{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:22:47Z","timestamp":1767666167034},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.canlet.2010.01.020","type":"journal-article","created":{"date-parts":[[2010,2,15]],"date-time":"2010-02-15T04:35:37Z","timestamp":1266208537000},"page":"43-48","source":"Crossref","is-referenced-by-count":9,"title":["Reproductive fitness advantage of BCR\u2013ABL expressing leukemia cells"],"prefix":"10.1016","volume":"294","author":[{"given":"Arne","family":"Traulsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge M.","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Dingli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2010.01.020_bib1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2010.01.020_bib2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nm1087","article-title":"Cancer genes and the pathways they control","volume":"10","author":"Vogelstein","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2010.01.020_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/4687","article-title":"Selection, the mutation rate and cancer: ensuring that the tail does not wag the dog","volume":"5","author":"Tomlinson","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2010.01.020_bib4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/255197a0","article-title":"Mutation selection and the natural history of cancer","volume":"255","author":"Cairns","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2010.01.020_bib5","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1093\/genetics\/148.4.1433","article-title":"Mutation and cancer: the antecedents to our studies of adaptive mutation","volume":"148","author":"Cairns","year":"1998","journal-title":"Genetics"},{"key":"10.1016\/j.canlet.2010.01.020_bib6","doi-asserted-by":"crossref","first-page":"e225","DOI":"10.1371\/journal.pcbi.0030225","article-title":"Genetic progression and the waiting time to cancer","volume":"3","author":"Beerenwinkel","year":"2007","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.canlet.2010.01.020_bib7","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1126\/science.2406902","article-title":"Induction of chronic myelogenous leukemia in mice by the P210bcr\/abl gene of the Philadelphia chromosome","volume":"247","author":"Daley","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.canlet.2010.01.020_bib8","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1182\/blood.V97.8.2406","article-title":"A model of human p210(BCR\/ABL)-mediated chronic myelogenous leukemia by transduction of primary normal human CD34(+) cells with a BCR\/ABL-containing retroviral vector","volume":"97","author":"Zhao","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2010.01.020_bib9","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/sj.leu.2401860","article-title":"Combination of interferon alpha with either Ara-C or ATRA in vitro reduces the selective action of interferon against CML CFU-GM","volume":"14","author":"Marley","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.canlet.2010.01.020_bib10","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1046\/j.1365-2141.2002.03237.x","article-title":"Effects of combinations of therapeutic agents on the proliferation of progenitor cells in chronic myeloid leukaemia","volume":"116","author":"Marley","year":"2002","journal-title":"Brit. J. Haematol."},{"key":"10.1016\/j.canlet.2010.01.020_bib11","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1046\/j.1365-2141.1996.d01-1738.x","article-title":"Abnormal kinetics of colony formation by erythroid burst-forming units (BFU-E) in chronic myeloid leukaemia","volume":"93","author":"Marley","year":"1996","journal-title":"Brit. J. Haematol."},{"key":"10.1016\/j.canlet.2010.01.020_bib12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3816\/CLK.2008.n.017","article-title":"Chronic myeloid leukemia: origin, development, response to therapy, and relapse","volume":"2","author":"Dingli","year":"2008","journal-title":"Clin. Leukemia"},{"key":"10.1016\/j.canlet.2010.01.020_bib13","doi-asserted-by":"crossref","first-page":"e345","DOI":"10.1371\/journal.pone.0000345","article-title":"Compartmental architecture and dynamics of hematopoiesis","volume":"2","author":"Dingli","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.canlet.2010.01.020_bib14","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1172\/JCI103750","article-title":"Quantitative measurement of the erythrocytic and granulocytic cells of the marrow and blood","volume":"37","author":"Donohue","year":"1958","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.canlet.2010.01.020_bib15","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1056\/NEJM196406252702608","article-title":"Granulocytopoiesis","volume":"270","author":"Cronkite","year":"1964","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.canlet.2010.01.020_bib16","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1056\/NEJM196406182702506","article-title":"Granulocytopoiesis","volume":"270","author":"Cronkite","year":"1964","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.canlet.2010.01.020_bib17","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.1073\/pnas.96.9.5209","article-title":"Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals","volume":"96","author":"Araten","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2010.01.020_bib18","doi-asserted-by":"crossref","first-page":"9857","DOI":"10.1073\/pnas.91.21.9857","article-title":"Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age","volume":"91","author":"Vaziri","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2010.01.020_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1084\/jem.190.2.157","article-title":"Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood","volume":"190","author":"Rufer","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2010.01.020_bib20","first-page":"1068","article-title":"Routes