{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:25:46Z","timestamp":1767626746656},"reference-count":76,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.canlet.2008.05.012","type":"journal-article","created":{"date-parts":[[2008,6,25]],"date-time":"2008-06-25T09:49:13Z","timestamp":1214387353000},"page":"12-22","source":"Crossref","is-referenced-by-count":17,"title":["New paradigms for the function of JNKK1\/MKK4 in controlling growth of disseminated cancer cells"],"prefix":"10.1016","volume":"272","author":[{"given":"Jennifer L.","family":"Taylor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell Z.","family":"Szmulewitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Lotan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Hickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald Vander","family":"Griend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiko Diane","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay","family":"Macleod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie W.","family":"Rinker-Schaeffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.canlet.2008.05.012_bib1","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nm1469","article-title":"Tumor metastasis: mechanistic insights and clinical challenges","volume":"12","author":"Steeg","year":"2006","journal-title":"Nat. Med."},{"issue":"13","key":"10.1016\/j.canlet.2008.05.012_bib2","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1158\/1078-0432.CCR-06-1014","article-title":"Metastasis suppressor proteins: discovery, molecular mechanisms, and clinical application","volume":"12","author":"Rinker-Schaeffer","year":"2006","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2008.05.012_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrc967","article-title":"Metastasis suppressors alter the signal transduction of cancer cells","volume":"3","author":"Steeg","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.canlet.2008.05.012_bib4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/jnci\/80.3.200","article-title":"Evidence for a novel gene associated with low tumor metastatic potential","volume":"80","author":"Steeg","year":"1988","journal-title":"J. Natl. Cancer Inst."},{"issue":"3\u20134","key":"10.1016\/j.canlet.2008.05.012_bib5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10863-006-9039-9","article-title":"Translational approaches using metastasis suppressor genes","volume":"38","author":"Palmieri","year":"2006","journal-title":"J. Bioenerg. Biomembr."},{"issue":"4","key":"10.1016\/j.canlet.2008.05.012_bib6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/(SICI)1097-0045(19971201)33:4<271::AID-PROS8>3.0.CO;2-K","article-title":"Localization of prostate cancer metastasis-suppressor activity on human chromosome 17","volume":"33","author":"Chekmareva","year":"1997","journal-title":"Prostate"},{"issue":"23","key":"10.1016\/j.canlet.2008.05.012_bib7","doi-asserted-by":"crossref","first-page":"10984","DOI":"10.1158\/0008-5472.CAN-05-2382","article-title":"Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1\/MKK4 and MKK7","volume":"65","author":"Vander Griend","year":"2005","journal-title":"Cancer Res."},{"issue":"22","key":"10.1016\/j.canlet.2008.05.012_bib8","first-page":"6717","article-title":"Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma","volume":"62","author":"Yamada","year":"2002","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.canlet.2008.05.012_bib9","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1158\/0008-5472.CAN-05-3676","article-title":"The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma","volume":"66","author":"Hickson","year":"2006","journal-title":"Cancer Res."},{"issue":"6824","key":"10.1016\/j.canlet.2008.05.012_bib10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/35065000","article-title":"Mammalian MAP kinase signalling cascades","volume":"410","author":"Chang","year":"2001","journal-title":"Nature"},{"issue":"5208","key":"10.1016\/j.canlet.2008.05.012_bib11","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1126\/science.7716521","article-title":"Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2","volume":"268","author":"Lin","year":"1995","journal-title":"Science"},{"issue":"5198","key":"10.1016\/j.canlet.2008.05.012_bib12","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.7839144","article-title":"Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms","volume":"267","author":"Derijard","year":"1995","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.canlet.2008.05.012_bib13","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1073\/pnas.94.7.3004","article-title":"Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity","volume":"94","author":"Yang","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6614","key":"10.1016\/j.canlet.2008.05.012_bib14","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/385350a0","article-title":"Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3","volume":"385","author":"Nishina","year":"1997","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.canlet.2008.05.012_bib15","doi-asserted-by":"crossref","first-page":"6881","DOI":"10.1073\/pnas.95.12.6881","article-title":"SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis","volume":"95","author":"Ganiatsas","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"40","key":"10.1016\/j.canlet.2008.05.012_bib16","doi-asserted-by":"crossref","first-page":"24994","DOI":"10.1074\/jbc.272.40.24994","article-title":"MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous","volume":"272","author":"Holland","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.canlet.2008.05.012_bib17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-5793(97)00990-3","article-title":"SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1\/JNK)","volume":"414","author":"Lawler","year":"1997","journal-title":"FEBS Lett."