{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:36:23Z","timestamp":1792060583391,"version":"4.4.0"},"reference-count":246,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.canlet.2011.12.012","type":"journal-article","created":{"date-parts":[[2011,12,17]],"date-time":"2011-12-17T01:00:41Z","timestamp":1324083641000},"page":"48-60","source":"Crossref","is-referenced-by-count":1436,"title":["Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury"],"prefix":"10.1016","volume":"327","author":[{"given":"Edouard I.","family":"Azzam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Jay-Gerin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debkumar","family":"Pain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2011.12.012_b0005","series-title":"Radiobiology for the Radiologist","author":"Hall","year":"2006"},{"key":"10.1016\/j.canlet.2011.12.012_b0010","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1023\/B:CANC.0000031769.14728.bc","article-title":"Metabolic oxidation\/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology","volume":"23","author":"Spitz","year":"2004","journal-title":"Cancer Metastasis Rev."},{"issue":"Suppl. 8","key":"10.1016\/j.canlet.2011.12.012_b0015","first-page":"87","article-title":"Role of superoxide dismutase in modification of radiation injury","author":"Petkau","year":"1987","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2011.12.012_b0020","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.mrfmmm.2010.12.016","article-title":"Role of oxidative stress and DNA damage in human carcinogenesis","volume":"711","author":"Kryston","year":"2011","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0025","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/1874467211104020115","article-title":"Role of DNA damage and epigenetic DNA methylation changes in radiation-induced genomic instability and bystander effects in germline in vivo","volume":"4","author":"Tamminga","year":"2011","journal-title":"Current Mol. Pharmacol."},{"key":"10.1016\/j.canlet.2011.12.012_b0030","doi-asserted-by":"crossref","first-page":"7050","DOI":"10.1038\/sj.onc.1206961","article-title":"gap junctions and the ionizing radiation-induced bystander effect","volume":"22","author":"Azzam","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2011.12.012_b0035","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2174\/1874467211104020096","article-title":"Radiation induced non-targeted response: mechanism and potential clinical implications","volume":"4","author":"Hei","year":"2011","journal-title":"Current Mol. Pharmacol."},{"key":"10.1016\/j.canlet.2011.12.012_b0040","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/nrc1277","article-title":"Radiation-induced bystander effects\u2013implications for cancer","volume":"4","author":"Mothersill","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2011.12.012_b0045","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nrc2603","article-title":"Radiation-induced bystander signalling in cancer therapy","volume":"9","author":"Prise","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2011.12.012_b0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021540","article-title":"Increased frequency of spontaneous neoplastic transformation in progeny of bystander cells from cultures exposed to densely-ionizing radiation","volume":"6","author":"Buonanno","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.canlet.2011.12.012_b0055","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1667\/RR2461.1","article-title":"Long-term consequences of radiation-induced bystander effects depend on radiation quality and dose and correlate with oxidative stress","volume":"175","author":"Buonanno","year":"2011","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0060","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mrfmmm.2010.01.012","article-title":"Non-targeted effects and the dose response for heavy ion tumor induction","volume":"687","author":"Cucinotta","year":"2010","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0065","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/09553000410001695895","article-title":"Distinguished Scientist Award 2003. The crooked shall be made straight; dose-response relationships for carcinogenesis","volume":"80","author":"Hall","year":"2004","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0070","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2008.12.016","article-title":"Can we reduce the incidence of second primary malignancies occurring after radiotherapy? A critical review","volume":"91","author":"Tubiana","year":"2009","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.canlet.2011.12.012_b0075","unstructured":"BEIR-VII, Health Risks from Exposure to Low Levels of Ionizing Radiation, in, National Research Council of the National Academies, Washington, D.C., 2005."},{"key":"10.1016\/j.canlet.2011.12.012_b0080","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0167-8140(01)00285-7","article-title":"Genomic instability: potential contributions to tumour and normal tissue response, and second tumours, after radiotherapy","volume":"59","author":"Hendry","year":"2001","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.canlet.2011.12.012_b0085","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1038\/sj.onc.1205563","article-title":"The p53 network in lung carcinogenesis","volume":"21","author":"Robles","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2011.12.012_b0090","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1007\/s10552-010-9613-7","article-title":"Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists","volume":"21","author":"Schonfeld","year":"2010","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.canlet.2011.12.012_b0095","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2174\/092986709787002790","article-title":"Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications","volume":"16","author":"Zhao","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.canlet.2011.12.012_b0100","series-title":"Radiation Biology and Medicine. Selected Reviews in the Life Sciences","first-page":"15","article-title":"The physical and chemical basis of mechanisms in radiation biology","author":"Platzman","year":"1958"},{"key":"10.1016\/j.canlet.2011.12.012_b0105","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1139\/v99-162","article-title":"Radiolysis of water and aqueous solutions: histrory and present state of the science","volume":"77","author":"Ferradini","year":"1999","journal-title":"Can. J. Chem."},{"key":"10.1016\/j.canlet.2011.12.012_b0110","series-title":"An Introduction to Radiation Chemistry","author":"Spinks","year":"1990"},{"key":"10.1016\/j.canlet.2011.12.012_b0115","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1063\/1.555739","article-title":"Reactivity of HO2 \/O2 - radicals in aqueous solution","volume":"14","author":"Bielski","year":"1985","journal-title":"J. Phys. Chem. Ref. Data"},{"key":"10.1016\/j.canlet.2011.12.012_b0120","series-title":"Peroxyl Radicals","year":"1997"},{"key":"10.1016\/j.canlet.2011.12.012_b0125","doi-asserted-by":"crossref","first-page":"20313","DOI":"10.1074\/jbc.272.33.20313","article-title":"Protein oxidation in aging, disease, and oxidative stress","volume":"272","author":"Berlett","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2011.12.012_b0130","doi-asserted-by":"crossref","first-page":"5734","DOI":"10.1038\/sj.onc.1206663","article-title":"Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms","volume":"22","author":"Mikkelsen","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2011.12.012_b0135","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0300-9084(00)00062-6","article-title":"Are there protective enzymatic pathways to regulate high local nitric oxide (NO) concentrations in cells under stress conditions?","volume":"82","author":"Jay-Gerin","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.canlet.2011.12.012_b0140","first-page":"245","article-title":"Monte Carlo simulation of fast electron and proton tracks in liquid water. II. Nonhomogeneous chemistry","volume":"51","author":"Frongillo","year":"1998","journal-title":"Radiat. Phys. Chem."},{"key":"10.1016\/j.canlet.2011.12.012_b0145","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0014-5793(92)80911-Y","article-title":"Biologically relevant metal ion-dependent hydroxyl radical generation: an update","volume":"307","author":"Halliwell","year":"1992","journal-title":"FEBS Lett."