{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:30:47Z","timestamp":1768807847301,"version":"3.49.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30 ES00210"],"award-info":[{"award-number":["P30 ES00210"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA090890"],"award-info":[{"award-number":["CA090890"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA122959"],"award-info":[{"award-number":["CA122959"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA65525"],"award-info":[{"award-number":["CA65525"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.canlet.2009.03.026","type":"journal-article","created":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T04:35:43Z","timestamp":1240202143000},"page":"36-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Activator protein 2\u03b1 suppresses intestinal tumorigenesis in the Apcmin mouse"],"prefix":"10.1016","volume":"283","author":[{"given":"Qingjie","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane V.","family":"L\u00f6hr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roderick H.","family":"Dashwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2009.03.026_bib1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/381238a0","article-title":"Neural tube skeletal and body wall defects in mice lacking transcription factor AP-2","volume":"381","author":"Zhang","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2009.03.026_bib2","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1101\/gad.8.11.1258","article-title":"N-ras oncogene causes AP-2 transcriptional self-interference which leads to transformation","volume":"8","author":"Kannan","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2009.03.026_bib3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/ng0197-78","article-title":"AP2 inhibits cancer cell growth and activates p21WAF1\/CIP1 expression","volume":"15","author":"Zeng","year":"1997","journal-title":"Nature Genet."},{"key":"10.1016\/j.canlet.2009.03.026_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/381235a0","article-title":"Transcription factor AP-2 essential for cranial closure and craniofacial development","volume":"381","author":"Schorle","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2009.03.026_bib5","doi-asserted-by":"crossref","first-page":"52093","DOI":"10.1074\/jbc.M305624200","article-title":"Cell cycle arrest and apoptosis induction by activator protein 2alpha (AP-2\u03b1) and the role of p53 and p21WAF1\/CIP1 in AP-2alpha-mediated growth inhibition","volume":"278","author":"Wajapeyee","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2009.03.026_bib6","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/(SICI)1096-9896(199912)189:4<514::AID-PATH463>3.0.CO;2-9","article-title":"Immunohistochemical analysis reveals a tumour suppressor-like role for the transcription factor AP-2 in invasive breast cancer","volume":"198","author":"Gee","year":"1999","journal-title":"J. Pathol."},{"key":"10.1016\/j.canlet.2009.03.026_bib7","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1136\/jcp.54.7.533","article-title":"Expression of transcription factor AP-2 in colorectal adenomas and adenocarcinomas; comparison of immunohistochemistry and in situ hybridisation","volume":"54","author":"Ropponen","year":"2001","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.canlet.2009.03.026_bib8","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1158\/0008-5472.CAN-03-2751","article-title":"Activator protein 2alpha inhibits tumorigenicity and represses vascular endothelial growth factor transcription in prostate cancer cells","volume":"64","author":"Ruiz","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2009.03.026_bib9","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1200\/JCO.1998.16.11.3584","article-title":"Downregulation of transcription factor AP-2 predicts poor survival in stage I cutaneous malignant melanoma","volume":"16","author":"Karjalainen","year":"1998","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2009.03.026_bib10","first-page":"1974","article-title":"Expression of transcription factor AP-2alpha predicts survival in epithelial ovarian cancer","volume":"82","author":"Anttila","year":"2000","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2009.03.026_bib11","doi-asserted-by":"crossref","first-page":"45669","DOI":"10.1074\/jbc.M405025200","article-title":"Activator protein 2alpha associates with adenomatous polyposis coli\/beta-catenin and Inhibits beta-catenin\/T-cell factor transcriptional activity in colorectal cancer cells","volume":"279","author":"Li","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2009.03.026_bib12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1136\/gut.2006.093310","article-title":"The canonical Wnt signalling pathway and its APC partner in colon cancer development","volume":"56","author":"Schneikert","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.canlet.2009.03.026_bib13","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1126\/science.2296722","article-title":"A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse","volume":"247","author":"Moser","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.canlet.2009.03.026_bib14","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1158\/0008-5472.CAN-05-3390","article-title":"In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor","volume":"66","author":"Yu","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2009.03.026_bib15","doi-asserted-by":"crossref","first-page":"29295","DOI":"10.1074\/jbc.M400580200","article-title":"Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin","volume":"279","author":"Wang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2009.03.026_bib16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/sj.gt.3301609","article-title":"Tumour cell radiosensitization using constitutive (CMV) and radiation inducible (WAF1) promoters to drive the iNOS gene: a novel suicide gene therapy","volume":"9","author":"Worthington","year":"2002","journal-title":"Gene Ther."},{"key":"10.1016\/j.canlet.2009.03.026_bib17","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1128\/MCB.21.8.2838-2846.2001","article-title":"The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver","volume":"21","author":"Zelko","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.canlet.2009.03.026_bib18","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/jsre.1997.5073","article-title":"Quantitation of in vivo gene delivery by restriction enzyme PCR generated polymorphism","volume":"69","author":"Fichera","year":"1997","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.canlet.2009.03.026_bib19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/carcin\/24.2.263","article-title":"Suppression of tumorigenesis in the Apcmin mouse: down-regulation of \u03b2-catenin signaling by a combination of tea plus sulindac","volume":"24","author":"Orner","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2009.03.026_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0027-5107(02)00158-6","article-title":"Response of Apcmin and A33\u0394N\u03b2-cat mutant mice to treatment with tea sulindac,and 2-amino-1-methyl-6-phenylimidazo[45-b]pyridine (PhIP)","volume":"506\u2013507","author":"Orner","year":"2002","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2009.03.026_bib21","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1096\/fj.05-4785fje","article-title":"Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apcmin mice","volume":"20","author":"Myzak","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.canlet.2009.03.026_bib22","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1093\/carcin\/bgm161","article-title":"Green tea selectively targets initial stages of intestinal carcinogenesis in the AOM-Apcmin mouse model","volume":"28","author":"Issa","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2009.03.026_bib23","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1242\/jcs.03485","article-title":"Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene","volume":"120","author":"Aoki","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.canlet.2009.03.026_bib24","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/emboj\/cdg105","article-title":"Nuclear export of the APC tumour suppressor controls \u03b2-catenin function in transcription","volume":"22","author":"Rosin-Arbesfeld","year":"2003","journal-title":"EMBO J."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383509002183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383509002183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:29:50Z","timestamp":1759591790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383509002183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0304383509002183"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2009.03.026","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activator protein 2\u03b1 suppresses intestinal tumorigenesis in the Apcmin mouse","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2009.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}