},{"issue":"40","key":"10.1016\/j.canlet.2008.05.012_bib18","doi-asserted-by":"crossref","first-page":"24751","DOI":"10.1074\/jbc.272.40.24751","article-title":"Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38","volume":"272","author":"Lu","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"23","key":"10.1016\/j.canlet.2008.05.012_bib19","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1093\/emboj\/16.23.7045","article-title":"A novel SAPK\/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses","volume":"16","author":"Moriguchi","year":"1997","journal-title":"EMBO J."},{"issue":"14","key":"10.1016\/j.canlet.2008.05.012_bib20","doi-asserted-by":"crossref","first-page":"7337","DOI":"10.1073\/pnas.94.14.7337","article-title":"Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase","volume":"94","author":"Tournier","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.canlet.2008.05.012_bib21","doi-asserted-by":"crossref","first-page":"7407","DOI":"10.1128\/MCB.17.12.7407","article-title":"Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase","volume":"17","author":"Wu","year":"1997","journal-title":"Mol. Cell. Biol."},{"issue":"51","key":"10.1016\/j.canlet.2008.05.012_bib22","doi-asserted-by":"crossref","first-page":"32378","DOI":"10.1074\/jbc.272.51.32378","article-title":"Activation of stress-activated protein kinases\/c-Jun N-terminal protein kinases (SAPKs\/JNKs) by a novel mitogen-activated protein kinase kinase","volume":"272","author":"Yao","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"15","key":"10.1016\/j.canlet.2008.05.012_bib23","doi-asserted-by":"crossref","first-page":"9344","DOI":"10.1074\/jbc.273.15.9344","article-title":"Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase\/stress-activated protein kinase (JNK\/SAPK) activated by environmental stresses and physiological stimuli","volume":"273","author":"Foltz","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"6782","key":"10.1016\/j.canlet.2008.05.012_bib24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/35011091","article-title":"JNK is required for effector T-cell function but not for T-cell activation","volume":"405","author":"Dong","year":"2000","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.canlet.2008.05.012_bib25","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1101\/gad.888501","article-title":"MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines","volume":"15","author":"Tournier","year":"2001","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/j.canlet.2008.05.012_bib26","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0955-0674(00)00140-X","article-title":"Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth","volume":"12","author":"Ossowski","year":"2000","journal-title":"Curr. Opin. Cell Biol."},{"issue":"16","key":"10.1016\/j.canlet.2008.05.012_bib27","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1038\/sj.onc.1205342","article-title":"Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo","volume":"21","author":"Aguirre Ghiso","year":"2002","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.canlet.2008.05.012_bib28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ng1317","article-title":"Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway","volume":"36","author":"Bulavin","year":"2004","journal-title":"Nat. Genet."},{"issue":"11","key":"10.1016\/j.canlet.2008.05.012_bib29","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nrc2256","article-title":"Models, mechanisms and clinical evidence for cancer dormancy","volume":"7","author":"Aguirre-Ghiso","year":"2007","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.canlet.2008.05.012_bib30","first-page":"1684","article-title":"ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK)","volume":"63","author":"Aguirre-Ghiso","year":"2003","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.canlet.2008.05.012_bib31","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1091\/mbc.12.4.863","article-title":"Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo","volume":"12","author":"Aguirre-Ghiso","year":"2001","journal-title":"Mol. Biol. Cell"},{"issue":"16","key":"10.1016\/j.canlet.2008.05.012_bib32","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1101\/gad.1107303","article-title":"Mechanism of p38 MAP kinase activation in vivo","volume":"17","author":"Brancho","year":"2003","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.canlet.2008.05.012_bib33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0955-0674(98)80143-9","article-title":"Signal transduction by the c-Jun N-terminal kinase (JNK) \u2013 from inflammation to development","volume":"10","author":"Ip","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"issue":"1","key":"10.1016\/j.canlet.2008.05.012_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/bies.10204","article-title":"Activation of the JNK signaling pathway: breaking the brake on apoptosis","volume":"25","author":"Lin","year":"2003","journal-title":"Bioessays"},{"issue":"1","key":"10.1016\/j.canlet.2008.05.012_bib35","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/sj.cr.7290262","article-title":"Role of JNK activation in apoptosis: a double-edged sword","volume":"15","author":"Liu","year":"2005","journal-title":"Cell Res."