenesis in health and disease","volume":"9","author":"Carmeliet","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2004.08.007_bib20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2004.08.007_bib21","doi-asserted-by":"crossref","first-page":"13595","DOI":"10.1074\/jbc.C200694200","article-title":"Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function","volume":"278","author":"Chen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib22","first-page":"3","article-title":"Molecular dissection of multi-stage tumorigenesis in transgenic mice","volume":"5","author":"Christofori","year":"1994","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2004.08.007_bib23","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1126\/science.7521539","article-title":"Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1","volume":"265","author":"Dameron","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.canlet.2004.08.007_bib24","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1073\/pnas.082121399","article-title":"Structural basis for Hif-1 alpha\/CBP recognition in the cellular hypoxic response","volume":"99","author":"Dames","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2004.08.007_bib25","doi-asserted-by":"crossref","first-page":"5907","DOI":"10.1038\/sj.onc.1206703","article-title":"Investigating hypoxic tumor physiology through gene expression patterns","volume":"22","author":"Denko","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2004.08.007_bib26","doi-asserted-by":"crossref","first-page":"6503","DOI":"10.1038\/sj.onc.1204816","article-title":"Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis","volume":"20","author":"Dohn","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2004.08.007_bib27","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1093\/emboj\/18.7.1905","article-title":"Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP\/p300","volume":"18","author":"Ema","year":"1999","journal-title":"Eur. Mol. Biol. Org. J."},{"key":"10.1016\/j.canlet.2004.08.007_bib28","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1073\/pnas.94.9.4273","article-title":"A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development","volume":"94","author":"Ema","year":"1997","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2004.08.007_bib29","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1073\/pnas.90.7.2646","article-title":"Role of oxygen vs glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR","volume":"90","author":"Eskey","year":"1993","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2004.08.007_bib30","first-page":"7964","article-title":"Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis","volume":"61","author":"Ettinger","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib31","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2004.08.007_bib32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0925-4773(97)00674-6","article-title":"HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels","volume":"63","author":"Flamme","year":"1997","journal-title":"Mech. Dev."},{"key":"10.1016\/j.canlet.2004.08.007_bib33","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","article-title":"Tumor angiogenesis: therapeutic implications","volume":"285","author":"Folkman","year":"1971","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2004.08.007_bib34","first-page":"967","article-title":"Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer","volume":"13","author":"Fukushima","year":"1998","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.canlet.2004.08.007_bib35","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1038\/sj.onc.1204630","article-title":"p53 directs conformational change and translation initiation blockade of human fibroblast growth factor 2 mRNA","volume":"20","author":"Galy","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2004.08.007_bib36","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1038\/sj.onc.1204271","article-title":"Tumour suppressor p53 inhibits human fibroblast growth factor 2 expression by a post-transcriptional mechanism","volume":"20","author":"Galy","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2004.08.007_bib37","first-page":"4151","article-title":"The potential role of transformation-induced metabolic changes in tumor\u2013host interaction","volume":"55","author":"Gatenby","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib38","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/sj.cgt.7700405","article-title":"Aerosol delivery of PEI-p53 complexes inhibits B16-F10 lung metastases through regulation of angiogenesis","volume":"9","author":"Gautam","year":"2002","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.canlet.2004.08.007_bib39","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbaexp.2004.03.002","article-title":"Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites","volume":"1678","author":"Golubovskaya","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2004.08.007_bib40","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/hh1301.092678","article-title":"Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase","volume":"89","author":"Gorlach","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib41","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/379088a0","article-title":"Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours","volume":"379","author":"Graeber","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2004.08.007_bib42","doi-asserted-by":"crossref","first-page":"22699","DOI":"10.1074\/jbc.M010231200","article-title":"Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1\/S100A4 protein: functional consequences of their interaction","volume":"276","author":"Grigorian","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib43","first-page":"327","article-title":"Extracellular compartments of solid tumors","volume":"vol. 3","author":"Gullino","year":"1975"},{"key":"10.1016\/j.canlet.2004.08.007_bib44","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0065-230X(08)60785-X","article-title":"p53 and human cancer: the first ten thousand mutations","volume":"77","author":"Hainaut","year":"2000","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib45","doi-asserted-by":"crossref","first-page":"10305","DOI":"10.1073\/pnas.122347199","article-title":"Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53","volume":"99","author":"Hansson","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2004.08.007_bib46","first-page":"2157","article-title":"Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumors in vivo and promotes capillary tube formation of brain microvascular endothelial cells","volume":"9","author":"Haskell","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib47","first-page":"1284","article-title":"Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism","volume":"8","author":"Helmlinger","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib48","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/sj.onc.1201993","article-title":"p53 