{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:28:42Z","timestamp":1777494522835,"version":"3.51.4"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1016\/j.canlet.2004.10.004","type":"journal-article","created":{"date-parts":[[2004,11,12]],"date-time":"2004-11-12T17:22:52Z","timestamp":1100280172000},"page":"93-103","source":"Crossref","is-referenced-by-count":78,"title":["The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression"],"prefix":"10.1016","volume":"224","author":[{"given":"Grit","family":"Kasper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Klaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rn","family":"Gr\u00f6ne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iver","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esmeralda","family":"Casta\u00f1os-V\u00e9lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eike","family":"Staub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlev","family":"Mennerich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2004.10.004_bib1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1006\/geno.1996.0364","article-title":"LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells","volume":"35","author":"Adra","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.canlet.2004.10.004_bib2","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.canlet.2004.10.004_bib3","first-page":"4890","article-title":"Mouse transporter protein, a membrane protein that regulates cellular multidrug resistance, is localized to lysosomes","volume":"59","author":"Cabrita","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.10.004_bib4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/bioinformatics\/17.9.845","article-title":"CHROMA: consensus-based colouring of multiple alignments for publication","volume":"17","author":"Goodstadt","year":"2001","journal-title":"Bioinformatics"},{"key":"10.1016\/j.canlet.2004.10.004_bib5","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/sj.leu.2403026","article-title":"Inactivation of the E3\/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma","volume":"17","author":"Hayami","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.canlet.2004.10.004_bib6","first-page":"348","article-title":"Effects of the novel gene, LAPTM4B, highly expression in hepatocellular carcinoma on cell proliferation and tumorigenesis of NIH3T3 cells","volume":"35","author":"He","year":"2003","journal-title":"Beijing Da Xue Xue Bao"},{"key":"10.1016\/j.canlet.2004.10.004_bib7","doi-asserted-by":"crossref","first-page":"12877","DOI":"10.1074\/jbc.274.18.12877","article-title":"A mammalian lysosomal membrane protein confers multidrug resistance upon expression in Saccharomyces cerevisiae","volume":"274","author":"Hogue","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2004.10.004_bib8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1042\/bj20020205","article-title":"Lysosome-associated protein transmembrane 4 alpha (LAPTM4 alpha) requires two tandemly arranged tyrosine-based signals for sorting to lysosomes","volume":"365","author":"Hogue","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2004.10.004_bib9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/bies.950180508","article-title":"Intracellular trafficking of lysosomal membrane proteins","volume":"18","author":"Hunziker","year":"1996","journal-title":"Bioessays"},{"key":"10.1016\/j.canlet.2004.10.004_bib10","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/gng015","article-title":"Summaries of Affymetrix GeneChip probe level data","volume":"31","author":"Irizarry","year":"2003","journal-title":"Nucleic Acid Res."},{"key":"10.1016\/j.canlet.2004.10.004_bib11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0968-0004(98)01285-7","article-title":"Multiple sequence alignment with Clustal X","volume":"23","author":"Jeanmougin","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.canlet.2004.10.004_bib12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"Krogh","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.canlet.2004.10.004_bib13","first-page":"881","article-title":"Biological function of a novel gene overexpressed in human hepatocellular carcinoma","volume":"113","author":"Liu","year":"2000","journal-title":"Chin. Med. J. (Engl.)"},{"key":"10.1016\/j.canlet.2004.10.004_bib14","first-page":"340","article-title":"Identification and characterization of LAPTM4B encoded by a human hepatocellular carcinoma-associated novel gene","volume":"35","author":"Liu","year":"2003","journal-title":"Beijing Da Xue Xue Bao"},{"key":"10.1016\/j.canlet.2004.10.004_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/4806","article-title":"Gene expression profiles of laser-captured adjacent neuronal subtypes","volume":"5","author":"Luo","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2004.10.004_bib16","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/bioinformatics\/17.7.646","article-title":"Evaluation of methods for the prediction of membrane spanning regions","volume":"17","author":"Moller","year":"2001","journal-title":"Bioinformatics"},{"key":"10.1016\/j.canlet.2004.10.004_bib17","first-page":"647","article-title":"Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer","volume":"61","author":"Muller-Tidow","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2004.10.004_bib18","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1038\/sj.onc.1206832","article-title":"Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma","volume":"22","author":"Shao","year":"2003","journal-title":"Oncogene"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383504007773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383504007773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T03:58:55Z","timestamp":1549079935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383504007773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S0304383504007773"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2004.10.004","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}