{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:44:33Z","timestamp":1790865873300,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.canlet.2011.02.043","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T16:21:14Z","timestamp":1302798074000},"page":"1-5","source":"Crossref","is-referenced-by-count":15,"title":["The controversial role of placental growth factor in tumor growth"],"prefix":"10.1016","volume":"307","author":[{"given":"Domenico","family":"Ribatti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2011.02.043_b0005","doi-asserted-by":"crossref","first-page":"9267","DOI":"10.1073\/pnas.88.20.9267","article-title":"Isolation of human placenta cDNA coding for a protein related to the vascular permeability factor","volume":"88","author":"Maglione","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2011.02.043_b0010","doi-asserted-by":"crossref","first-page":"12153","DOI":"10.1074\/jbc.M008055200","article-title":"The crystal structure of human placental growth factor-1 (PlGF), an angiogenic protein at 2 \u00c5 resolution","volume":"276","author":"Iyer","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2011.02.043_b0015","first-page":"925","article-title":"Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14","volume":"8","author":"Maglione","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2011.02.043_b0020","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1006\/bbrc.1997.6813","article-title":"Placenta growth factor: identification and characterization of a novel isoform generated by mRNA alternative splicing","volume":"235","author":"Cao","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.canlet.2011.02.043_b0025","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0165-0378(03)00082-2","article-title":"Evidence of a novel isoform of placenta growth factor (PlGF-4) expressed in human throphoblast and endothelial cells","volume":"60","author":"Yang","year":"2003","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.canlet.2011.02.043_b0030","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/nm884","article-title":"Role of PlGF in the intra and intermolecular crosstalk between the VEGF receptors and Flt1 and Flk1","volume":"9","author":"Autiero","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2011.02.043_b0035","doi-asserted-by":"crossref","first-page":"22272","DOI":"10.1074\/jbc.273.35.22272","article-title":"Neuropilin-1 is a placenta growth factor-2 receptor","volume":"273","author":"Migdal","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2011.02.043_b0040","first-page":"233","article-title":"Neuropilin-1 mediates collapsin-1\/ semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165","volume":"146","author":"Miao","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.canlet.2011.02.043_b0045","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/87904","article-title":"Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions","volume":"7","author":"Carmeliet","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2011.02.043_b0050","first-page":"517","article-title":"Placenta growth factor-1 is chemotactic, mitogenic and angiogenic","volume":"176","author":"Ziche","year":"1997","journal-title":"Lab. Invest."},{"key":"10.1016\/j.canlet.2011.02.043_b0055","doi-asserted-by":"crossref","first-page":"35172","DOI":"10.1074\/jbc.274.49.35172","article-title":"Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis","volume":"274","author":"Yonekura","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2011.02.043_b0060","first-page":"8: 841","article-title":"Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment","author":"Hattori","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2011.02.043_b0065","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1182\/blood-2002-11-3423","article-title":"Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor","volume":"102","author":"Selvaraj","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2011.02.043_b0070","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1053\/hupa.2002.129420","article-title":"Expression of vascular endothelial growth factor, placental growth factor, and their receptors Flt-1 and KDR in human placenta under pathological conditions","volume":"33","author":"Kumazaki","year":"2002","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.canlet.2011.02.043_b0075","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1172\/JCI26772","article-title":"Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair","volume":"116","author":"Maes","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.canlet.2011.02.043_b0080","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1161\/CIRCULATIONAHA.104.495887","article-title":"Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation","volume":"111","author":"Khurana","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.canlet.2011.02.043_b0085","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.healun.2008.11.917","article-title":"Hypoxia increases placenta growth factor expression in human myocardium and cultured neonatal rat cardiomyocytes","volume":"28","author":"Torry","year":"2009","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.canlet.2011.02.043_b0090","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2353\/ajpath.2006.051314","article-title":"Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential","volume":"169","author":"Cianfarani","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.canlet.2011.02.043_b0095","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/glia.21108","article-title":"Involvement of placental growth factor in Wallerian degeneration","volume":"59","author":"Chaballe","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.canlet.2011.02.043_b0100","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1074\/jbc.271.6.3154","article-title":"Heterodimers of placenta growth factor\/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1\/KDR","volume":"271","author":"Cao","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2011.02.043_b0105","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1158\/0008-5472.CAN-04-3085","article-title":"Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models","volume":"66","author":"Xu","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2011.02.043_b0110","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1535-6108(02)00028-4","article-title":"Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1\/VEGF heterodimers","volume":"1","author":"Eriksson","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2011.02.043_b0115","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1161\/01.RES.0000129194.61747.bf","article-title":"Blockage of VEGF-induced angiogenesis by preventing VEGF secretion","volume":"94","author":"Bjorndahl","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.canlet.2011.02.043_b0120","doi-asserted-by":"crossref","first-page":"643","DOI":"10.2353\/ajpath.2006.051041","article-title":"Increased