},{"issue":"5240","key":"10.1016\/j.canlet.2008.05.012_bib36","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","article-title":"Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis","volume":"270","author":"Xia","year":"1995","journal-title":"Science"},{"issue":"5467","key":"10.1016\/j.canlet.2008.05.012_bib37","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1126\/science.288.5467.870","article-title":"Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway","volume":"288","author":"Tournier","year":"2000","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.canlet.2008.05.012_bib38","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0092-8674(04)00166-7","article-title":"Tumor necrosis factor: an apoptosis JuNKie?","volume":"116","author":"Varfolomeev","year":"2004","journal-title":"Cell"},{"issue":"25","key":"10.1016\/j.canlet.2008.05.012_bib39","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1038\/sj.onc.1202569","article-title":"The inhibitors of apoptosis (IAPs) and their emerging role in cancer","volume":"17","author":"LaCasse","year":"1998","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.canlet.2008.05.012_bib40","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1073\/pnas.0438011100","article-title":"JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis","volume":"100","author":"Lei","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.canlet.2008.05.012_bib41","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cell.2006.01.021","article-title":"The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover","volume":"124","author":"Chang","year":"2006","journal-title":"Cell"},{"issue":"6861","key":"10.1016\/j.canlet.2008.05.012_bib42","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/35104568","article-title":"Inhibition of JNK activation through NF-kappaB target genes","volume":"414","author":"Tang","year":"2001","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.canlet.2008.05.012_bib43","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.devcel.2006.02.006","article-title":"A five-year itch in TNF-alpha cytotoxicity: the time factor determines JNK action","volume":"10","author":"Lin","year":"2006","journal-title":"Dev. Cell"},{"issue":"6833","key":"10.1016\/j.canlet.2008.05.012_bib44","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/35075107","article-title":"Initiation of a G2\/M checkpoint after ultraviolet radiation requires p38 kinase","volume":"411","author":"Bulavin","year":"2001","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.canlet.2008.05.012_bib45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.molcel.2004.11.021","article-title":"MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2\/M transition and S phase progression in response to UV irradiation","volume":"17","author":"Manke","year":"2005","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.canlet.2008.05.012_bib46","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ccr.2006.12.013","article-title":"p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis","volume":"11","author":"Dolado","year":"2007","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.canlet.2008.05.012_bib47","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ccr.2006.11.024","article-title":"p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK\/MK2 pathway for survival after DNA damage","volume":"11","author":"Reinhardt","year":"2007","journal-title":"Cancer Cell"},{"issue":"19","key":"10.1016\/j.canlet.2008.05.012_bib48","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1038\/sj.onc.1204383","article-title":"AP-1 in cell proliferation and survival","volume":"20","author":"Shaulian","year":"2001","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.canlet.2008.05.012_bib49","doi-asserted-by":"crossref","first-page":"E131","DOI":"10.1038\/ncb0502-e131","article-title":"AP-1 as a regulator of cell life and death","volume":"4","author":"Shaulian","year":"2002","journal-title":"Nat. Cell Biol."},{"issue":"19","key":"10.1016\/j.canlet.2008.05.012_bib50","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1038\/sj.onc.1204239","article-title":"Distinct roles of Jun: Fos and Jun: ATF dimers in oncogenesis","volume":"20","author":"van Dam","year":"2001","journal-title":"Oncogene"},{"issue":"19","key":"10.1016\/j.canlet.2008.05.012_bib51","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1038\/sj.onc.1204443","article-title":"Jun, the oncoprotein","volume":"20","author":"Vogt","year":"2001","journal-title":"Oncogene"},{"issue":"10","key":"10.1016\/j.canlet.2008.05.012_bib52","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s001090050063","article-title":"Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways","volume":"74","author":"Whitmarsh","year":"1996","journal-title":"J. Mol. Med."},{"issue":"34","key":"10.1016\/j.canlet.2008.05.012_bib53","doi-asserted-by":"crossref","first-page":"20608","DOI":"10.1074\/jbc.271.34.20608","article-title":"Cyclin D1 expression is regulated positively by the p42\/p44MAPK and negatively by the p38\/HOGMAPK pathway","volume":"271","author":"Lavoie","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.canlet.2008.05.012_bib54","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/1097-0215(20001015)88:2<180::AID-IJC6>3.0.CO;2-H","article-title":"Alterations in the gene expression profile of MCF-7 breast tumor cells in response to c-Jun","volume":"88","author":"Rinehart-Kim","year":"2000","journal-title":"Int. J. Cancer"},{"issue":"4","key":"10.1016\/j.canlet.2008.05.012_bib55","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.molcel.2004.10.024","article-title":"Identification of promoters bound by c-Jun\/ATF2 during rapid large-scale gene activation following genotoxic stress","volume":"16","author":"Hayakawa","year":"2004","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.canlet.2008.05.012_bib56","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/ncb1098","article-title":"MKK7 couples stress signalling to G2\/M cell-cycle progression and cellular senescence","volume":"6","author":"Wada","year":"2004","journal-title":"Nat. Cell Biol."