{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:56:22Z","timestamp":1783122982503,"version":"3.54.6"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.canlet.2004.08.016","type":"journal-article","created":{"date-parts":[[2004,10,14]],"date-time":"2004-10-14T11:19:00Z","timestamp":1097752740000},"page":"29-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats"],"prefix":"10.1016","volume":"221","author":[{"given":"Koujiro","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Toida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Sugie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2004.08.016_bib1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/bjc.1996.141","article-title":"Trends in survival from cancers of the oral cavity and pharynx in Scotland: a clue as to why the disease is becoming more common?","volume":"73","author":"Macfarlane","year":"1996","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2004.08.016_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1034\/j.1600-0528.2000.280402.x","article-title":"Trends in oral cancer rates in the United States, 1973\u20131996","volume":"28","author":"Shiboski","year":"2000","journal-title":"Commun. Dent. Oral Epidemiol."},{"key":"10.1016\/j.canlet.2004.08.016_bib3","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/0959-8049(93)90057-M","article-title":"Trends in cancer mortality, 1955\u20131989: Asia, Africa and Oceania","volume":"29A","author":"La Vecchia","year":"1993","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.canlet.2004.08.016_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1601-0825.1999.tb00056.x","article-title":"Trends in oral cancer mortality in Japan: 1950\u20131993","volume":"5","author":"Zhang","year":"1999","journal-title":"Oral Dis."},{"key":"10.1016\/j.canlet.2004.08.016_bib5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0360-3016(89)90096-5","article-title":"Multiple primary cancer in patients with cancer of the head and neck: second cancer of the head and neck, esophagus, and lung","volume":"17","author":"Licciardello","year":"1989","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.canlet.2004.08.016_bib6","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0360-3016(89)90126-0","article-title":"Second malignant tumors in head and neck squamous cell carcinoma: the overshadowing threat for patients with early-stage disease","volume":"17","author":"Lippman","year":"1989","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.canlet.2004.08.016_bib7","first-page":"3282","article-title":"Smoking and drinking in relation to oral and pharyngeal cancer","volume":"48","author":"Blot","year":"1988","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.016_bib8","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0895-4356(91)90021-Z","article-title":"Risk factors for second cancers of the upper respiratory and digestive systems: a case\u2013control study","volume":"44","author":"Franco","year":"1991","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.canlet.2004.08.016_bib9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1600-0714.1993.tb00125.x","article-title":"Tobacco and alcohol related to the anatomical site of oral squamous cell carcinoma","volume":"22","author":"Jovanovic","year":"1993","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.canlet.2004.08.016_bib10","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1002\/1097-0142(19930815)72:4<1369::AID-CNCR2820720436>3.0.CO;2-L","article-title":"Tobacco smoking, alcohol drinking, and cancer of the oral cavity and oropharynx among U.S. veterans","volume":"72","author":"Mashberg","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2004.08.016_bib11","first-page":"2699","article-title":"Approaches to prevention of epithelial cancer during the preneoplastic period","volume":"36","author":"Sporn","year":"1976","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.016_bib12","first-page":"2024s","article-title":"The lessons of life: keynote address to the nutrition and cancer conference","volume":"52","author":"Doll","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.016_bib13","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1093\/carcin\/14.11.2205","article-title":"Diet and carcinogenesis","volume":"14","author":"Rogers","year":"1993","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2004.08.016_bib14","first-page":"1041","article-title":"Environmental pollution, pesticides, and the prevention of cancer: misconceptions","volume":"11","author":"Ames","year":"1997","journal-title":"Fed. Am. Soc. Eur. Biol. J."},{"key":"10.1016\/j.canlet.2004.08.016_bib15","first-page":"11","article-title":"Cancer chemoprevention","volume":"5","author":"Tanaka","year":"1992","journal-title":"Cancer J."},{"key":"10.1016\/j.canlet.2004.08.016_bib16","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0040-4039(00)93661-X","article-title":"Garcinol and cambogin","volume":"21","author":"Rama Rao","year":"1980","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.canlet.2004.08.016_bib17","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1021\/jf990845y","article-title":"Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind","volume":"48","author":"Yamaguchi","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.canlet.2004.08.016_bib18","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1093\/carcin\/21.6.1183","article-title":"Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats","volume":"21","author":"Tanaka","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2004.08.016_bib19","first-page":"991","article-title":"Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck","volume":"59","author":"Chan","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.016_bib20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1288\/00005537-198503000-00014","article-title":"Prostaglandins in squamous cell carcinoma of the head and neck: a preliminary study","volume":"95","author":"Jung","year":"1985","journal-title":"Laryngoscope"},{"key":"10.1016\/j.canlet.2004.08.016_bib21","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s00428-002-0616-y","article-title":"Expression of cyclo-oxygenase-2 in human tongue carcinoma and its precursor lesions","volume":"440","author":"Renkonen","year":"2002","journal-title":"Virch. Arch."