},{"key":"10.1016\/j.canlet.2011.12.012_b0150","series-title":"Free Radicals in Biology and Medicine","author":"Halliwell","year":"2007"},{"key":"10.1016\/j.canlet.2011.12.012_b0155","series-title":"Charged Particle and Photon Interactions with Matter. Chemical","first-page":"403","article-title":"Radiation chemical effects of heavy ions","author":"La Verne","year":"2004"},{"key":"10.1016\/j.canlet.2011.12.012_b0160","series-title":"Charged Particle and Photon Interactions with Matter. Recent Advances","first-page":"355","article-title":"Radiation chemistry of liquid water with heavy ions: Monte Carlo simulation studies","author":"Meesungnoen","year":"2011"},{"key":"10.1016\/j.canlet.2011.12.012_b0165","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/09553008914551841","article-title":"The initial physical damage produced by ionizing radiations","volume":"56","author":"Goodhead","year":"1989","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0170","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1080\/09553000500530888","article-title":"DNA DSB induced in human cells by charged particles and gamma rays: experimental results and theoretical approaches","volume":"81","author":"Campa","year":"2005","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0175","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/09553000802640401","article-title":"Radiation chemistry comes before radiation biology","volume":"85","author":"O\u2019Neill","year":"2009","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0180","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nature09787","article-title":"Telomere dysfunction induces metabolic and mitochondrial compromise","volume":"470","author":"Sahin","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2011.12.012_b0185","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1158\/1535-7163.MCT-06-0596","article-title":"Radiation-induced cell signaling: inside-out and outside-in","volume":"6","author":"Valerie","year":"2007","journal-title":"Mol. Can. Ther."},{"key":"10.1016\/j.canlet.2011.12.012_b0190","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1088\/0031-9155\/21\/4\/001","article-title":"Systematic evaluation of cellular radiosensitivity parameters","volume":"21","author":"Roth","year":"1976","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0195","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s004110050060","article-title":"DNA complex lesions induced by protons and alpha-particles: track structure characteristics determining linear energy transfer and particle type dependence","volume":"36","author":"Ottolenghi","year":"1997","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.canlet.2011.12.012_b0200","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/rpd\/ncl498","article-title":"Energy deposition stochastics and track structure: what about the target?","volume":"122","author":"Goodhead","year":"2006","journal-title":"Radiat. Prot. Dosimetry"},{"issue":"Suppl. 8","key":"10.1016\/j.canlet.2011.12.012_b0205","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.2307\/3576637","article-title":"Biochemistry of DNA lesions","author":"Ward","year":"1985","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrfmmm.2011.04.001","article-title":"From chemistry of DNA damage to repair and biological significance Comprehending the future","volume":"711","author":"Georgakilas","year":"2011","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0215","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1667\/RR0659.1","article-title":"Detection of oxidative clustered DNA lesions in X-irradiated mouse skin tissues and human MCF-7 breast cancer cells","volume":"167","author":"Gollapalle","year":"2007","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0220","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00411-006-0070-3","article-title":"Low levels of clustered oxidative DNA damage induced at low and high LET irradiation in mammalian cells","volume":"45","author":"Boucher","year":"2006","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.canlet.2011.12.012_b0225","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1667\/RR2372.1","article-title":"The role of gap junction communication and oxidative stress in the propagation of toxic effects among high-dose \u03b1-particle-irradiated human cells","volume":"175","author":"Autsavapromporn","year":"2011","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0230","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1073\/pnas.97.1.103","article-title":"Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation","volume":"97","author":"Sutherland","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.canlet.2011.12.012_b0235","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1080\/09553009114552561","article-title":"Energy deposition in small cylindrical targets by monoenergetic electrons","volume":"60","author":"Nikjoo","year":"1991","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0240","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1667\/RR0640.1","article-title":"Adaptive responses to low-dose\/low-dose-rate \u03b3 rays in normal human fibroblasts: the role of growth architecture and oxidative metabolism","volume":"166","author":"de Toledo","year":"2006","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0245","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.exphem.2007.01.011","article-title":"Whole-body responses to low-level radiation exposure: new concepts in mammalian radiobiology","volume":"35","author":"Feinendegen","year":"2007","journal-title":"Exp. Hematol."},{"issue":"Suppl 1","key":"10.1016\/j.canlet.2011.12.012_b0250","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1289\/ehp.98106s1277","article-title":"The adaptive response in radiobiology: evolving insights and implications","volume":"106","author":"Wolff","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.canlet.2011.12.012_b0255","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1667\/RR2559.1","article-title":"Suppressive Effects of Continuous Low-Dose-Rate gamma Irradiation on Diabetic Nephropathy in Type II Diabetes Mellitus Model Mice","volume":"176","author":"Nomura","year":"2011","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0260","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mrgentox.2011.07.008","article-title":"Exposure to low level environmental agents: The induction of hormesis","volume":"726","author":"Azzam","year":"2011","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0265","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/355738a0","article-title":"Transmission of chromosomal instability after plutonium \u03b1-particle irradiation [see comments]","volume":"355","author":"Kadhim","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2011.12.012_b0270","first-page":"6394","article-title":"Induction of sister chromatid exchanges by extremely low doses of \u03b1-particles","volume":"52","author":"Nagasawa","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0275","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1667\/RR2428.1","article-title":"Detection of chromosomal instability in bystander cells after Si490-ion irradiation","volume":"176","author":"Ponnaiya","year":"2011","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0280","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2174\/1874467211104020126","article-title":"Nitric oxide is a key molecule serving as a bridge between radiation-induced bystander and adaptive responses","volume":"4","author":"Matsumoto","year":"2011","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.canlet.2011.12.012_b0285","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s004110050127","article-title":"Radial distribution of electron spectra from high-energy ions","volume":"37","author":"Cucinotta","year":"1998","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.canlet.2011.12.012_b0290","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/09553009314450721","article-title":"Effects of radiations of different qualities on cells: molecular mechanisms of damage and repair (Weiss Lecture)","volume":"63","author":"Goodhead","year":"1993","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0295","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1667\/RR3540.1","article-title":"High-LET ion radiolysis of water: visualization of the formation and evolution of ion tracks and relevance to the radiation-induced bystander effect","volume":"165","author":"Muroya","year":"2006","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0300","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/rpd\/ncq526","article-title":"3D