},{"issue":"22","key":"10.1016\/j.canlet.2008.05.012_bib57","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1038\/sj.onc.1210410","article-title":"Role of mitogen-activated protein kinase kinase 4 in cancer","volume":"26","author":"Whitmarsh","year":"2007","journal-title":"Oncogene"},{"issue":"19","key":"10.1016\/j.canlet.2008.05.012_bib58","first-page":"4177","article-title":"Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor","volume":"57","author":"Teng","year":"1997","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2008.05.012_bib59","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/humu.9002","article-title":"Mutation rate of MAP2K4\/MKK4 in breast carcinoma","volume":"19","author":"Su","year":"2002","journal-title":"Hum. Mutat."},{"issue":"11","key":"10.1016\/j.canlet.2008.05.012_bib60","first-page":"2339","article-title":"and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene","volume":"58","author":"Su","year":"1998","journal-title":"Cancer Res."},{"issue":"24","key":"10.1016\/j.canlet.2008.05.012_bib61","doi-asserted-by":"crossref","first-page":"8516","DOI":"10.1158\/1078-0432.CCR-04-0885","article-title":"MAP2K4\/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course","volume":"10","author":"Xin","year":"2004","journal-title":"Clin. Cancer Res."},{"issue":"11","key":"10.1016\/j.canlet.2008.05.012_bib62","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1001\/archsurg.141.11.1095","article-title":"MKK4 status predicts survival after resection of gastric adenocarcinoma","volume":"141","author":"Cunningham","year":"2006","journal-title":"Arch. Surg."},{"issue":"3","key":"10.1016\/j.canlet.2008.05.012_bib63","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00432-004-0629-9","article-title":"Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases","volume":"131","author":"Stark","year":"2005","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.canlet.2008.05.012_bib64","first-page":"2833","article-title":"Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers","volume":"61","author":"Kim","year":"2001","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.canlet.2008.05.012_bib65","first-page":"199","article-title":"Role of JNK in tumor development","volume":"2","author":"Kennedy","year":"2003","journal-title":"Cell Cycle"},{"key":"10.1016\/j.canlet.2008.05.012_bib66","first-page":"7","article-title":"Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors","volume":"7","author":"Wang","year":"2004","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.canlet.2008.05.012_bib67","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.1158\/0008-5472.CAN-06-0555","article-title":"Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss","volume":"66","author":"Cunningham","year":"2006","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.canlet.2008.05.012_bib68","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/path.2194","article-title":"Up-regulation of MKK4, MKK6 and MKK7 during prostate cancer progression: an important role for SAPK signalling in prostatic neoplasia","volume":"212","author":"Lotan","year":"2007","journal-title":"J. Pathol."},{"issue":"7","key":"10.1016\/j.canlet.2008.05.012_bib69","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1158\/0008-5472.CAN-07-1568","article-title":"c-Jun NH2-terminal kinase activating kinase 1\/mitogen-activated protein kinase kinase 4-mediated inhibition of SKOV3ip.1 ovarian cancer metastasis involves growth arrest and p21 up-regulation","volume":"68","author":"Lotan","year":"2008","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.canlet.2008.05.012_bib70","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1083\/jcb.142.2.557","article-title":"E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1)","volume":"142","author":"St Croix","year":"1998","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.canlet.2008.05.012_bib71","first-page":"225","article-title":"Rapid phenotype variation in cells derived from lung metastases of KHT fibrosarcoma","volume":"4","author":"Chambers","year":"1984","journal-title":"Invasion Metastasis"},{"issue":"2","key":"10.1016\/j.canlet.2008.05.012_bib72","first-page":"91","article-title":"Therapeutic implications of tumor heterogeneity","volume":"16","author":"Heppner","year":"1989","journal-title":"Semin. Oncol."},{"issue":"9","key":"10.1016\/j.canlet.2008.05.012_bib73","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1093\/jnci\/81.9.648","article-title":"Tumor cell societies","volume":"81","author":"Heppner","year":"1989","journal-title":"J. Natl. Cancer Inst."},{"issue":"4652","key":"10.1016\/j.canlet.2008.05.012_bib74","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1126\/science.6719130","article-title":"Dynamic heterogeneity: rapid generation of metastatic variants in mouse B16 melanoma cells","volume":"224","author":"Hill","year":"1984","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.canlet.2008.05.012_bib75","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1158\/1541-7786.MCR-07-2075","article-title":"Map Kinase Kinase 4\/c-Jun NH2-terminal kinase kinase 1 (MKK4\/JNKK1) protein expression is subject to translational regulation in prostate cancer cell lines","volume":"6","author":"Robinson","year":"2008","journal-title":"Mol. Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2008.05.012_bib76","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1023\/A:1022586318678","article-title":"MKK4 and metastasis suppression: a marriage of signal transduction and metastasis research","volume":"20","author":"Robinson","year":"2003","journal-title":"Clin. Exp. Metastasis"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383508003868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383508003868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T17:23:04Z","timestamp":1545931384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383508003868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":76,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0304383508003868"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2008.05.012","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}