},{"key":"10.1016\/j.canlet.2004.08.016_bib22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0964-1955(94)00026-Z","article-title":"Chemoprevention of oral carcinogenesis","volume":"31B","author":"Tanaka","year":"1995","journal-title":"Eur. J. Cancer B Oral. Oncol."},{"key":"10.1016\/j.canlet.2004.08.016_bib23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/carcin\/12.2.329","article-title":"Alterations of the nucleolar organizer regions during 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats","volume":"12","author":"Tanaka","year":"1991","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2004.08.016_bib24","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/0030-4220(76)90099-2","article-title":"Occurrence of epithelial dysplasia in oral leukoplakia. Analysis and follow-up study of 12 cases","volume":"42","author":"Banoczy","year":"1976","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"10.1016\/j.canlet.2004.08.016_bib25","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/0030-4220(78)90383-3","article-title":"Definition of leukoplakia and related lesions: an aid to studies on oral precancer","volume":"46","author":"Kramer","year":"1978","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"10.1016\/j.canlet.2004.08.016_bib26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1383-5742(99)00055-1","article-title":"Control of cell proliferation in cancer prevention","volume":"428","author":"Mori","year":"1999","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2004.08.016_bib27","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1126\/science.2204108","article-title":"Cell proliferation in carcinogenesis","volume":"249","author":"Cohen","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.canlet.2004.08.016_bib28","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0092-8674(91)90101-4","article-title":"Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle","volume":"65","author":"Matsushime","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2004.08.016_bib29","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/350512a0","article-title":"A novel cyclin encoded by a bcl1-linked candidate oncogene","volume":"350","author":"Motokura","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2004.08.016_bib30","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1101\/gad.7.5.812","article-title":"Cyclin D1 is a nuclear protein required for cell cycle progression in G1","volume":"7","author":"Baldin","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2004.08.016_bib31","first-page":"103","article-title":"Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins","volume":"1287","author":"Beijersbergen","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2004.08.016_bib32","first-page":"949","article-title":"Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer","volume":"55","author":"Bartkova","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.016_bib33","first-page":"975","article-title":"Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck","volume":"55","author":"Michalides","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.016_bib34","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S1368-8375(00)00141-X","article-title":"Alteration of pRb expression in the development of rat tongue carcinoma induced by 4-nitroquinoline 1-oxide","volume":"37","author":"Niwa","year":"2001","journal-title":"Oral Oncol."},{"key":"10.1016\/j.canlet.2004.08.016_bib35","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/(SICI)1097-0215(19971219)74:6<576::AID-IJC3>3.0.CO;2-R","article-title":"Cyclin-D1-gene amplification is a more potent prognostic factor than its protein over-expression in human head-and-neck squamous-cell carcinoma","volume":"74","author":"Kyomoto","year":"1997","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2004.08.016_bib36","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1001\/archotol.1995.01890070076016","article-title":"Chromosome 11q13 amplification in head and neck squamous cell carcinoma. Association with poor prognosis","volume":"121","author":"Meredith","year":"1995","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.canlet.2004.08.016_bib37","first-page":"97","article-title":"NSAIDs as cancer preventive agents","volume":"1","author":"Wakabayashi","year":"2000","journal-title":"Asian Pacific J. Cancer Prev."},{"key":"10.1016\/j.canlet.2004.08.016_bib38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0304-3835(89)90115-8","article-title":"Inhibitory effects of non-steroidal anti-inflammatory drugs, piroxicam and indomethacin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male ACI\/N rats","volume":"48","author":"Tanaka","year":"1989","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2004.08.016_bib39","first-page":"1885","article-title":"The cyclooxygenase 2-selective inhibitor NS398 inhibits proliferation of oral carcinoma cell lines by mechanisms dependent and independent of reduced prostaglandin E2 synthesis","volume":"9","author":"Minter","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.016_bib40","first-page":"1451","article-title":"Cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide","volume":"61","author":"Shiotani","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.08.016_bib41","first-page":"39","article-title":"A COX-2 inhibitor, nimesulide, inhibits chemically-induced rat tongue carcinogenesis through suppression of cell proliferation activity and COX-2 and inducible nitric oxide synthase expression","volume":"18","author":"Yoshida","year":"2003","journal-title":"Histol. Histopathol."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383504006433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383504006433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:26:26Z","timestamp":1759591586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383504006433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0304383504006433"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2004.08.016","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2004.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}