to repopulation \u2013 a unification of the stochastic model and separation of stem-cell subpopulations","volume":"8","author":"Gordon","year":"1994","journal-title":"Leukemia"},{"key":"10.1016\/j.canlet.2010.01.020_bib21","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nm0296-190","article-title":"Evidence that hematopoiesis may be a stochastic process in vivo","volume":"2","author":"Abkowitz","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2010.01.020_bib22","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1371\/journal.pcbi.0030053","article-title":"(A) Symmetric stem cell replication and cancer","volume":"3","author":"Dingli","year":"2007","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.canlet.2010.01.020_bib23","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1365-2141.2005.05944.x","article-title":"Lineage involvement in chronic myeloid leukaemia: comparison between MBCR\/ABL and mBCR\/ABL cases","volume":"132","author":"Primo","year":"2006","journal-title":"Brit. J. Haematol."},{"key":"10.1016\/j.canlet.2010.01.020_bib24","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/sj.leu.2402444","article-title":"Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia","volume":"16","author":"Holyoake","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.canlet.2010.01.020_bib25","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nm0596-561","article-title":"Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr\u2013Abl positive cells","volume":"2","author":"Druker","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2010.01.020_bib26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ccr.2004.10.015","article-title":"MOZ-TIF2, but not BCR\u2013ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors","volume":"6","author":"Huntly","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2010.01.020_bib27","article-title":"Tyrosine kinase inhibitor therapy can cure chronic myeloid leukemia without hitting leukemic stem cells","author":"Lenaerts","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.canlet.2010.01.020_bib28","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/nature03669","article-title":"Dynamics of chronic myeloid leukaemia","volume":"435","author":"Michor","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2010.01.020_bib29","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/nm1487","article-title":"Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications","volume":"12","author":"Roeder","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2010.01.020_bib30","unstructured":"M. Ichimaru, T. Ishimaru, M. Mikami, Y. Yamada, T. Ohkita, Incidence of leukemia in a fixed cohort of atomic bomb survivors and controls, Hiroshima and Nagasaki October 1950\u2013December 1978, Technical Report RERF TR 13-81, Radiation Effects Research Foundation, Hiroshima, 1981."},{"key":"10.1016\/j.canlet.2010.01.020_bib31","doi-asserted-by":"crossref","first-page":"021915","DOI":"10.1103\/PhysRevE.77.021915","article-title":"Multiple mutant clones in blood rarely coexist","volume":"77","author":"Dingli","year":"2008","journal-title":"Phys. Rev. E Stat. Nonlin. Soft. Matter Phys."},{"key":"10.1016\/j.canlet.2010.01.020_bib32","first-page":"13","article-title":"A mathematical model of erythropoiesis in mice and rats. Part 1: structure of the model","volume":"22","author":"Loeffler","year":"1989","journal-title":"Cell Tissue Kinet."},{"key":"10.1016\/j.canlet.2010.01.020_bib33","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00285-006-0027-9","article-title":"High frequency spikes in long period blood cell oscillations","volume":"53","author":"Colijn","year":"2006","journal-title":"J. Math. Biol."},{"key":"10.1016\/j.canlet.2010.01.020_bib34","doi-asserted-by":"crossref","first-page":"16616","DOI":"10.1073\/pnas.0908107106","article-title":"A progenitor cell origin of myeloid malignancies","volume":"106","author":"Haeno","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2010.01.020_bib35","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1182\/blood.V95.6.1883","article-title":"Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry","volume":"95","author":"Brummendorf","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2010.01.020_bib36","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1056\/NEJMoa062867","article-title":"Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia","volume":"355","author":"Druker","year":"2006","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.canlet.2010.01.020_bib37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1042\/CS20040336","article-title":"Chronic myeloid leukaemia: stem cell derived but progenitor cell driven","volume":"109","author":"Marley","year":"2005","journal-title":"Clin. Sci. (London)"},{"key":"10.1016\/j.canlet.2010.01.020_bib38","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2165\/00003088-200544090-00001","article-title":"Clinical pharmacokinetics of imatinib","volume":"44","author":"Peng","year":"2005","journal-title":"Clin. Pharmacokinet."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383510000467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383510000467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T21:09:57Z","timestamp":1634936997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383510000467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0304383510000467"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2010.01.020","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}