{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:44:56Z","timestamp":1791852296845,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.canlet.2011.11.030","type":"journal-article","created":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T17:19:03Z","timestamp":1323278343000},"page":"218-225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Targeting Bcl-2 family proteins in adult T-cell leukemia\/lymphoma: In vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737"],"prefix":"10.1016","volume":"317","author":[{"given":"Kenji","family":"Ishitsuka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Kunami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Katsuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumiko","family":"Nogami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusanori","family":"Yotsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroe","family":"Tanji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morishige","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2011.11.030_b0005","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2141.1991.tb08051.x","article-title":"Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia\u2013lymphoma. A report from the Lymphoma Study Group (1984\u201387)","volume":"79","author":"Shimoyama","year":"1991","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.canlet.2011.11.030_b0010","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/sj.thj.6200195","article-title":"A prospective phase II clinical trial with the use of zidovudine and interferon-alpha in the acute and lymphoma forms of adult T-cell leukemia\/lymphoma","volume":"3","author":"Hermine","year":"2002","journal-title":"Hematol. J."},{"key":"10.1016\/j.canlet.2011.11.030_b0015","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1200\/JCO.2008.18.2428","article-title":"Definition Prognostic factors, treatment, and response criteria of adult T-cell leukemia\u2013lymphoma: a proposal from an international consensus meeting","volume":"27","author":"Tsukasaki","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2011.11.030_b0020","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1046\/j.1365-2141.2001.02737.x","article-title":"A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia\u2013lymphoma: Japan Clinical Oncology Group Study 9303","volume":"113","author":"Yamada","year":"2001","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.canlet.2011.11.030_b0025","doi-asserted-by":"crossref","first-page":"5458","DOI":"10.1200\/JCO.2007.11.9958","article-title":"VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia\u2013lymphoma: Japan Clinical Oncology Group Study JCOG9801","volume":"25","author":"Tsukasaki","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2011.11.030_b0030","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/sj.leu.2403682","article-title":"Allogeneic hematopoietic stem cell transplantation provides sustained long-term survival for patients with adult T-cell leukemia\/lymphoma","volume":"19","author":"Fukushima","year":"2005","journal-title":"Leukemia"},{"key":"10.1016\/j.canlet.2011.11.030_b0035","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbmt.2006.09.002","article-title":"Allogeneic bone marrow transplantation from unrelated human T-Cell leukemia virus-I-negative donors for adult T-cell Leukemia\/Lymphoma: retrospective analysis of data from the Japan marrow donor program","volume":"13","author":"Kato","year":"2007","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.canlet.2011.11.030_b0040","article-title":"Bcl-2 inhibitors small molecules with a big impact on cancer therapy","author":"Vogler","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.canlet.2011.11.030_b0045","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1172\/JCI28281","article-title":"Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737","volume":"117","author":"Del Gaizo Moore","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.canlet.2011.11.030_b0050","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1182\/blood-2007-11-124487","article-title":"Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis","volume":"112","author":"Stolz","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2011.11.030_b0055","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1038\/sj.leu.2404719","article-title":"ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells","volume":"21","author":"Kline","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.canlet.2011.11.030_b0060","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ccr.2006.10.006","article-title":"Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia","volume":"10","author":"Konopleva","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2011.11.030_b0065","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1182\/blood-2007-03-080325","article-title":"Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo","volume":"110","author":"Kang","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2011.11.030_b0070","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1158\/1541-7786.MCR-06-0367","article-title":"Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains","volume":"5","author":"Olejniczak","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.canlet.2011.11.030_b0075","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1124\/mol.109.060780","article-title":"The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs","volume":"77","author":"High","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.canlet.2011.11.030_b0080","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S1470-2045(10)70261-8","article-title":"Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity","volume":"11","author":"Wilson","year":"2010","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canlet.2011.11.030_b0085","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2010.31.6208","article-title":"Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors","author":"Gandhi","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2011.11.030_b0090","first-page":"2360","article-title":"Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells","volume":"93","author":"Mori","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2011.11.030_b0095","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1073\/pnas.0507809103","article-title":"The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas","volume":"103","author":"Bernal-Mizrachi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2011.11.030_b0100","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1182\/blood.V98.13.3762","article-title":"Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1- and type 2-infected cells by a caspase-3-dependent mechanism involving Bcl-2 cleavage","volume":"98","author":"Mahieux","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2011.11.030_b0105","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood.V96.1.275.013k43_275_281","article-title":"Bcl-X(L) is up-regulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples","volume":"96","author":"Nicot","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2011.11.030_b0110","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1023\/A:1011158021749","article-title":"Human