induces angiogenesis-restricted dormancy in a mouse fibrosarcoma","volume":"17","author":"Holmgren","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2004.08.007_bib49","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0024-3205(02)01842-8","article-title":"Vascular endothelial growth factor gene expression in a retinal pigmented cell is up-regulated by glucose deprivation through 3\u2032 UTR","volume":"71","author":"Iida","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.canlet.2004.08.007_bib50","doi-asserted-by":"crossref","first-page":"19761","DOI":"10.1074\/jbc.270.34.19761","article-title":"Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells","volume":"270","author":"Ikeda","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib51","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1101\/gad.12.2.149","article-title":"Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha","volume":"12","author":"Iyer","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2004.08.007_bib52","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1471-4914(02)02394-8","article-title":"The role of fibroblast growth factors in vascular development","volume":"8","author":"Javerzat","year":"2002","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.canlet.2004.08.007_bib53","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1101\/gad.11.5.558","article-title":"Identification of redox\/repair protein Ref-1 as a potent activator of p53","volume":"11","author":"Jayaraman","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2004.08.007_bib54","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0092-8674(02)01085-1","article-title":"Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation","volume":"111","author":"Jeong","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2004.08.007_bib55","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrm829","article-title":"The unfolded protein response in nutrient sensing and differentiation","volume":"3","author":"Kaufman","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2004.08.007_bib56","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/0003-9861(91)90084-V","article-title":"Regulation of 6-phosphofructo-1-kinase activity in ras-transformed rat-1 fibroblasts","volume":"286","author":"Kole","year":"1991","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.canlet.2004.08.007_bib57","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1006\/dbio.1999.9253","article-title":"Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death","volume":"209","author":"Kotch","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.canlet.2004.08.007_bib58","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1172\/JCI118962","article-title":"Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo","volume":"98","author":"Kuroki","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.canlet.2004.08.007_bib59","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1101\/gad.991402","article-title":"FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor","volume":"16","author":"Lando","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2004.08.007_bib60","doi-asserted-by":"crossref","first-page":"4618","DOI":"10.1074\/jbc.275.7.4618","article-title":"A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor","volume":"275","author":"Lando","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib61","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0002-9440(10)63042-8","article-title":"Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice","volume":"159","author":"Lawler","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.canlet.2004.08.007_bib62","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.expneurol.2004.01.030","article-title":"The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha","volume":"187","author":"Leker","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.canlet.2004.08.007_bib63","doi-asserted-by":"crossref","first-page":"13333","DOI":"10.1074\/jbc.270.22.13333","article-title":"Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia","volume":"270","author":"Levy","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib64","doi-asserted-by":"crossref","first-page":"6417","DOI":"10.1074\/jbc.273.11.6417","article-title":"Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR","volume":"273","author":"Levy","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib65","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/(SICI)1097-0215(20000120)89:1<51::AID-IJC9>3.0.CO;2-8","article-title":"p53 and vascular-endothelial-growth-factor (VEGF) expression predicts outcome in 833 patients with primary breast carcinoma","volume":"89","author":"Linderholm","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2004.08.007_bib66","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1349-7006.2004.tb03247.x","article-title":"Kigamicin D, a novel anticancer agent based on a new anti-austerity strategy targeting cancer cells' tolerance to nutrient starvation","volume":"95","author":"Lu","year":"2004","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2004.08.007_bib67","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1101\/gad.924501","article-title":"FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity","volume":"15","author":"Mahon","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2004.08.007_bib68","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1476-4598-3-4","article-title":"Expression of the pro-angiogenic factors vascular endothelial growth factor and interleukin-8\/CXCL8 by human breast carcinomas is responsive to nutrient deprivation and endoplasmic reticulum stress","volume":"3","author":"Marjon","year":"2004","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2004.08.007_bib69","first-page":"1149","article-title":"The tumor metabolome","volume":"23","author":"Mazurek","year":"2003","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib70","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1074\/jbc.M110978200","article-title":"Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase\/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect","volume":"277","author":"Minchenko","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib71","first-page":"6161","article-title":"Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression","volume":"55","author":"Mukhopadhyay","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib72","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1038\/sj.onc.1201542","article-title":"A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis","volume":"15","author":"Nishimori","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2004.08.007_bib73","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/sj.cdd.4401183","article-title":"Decision making by p53: life, death and