{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:33:54Z","timestamp":1772969634395,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.canlet.2005.02.001","type":"journal-article","created":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T21:24:01Z","timestamp":1111094641000},"page":"228-239","source":"Crossref","is-referenced-by-count":46,"title":["Human endogenous retrovirus HERV-H family in human tissues and cancer cells: expression, identification, and phylogeny"],"prefix":"10.1016","volume":"231","author":[{"given":"Joo-Mi","family":"Yi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwan-Mook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heui-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2005.02.001_bib1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2005.02.001_bib2","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1128\/JVI.74.8.3715-3730.2000","article-title":"Identification and characterization of novel human endogenous retrovirus families by phylogenetic screening of the human genome mapping project database","volume":"74","author":"Tristem","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.canlet.2005.02.001_bib3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/(SICI)1521-1878(200002)22:2<161::AID-BIES7>3.0.CO;2-X","article-title":"Retroviruses and primate evolution","volume":"22","author":"Sverdlov","year":"2000","journal-title":"Bioessays"},{"key":"10.1016\/j.canlet.2005.02.001_bib4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0042-6822(85)90147-3","article-title":"The nucleotide sequence of the env gene from the human provirus ERV3 and isolation and characterization of an ERV3-specific cDNA","volume":"147","author":"Cohen","year":"1985","journal-title":"Virology"},{"key":"10.1016\/j.canlet.2005.02.001_bib5","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1128\/JVI.60.2.589-598.1986","article-title":"Nucleotide sequence of human endogenous retrovirus genome related to the mouse mammary tumor virus genome","volume":"60","author":"Ono","year":"1986","journal-title":"J. Virol."},{"key":"10.1016\/j.canlet.2005.02.001_bib6","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1073\/pnas.90.10.4480","article-title":"Identification of human endogenous retroviruses with complex mRNA expression and particle formation","volume":"90","author":"Lower","year":"1993","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2005.02.001_bib7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1006\/viro.1995.1442","article-title":"Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function","volume":"211","author":"Venables","year":"1995","journal-title":"Virology"},{"key":"10.1016\/j.canlet.2005.02.001_bib8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1006\/viro.1996.0443","article-title":"Endogenous D-type (HERV-K) related sequences are packaged into retroviral particles in the placenta and possess open reading frames for reverse transcriptase","volume":"222","author":"Simpson","year":"1996","journal-title":"Virology"},{"key":"10.1016\/j.canlet.2005.02.001_bib9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1128\/JVI.69.1.141-149.1995","article-title":"Identification of a Rev-related protein by analysis of spliced transcripts of the human endogenous retroviruses HTDV\/HERV-K","volume":"69","author":"Lower","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.canlet.2005.02.001_bib10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1128\/JVI.69.1.414-421.1995","article-title":"Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas","volume":"69","author":"Sauter","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.canlet.2005.02.001_bib11","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1099\/0022-1317-73-5-1087","article-title":"Retrovirus-like particles from the human T47D cell line are related to mouse mammary tumour virus and are of human endogenous origin","volume":"73","author":"Faff","year":"1992","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.canlet.2005.02.001_bib12","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/35001608","article-title":"Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis","volume":"403","author":"Mi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2005.02.001_bib13","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1089\/aid.1996.12.833","article-title":"Differential expression of human endogenous retroviral sequences similar to mouse mammary tumor virus in normal peripheral blood mononuclear cells","volume":"12","author":"Andersson","year":"1996","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.canlet.2005.02.001_bib14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1046\/j.1365-3083.1998.00428.x","article-title":"Beneficial role of human endogenous retroviruses: facts and hypotheses","volume":"48","author":"Larsson","year":"1998","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.canlet.2005.02.001_bib15","series-title":"The Retroviridae","first-page":"465","article-title":"Endogenous human retroviruses","author":"Wilkinson","year":"1994"},{"key":"10.1016\/j.canlet.2005.02.001_bib16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/viro.1993.1007","article-title":"Presence of env genes in members of the RTVL-H