melanoma growth and metastasis spreading in mice overexpressing placenta growth factor","volume":"169","author":"Marcellini","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.canlet.2011.02.043_b0125","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1158\/1541-7786.MCR-06-0141","article-title":"Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma","volume":"5","author":"Xu","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.canlet.2011.02.043_b0130","doi-asserted-by":"crossref","first-page":"E70","DOI":"10.1096\/fj.05-4481fje","article-title":"PlGF -\/- eNos -\/- mice show defective angiogenesis associated with increased oxidative stress in response to tissue ischemia","volume":"20","author":"Gigante","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.canlet.2011.02.043_b0135","doi-asserted-by":"crossref","first-page":"10840","DOI":"10.1158\/0008-5472.CAN-07-1034","article-title":"Placental growth factor-1 attenuates vascular endothelial growth factor-A-dependent tumor angiogenesis during \u03b2 cell carcinogenesis","volume":"67","author":"Schomber","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2011.02.043_b0140","doi-asserted-by":"crossref","first-page":"17505","DOI":"10.1073\/pnas.0908026106","article-title":"Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature","volume":"106","author":"Hedlund","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2011.02.043_b0145","first-page":"4233","article-title":"Markedly increased amount of messenger RNAs for vascular endothelial growth factor in renal cell carcinoma associated with angiogenesis","volume":"54","author":"Takahashi","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2011.02.043_b0150","first-page":"1569","article-title":"Upregulation of Vascular endothelial growth factor (VEGF) and downregulation of Placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines","volume":"11","author":"Viglietto","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2011.02.043_b0155","first-page":"577","article-title":"Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta growth factor","volume":"13","author":"Viglietto","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2011.02.043_b0160","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1477-7819-3-68","article-title":"Expression of Placenta growth factor (PlGF) in non small cell lung cancer (NSCLC) and the clinical and prognostic significance","volume":"3","author":"Zhang","year":"2005","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.canlet.2011.02.043_b0165","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/gut.2004.050831","article-title":"Placenta growth factor expression is correlated with survival of patients with colorectal cancer","volume":"54","author":"Wei","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.canlet.2011.02.043_b0170","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.canlet.2004.05.020","article-title":"The significance of placenta growth factor in angiogenesis and clinical outcome of human gastric cancer","volume":"213","author":"Chen","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2011.02.043_b0175","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1016\/j.ejca.2005.07.022","article-title":"Placental growth factor is over-expressed and has prognostic value in human breast cancer","volume":"41","author":"Parr","year":"2005","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.canlet.2011.02.043_b0180","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.canlet.2006.10.005","article-title":"Placenta growth factor not vascular endothelial growth factor A or C can predict the early recurrence after radical resection of hepatocellular carcinoma","volume":"250","author":"Ho","year":"2007","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2011.02.043_b0185","first-page":"4953","article-title":"Prognostic significance of plasma placental growth factor levels in renal cell cancer: an association with clinical characteristics and vascular endothelial growth factor levels","volume":"23","author":"Matsumoto","year":"2003","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2011.02.043_b0190","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1023\/A:1006198422718","article-title":"Placenta growth factor (PlGF) mRNA expression in brain tumors","volume":"40","author":"Nomura","year":"1998","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.canlet.2011.02.043_b0195","doi-asserted-by":"crossref","first-page":"8136","DOI":"10.1200\/JCO.2005.02.5635","article-title":"Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in renal cancer patients","volume":"23","author":"Willett","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2011.02.043_b0200","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1200\/JCO.2007.15.5416","article-title":"Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma","volume":"26","author":"Rini","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2011.02.043_b0205","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ccr.2006.11.021","article-title":"AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients","volume":"11","author":"Batchelor","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2011.02.043_b0210","first-page":"607","article-title":"Expression and localization of the vascular endothelial growth factor family in ovarian epithelial tumors","volume":"77","author":"Sowter","year":"1997","journal-title":"Lab. Invest."},{"key":"10.1016\/j.canlet.2011.02.043_b0215","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1161\/CIRCRESAHA.108.174128","article-title":"Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt","volume":"103","author":"Nishi","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.canlet.2011.02.043_b0220","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1161\/ATVBAHA.107.158022","article-title":"The molecular basis of VEGFR-1 signal transduction pathways in primary human monocytes","volume":"28","author":"Tchaikovski V","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.canlet.2011.02.043_b0225","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1161\/ATVBAHA.107.150433","article-title":"VEGFR-1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment","volume":"28","author":"Murakami","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.canlet.2011.02.043_b0230","first-page":"1207","article-title":"Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis","volume":"61","author":"Hiratsuka","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2011.02.043_b0235","first-page":"3","article-title":"Expression of vascular endothelial growth factor receptors is closely related to the histologic grade of hepatocellular carcinoma","volume":"16","author":"Amaoka","year":"2006","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.canlet.2011.02.043_b0240","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/(SICI)1097-0215(20000415)86:2<174::AID-IJC5>3.0.CO;2-E","article-title":"Vegf, Vegf-B, Vegf-C