visualisation of the stochastic patterns of the radial dose in nano-volumes by a Monte Carlo simulation of HZE ion track structure","volume":"143","author":"Plante","year":"2011","journal-title":"Radiat. Prot. Dosimetry"},{"key":"10.1016\/j.canlet.2011.12.012_b0305","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1089\/ars.2010.3831","article-title":"Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies","volume":"15","author":"Wu","year":"2011","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.canlet.2011.12.012_b0310","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/bcr2160","article-title":"Local control by radiotherapy: is that all there is?","volume":"10","author":"Formenti","year":"2008","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0315","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/09553000410001692726","article-title":"Chronic oxidative stress and radiation-induced late normal tissue injury: a review","volume":"80","author":"Robbins","year":"2004","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0320","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/0955300021000038662","article-title":"Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors","volume":"79","author":"Hayashi","year":"2003","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0325","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/09553000701481816","article-title":"Sensors of ionizing radiation effects on the immunological microenvironment of cancer","volume":"83","author":"Demaria","year":"2007","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0330","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/09553000010024911","article-title":"Persistent subclinical inflammation among A-bomb survivors","volume":"77","author":"Neriishi","year":"2001","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0335","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.abb.2003.12.017","article-title":"Reactive nitrogen species in the chemical biology of inflammation","volume":"423","author":"Dedon","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.canlet.2011.12.012_b0340","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mrfmmm.2011.02.004","article-title":"Measurement of oxidatively generated base damage in cellular, DNA","volume":"711","author":"Cadet","year":"2011","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0345","doi-asserted-by":"crossref","first-page":"17992","DOI":"10.1073\/pnas.1008260107","article-title":"Tumors induce complex DNA damage in distant proliferative tissues in vivo","volume":"107","author":"Redon","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2011.12.012_b0350","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.cbi.2010.03.046","article-title":"BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions","volume":"188","author":"Hair","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.canlet.2011.12.012_b0355","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.mrrev.2009.12.005","article-title":"Role of oxidatively induced DNA lesions in human pathogenesis","volume":"704","author":"Sedelnikova","year":"2010","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0360","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1158\/0008-5472.CAN-10-4579","article-title":"Systemic DNA damage related to cancer","volume":"71","author":"Martin","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2011.12.012_b0365","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2174\/1874467211104020106","article-title":"In vivo space radiation-induced non-targeted responses: late effects on molecular signaling in mitochondria","volume":"4","author":"Jain","year":"2011","journal-title":"Current Mol. Pharmacol."},{"key":"10.1016\/j.canlet.2011.12.012_b0370","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1259\/0007-1285-26-305-234","article-title":"Whole body irradiation; radiobiology or medicine?","volume":"26","author":"Mole","year":"1953","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.canlet.2011.12.012_b0375","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/gut.43.4.575","article-title":"Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis","volume":"43","author":"Ohba","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.canlet.2011.12.012_b0380","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.canlet.2011.12.012_b0385","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2307\/3579106","article-title":"Failla Memorial Lecture. Changing views of cellular radiosensitivity","volume":"140","author":"Little","year":"1994","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0390","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/09553002.2010.522686","article-title":"Radiation-induced genomic instability: are epigenetic mechanisms the missing link?","volume":"87","author":"Aypar","year":"2011","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0395","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.mrfmmm.2011.06.014","article-title":"Non-targeted radiation effects-an epigenetic connection","volume":"714","author":"Ilnytskyy","year":"2011","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0400","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ng0993-92","article-title":"Mouse minisatellite mutations induced by ionizing radiation","volume":"5","author":"Dubrova","year":"1993","journal-title":"Nat Genet"},{"key":"10.1016\/j.canlet.2011.12.012_b0405","doi-asserted-by":"crossref","first-page":"6485","DOI":"10.1158\/0008-5472.CAN-11-1926","article-title":"Long-lived inflammatory signaling in irradiated bone marrow is genome dependent","volume":"71","author":"Lorimore","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2011.12.012_b0410","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1126\/science.2981433","article-title":"Prooxidant states and tumor promotion","volume":"227","author":"Cerutti","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.canlet.2011.12.012_b0415","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2307\/3579454","article-title":"Genomic instability induced by ionizing radiation","volume":"146","author":"Morgan","year":"1996","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0420","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1007\/s00018-009-0099-y","article-title":"Reactive oxygen species-dependent signaling regulates cancer","volume":"66","author":"Weinberg","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.canlet.2011.12.012_b0425","series-title":"The biology of cancer","author":"Weinberg","year":"2007"},{"key":"10.1016\/j.canlet.2011.12.012_b0430","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/362709a0","article-title":"Instability and decay of the primary structure of DNA","volume":"362","author":"Lindahl","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2011.12.012_b0435","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/10715768909087933","article-title":"Endogenous oxidative DNA damage, aging, and cancer","volume":"7","author":"Ames","year":"1989","journal-title":"Free Radic. Res. Commun."},{"key":"10.1016\/j.canlet.2011.12.012_b0440","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0027-5107(93)90052-H","article-title":"DNA methylation and mutation","volume":"285","author":"Holliday","year":"1993","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0445","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0891-5849(02)00787-6","article-title":"Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells","volume":"32","author":"Bohr","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.canlet.2011.12.012_b0450","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.mrfmmm.2010.12.004","article-title":"Variation in base excision repair capacity","volume":"711","author":"Wilson","year":"2011","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0455","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.gde.2003.11.001","article-title":"The role of endogenous and exogenous DNA damage and mutagenesis","volume":"14","author":"Friedberg","year":"2004","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.canlet.2011.12.012_b0460","unstructured":"L.E. Feinendegen, R.D. Neumann, (Eds.), Workshop Report: Cellular Responses to Low Doses of Ionizing Radiation, United States Department of Energy and the National Institutes of Health, Bethesda, 1999."