{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:27:33Z","timestamp":1790875653969,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.canlet.2005.11.029","type":"journal-article","created":{"date-parts":[[2006,1,19]],"date-time":"2006-01-19T14:06:46Z","timestamp":1137679606000},"page":"42-52","source":"Crossref","is-referenced-by-count":28,"title":["Skin delivery potency and antitumor activities of temozolomide ester prodrugs"],"prefix":"10.1016","volume":"244","author":[{"given":"Panassaya","family":"Suppasansatorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guocheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara R.","family":"Conway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2005.11.029_bib1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/BF00688855","article-title":"Comparison of cytotoxicity in vitro of temozolomide and dacarbazine, prodrugs of 3-methyl-(triazen-1-yl)imidazole-4-carboxamide","volume":"27","author":"Tsang","year":"1991","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.canlet.2005.11.029_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0304-3835(92)90065-4","article-title":"Antitumour imidazotetrazines XXVIII 3-methyladenine DNA glycosylase activity in cell lines sensitive and resistant to temozolomide","volume":"63","author":"Deans","year":"1992","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2005.11.029_bib3","first-page":"5846","article-title":"Antitumour activity and pharmacokinetics in mice of 8-carmaboyl-3-methyl-imidazo[5,1 d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M&B 39831), a novel drug with potential as an alternative to dacarbazine","volume":"47","author":"Stevens","year":"1987","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2005.11.029_bib4","first-page":"1769","article-title":"Activity of temozolomide against human tumour colony-forming units","volume":"3","author":"Raymond","year":"1997","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2005.11.029_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2165\/00024669-200201010-00006","article-title":"Temozolomide: a review of its use in the treatment of malignant gliomas, malignant melanoma and other advanced cancers","volume":"1","author":"Darkes","year":"2002","journal-title":"Am. J. Cancer"},{"key":"10.1016\/j.canlet.2005.11.029_bib6","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1200\/JCO.1995.13.4.910","article-title":"Cancer research campaign phase II trial of temozolomide in metastatic melanoma","volume":"13","author":"Bleehen","year":"1995","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2005.11.029_bib7","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1200\/JCO.2000.18.1.158","article-title":"Randomised phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma","volume":"18","author":"Middleton","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2005.11.029_bib8","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S1470-2045(01)00522-8","article-title":"Treatment of metastatic melanoma in the brain with temozolomide and thalidomide","volume":"2","author":"Hwu","year":"2001","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canlet.2005.11.029_bib9","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1200\/JCO.2004.07.060","article-title":"Selective CD4+lymphopenia in melanoma patients treated with temozolomide: a toxicity with therapeutic implications","volume":"22","author":"Su","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2005.11.029_bib10","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/annonc\/mdg157","article-title":"Second-line chemotherapy with temozolomide in recurrent oligodendroglioma after PCV (procarbazine, lomustine and vincristine) chemotherapy: EORTC brain tumor group phase II study 26972","volume":"14","author":"van den Bent","year":"2003","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.canlet.2005.11.029_bib11","first-page":"1183","article-title":"Treatment of neoplastic meningitis with intrathecal temozolomide","volume":"5","author":"Sampson","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2005.11.029_bib12","first-page":"4148","article-title":"Temozolomide delivered by intracerebral microinfusion is safe and efficacious against malignant gliomas in rats","volume":"6","author":"Heimberger","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2005.11.029_bib13","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/BF02994094","article-title":"Characterisation of urinary metabolites of temozolomide in humans and mice and evaluation of their cytotoxicity","volume":"27","author":"Tsang","year":"1990","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.canlet.2005.11.029_bib14","doi-asserted-by":"crossref","first-page":"7194","DOI":"10.1021\/jo970802l","article-title":"New synthetic routes to the antitumour drug temozolomide","volume":"62","author":"Wang","year":"1997","journal-title":"J. Org. Chem."