{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:29:04Z","timestamp":1791120544572,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.canlet.2008.02.031","type":"journal-article","created":{"date-parts":[[2008,3,25]],"date-time":"2008-03-25T17:46:11Z","timestamp":1206467171000},"page":"53-59","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":342,"title":["Reactive oxygen species in tumor metastasis"],"prefix":"10.1016","volume":"266","author":[{"given":"Makiya","family":"Nishikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2008.02.031_bib1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2008.02.031_bib2","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1007\/s004320000148","article-title":"Mechanisms of tumor metastasis: cell biological aspects and clinical implications","volume":"126","author":"Engers","year":"2000","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.canlet.2008.02.031_bib3","doi-asserted-by":"crossref","first-page":"6524","DOI":"10.1038\/sj.onc.1206757","article-title":"Axis of evil: molecular mechanisms of cancer metastasis","volume":"22","author":"Bogenrieder","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2008.02.031_bib4","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2006.11.001","article-title":"Cancer metastasis: building a framework","volume":"127","author":"Gupta","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2008.02.031_bib5","first-page":"598","article-title":"Free radicals, antioxidants, and human disease: where are we now?","volume":"119","author":"Halliwell","year":"1992","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.canlet.2008.02.031_bib6","first-page":"1890s","article-title":"Reactive oxygen species in tumorigenesis","volume":"54","author":"Feig","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.02.031_bib7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF00207507","article-title":"Cancer risk and oxidative DNA damage in man","volume":"74","author":"Loft","year":"1996","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.canlet.2008.02.031_bib8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0005-2728(99)00011-0","article-title":"Cardioselective and cumulative oxidation of mitochondrial DNA following subchronic doxorubicin administration","volume":"1411","author":"Serrano","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2008.02.031_bib9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S1535-6108(04)00115-1","article-title":"Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules","volume":"5","author":"Moeller","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2008.02.031_bib10","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1096\/fasebj.10.7.8635688","article-title":"Antioxidant and redox regulation of gene transcription","volume":"10","author":"Sen","year":"1996","journal-title":"FASEB J."},{"key":"10.1016\/j.canlet.2008.02.031_bib11","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0891-5849(96)00275-4","article-title":"Oxidants as stimulators of signal transduction","volume":"22","author":"Suzuki","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.canlet.2008.02.031_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Droge","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.canlet.2008.02.031_bib13","first-page":"794","article-title":"Production of large amounts of hydrogen peroxide by human tumor cells","volume":"51","author":"Szatrowski","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.02.031_bib14","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1172\/JCI107236","article-title":"Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent","volume":"52","author":"Babior","year":"1973","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.canlet.2008.02.031_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1056\/NEJM198007033030109","article-title":"Release of inflammatory mediators from stimulated neutrophils","volume":"303","author":"Weissmann","year":"1980","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2008.02.031_bib16","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nri1415","article-title":"Inflammation and necrosis promote tumour growth","volume":"4","author":"Vakkila","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.canlet.2008.02.031_bib17","first-page":"2759","article-title":"A preliminary study of the superoxide dismutase content of some human tumors","volume":"38","author":"Sykes","year":"1978","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.02.031_bib18","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1158\/0008-5472.948.65.3","article-title":"Controlling tumor growth by modulating endogenous production of reactive oxygen species","volume":"65","author":"Laurent","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.02.031_bib19","first-page":"525","article-title":"Antioxidant enzyme levels in cancer","volume":"12","author":"Oberley","year":"1997","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.canlet.2008.02.031_bib20","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/carcin\/14.8.1505","article-title":"Depression of catalase gene expression after immortalization and transformation of mouse liver cells","volume":"14","author":"Sun","year":"1993","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2008.02.031_bib21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0304-3835(01)00656-5","article-title":"Attenuation of catalase activity in the malignant phenotype plays a functional role in an in vitro model for tumor progression","volume":"173","author":"Gupta","year":"2001","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2008.02.031_bib22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1006\/geno.1994.1273","article-title":"Complete cDNA and 5\u2032 genomic sequences and multilevel regulation of the mouse catalase gene","volume":"21","author":"Reimer","year":"1994","journal-title":"Genomics"},{"key":"10.1016\/j.canlet.2008.02.031_bib23","first-page":"1190","article-title":"Liver and blood cell catalase activity of tumor-bearing mice","volume":"32","author":"Kaplan","year":"1972","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.02.031_bib24","first-page":"283","article-title":"The liver catalase activity of tumor-bearing rats and the effect of extirpation of the tumors","volume":"2","author":"Greenstein","year":"1941","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.canlet.2008.02.031_bib25","first-page":"3990","article-title":"Tumor necrosis factor\/cachectin decreases catalase activity of rat liver","volume":"51","author":"Yasmineh","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.02.031_bib26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0014-5793(97)00805-3","article-title":"TNF-\u03b1 downregulates the peroxisome proliferator activated receptor-\u03b1 and the mRNAs encoding peroxisomal proteins in rat liver","volume":"412","author":"Beier","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.canlet.2008.02.031_bib27","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1593\/neo.04127","article-title":"Transcriptional repression of catalase in mouse skin tumor progression","volume":"6","author":"Kwei","year":"2004","journal-title":"Neoplasia"},{"key":"10.1016\/j.canlet.2008.02.031_bib28","first-page":"151","article-title":"Recognition and destruction of neoplastic cells by activated macrophages: discrimination of altered self","volume":"948","author":"Fidler","year":"1988","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2008.02.031_bib29","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/sj.bjc.6690118","article-title":"Induction of reactive oxygen intermediates in human monocytes by tumour cells and their role in spontaneous monocyte cytotoxicity","volume":"79","author":"Mytar","year":"1999","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2008.02.031_bib30","first-page":"2287","article-title":"Involvement of pattern recognition receptors in the induction of cytokines and reactive