family of human endogenous retrovirus-like elements","volume":"192","author":"Hirose","year":"1993","journal-title":"Virology"},{"key":"10.1016\/j.canlet.2005.02.001_bib17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/viro.1997.8590","article-title":"Comparative analyses of LTRs of the ERV-H family of primate-specific retrovirus-like elements isolated from marmoset, African green monkey, and man","volume":"234","author":"Anderssen","year":"1997","journal-title":"Virology"},{"key":"10.1016\/j.canlet.2005.02.001_bib18","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1006\/viro.1995.0012","article-title":"HERV-H endogenous retroviruses: presence in the New World branch but amplification in the Old World primate lineage","volume":"213","author":"Mager","year":"1995","journal-title":"Virology"},{"key":"10.1016\/j.canlet.2005.02.001_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1006\/viro.1998.9106","article-title":"Coamplification and dispersion of adjacent human endogenous retroviral HERV-H and HERV-E elements; presence of spliced hybrid transcripts in normal leukocytes","volume":"244","author":"Lindeskog","year":"1998","journal-title":"Virology"},{"key":"10.1016\/j.canlet.2005.02.001_bib20","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1006\/viro.2000.0737","article-title":"Characterization of the three HERV-H proviruses with an open envelope reading frame encompassing the immunosuppressive domain and evolutionary history in primates","volume":"279","author":"de Parseval","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.canlet.2005.02.001_bib21","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1128\/JVI.64.5.2157-2167.1990","article-title":"Autonomous expression of RTVL-H endogenous retroviruslike elements in human cells","volume":"64","author":"Wilkinson","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/j.canlet.2005.02.001_bib22","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1128\/JVI.67.2.1122-1126.1993","article-title":"Sequence variation of human endogenous retrovirus ERV9-related elements in an env region corresponding to an immunosuppressive peptide: transcription in normal and neoplastic cells","volume":"67","author":"Lindeskog","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/j.canlet.2005.02.001_bib23","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1099\/0022-1317-77-5-1101","article-title":"Expression of novel-transposon-containing mRNAs in human T cells","volume":"77","author":"Kelleher","year":"1996","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.canlet.2005.02.001_bib24","doi-asserted-by":"crossref","unstructured":"J.M. Yi, H.S. Kim, Evolutionary implication of human endogenous retrovirus HERV-H family, J. Hum. Genet., in press.","DOI":"10.1007\/s10038-004-0132-9"},{"key":"10.1016\/j.canlet.2005.02.001_bib25","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1093\/bioinformatics\/17.12.1244","article-title":"MEGA2: molecular evolutionary genetics analysis software","volume":"17","author":"Kumar","year":"2001","journal-title":"Bioinformatics"},{"key":"10.1016\/j.canlet.2005.02.001_bib26","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1099\/0022-1317-78-10-2575","article-title":"Spliced human endogenous retroviral HERV-H env transcripts in T-cell leukaemia cell lines and normal leukocytes: alternative splicing pattern of HERV-H transcripts","volume":"78","author":"Lindeskog","year":"1997","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.canlet.2005.02.001_bib27","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/viro.2002.1428","article-title":"Developmental expression of HERV-R (ERV3) and HERV-K in human tissue","volume":"297","author":"Andersson","year":"2002","journal-title":"Virology"},{"key":"10.1016\/j.canlet.2005.02.001_bib28","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1084\/jem.159.3.964","article-title":"Human malignant and mitogen-transformed cells contain retroviral P15E-related antigen","volume":"159","author":"Cianciolo","year":"1984","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2005.02.001_bib29","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1126\/science.2996136","article-title":"Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins","volume":"230","author":"Cianciolo","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.canlet.2005.02.001_bib30","doi-asserted-by":"crossref","first-page":"14920","DOI":"10.1073\/pnas.95.25.14920","article-title":"Tumor cells expressing a retroviral envelope escape immune rejection in vivo","volume":"95","author":"Mangeney","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2005.02.001_bib31","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1099\/0022-1317-82-10-2515","article-title":"The full-length envelope of an HERV-H human endogenous retrovirus has immunosuppressive properties","volume":"82","author":"Mangeney","year":"2001","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.canlet.2005.02.001_bib32","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1128\/JVI.72.4.2671-2676.1998","article-title":"Packaging of endogenous retroviral sequences in retroviral vectors produced by murine and human packaging