},{"key":"10.1016\/j.canlet.2011.12.012_b0465","doi-asserted-by":"crossref","DOI":"10.1002\/0471143030.cb0611s49","article-title":"Measurement of oxidatively-induced clustered DNA lesions using a novel adaptation of single cell gel electrophoresis (comet assay)","author":"Georgakilas","year":"2010","journal-title":"Curr. Protoc. Cell Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0470","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mrrev.2007.11.001","article-title":"Impact of the comet assay in radiobiology","volume":"681","author":"Olive","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0475","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1191\/0960327102ht216oa","article-title":"Reactive oxygen species in cell responses to toxic agents","volume":"21","author":"Feinendegen","year":"2002","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.canlet.2011.12.012_b0480","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3109\/10715768909087937","article-title":"Cell proliferation and oxidative stress","volume":"7","author":"Burdon","year":"1989","journal-title":"Free Radic. Res. Commun."},{"key":"10.1016\/j.canlet.2011.12.012_b0485","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Droge","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.canlet.2011.12.012_b0490","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1089\/ars.2009.2513","article-title":"Redox control of the cell cycle in health and disease","volume":"11","author":"Sarsour","year":"2009","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.canlet.2011.12.012_b0495","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0891-5849(01)00480-4","article-title":"Redox environment of the cell as viewed through the redox state of the glutathione disulfide\/glutathione couple","volume":"30","author":"Schafer","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.canlet.2011.12.012_b0500","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0891-5849(99)00242-7","article-title":"Oxidative stress and gene regulation","volume":"28","author":"Allen","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.canlet.2011.12.012_b0505","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0006-2952(99)00298-1","article-title":"Redox regulation of signal transduction in mammalian cells","volume":"59","author":"Herrlich","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.canlet.2011.12.012_b0510","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0006-2952(99)00297-X","article-title":"Redox signalling and transition metals in the control of the p53 pathway","volume":"59","author":"Meplan","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.canlet.2011.12.012_b0515","first-page":"3814","article-title":"Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins","volume":"52","author":"Price","year":"1992","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2011.12.012_b0520","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.2456613","article-title":"Chemotransduction in the carotid body: K+ current modulated by PO2 in type I chemoreceptor cells","volume":"241","author":"Lopez-Barneo","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.canlet.2011.12.012_b0525","series-title":"Oxidative Stress and Signal Transduction","first-page":"239","article-title":"Reactive Oxygen Intermediates as Primary Signals and Second Mesengers in the Activation of transcription Factors","author":"Schulze-Osthoff","year":"1997"},{"key":"10.1016\/j.canlet.2011.12.012_b0530","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0305-7372(86)90012-5","article-title":"Scientific basis for the clinical use of superoxide dismutase","volume":"13","author":"Petkau","year":"1986","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.canlet.2011.12.012_b0535","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0014-5793(00)01669-0","article-title":"Redox-dependent signal transduction","volume":"476","author":"Finkel","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.canlet.2011.12.012_b0540","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0014-5793(79)80592-X","article-title":"Permeation of liposome membrane by superoxide radical","volume":"108","author":"Rumyantseva","year":"1979","journal-title":"FEBS Lett."},{"key":"10.1016\/j.canlet.2011.12.012_b0545","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1016\/S0021-9258(17)30446-5","article-title":"Permeation of the erythrocyte stroma by superoxide radical","volume":"253","author":"Lynch","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2011.12.012_b0550","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2011.12.012_b0555","first-page":"2109","article-title":"Redox regulation of the G1 to S phase transition in the mouse embryo fibroblast cell cycle","volume":"63","author":"Menon","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2011.12.012_b0560","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/sj.onc.1210634","article-title":"Regulation of normal cell cycle progression by flavin-containing oxidaseso","volume":"27","author":"Venkatachalam","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2011.12.012_b0565","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrc1011","article-title":"ATM and related protein kinases: safeguarding genome integrity","volume":"3","author":"Shiloh","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2011.12.012_b0570","doi-asserted-by":"crossref","first-page":"23317","DOI":"10.1074\/jbc.271.38.23317","article-title":"p22phox is a critical component of the superoxide-generating NADH\/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells","volume":"271","author":"Ushio-Fukai","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2011.12.012_b0575","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1006\/abbi.2001.2641","article-title":"Inhibition of NADH\/NADPH oxidase affects signal transduction by growth factor receptors in normal fibroblasts","volume":"397","author":"Ammendola","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.canlet.2011.12.012_b0580","doi-asserted-by":"crossref","unstructured":"K. Irani, P.J. Goldschmidt-Clermont, Ras, superoxide and signal transduction, Biochem. Pharmacol. 55 (1998) 1339\u20131346.","DOI":"10.1016\/S0006-2952(97)00616-3"},{"key":"10.1016\/j.canlet.2011.12.012_b0585","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1074\/jbc.272.51.32071","volume":"272","author":"Bae","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2011.12.012_b0590","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1158\/0008-5472.CAN-07-0225","article-title":"Superoxide signaling mediates N-acetyl-L-cysteine-induced G1 arrest: regulatory role of cyclin D1 and manganese superoxide dismutase","volume":"67","author":"Menon","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2011.12.012_b0595","first-page":"794","article-title":"Production of large amounts of hydrogen peroxide by human tumor cells","volume":"51","author":"Szatrowski","year":"1991","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2011.12.012_b0600","doi-asserted-by":"crossref","first-page":"40591","DOI":"10.1074\/jbc.M100975200","article-title":"N-acetylcysteine induces cell cycle arrest in hepatic stellate cells through its reducing activity","volume":"276","author":"Kim","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2011.12.012_b0605","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1254\/jphs.SC0040061","article-title":"Antioxidant effects of stereoisomers of N-acetylcysteine (NAC), L-NAC and D-NAC, on angiotensin II-stimulated MAP kinase activation and vascular smooth muscle cell proliferation","volume":"95","author":"Kyaw","year":"2004","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.canlet.2011.12.012_b0610","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.radphyschem.2004.01.010","article-title":"Flavin-containing oxidases regulate progression from G1 to S phase of the cell cycle in normal human fibroblasts","volume":"72","author":"Venkatachalam","year":"2004","journal-title":"Radiat. Phys. Chem."