{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:00:34Z","timestamp":1772463634702,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.canlet.2005.04.014","type":"journal-article","created":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T16:27:57Z","timestamp":1119976077000},"page":"77-83","source":"Crossref","is-referenced-by-count":31,"title":["A p53 polymorphism modifies the risk of hepatocellular carcinoma among non-carriers but not carriers of chronic hepatitis B virus infection"],"prefix":"10.1016","volume":"229","author":[{"given":"Zhong-Zheng","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Ming","family":"Cong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Hong","family":"Xian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Qing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Chao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Fang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan-Shan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2005.04.014_bib1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1055\/s-2007-1007117","article-title":"Epidemiology of primary liver cancer","volume":"19","author":"Bosch","year":"1999","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.canlet.2005.04.014_bib2","first-page":"239","article-title":"Recent research progress in hepatocellular carcinoma","volume":"101","author":"Kao","year":"2002","journal-title":"J. Formos. Med. Assoc."},{"key":"10.1016\/j.canlet.2005.04.014_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ijc.1440","article-title":"Estimating the world cancer burden: Globocan 2000","volume":"94","author":"Parkin","year":"2001","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2005.04.014_bib4","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/S0140-6736(03)14964-1","article-title":"Hepatocellular carcinoma","volume":"362","author":"Llovet","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2005.04.014_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/ng0802-339","article-title":"Molecular pathogenesis of human hepatocellular carcinoma","volume":"31","author":"Thorgeirsson","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.canlet.2005.04.014_bib6","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/scbi.2000.0319","article-title":"Genetics of hepatocellular carcinoma","volume":"10","author":"Buendia","year":"2000","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2005.04.014_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00042737-200401000-00004","article-title":"P14ARF gene alterations in human hepatocellular carcinoma","volume":"16","author":"Anzola","year":"2004","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2005.04.014_bib8","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1093\/jnci\/djg051","article-title":"Polymorphisms in XRCC1 and glutathione S-transferase genes and hepatitis B-related hepatocellular carcinoma","volume":"95","author":"Yu","year":"2003","journal-title":"J. Natl Cancer Inst."},{"key":"10.1016\/j.canlet.2005.04.014_bib9","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1053\/gast.2001.28655","article-title":"Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene","volume":"121","author":"Vogel","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2005.04.014_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1053\/jhep.2003.50017","article-title":"Interleukin-1beta gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection","volume":"37","author":"Wang","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2005.04.014_bib11","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/hmg\/ddg104","article-title":"Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma","volume":"12","author":"Shin","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.canlet.2005.04.014_bib12","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/sj.bjc.6690397","article-title":"Cytochrome P450 1A1 genetic polymorphisms and risk of hepatocellular carcinoma among chronic hepatitis B carriers","volume":"80","author":"Yu","year":"1999","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2005.04.014_bib13","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1136\/gut.47.5.703","article-title":"Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: impact of smoking on risk","volume":"47","author":"Yu","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.canlet.2005.04.014_bib14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng1093","article-title":"The codon 72 polymorphic variants of p53 have markedly different apoptotic potential","volume":"33","author":"Dumont","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.canlet.2005.04.014_bib15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0378-4274(02)00336-3","article-title":"Chilean pilot study on the risk of lung cancer associated with codon 72 polymorphism in the gene of protein p53","volume":"144","author":"Irarrazabal","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.canlet.2005.04.014_bib16","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/1097-0215(20000920)89:5<458::AID-IJC10>3.0.CO;2-R","article-title":"Genetic polymorphisms of p53 and GSTP1,but not NAT2,are associated with susceptibility to squamous-cell carcinoma of the esophagus","volume":"89","author":"Lee","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2005.04.014_bib17","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/ijc.10483","article-title":"p53 Codon 72 polymorphism in gastric cancer susceptibility in patients with Helicobacter pylori-associated chronic gastritis","volume":"100","author":"Hiyama","year":"2002","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2005.04.014_bib18","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1093\/carcin\/17.6.1313","article-title":"p53 polymorphisms and haplotypes in breast cancer","volume":"17","author":"Sjalander","year":"1996","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2005.04.014_bib19","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/00005537-200201000-00020","article-title":"Prognostic significance of the proline form of p53 codon 72 polymorphism in nasopharyngeal carcinoma","volume":"112","author":"Tsai","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.canlet.2005.04.014_bib20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0304-3835(02)00518-9","article-title":"p53 Codon 72 polymorphism and urothelial cancer risk","volume":"189","author":"Kuroda","year":"2003","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2005.04.014_bib21","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/BF02256434","article-title":"A p53 codon 72 polymorphism associated with prostate cancer development and progression in Japanese","volume":"10","author":"Suzuki","year":"2003","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.canlet.2005.04.014_bib22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1081\/ESE-120016889","article-title":"Genetic polymorphism in p53 codon 72 and skin cancer in southwestern Taiwan","volume":"38","author":"Chen","year":"2003","journal-title":"J. Environ. Sci. Health Part A Tox. Hazard Subst. Environ. Eng."