and their receptors KDR, FLT-1 and FLT-4 during the neoplastic progression of human colonic mucosa","volume":"86","author":"Andre","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2011.02.043_b0245","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.1158\/1078-0432.CCR-07-0414","article-title":"Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer","volume":"13","author":"Donnem","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2011.02.043_b0250","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1136\/jcp.56.2.107","article-title":"Expression and prognostic relevance of vascular endothelial growth factor (VEGF) and its receptor (FLT-1) in nephroblastoma","volume":"56","author":"Ghanem","year":"2003","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.canlet.2011.02.043_b0255","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0022-5347(05)67414-9","article-title":"Expression of the VEGF-receptor Flt-1 in benign, premalignant and malignant prostate tissues","volume":"164","author":"Hahn","year":"2000","journal-title":"J. Urol."},{"key":"10.1016\/j.canlet.2011.02.043_b0260","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ijc.2910590415","article-title":"Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms","volume":"59","author":"Plate","year":"1994","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2011.02.043_b0265","first-page":"1719","article-title":"Expression of VEGFR-1 (Flt-1) in breast cancer is associated with VEGF expression and with node-negative tumor stage","volume":"28","author":"Schmidt","year":"2008","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2011.02.043_b0270","first-page":"2811","article-title":"Vascular endothelial growth factor and its receptors correlate with angiogenesis and survival in pulmonary adenocarcinoma","volume":"17","author":"Takanami","year":"1997","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2011.02.043_b0275","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.exphem.2008.04.023","article-title":"VEGF signaling of hematopietic precursors restricts B-lymphoid commitment in vitro and in vivo","volume":"36","author":"Fragoso","year":"2008","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.canlet.2011.02.043_b0280","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ygyno.2006.09.031","article-title":"The prognostic value of vascular endothelial growth factors (VEGFs)-A and \u2013B and their receptor VEGFR-1 in invasive breast carcinoma","volume":"104","author":"Mylona","year":"2007","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.canlet.2011.02.043_b0285","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.lungcan.2006.02.009","article-title":"Prognostic value of expression of vascular endothelial growth factor and its flt-1 and KDR receptors in stage I non small-cell lung cancer","volume":"53","author":"Seto","year":"2006","journal-title":"Lung. Cancer"},{"key":"10.1016\/j.canlet.2011.02.043_b0290","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nm731","article-title":"Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1","volume":"8","author":"Luttun","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2011.02.043_b0295","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cell.2007.08.038","article-title":"Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels","volume":"131","author":"Fisher","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2011.02.043_b0300","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1172\/JCI20465","article-title":"VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment","volume":"113","author":"Cursiefen","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.canlet.2011.02.043_b0305","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0002-9440(10)64255-1","article-title":"Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis","volume":"161","author":"Schoppmann","year":"2002","journal-title":"Am. J. Pathos."},{"key":"10.1016\/j.canlet.2011.02.043_b0310","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nrc2524","article-title":"FLT1 and its ligands VEGFB and PlGF: drug targets for antiangiogenic therapy?","volume":"12","author":"Fisher","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2011.02.043_b0315","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1158\/1535-7163.MCT-06-0461","article-title":"Role of placenta growth factor in malignancy and evidence that an antagonistic PlGF\/Flt-1 peptide inhibits the growth and metastasis of human breast cancer xenografts","volume":"6","author":"Taylor","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.canlet.2011.02.043_b0320","doi-asserted-by":"crossref","first-page":"e6525","DOI":"10.1371\/journal.pone.0006525","article-title":"VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation","volume":"4","author":"Dawson","year":"2009","journal-title":"PLoSONE"},{"key":"10.1016\/j.canlet.2011.02.043_b0325","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cell.2010.01.033","article-title":"PlGF blockade does not inhibit angiogenesis during primary tumor growth","volume":"141","author":"Bais","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2011.02.043_b0330","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.cell.2010.02.039","article-title":"Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer an eye disease","volume":"141","author":"Van De Viere","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2011.02.043_b0355","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1158\/1535-7163.MCT-10-0813","article-title":"SFLT01: a novel fusion protein with anti-angiogenic activity","volume":"10","author":"Bagley","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.canlet.2011.02.043_b0340","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ccr.2010.11.009","article-title":"HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF","volume":"19","author":"Rolny","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2011.02.043_b0345","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrc2152","article-title":"Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition","volume":"7","author":"Verhel","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2011.02.043_b0350","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nrc2106","article-title":"Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition","volume":"7","author":"Force","year":"2007","journal-title":"Nat. Rev. Cancer"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383511001388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383511001388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T15:02:55Z","timestamp":1529679775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383511001388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0304383511001388"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2011.02.043","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}