},{"key":"10.1016\/j.canlet.2011.12.012_b0615","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.140.3566.490","article-title":"X-ray sensitivity and DNA synthesis in synchronous populations of Hela cells","volume":"140","author":"Terasima","year":"1963","journal-title":"Science"},{"key":"10.1016\/j.canlet.2011.12.012_b0620","first-page":"1842","article-title":"Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells","volume":"55","author":"Nagasawa","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2011.12.012_b0625","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.resp.2010.08.019","article-title":"Redox-control of matrix metalloproteinase-1: a critical link between free radicals, matrix remodeling and degenerative disease","volume":"174","author":"Kar","year":"2010","journal-title":"Respir. Physiol. Neurobiol.iochem J"},{"key":"10.1016\/j.canlet.2011.12.012_b0630","first-page":"3894","article-title":"Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen\/nitrogen","volume":"61","author":"Leach","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2011.12.012_b0635","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1042\/bj1340707","article-title":"The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen","volume":"134","author":"Boveris","year":"1973","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2011.12.012_b0640","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0891-5849(00)00317-8","article-title":"Mitochondrial free radical generation, oxidative stress, and aging","volume":"29","author":"Cadenas","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.canlet.2011.12.012_b0645","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1182\/blood.V93.5.1464","article-title":"NADPH oxidase: an update","volume":"93","author":"Babior","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2011.12.012_b0650","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1002\/j.1460-2075.1995.tb00043.x","article-title":"IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase","volume":"14","author":"Los","year":"1995","journal-title":"Embo J."},{"key":"10.1016\/j.canlet.2011.12.012_b0655","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1042\/bj1560435","article-title":"Role of ubiquinone in the mitochondrial generation of hydrogen peroxide","volume":"156","author":"Boveris","year":"1976","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2011.12.012_b0660","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1126\/science.1098146","article-title":"The coming of age of the cell","volume":"189","author":"Claude","year":"1975","journal-title":"Science"},{"key":"10.1016\/j.canlet.2011.12.012_b0665","series-title":"Biochemistry","author":"Champe","year":"2008"},{"key":"10.1016\/j.canlet.2011.12.012_b0670","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0003-9861(85)90293-0","article-title":"Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria","volume":"237","author":"Turrens","year":"1985","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.canlet.2011.12.012_b0675","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0006-291X(86)80529-0","article-title":"The mitochondrial site of superoxide formation","volume":"138","author":"Nohl","year":"1986","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.canlet.2011.12.012_b0680","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-1-4615-9035-4_5","article-title":"Mitochondrial production of superoxide radical and hydrogen peroxide","volume":"78","author":"Boveris","year":"1977","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0685","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/biof.5520100210","article-title":"Redox regulation of TNF signaling","volume":"10","author":"Goossens","year":"1999","journal-title":"Biofactors"},{"key":"10.1016\/j.canlet.2011.12.012_b0690","doi-asserted-by":"crossref","first-page":"18092","DOI":"10.1074\/jbc.273.29.18092","article-title":"Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes","volume":"273","author":"Vanden Hoek","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2011.12.012_b0695","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1083\/jcb.200111028","article-title":"Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases","volume":"158","author":"Werner","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.canlet.2011.12.012_b0700","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/sj.onc.1202094","article-title":"TNF-alpha activates at least two apoptotic signaling cascades","volume":"17","author":"Sidoti-de Fraisse","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2011.12.012_b0705","first-page":"721","article-title":"The increase in mitochondrial DNA copy number in the tissues of gamma-irradiated mice","volume":"10","author":"Malakhova","year":"2005","journal-title":"Cell Mol Biol Lett"},{"key":"10.1016\/j.canlet.2011.12.012_b0710","first-page":"439","article-title":"[Detection of large deletions of mitochondrial DNA in tissues of mice exposed to X-rays]","volume":"56","author":"Antipova","year":"2011","journal-title":"Biofizika"},{"key":"10.1016\/j.canlet.2011.12.012_b0715","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/sj.cdd.4401148","article-title":"The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction","volume":"10","author":"Chen","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.canlet.2011.12.012_b0720","doi-asserted-by":"crossref","DOI":"10.1089\/cbr.2010.0940","article-title":"Mitochondrial Gene Expression in Directly Irradiated and Nonirradiated Bystander Cells","author":"Chaudhry","year":"2011","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.canlet.2011.12.012_b0725","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1667\/RR2380.1","article-title":"Synergistic effects of arsenic trioxide and radiation in osteosarcoma cells through the induction of both autophagy and apoptosis","volume":"175","author":"Chiu","year":"2011","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0730","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/ijc.24402","article-title":"The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells","volume":"125","author":"Lomonaco","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.canlet.2011.12.012_b0735","first-page":"1033","article-title":"Chronic hypoxia protects against gamma-irradiation-induced apoptosis by inducing bcl-2 up-regulation and inhibiting mitochondrial translocation and conformational change of bax protein","volume":"23","author":"Cuisnier","year":"2003","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.canlet.2011.12.012_b0740","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.canlet.2008.11.021","article-title":"Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells","volume":"277","author":"Ogura","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1016\/j.canlet.2011.12.012_b0745","first-page":"1489","article-title":"Suppression of apoptosis by Bcl-2 or Bcl-xL promotes susceptibility to mutagenesis","volume":"13","author":"Cherbonnel-Lasserre","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2011.12.012_b0750","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mrfmmm.2009.04.006","article-title":"Up-regulation of ROS by mitochondria-dependent bystander signaling contributes to genotoxicity of bystander effects","volume":"666","author":"Chen","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0755","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1667\/RR3325","article-title":"Medium from irradiated cells induces dose-dependent mitochondrial changes and BCL2 responses in unirradiated human keratinocytes","volume":"163","author":"Maguire","year":"2005","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0760","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1667\/RR2296.1","article-title":"The role of mitochondria in the radiation-induced bystander effect in human lymphoblastoid cells","volume":"175","author":"Rajendran","year":"2011","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0765","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1158\/0008-5472.CAN-07-0188","article-title":"Cytoplasmic irradiation induces mitochondrial-dependent 53BP1 protein relocalization in irradiated and bystander cells","volume":"67","author":"Tartier","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2011.12.012_b0770","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1158\/0008-5472.CAN-07-5278","article-title":"Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects","volume":"68","author":"Zhou","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2011.12.012_b0775","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1038\/onc.2010.567","article-title":"Radiation-induced intercellular signaling mediated by cytochrome-c via a p53-dependent pathway in hepatoma cells","volume":"30","author":"He","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2011.12.012_b0780","first-page":"1183","article-title":"Ionizing radiation-induced micronucleus formation is mediated by reactive oxygen species that are produced in a manner dependent on mitochondria, Nox1, and JNK","volume":"17","author":"Choi","year":"2007","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.canlet.2011.12.012_b0785","first-page":"3107","article-title":"Persistent oxidative stress in chromosomally unstable cells","volume":"63","author":"Limoli","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2011.12.012_b0790","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.4161\/cbt.8.20.9648","article-title":"Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts","volume":"8","author":"Du","year":"2009","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.canlet.2011.12.012_b0795","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.semradonc.2008.12.003","article-title":"Neural precursor cells and central nervous system radiation sensitivity","volume":"19","author":"Fike","year":"2009","journal-title":"Semin. Radiat. Oncol."