},{"key":"10.1016\/j.canlet.2005.04.014_bib23","first-page":"1199","article-title":"Relationships of TP53 codon 72 and HRAS1 polymorphisms with lung cancer risk in an ethnically diverse population","volume":"9","author":"Pierce","year":"2000","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.canlet.2005.04.014_bib24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2003.11.026","article-title":"Influences of lifestyle habits and p53 codon 72 and p21 codon 31 polymorphisms on gastric cancer risk in Taiwan","volume":"205","author":"Wu","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2005.04.014_bib25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1006\/mcbr.2000.0241","article-title":"p53 codon 72 polymorphism as a risk factor in the development of breast cancer","volume":"3","author":"Papadakis","year":"2000","journal-title":"Mol. Cell Biol. Res. Commun."},{"key":"10.1016\/j.canlet.2005.04.014_bib26","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s002400100218","article-title":"P53 codon 72 polymorphism in bladder cancer\u2014no evidence of association with increased risk or invasiveness","volume":"29","author":"Toruner","year":"2001","journal-title":"Urol. Res."},{"key":"10.1016\/j.canlet.2005.04.014_bib27","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1158\/1055-9965.2217.13.12","article-title":"p53 Codon 72 and p21 codon 31 polymorphisms in prostate cancer","volume":"13","author":"Huang","year":"2004","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.canlet.2005.04.014_bib28","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/jcp.54.7.539","article-title":"p53 codon 72 polymorphism and human papillomavirus associated skin cancer","volume":"54","author":"O'Connor","year":"2001","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.canlet.2005.04.014_bib29","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/hep.510290330","article-title":"A p53 genetic polymorphism as a modulator of hepatocellular carcinoma risk in relation to chronic liver disease, familial tendency, and cigarette smoking in hepatitis B carriers","volume":"29","author":"Yu","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2005.04.014_bib30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.canlet.2004.02.016","article-title":"Codon 72 polymorphism of P53 gene does not affect the risk of cirrhosis and hepatocarcinoma in HCV-infected patients","volume":"208","author":"Leveri","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2005.04.014_bib31","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0304-3835(03)00046-6","article-title":"Frequent loss of p53 codon 72 Pro variant in hepatitis C virus-positive carriers with hepatocellular carcinoma","volume":"193","author":"Anzola","year":"2003","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2005.04.014_bib32","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1093\/nar\/18.16.4961","article-title":"Codon 72 polymorphism of the TP53 gene","volume":"18","author":"Ara","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.canlet.2005.04.014_bib33","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(81)90585-7","article-title":"Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22707 men in Taiwan","volume":"2","author":"Beasley","year":"1981","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2005.04.014_bib34","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1056\/NEJMoa013215","article-title":"Hepatitis B e antigen and the risk of hepatocellular carcinoma","volume":"347","author":"Yang","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2005.04.014_bib35","first-page":"49","article-title":"Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas","volume":"51","author":"Slagle","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2005.04.014_bib36","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<875::AID-IJC13>3.0.CO;2-Z","article-title":"Hepatitis B virus X protein inhibits nucleotide excision repair","volume":"80","author":"Jia","year":"1999","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2005.04.014_bib37","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/sj.onc.1203312","article-title":"Transcriptional repression of the human p53 gene by hepatitis B viral X protein","volume":"19","author":"Lee","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2005.04.014_bib38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/ng0195-41","article-title":"Functional inactivation but not structural mutation of p53 causes liver cancer","volume":"9","author":"Ueda","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.canlet.2005.04.014_bib39","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1073\/pnas.91.6.2230","article-title":"Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3","volume":"91","author":"Wang","year":"1994","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2005.04.014_bib40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/30400","article-title":"Role of a p53 polymorphism in the development of human papillomavirus-associated cancer","volume":"393","author":"Storey","year":"1998","journal-title":"Nature"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383505003873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383505003873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T15:21:02Z","timestamp":1683127262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383505003873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0304383505003873"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2005.04.014","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}