},{"issue":"Suppl.","key":"10.1016\/j.canlet.2005.11.029_bib15","first-page":"26","article-title":"Soluble prodrugs of the anticancer drugs temozolomide and mitozolomide","volume":"51","author":"Rathbone","year":"1999","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.canlet.2005.11.029_bib16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0378-5173(95)04327-6","article-title":"Transdermal delivery of 5-fluorouracil (5-FU) by 1-alkylcarbonyl-5-FU prodrugs","volume":"129","author":"Beall","year":"1996","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.canlet.2005.11.029_bib17","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1023\/B:PHAM.0000029281.12753.25","article-title":"Topical delivery of a model phenolic drug: alkyloxycarbonyl prodrugs of acetaminophen","volume":"21","author":"Waston","year":"2004","journal-title":"Pharm. Res."},{"key":"10.1016\/j.canlet.2005.11.029_bib18","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s002800050607","article-title":"Tissue distribution of transdermal toremifene","volume":"39","author":"Soe","year":"1997","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.canlet.2005.11.029_bib19","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/BF00735925","article-title":"Topical toremifene\u2014a new approach for cutaneous melanoma","volume":"32","author":"Maenpaa","year":"1993","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.canlet.2005.11.029_bib20","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.3109\/03639048509059861","article-title":"Long-term permeation kinetics of estradiol: (III) kinetic analyses of the simultaneous skin permeation and bioconversion of estradiol esters","volume":"11","author":"Valia","year":"1985","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.canlet.2005.11.029_bib21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0928-0987(01)00167-1","article-title":"Novel mechanisms and devices to enable successful transdermal drug delivery","volume":"14","author":"Barry","year":"2001","journal-title":"Eur J. Pharm. Sci."},{"key":"10.1016\/j.canlet.2005.11.029_bib22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/jm00385a018","article-title":"Antitumor imidazotetrazines. 14. synthesis and antitumor activity of 6- and 8-substituted imidazo[5,1-d]-1,2,3,5-tetrazinones and 8-substituted pyrazolo[5,1-d]-1,2,3,5-tetrazinones","volume":"30","author":"Lunt","year":"1987","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.canlet.2005.11.029_bib23","doi-asserted-by":"crossref","first-page":"9045","DOI":"10.1021\/bi00197a003","article-title":"NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA","volume":"33","author":"Denny","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.canlet.2005.11.029_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0304-3835(02)00343-9","article-title":"Immunophenotypical markers, ultrastructure and chemosensitivity profile of metastatic melanoma cells","volume":"86","author":"Prignano","year":"2002","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2005.11.029_bib25","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1023\/A:1010996513458","article-title":"Probing the effect of vehicles on topical delivery: understanding the relationship between solvent and solute parameters using silicone membranes","volume":"18","author":"Cross","year":"2001","journal-title":"Pharm. Res."},{"key":"10.1016\/j.canlet.2005.11.029_bib26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0168-3659(87)90066-6","article-title":"Mode of action of penetration enhancers in human skin","volume":"6","author":"Barry","year":"1987","journal-title":"J. Control. Release"},{"key":"10.1016\/j.canlet.2005.11.029_bib27","first-page":"61","article-title":"Animal models for transdermal delivery","volume":"vol. 1","author":"Wester","year":"1987"},{"key":"10.1016\/j.canlet.2005.11.029_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0168-3659(01)00439-4","article-title":"Comparison of the effect of fatty alcohols on the permeation of melatonin between porcine and human skin","volume":"77","author":"Andega","year":"2001","journal-title":"J. Control. Release"},{"key":"10.1016\/j.canlet.2005.11.029_bib29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0939-6411(97)00060-X","article-title":"Bioconversion of estradiol esters in the skin of various animal models in vitro","volume":"43","author":"Yamada","year":"1997","journal-title":"Eur J. Pharm. Biopharm."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030438350501030X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030438350501030X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T10:41:28Z","timestamp":1555324888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030438350501030X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S030438350501030X"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2005.11.029","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}