},{"key":"10.1016\/j.canlet.2011.12.012_b0800","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1269\/jrr.10114","article-title":"Intercellular communication amplifies stressful effects in high-charge, high-energy (HZE) particle-irradiated human cells","volume":"52","author":"Autsavapromporn","year":"2011","journal-title":"J. Radiat. Res. (Tokyo)."},{"key":"10.1016\/j.canlet.2011.12.012_b0805","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1089\/ars.2006.8.1253","article-title":"Normal human fibroblasts exposed to high or low dose ionizing radiation: differential effects on mitochondrial protein import and membrane potential","volume":"8","author":"Pandey","year":"2006","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.canlet.2011.12.012_b0810","doi-asserted-by":"crossref","first-page":"10377","DOI":"10.1158\/0008-5472.CAN-05-3036","article-title":"A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability","volume":"66","author":"Kim","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2011.12.012_b0815","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1532-5415.1972.tb00787.x","article-title":"The biologic clock: the mitochondria?","volume":"20","author":"Harman","year":"1972","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.canlet.2011.12.012_b0820","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/331717a0","article-title":"Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies","volume":"331","author":"Holt","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2011.12.012_b0825","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.3201231","article-title":"Mitochondrial DNA mutation associated with Leber\u2019s hereditary optic neuropathy","volume":"242","author":"Wallace","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.canlet.2011.12.012_b0830","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/0092-8674(88)90218-8","article-title":"Familial mitochondrial encephalomyopathy (MERRF): genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease","volume":"55","author":"Wallace","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2011.12.012_b0835","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/978-90-481-2813-6_10","article-title":"Pathogenesis and treatment of mitochondrial disorders","volume":"652","author":"DiMauro","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0840","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1152\/physrev.1998.78.2.547","article-title":"The free radical theory of aging matures","volume":"78","author":"Beckman","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.canlet.2011.12.012_b0845","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0027-5107(98)00220-6","article-title":"Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin","volume":"423","author":"Lu","year":"1999","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0850","series-title":"Biochemistry","author":"Berg","year":"2006"},{"key":"10.1016\/j.canlet.2011.12.012_b0855","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1248\/jhs.51.385","article-title":"Role of mitochondrial DNA in cells exposed to irradiation: generation of reactive oxygen species (ROS) is required for G2 checkpoint upon irradiation","volume":"51","author":"Kawamura","year":"2005","journal-title":"J. Health Sci."},{"key":"10.1016\/j.canlet.2011.12.012_b0860","doi-asserted-by":"crossref","first-page":"8901","DOI":"10.1074\/jbc.M413022200","article-title":"Contribution of mitochondrial DNA repair to cell resistance from oxidative stress","volume":"280","author":"Grishko","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2011.12.012_b0865","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/nar\/gkg167","article-title":"Mismatch repair activity in mammalian mitochondria","volume":"31","author":"Mason","year":"2003","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0870","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1093\/nar\/gkf392","article-title":"The mitochondrial DNA polymerase as a target of oxidative damage","volume":"30","author":"Graziewicz","year":"2002","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0875","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0891-5849(97)00331-6","article-title":"Comparison of oxidative base damage in mitochondrial and nuclear DNA","volume":"24","author":"Zastawny","year":"1998","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.canlet.2011.12.012_b0880","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1146\/annurev.bi.61.070192.005523","article-title":"Diseases of the mitochondrial DNA","volume":"61","author":"Wallace","year":"1992","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.canlet.2011.12.012_b0885","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1073\/pnas.85.17.6465","article-title":"Normal oxidative damage to mitochondrial and nuclear DNA is extensive","volume":"85","author":"Richter","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2011.12.012_b0890","doi-asserted-by":"crossref","first-page":"9746","DOI":"10.1523\/JNEUROSCI.0852-11.2011","article-title":"Mitochondrial DNA damage level determines neural stem cell differentiation fate","volume":"31","author":"Wang","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.canlet.2011.12.012_b0895","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0092-8674(77)90286-0","article-title":"Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle","volume":"11","author":"Bogenhagen","year":"1977","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2011.12.012_b0900","unstructured":"A.I. Gaziev, G.O. Shaikhaev, [Ionizing radiation can activate the insertion of mitochondrial DNA fragments in the nuclear genome] Radiatsionnaia biologiia, radioecologiia\/Rossiiskaia akademiia nauk 47 (2007) 673\u2013683."},{"key":"10.1016\/j.canlet.2011.12.012_b0905","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.febslet.2004.06.078","article-title":"Accumulation of the common mitochondrial DNA deletion induced by ionizing radiation","volume":"571","author":"Prithivirajsingh","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.canlet.2011.12.012_b0910","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1007\/s11033-010-0476-5","article-title":"Increased mitochondrial DNA damage and decreased base excision repair in the auditory cortex of D-galactose-induced aging rats","volume":"38","author":"Chen","year":"2011","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.canlet.2011.12.012_b0915","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/bies.20471","article-title":"aging and Parkinson\u2019s disease","volume":"28","author":"Biskup","year":"2006","journal-title":"Bioessays"},{"key":"10.1016\/j.canlet.2011.12.012_b0920","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/346376a0","article-title":"Escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae","volume":"346","author":"Thorsness","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2011.12.012_b0925","doi-asserted-by":"crossref","first-page":"E273","DOI":"10.1371\/journal.pbio.0020273","article-title":"Continued colonization of the human genome by mitochondrial DNA","volume":"2","author":"Ricchetti","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0930","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/47076","article-title":"Mitochondrial DNA repairs double-strand breaks in yeast chromosomes","volume":"402","author":"Ricchetti","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2011.12.012_b0935","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mito.2005.12.001","article-title":"Release of mitochondrial DNA fragments from brain mitochondria of irradiated mice","volume":"6","author":"Patrushev","year":"2006","journal-title":"Mitochondrion"},{"key":"10.1016\/j.canlet.2011.12.012_b0940","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0921-8734(92)90026-L","article-title":"New