cancer","volume":"10","author":"Oren","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.canlet.2004.08.007_bib74","first-page":"4206","article-title":"Regulation of tumor angiogenesis by oxygen-regulated protein 150, an inducible endoplasmic reticulum chaperone","volume":"61","author":"Ozawa","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib75","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1038\/sj.onc.1207657","article-title":"p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment","volume":"23","author":"Pan","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2004.08.007_bib76","first-page":"91","article-title":"Hypoglycemia-induced VEGF expression is mediated by intracellular Ca2+ and protein kinase C signaling pathway in HepG2 human hepatoblastoma cells","volume":"7","author":"Park","year":"2001","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.canlet.2004.08.007_bib77","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1128\/MCB.23.14.4959-4971.2003","article-title":"Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha","volume":"23","author":"Park","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.canlet.2004.08.007_bib78","doi-asserted-by":"crossref","first-page":"8386","DOI":"10.1073\/pnas.140087397","article-title":"The transcription factor EPAS-1\/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling","volume":"97","author":"Peng","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2004.08.007_bib79","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0006-2952(02)01155-3","article-title":"Is HIF-1alpha a pro- or an anti-apoptotic protein?","volume":"64","author":"Piret","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.canlet.2004.08.007_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3835(01)00698-X","article-title":"Genotoxic and non-genotoxic pathways of p53 induction","volume":"174","author":"Pluquet","year":"2001","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2004.08.007_bib81","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1101\/gad.14.1.34","article-title":"Regulation of tumor angiogenesis by p53-induced degradation of hypoxia- inducible factor 1alpha","volume":"14","author":"Ravi","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2004.08.007_bib82","doi-asserted-by":"crossref","first-page":"20915","DOI":"10.1074\/jbc.M212328200","article-title":"Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation","volume":"278","author":"Reddy","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib83","doi-asserted-by":"crossref","first-page":"32631","DOI":"10.1074\/jbc.274.46.32631","article-title":"p42\/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1","volume":"274","author":"Richard","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib84","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1093\/emboj\/17.11.3005","article-title":"HIF-1 alpha is required for solid tumor formation and embryonic vascularization","volume":"17","author":"Ryan","year":"1998","journal-title":"Eur. Mol. Biol. Org. J."},{"key":"10.1016\/j.canlet.2004.08.007_bib85","doi-asserted-by":"crossref","first-page":"6217","DOI":"10.1093\/emboj\/16.20.6217","article-title":"Regulation of ES cell differentiation by functional and conformational modulation of p53","volume":"16","author":"Sabapathy","year":"1997","journal-title":"Eur. Mol. Biol. Org. J."},{"key":"10.1016\/j.canlet.2004.08.007_bib86","doi-asserted-by":"crossref","first-page":"14013","DOI":"10.1074\/jbc.M209702200","article-title":"MAPK signalling up-regulates the activity of hypoxia-inducible factors by its effects on p300","volume":"278","author":"Sang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib87","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0248-4900(98)80337-7","article-title":"Up-regulation of vascular endothelial growth factor in response to glucose deprivation","volume":"90","author":"Satake","year":"1998","journal-title":"Biol. Cell."},{"key":"10.1016\/j.canlet.2004.08.007_bib88","doi-asserted-by":"crossref","first-page":"8190","DOI":"10.1074\/jbc.M211999200","article-title":"Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements","volume":"278","author":"Schafer","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib89","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1042\/bj20031299","article-title":"p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1)","volume":"380","author":"Schmid","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2004.08.007_bib90","first-page":"1","article-title":"Extracellular S100A4(mts1) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity","author":"Schmidt-Hansen","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2004.08.007_bib91","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1038\/sj.onc.1201835","article-title":"Absence of p53-dependent cell cycle regulation in pluripotent mouse cell lines","volume":"16","author":"Schmidt-Kastner","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2004.08.007_bib92","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/ng1266","article-title":"Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1\u2212\/\u2212 mice","volume":"35","author":"Scortegagna","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.canlet.2004.08.007_bib93","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1128\/MCB.21.10.3436-3444.2001","article-title":"Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells","volume":"21","author":"Seagroves","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.canlet.2004.08.007_bib94","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","author":"Semenza","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2004.08.007_bib95","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/sj.cgt.7700361","article-title":"Downmodulation of bFGF-binding protein expression following restoration of p53 function","volume":"8","author":"Sherif","year":"2001","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.canlet.2004.08.007_bib96","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1128\/MCB.16.8.4231","article-title":"Involvement of the transcription factor NF-kappaB in tubular morphogenesis of human microvascular endothelial cells by oxidative stress","volume":"16","author":"Shono","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.canlet.2004.08.007_bib97","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1073\/pnas.92.3.768","article-title":"Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis","volume":"92","author":"Shweiki","year":"1995","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2004.08.007_bib98","first-page":"4873","article-title":"The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha","volume":"60","author":"Sodhi","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib99","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1749-6632.2000.tb06199.x","article-title":"Glucose deprivation-induced oxidative stress in human tumor