cells","volume":"72","author":"Patience","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.canlet.2005.02.001_bib33","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1128\/JVI.73.2.1175-1185.1999","article-title":"Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family","volume":"73","author":"Blond","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.canlet.2005.02.001_bib34","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(05)60075-X","article-title":"Expression of sequence variants of endogenous retrovirus RGH in particle form in multiple sclerosis","volume":"352","author":"Christensen","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2005.02.001_bib35","doi-asserted-by":"crossref","first-page":"7583","DOI":"10.1073\/pnas.94.14.7583","article-title":"Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis","volume":"94","author":"Perron","year":"1997","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2005.02.001_bib36","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00284-001-0033-5","article-title":"Molecular cloning and phylogenetic analysis of new human endogenous retrovirus HERV-W family in cancer cells","volume":"44","author":"Yi","year":"2002","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.canlet.2005.02.001_bib37","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s00705-003-0127-4","article-title":"Molecular characterization and phylogenetic relationship of HERV-W family in the Macaca fuscata","volume":"148","author":"Yi","year":"2003","journal-title":"Arch. Virol."},{"key":"10.1016\/j.canlet.2005.02.001_bib38","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/sj.onc.1206241","article-title":"Quantitation of HERV-K env gene expression and splicing in human breast cancer","volume":"22","author":"Wang-Johanning","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2005.02.001_bib39","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s100380170012","article-title":"Search for active endogenous retroviruses: identification and characterization of a HERV-E gene that is expressed in the pancreas and thyroid","volume":"46","author":"Shiroma","year":"2001","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.canlet.2005.02.001_bib40","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/cncr.11451","article-title":"Detecting the expression of human endogenous retrovirus E envelope transcripts in human prostate adenocarcinoma","volume":"98","author":"Wang-Johanning","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2005.02.001_bib41","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1006\/geno.1999.5787","article-title":"Intergenic splicing between a HERV-H endogenous retrovirus and two adjacent human genes","volume":"57","author":"Kowalski","year":"1999","journal-title":"Genomics"},{"key":"10.1016\/j.canlet.2005.02.001_bib42","doi-asserted-by":"crossref","first-page":"14759","DOI":"10.1073\/pnas.93.25.14759","article-title":"Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus","volume":"93","author":"Schulte","year":"1996","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2005.02.001_bib43","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1101\/gad.6.8.1457","article-title":"Endogenous retroviral sequences are required for tissue-specific expression of a human salivary amylase gene","volume":"6","author":"Ting","year":"1992","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2005.02.001_bib44","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.1128\/JVI.77.13.7459-7466.2003","article-title":"Functional analysis of the endogenous retroviral promoter of the human endothelin B receptor gene","volume":"77","author":"Landry","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.canlet.2005.02.001_bib45","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0092-8674(00)80338-4","article-title":"A human endogenous retroviral superantigen as candidate autoimmune gene in the type I diabetes","volume":"90","author":"Conrad","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2005.02.001_bib46","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/art.1780400407","article-title":"Direct evidence for the expression of multiple endogenous retroviruses in the synovial compartment in rheumatoid arthritis","volume":"40","author":"Nakagawa","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.canlet.2005.02.001_bib47","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0966-842X(99)01565-6","article-title":"Te pathogenic potential of endogenous retroviruses: facts and fantasies","volume":"7","author":"Lower","year":"1999","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.canlet.2005.02.001_bib48","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1073\/pnas.061021998","article-title":"Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia","volume":"98","author":"Karlsson","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383505001084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383505001084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T11:09:31Z","timestamp":1586171371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383505001084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0304383505001084"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2005.02.001","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}