evidence for the insertion of mitochondrial DNA into the human genome: significance for cancer and aging","volume":"275","author":"Shay","year":"1992","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b0945","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/j.1474-9726.2010.00607.x","article-title":"The migration of mitochondrial DNA fragments to the nucleus affects the chronological aging process of Saccharomyces cerevisiae","volume":"9","author":"Cheng","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.canlet.2011.12.012_b0950","series-title":"Mitochondria","author":"Scheffler","year":"2008"},{"key":"10.1016\/j.canlet.2011.12.012_b0955","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/347444a0","article-title":"Identification of a receptor for protein import into mitochondria","volume":"347","author":"Pain","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2011.12.012_b0960","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/jmg.2005.036657","article-title":"Mutation of DNAJC19, a human homologue of yeast inner mitochondrial membrane co-chaperones, causes DCMA syndrome, a novel autosomal recessive Barth syndrome-like condition","volume":"43","author":"Davey","year":"2006","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.canlet.2011.12.012_b0965","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF00196521","article-title":"Morphology of the mitochondria in heat shock protein 60 deficient fibroblasts from mitochondrial myopathy patients. Effects of stress conditions","volume":"427","author":"Huckriede","year":"1995","journal-title":"Virchows. Arch."},{"key":"10.1016\/j.canlet.2011.12.012_b0970","doi-asserted-by":"crossref","first-page":"37327","DOI":"10.1074\/jbc.M105313200","article-title":"Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria","volume":"276","author":"Rothbauer","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2011.12.012_b0975","first-page":"772","article-title":"An amino acid substitution in the pyruvate dehydrogenase E1 alpha gene, affecting mitochondrial import of the precursor protein","volume":"57","author":"Takakubo","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.canlet.2011.12.012_b0980","doi-asserted-by":"crossref","unstructured":"C. Wang, S. Rajput, K. Watabe, D.F. Liao, D. Cao, Acetyl-CoA carboxylase-a as a novel target for cancer therapy, Frontiers in bioscience (Scholar edition), vol. 2, pp. 515\u2013526.","DOI":"10.2741\/s82"},{"key":"10.1016\/j.canlet.2011.12.012_b0985","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1128\/MCB.22.9.2883-2892.2002","article-title":"Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter","volume":"22","author":"Kwak","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b0990","doi-asserted-by":"crossref","first-page":"8135","DOI":"10.1074\/jbc.M211898200","article-title":"Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival","volume":"278","author":"Kwak","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2011.12.012_b0995","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrm1620","article-title":"Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis","volume":"6","author":"Rouault","year":"2005","journal-title":"Nature Rev."},{"key":"10.1016\/j.canlet.2011.12.012_b1000","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0165-1161(85)90015-9","article-title":"Measurement of micronuclei in lymphocytes","volume":"147","author":"Fenech","year":"1985","journal-title":"Mutat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1005","doi-asserted-by":"crossref","first-page":"14846","DOI":"10.1021\/bi0353979","article-title":"Redox-dependent modulation of aconitase activity in intact mitochondria","volume":"42","author":"Bulteau","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.canlet.2011.12.012_b1010","unstructured":"Managing Space Radiation Risk in the New Era of Space Exploration, in: National Research Council of the National Academies (Ed.), Springer, berlin, 2008."},{"key":"10.1016\/j.canlet.2011.12.012_b1015","unstructured":"BEIR-IV, Health Risks of Radon and Other Internally Deposited Alpha-Emitters (BEIR IV), Springer, Berlin, 1988."},{"key":"10.1016\/j.canlet.2011.12.012_b1020","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/ncb836","article-title":"Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism","volume":"4","author":"Bota","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b1025","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1126\/science.8178144","article-title":"Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration","volume":"264","author":"Suzuki","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.canlet.2011.12.012_b1030","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1667\/RR1617.1","article-title":"Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation","volume":"172","author":"Dayal","year":"2009","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1035","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1021\/ja057358l","article-title":"Inhibition of thioredoxin and thioredoxin reductase by 4-hydroxy-2-nonenal in vitro and in vivo","volume":"128","author":"Fang","year":"2006","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.canlet.2011.12.012_b1040","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/sj.emboj.7600599","article-title":"Role of oxidative carbonylation in protein quality control and senescence","volume":"24","author":"Nystrom","year":"2005","journal-title":"Embo J."},{"key":"10.1016\/j.canlet.2011.12.012_b1045","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s004110050100","article-title":"Investigation of lipid peroxidation in liposomes induced by heavy ion irradiation","volume":"37","author":"Ziegler","year":"1998","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.canlet.2011.12.012_b1050","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1042\/0264-6021:3510769","article-title":"Histone carbonylation in vivo and in vitro","volume":"351 Pt 3","author":"Wondrak","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2011.12.012_b1055","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0070-2137(01)80004-2","article-title":"Regulation of glutathione synthesis","volume":"36","author":"Lu","year":"2000","journal-title":"Curr. Top Cell Regul."},{"key":"10.1016\/j.canlet.2011.12.012_b1060","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1152\/physrev.1979.59.3.527","article-title":"Hydroperoxide metabolism in mammalian organs","volume":"59","author":"Chance","year":"1979","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.canlet.2011.12.012_b1065","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1667\/RR2398.1","article-title":"Antioxidant-chemoprevention diet ameliorates late effects of total-body irradiation and supplements radioprotection by MnSOD-plasmid liposome administration","volume":"175","author":"Epperly","year":"2011","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1070","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1016\/S0021-9258(18)63504-5","article-title":"Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)","volume":"244","author":"McCord","year":"1969","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2011.12.012_b1075","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.freeradbiomed.2006.03.015","article-title":"Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth","volume":"41","author":"Weydert","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.canlet.2011.12.012_b1080","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2203\/dose-response.08-012.McCord","article-title":"Superoxide dismutase, lipid peroxidation, and bell-shaped dose response curves","volume":"6","author":"McCord","year":"2008","journal-title":"Dose Response"},{"key":"10.1016\/j.canlet.2011.12.012_b1085","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1667\/0033-7587(2002)157[0275:EOGIBL]2.0.CO;2","article-title":"Elevation of glutathione induced by low-dose gamma rays and its involvement in increased natural killer activity","volume":"157","author":"Kojima","year":"2002","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1090","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1080\/095530099140285","article-title":"Contribution of antioxidant enzymes to the adaptive response to ionizing radiation of human