oxygen intermediates production by human monocytes\/macrophages stimulated with tumour cells","volume":"24","author":"Mytar","year":"2004","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2008.02.031_bib31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cell.2006.01.007","article-title":"Macrophages: obligate partners for tumor cell migration, invasion, and metastasis","volume":"124","author":"Condeelis","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2008.02.031_bib32","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1042\/bj2630539","article-title":"Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha","volume":"263","author":"Meier","year":"1989","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2008.02.031_bib33","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1432-1033.1990.tb19222.x","article-title":"Biologically active products of stimulated liver macrophages (Kupffer cells)","volume":"192","author":"Decker","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.canlet.2008.02.031_bib34","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/hep.510230542","article-title":"Role of Kupffer cells in arresting circulating tumor cells and controlling metastatic growth in the liver","volume":"23","author":"Bayon","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2008.02.031_bib35","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1470-2045(02)00789-1","article-title":"Platelets and cancer","volume":"3","author":"Nash","year":"2002","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canlet.2008.02.031_bib36","doi-asserted-by":"crossref","first-page":"7685","DOI":"10.1158\/1078-0432.CCR-04-1020","article-title":"Inhibition of metastatic tumor growth in mouse lung by repeated administration of polyethylene glycol-conjugated catalase: quantitative analysis with firefly luciferase-expressing melanoma cells","volume":"10","author":"Hyoudou","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2008.02.031_bib37","doi-asserted-by":"crossref","first-page":"G15","DOI":"10.1152\/ajpgi.00342.2002","article-title":"Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning","volume":"284","author":"Jaeschke","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.canlet.2008.02.031_bib38","first-page":"1825","article-title":"Reactive nitrogen and oxygen radicals formed during hepatic ischemia-reperfusion kill weakly metastatic colorectal cancer cells","volume":"59","author":"Jessup","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.02.031_bib39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.drup.2004.01.004","article-title":"ROS stress in cancer cells and therapeutic implications","volume":"7","author":"Pelicano","year":"2004","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.canlet.2008.02.031_bib40","first-page":"666","article-title":"Tumor-targeting chemotherapy by a xanthine oxidase\u2013polymer conjugate that generates oxygen-free radicals in tumor tissue","volume":"60","author":"Sawa","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.02.031_bib41","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1158\/1535-7163.MCT-06-0596","article-title":"Radiation-induced cell signaling: inside-out and outside-in","volume":"6","author":"Valerie","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.canlet.2008.02.031_bib42","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/bj2960341","article-title":"Cytotoxicity of nitric oxide in Fu5 rat hepatoma cells: evidence for co-operative action with hydrogen peroxide","volume":"296","author":"Ioannidis","year":"1993","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2008.02.031_bib43","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0009-3084(87)90049-1","article-title":"Biophysical consequences of lipid peroxidation in membranes","volume":"44","author":"Richter","year":"1987","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.canlet.2008.02.031_bib44","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0891-5849(94)00198-S","article-title":"Superoxide and hydrogen peroxide in relation to mammalian cell proliferation","volume":"18","author":"Burdon","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.canlet.2008.02.031_bib45","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1126\/science.275.5306.1649","article-title":"Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts","volume":"275","author":"Irani","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.canlet.2008.02.031_bib46","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1158\/1078-0432.CCR-06-2082","article-title":"Reactive oxygen species: a breath of life or death?","volume":"13","author":"Fruehauf","year":"2007","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.canlet.2008.02.031_bib47","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1161\/01.RES.85.6.524","article-title":"Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells","volume":"85","author":"Brown","year":"1999","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.canlet.2008.02.031_bib48","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.1073\/pnas.101505898","article-title":"Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1","volume":"98","author":"Arnold","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2008.02.031_bib49","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/1074-5521(95)90076-4","article-title":"The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-\u03baB","volume":"2","author":"Schmidt","year":"1995","journal-title":"Chem. Biol."},{"key":"10.1016\/j.canlet.2008.02.031_bib50","doi-asserted-by":"crossref","first-page":"25869","DOI":"10.1074\/jbc.274.36.25869","article-title":"Stable overexpression of manganese superoxide dismutase in mitochondria identifies hydrogen peroxide as a major oxidant in the AP-1-mediated induction of matrix-degrading metalloprotease-1","volume":"274","author":"Wenk","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2008.02.031_bib51","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0891-5849(99)00242-7","article-title":"Oxidative stress and gene regulation","volume":"28","author":"Allen","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.canlet.2008.02.031_bib52","first-page":"533","article-title":"Increased expression of activated matrix metalloproteinase-2 by human endothelial cells after sublethal H2O2 exposure","volume":"77","author":"Belkhiri","year":"1997","journal-title":"Lab. Invest."},{"key":"10.1016\/j.canlet.2008.02.031_bib53","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/1040-8428(94)00144-I","article-title":"Epidermal growth factor-related peptides and their receptors in human malignancies","volume":"19","author":"Salomon","year":"1995","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.canlet.2008.02.031_bib54","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.freeradbiomed.2006.08.004","article-title":"PEGylated catalase prevents metastatic tumor growth aggravated by tumor removal","volume":"41","author":"Hyoudou","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.canlet.2008.02.031_bib55","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1517\/17425247.3.3.355","article-title":"Inhibition of tumour metastasis by targeted delivery of antioxidant enzymes","volume":"3","author":"Nishikawa","year":"2006","journal-title":"Expert Opin. Drug Deliv."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030438350800147X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030438350800147X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:28:14Z","timestamp":1759591694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030438350800147X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S030438350800147X"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2008.02.031","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reactive oxygen species in tumor metastasis","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2008.02.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}