cells","volume":"899","author":"Spitz","year":"2000","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.canlet.2004.08.007_bib100","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.1128\/MCB.15.10.5363","article-title":"Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes","volume":"15","author":"Stein","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.canlet.2004.08.007_bib101","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/(SICI)1098-1004(1998)12:6<417::AID-HUMU8>3.0.CO;2-K","article-title":"Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene","volume":"12","author":"Stolle","year":"1998","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.canlet.2004.08.007_bib102","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2174\/1566524033361645","article-title":"Understanding the tumor metabolic phenotype in the genomic era","volume":"3","author":"Stubbs","year":"2003","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.canlet.2004.08.007_bib103","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1074\/jbc.274.16.10911","article-title":"Inhibition of cyclooxygenase-2 gene expression by p53","volume":"274","author":"Subbaramaiah","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib104","doi-asserted-by":"crossref","first-page":"11327","DOI":"10.1074\/jbc.275.15.11327","article-title":"Wild type and mutant p53 differentially regulate the gene expression of human collagenase-3 (hMMP-13)","volume":"275","author":"Sun","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.08.007_bib105","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.1038\/sj.onc.1204742","article-title":"Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53- dependent apoptosis during hypoxia","volume":"20","author":"Suzuki","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2004.08.007_bib106","first-page":"794","article-title":"Production of large amounts of hydrogen peroxide by human tumor cells","volume":"51","author":"Szatrowski","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib107","first-page":"2309","article-title":"Increased expression of S100A4, a metastasis-associated gene, in human colorectal adenocarcinomas","volume":"3","author":"Takenaga","year":"1997","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib108","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1093\/emboj\/19.16.4298","article-title":"Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein","volume":"19","author":"Tanimoto","year":"2000","journal-title":"Eur. Mol. Biol. Org. J."},{"key":"10.1016\/j.canlet.2004.08.007_bib109","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1101\/gad.12.21.3320","article-title":"The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development","volume":"12","author":"Tian","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2004.08.007_bib110","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1101\/gad.11.1.72","article-title":"Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells","volume":"11","author":"Tian","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2004.08.007_bib111","series-title":"Human Physiology: The Mechanisms of Body Function","author":"Vander","year":"2004"},{"key":"10.1016\/j.canlet.2004.08.007_bib112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-230X(03)01001-7","article-title":"Mdm2: a regulator of cell growth and death","volume":"89","author":"Vargas","year":"2003","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib113","first-page":"6449","article-title":"Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review","volume":"49","author":"Vaupel","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib114","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1389-0344(01)00107-1","article-title":"Metabolic mapping with bioluminescence: basic and clinical relevance","volume":"18","author":"Walenta","year":"2002","journal-title":"Biomol. Eng."},{"key":"10.1016\/j.canlet.2004.08.007_bib115","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.canlet.2004.08.007_bib116","first-page":"5089","article-title":"The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis","volume":"62","author":"Welsh","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib117","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/j.1460-2075.1992.tb05097.x","article-title":"Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity","volume":"11","author":"Xanthoudakis","year":"1992","journal-title":"Eur. Mol. Biol. Org. J."},{"key":"10.1016\/j.canlet.2004.08.007_bib118","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1073\/pnas.91.1.23","article-title":"The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains","volume":"91","author":"Xanthoudakis","year":"1994","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2004.08.007_bib119","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0024-3205(98)00560-8","article-title":"Stimulation of in vitro angiogenesis by hydrogen peroxide and the relation with ETS-1 in endothelial cells","volume":"64","author":"Yasuda","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.canlet.2004.08.007_bib120","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0027-5107(99)00234-1","article-title":"Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis","volume":"448","author":"Yeldandi","year":"2000","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib121","first-page":"1164","article-title":"Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers","volume":"56","author":"Younes","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib122","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1126\/science.1068327","article-title":"Effect of p53 status on tumor response to antiangiogenic therapy","volume":"295","author":"Yu","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.canlet.2004.08.007_bib123","first-page":"3655","article-title":"Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression","volume":"60","author":"Zhang","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.007_bib124","first-page":"5595","article-title":"High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging","volume":"61","author":"Ziegler","year":"2001","journal-title":"Cancer Res."},{"issue":"9","key":"10.1016\/j.canlet.2004.08.007_bib125","doi-asserted-by":"crossref","first-page":"7520","DOI":"10.1074\/jbc.M211298200","article-title":"Cooperative interaction of hypoxia-inducible factor-2\u03b1 (HIF-2\u03b1) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)","volume":"278","author":"Elvert","year":"2003","journal-title":"J. Biol. Chem."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383504006275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383504006275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T12:55:12Z","timestamp":1682772912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383504006275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":125,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S0304383504006275"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2004.08.007","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}