{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:39:02Z","timestamp":1761237542290},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.canlet.2008.04.008","type":"journal-article","created":{"date-parts":[[2008,5,20]],"date-time":"2008-05-20T09:03:00Z","timestamp":1211274180000},"page":"252-259","source":"Crossref","is-referenced-by-count":12,"title":["Heparanase promotes bone destruction and invasiveness in prostate cancer"],"prefix":"10.1016","volume":"268","author":[{"given":"Yu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-jun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Luan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tie-jun","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-gang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2008.04.008_bib1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3322\/canjclin.55.1.10","article-title":"Cancer statistics","volume":"55","author":"Jemal","year":"2005","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.canlet.2008.04.008_bib2","first-page":"1391","article-title":"Changing constituents of genitourinary cancer in recent 50 years in Beijing","volume":"116","author":"Gu","year":"2003","journal-title":"Chin. Med. J. (Engl.)"},{"key":"10.1016\/j.canlet.2008.04.008_bib3","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1053\/hp.2000.6698","article-title":"Metastatic patterns of prostate cancer: an autopsy study of 1589 patients","volume":"31","author":"Bubendorf","year":"2000","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.canlet.2008.04.008_bib4","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1056\/NEJMra030831","article-title":"Mechanisms of bone metastasis","volume":"350","author":"Roodman","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2008.04.008_bib5","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1146\/annurev.biochem.68.1.729","article-title":"Functions of cell surface heparan sulfate proteoglycans","volume":"68","author":"Bernfield","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.canlet.2008.04.008_bib6","doi-asserted-by":"crossref","first-page":"10031","DOI":"10.1073\/pnas.152070599","article-title":"Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis","volume":"99","author":"Goldshmidt","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2008.04.008_bib7","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/jnci\/djh230","article-title":"Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis","volume":"96","author":"Edovitsky","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.canlet.2008.04.008_bib8","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1002\/ijc.21552","article-title":"Heparanase promotes growth, angiogenesis and survival of primary breast tumors","volume":"118","author":"Cohen","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2008.04.008_bib9","first-page":"8749","article-title":"High heparanase activity in multiple myeloma is associated with elevated microvessel density","volume":"63","author":"Kelly","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.04.008_bib10","first-page":"4655","article-title":"Heparanase expression in primary and metastatic pancreatic cancer","volume":"61","author":"Koliopanos","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.04.008_bib11","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/S0022-5347(05)65754-0","article-title":"Heparanase protein and gene expression in bladder cancer","volume":"166","author":"Gohji","year":"2001","journal-title":"J. Urol."},{"key":"10.1016\/j.canlet.2008.04.008_bib12","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/S0959-8049(03)00457-X","article-title":"Heparanase-1 gene expression in normal, hyperplastic and neoplastic prostatic tissue","volume":"39","author":"Stadlmann","year":"2003","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.canlet.2008.04.008_bib13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.matbio.2004.08.004","article-title":"Heparan sulfate proteoglycans and heparanase-partners in osteolytic tumor growth and metastasis","volume":"23","author":"Sanderson","year":"2004","journal-title":"Matrix Biol."},{"key":"10.1016\/j.canlet.2008.04.008_bib14","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.1158\/0008-5472.CAN-05-0749","article-title":"Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases","volume":"65","author":"Kelly","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.04.008_bib15","doi-asserted-by":"crossref","first-page":"8229","DOI":"10.1021\/jm050618p","article-title":"Synthesis, biological activity, and preliminary pharmacokinetic evaluation of analogues of a phosphosulfomannan angiogenesis inhibitor (PI-88)","volume":"48","author":"Karoli","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.canlet.2008.04.008_bib16","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1158\/1535-7163.1069.3.9","article-title":"Structure-based design of a selective heparanase inhibitor as an antimetastatic agent","volume":"3","author":"Ishida","year":"2004","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.canlet.2008.04.008_bib17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ijc.10930","article-title":"Inhibition of heparanase activity and heparanase-induced angiogenesis by suramin analogues","volume":"104","author":"Marchetti","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2008.04.008_bib18","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1038\/sj.onc.1208602","article-title":"A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer","volume":"24","author":"Joyce","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2008.04.008_bib19","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1158\/1078-0432.CCR-05-2423","article-title":"A phase I biological and pharmacologic study of the heparanase inhibitor PI-88 in patients with advanced solid tumors","volume":"12","author":"Basche","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2008.04.008_bib20","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1182\/blood-2004-06-2141","article-title":"Heparanase promotes the spontaneous metastasis of myeloma cells to bone","volume":"105","author":"Yang","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2008.04.008_bib21","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/jcp.20625","article-title":"Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass","volume":"207","author":"Kram","year":"2006","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.canlet.2008.04.008_bib22","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1158\/0008-5472.CAN-03-2968","article-title":"Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype","volume":"64","author":"Wang","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.04.008_bib23","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.orthres.2005.05.004.1100230634","article-title":"The effects of RANK blockade and osteoclast depletion in a model of pure osteoblastic prostate cancer metastasis in bone","volume":"23","author":"Whang","year":"2005","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.canlet.2008.04.008_bib24","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1158\/1535-7163.MCT-05-0313","article-title":"A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model","volume":"5","author":"Ohno","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.canlet.2008.04.008_bib25","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/sj.bjc.6600232","article-title":"Heparanase expression is a prognostic indicator for postoperative survival in pancreatic adenocarcinoma","volume":"86","author":"Rohloff","year":"2002","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2008.04.008_bib26","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/01.LAB.0000067482.84946.BD","article-title":"Heparanase expression correlates with invasion and poor prognosis in gastric cancers","volume":"83","author":"Takaoka","year":"2003","journal-title":"Lab. Invest."},{"key":"10.1016\/j.canlet.2008.04.008_bib27","doi-asserted-by":"crossref","first-page":"12665","DOI":"10.1016\/S0021-9258(18)67143-1","article-title":"Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin\u2013sepharose","volume":"261","author":"Hauschka","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2008.04.008_bib28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/pros.10050","article-title":"Human prostatic carcinoma cells produce an increase in the synthesis of interleukin-6 by human osteoblasts","volume":"50","author":"Garc\u00eda-Moreno","year":"2002","journal-title":"Prostate"},{"key":"10.1016\/j.canlet.2008.04.008_bib29","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1359\/jbmr.2001.16.6.1077","article-title":"Monitoring metastatic behavior of human tumor cells in mice with species-specific polymerase chain reaction: elevated expression of angiogenesis and bone resorption stimulators by breast cancer in bone metastases","volume":"16","author":"van der Pluijm","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.canlet.2008.04.008_bib30","doi-asserted-by":"crossref","first-page":"10921","DOI":"10.1158\/0008-5472.CAN-05-1809","article-title":"Vascular endothelial growth factor contributes to prostate cancer-mediated osteoblastic activity","volume":"65","author":"Kitagawa","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.04.008_bib31","doi-asserted-by":"crossref","first-page":"7548","DOI":"10.1158\/0008-5472.CAN-06-0452","article-title":"The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells","volume":"66","author":"Sterling","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.04.008_bib32","doi-asserted-by":"crossref","first-page":"9065","DOI":"10.1158\/0008-5472.CAN-06-0317","article-title":"Extracellular calcium as a candidate mediator of prostate cancer skeletal metastasis","volume":"66","author":"Liao","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2008.04.008_bib33","first-page":"917","article-title":"Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer","volume":"62","author":"Yi","year":"2002","journal-title":"Cancer Res."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383508002802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383508002802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:46:44Z","timestamp":1684414004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383508002802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0304383508002802"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2008.04.008","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}