lymphoblasts","volume":"75","author":"Bravard","year":"1999","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b1095","first-page":"5436","article-title":"Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures","volume":"62","author":"Azzam","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1100","first-page":"3963","article-title":"Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells","volume":"57","author":"Narayanan","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2307\/3580049","article-title":"Alpha particles induce the production of interleukin-8 by human cells","volume":"152","author":"Narayanan","year":"1999","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1110","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF00421049","article-title":"Role of antioxidant enzymes in cell immortalization and transformation","volume":"84","author":"Oberley","year":"1988","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.canlet.2011.12.012_b1115","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1191\/0960327104ht418oa","article-title":"The radiation-induced bystander effect: evidence and significance","volume":"23","author":"Azzam","year":"2004","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.canlet.2011.12.012_b1120","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2203\/dose-response.06-103.deToledo","article-title":"Adaptive and bystander responses in human and rodent cell cultures exposed to low level ionizing radiation: the impact of linear energy transfer","volume":"4","author":"de Toledo","year":"2006","journal-title":"Dose Response"},{"key":"10.1016\/j.canlet.2011.12.012_b1125","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1667\/RR3324.1","article-title":"Paradigm shifts in radiation biology: their impact on intervention for radiation-induced disease","volume":"164","author":"Brooks","year":"2005","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1130","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1667\/0033-7587(2003)159[0581:NADEOE]2.0.CO;2","article-title":"Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects","volume":"159","author":"Morgan","year":"2003","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1135","unstructured":"T. Lindahl, DNA repair enzymes acting on spontaneous lesions in DNA, in: W.W. Nichols, D.G. Murphy, (Eds.), DNA Repair Processes, Symposia Specialists, Miami, 1977, pp. 225\u2013240."},{"key":"10.1016\/j.canlet.2011.12.012_b1140","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/HP.0b013e31820a83ae","article-title":"Biological consequences and health risks of low-level exposure to ionizing radiation: commentary on the workshop","volume":"100","author":"Feinendegen","year":"2011","journal-title":"Health Phys"},{"key":"10.1016\/j.canlet.2011.12.012_b1145","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1080\/09553000500519808","article-title":"Activation of immunological network by chronic low-dose-rate irradiation in wild-type mouse strains: analysis of immune cell populations and surface molecules","volume":"81","author":"Ina","year":"2005","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.canlet.2011.12.012_b1150","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2307\/3579298","article-title":"Low-dose ionizing radiation decreases the frequency of neoplastic transformation to a level below the spontaneous rate in C3H 10T1\/2 cells","volume":"146","author":"Azzam","year":"1996","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1155","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.2307\/3578755","article-title":"Radiation-induced adaptive response for protection against micronucleus formation and neoplastic transformation in C3H 10T1\/2 mouse embryo cells","volume":"138","author":"Azzam","year":"1994","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1160","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2307\/3580327","article-title":"The adaptive response modifies latency for radiation-induced myeloid leukemia in CBA\/H mice","volume":"152","author":"Mitchel","year":"1999","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1165","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1126\/science.6695170","article-title":"Adaptive response of human lymphocytes to low concentrations of radioactive thymidine","volume":"223","author":"Olivieri","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.canlet.2011.12.012_b1170","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2307\/3579792","article-title":"Induction of an adaptive response against spontaneous neoplastic transformation in vitro by low-dose gamma radiation","volume":"149","author":"Redpath","year":"1998","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1175","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1126\/science.280.5366.1066","article-title":"Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage","volume":"280","author":"Le","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.canlet.2011.12.012_b1180","doi-asserted-by":"crossref","first-page":"13761","DOI":"10.1073\/pnas.2235592100","article-title":"Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know","volume":"100","author":"Brenner","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2011.12.012_b1185","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1667\/0033-7587(2001)156[0612:TPIOBE]2.0.CO;2","article-title":"The potential impact of bystander effects on radiation risks in a Mars mission","volume":"156","author":"Brenner","year":"2001","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1190","first-page":"380","article-title":"Differences between biological effects of high LET and low LET radiations in relation to their application in radiotherapy","volume":"46","author":"Barendsen","year":"1977","journal-title":"Radiol Clin (Basel)"},{"key":"10.1016\/j.canlet.2011.12.012_b1235","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1126\/science.1188384","article-title":"Chromosome damage in liver cells from low dose rate alpha, beta, and gamma irradiation: Derivation of RBE","volume":"190","author":"Brooks","year":"1975","journal-title":"Science"},{"key":"10.1016\/j.canlet.2011.12.012_b1200","first-page":"11","article-title":"Radiation dosimetry and biophysical models of space radiation effects","volume":"16","author":"Cucinotta","year":"2003","journal-title":"Gravit. Space Biol. Bull."},{"key":"10.1016\/j.canlet.2011.12.012_b1205","unstructured":"J. Meesungnoen, M. Benrahmoune, A. Filali-Mouhim, S. Mankhetkorn, J.P. Jay-Gerin, Monte Carlo calculation of the primary radical and molecular yields of liquid water radiolysis in the linear energy transfer range 0.3-6.5 keV\/um: application to 137Cs gamma rays, Radiat. Res. 155 (2001) 269\u2013278 (Erratum Published in Radiat. Res. 155 (2001) 2873)."},{"key":"10.1016\/j.canlet.2011.12.012_b1210","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1667\/RR2605.1","article-title":"Exposure to 16O-particle radiation causes aging-like decrements in rats through increased oxidative stress, inflammation and loss of autophagy","volume":"176","author":"Poulose","year":"2011","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2011.12.012_b1215","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ccr.2006.08.015","article-title":"Reactive oxygen species in cancer cells: live by the sword, die by the sword","volume":"10","author":"Schumacker","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2011.12.012_b1220","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-genom-082509-141720","article-title":"The mitochondrial proteome and human disease","volume":"11","author":"Calvo","year":"2010","journal-title":"Annu. Rev. Genomics. Hum. Genet."},{"key":"10.1016\/j.canlet.2011.12.012_b1225","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0248-4900(03)00062-5","article-title":"New perspectives on mitochondrial morphology in cell function","volume":"95","author":"Brocard","year":"2003","journal-title":"Biol Cell"},{"key":"10.1016\/j.canlet.2011.12.012_b1230","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1034\/j.1600-0854.2001.1r008.x","article-title":"The many shapes of mitochondrial membranes","volume":"2","author":"Griparic","year":"2001","journal-title":"Traffic"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383511007592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383511007592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T17:22:56Z","timestamp":1640020976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383511007592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":246,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0304383511007592"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2011.12.012","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}