T-cell leukemia virus type I tax protein induces the expression of anti-apoptotic gene Bcl-xL in human T-cells through nuclear factor-kappaB and c-AMP responsive element binding protein pathways","volume":"22","author":"Mori","year":"2001","journal-title":"Virus Genes"},{"key":"10.1016\/j.canlet.2011.11.030_b0115","first-page":"155","article-title":"A novel T-cell line derived from adult T-cell leukemia","volume":"71","author":"Miyoshi","year":"1980","journal-title":"Gann"},{"key":"10.1016\/j.canlet.2011.11.030_b0120","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1073\/pnas.77.12.7415","article-title":"Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma","volume":"77","author":"Poiesz","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2011.11.030_b0125","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/294770a0","article-title":"Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells","volume":"294","author":"Miyoshi","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2011.11.030_b0130","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0304-3835(01)00742-X","article-title":"Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts","volume":"176","author":"Nabeshima","year":"2002","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2011.11.030_b0135","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.1038\/sj.onc.1208739","article-title":"Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF\/Endo G pathway","volume":"24","author":"Ishitsuka","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2011.11.030_b0140","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors","volume":"22","author":"Chou","year":"1984","journal-title":"Adv. Enzyme Regul."},{"key":"10.1016\/j.canlet.2011.11.030_b0145","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00280-005-0033-4","article-title":"Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells","volume":"57","author":"Temmink","year":"2006","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.canlet.2011.11.030_b0150","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1182\/blood.V76.10.2065.2065","article-title":"Expression of P-glycoprotein in adult T-cell leukemia cells","volume":"76","author":"Kuwazuru","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2011.11.030_b0155","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1182\/blood.V98.4.1160","article-title":"Expression of functional lung resistance\u2013related protein predicts poor outcome in adult T-cell leukemia","volume":"98","author":"Ohno","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2011.11.030_b0160","doi-asserted-by":"crossref","first-page":"13897","DOI":"10.1073\/pnas.94.25.13897","article-title":"Proliferation of adult T cell leukemia\/lymphoma cells is associated with the constitutive activation of JAK\/STAT proteins","volume":"94","author":"Takemoto","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2011.11.030_b0165","doi-asserted-by":"crossref","first-page":"10497","DOI":"10.1128\/JVI.00739-06","article-title":"Human T-cell leukemia virus type 1 tax dysregulates beta-catenin signaling","volume":"80","author":"Tomita","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.canlet.2011.11.030_b0170","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1600-0609.2007.01016.x","article-title":"Treatment of adult T-cell leukemia\/lymphoma: past, present, and future","volume":"80","author":"Ishitsuka","year":"2008","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.canlet.2011.11.030_b0175","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1535-6108(02)00241-6","article-title":"Apoptosis-targeted therapies for cancer","volume":"3","author":"Reed","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2011.11.030_b0180","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1182\/blood-2007-09-078162","article-title":"Bcl-2-family proteins and hematologic malignancies: history and future prospects","volume":"111","author":"Reed","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2011.11.030_b0185","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/nrc1736","article-title":"Promoting apoptosis as a strategy for cancer drug discovery","volume":"5","author":"Fesik","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2011.11.030_b0190","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nature03579","article-title":"An inhibitor of Bcl-2 family proteins induces regression of solid tumours","volume":"435","author":"Oltersdorf","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2011.11.030_b0195","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1158\/0008-5472.CAN-06-3964","article-title":"Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation","volume":"67","author":"Chen","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2011.11.030_b0200","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ccr.2006.08.027","article-title":"The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak\/Bax if Mcl-1 is neutralized","volume":"10","author":"van Delft","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2011.11.030_b0205","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1182\/blood-2005-04-1678","article-title":"Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death","volume":"106","author":"Chen","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2011.11.030_b0210","first-page":"3527","article-title":"The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1","volume":"8","author":"Gojo","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2011.11.030_b0215","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1182\/blood-2008-08-173310","article-title":"Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia","volume":"113","author":"Vogler","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2011.11.030_b0220","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1182\/blood-2006-07-025809","article-title":"Aberrant NF-kappaB signaling in lymphoma: mechanisms consequences, and therapeutic implications","volume":"109","author":"Jost","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2011.11.030_b0225","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1083\/jcb.144.2.281","article-title":"Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner","volume":"144","author":"Slee","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.canlet.2011.11.030_b0230","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1038\/sj.onc.1210028","article-title":"A novel Bcl-2\/Bcl-X(L)\/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma","volume":"26","author":"Chauhan","year":"2007","journal-title":"Oncogene"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383511007312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383511007312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:33:34Z","timestamp":1759592014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383511007312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0304383511007312"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2011.11.030","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting Bcl-2 family proteins in adult T-cell leukemia\/lymphoma: In vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2011.11.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}