{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:53:29Z","timestamp":1777737209518,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.canlet.2012.04.015","type":"journal-article","created":{"date-parts":[[2012,5,11]],"date-time":"2012-05-11T02:59:46Z","timestamp":1336705186000},"page":"215-222","source":"Crossref","is-referenced-by-count":31,"title":["Synergistic growth inhibition of human hepatocellular carcinoma cells by acyclic retinoid and GW4064, a farnesoid X receptor ligand"],"prefix":"10.1016","volume":"323","author":[{"given":"Tomohiko","family":"Ohno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Shirakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Kochi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Tsurumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisataka","family":"Moriwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2012.04.015_b0005","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(95)90199-X","article-title":"The nuclear receptor superfamily: the second decade","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2012.04.015_b0010","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1096\/fasebj.10.9.8801176","article-title":"A decade of molecular biology of retinoic acid receptors","volume":"10","author":"Chambon","year":"1996","journal-title":"Faseb. J."},{"key":"10.1016\/j.canlet.2012.04.015_b0015","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nrd2397","article-title":"RAR and RXR modulation in cancer and metabolic disease","volume":"6","author":"Altucci","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.canlet.2012.04.015_b0020","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/carcin\/bgg090","article-title":"Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid","volume":"24","author":"Matsushima-Nishiwaki","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2012.04.015_b0025","first-page":"7675","article-title":"Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma","volume":"61","author":"Matsushima-Nishiwaki","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2012.04.015_b0030","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1053\/jhep.2002.31164","article-title":"Phosphorylation of retinoid X receptor suppresses its ubiquitination in human hepatocellular carcinoma","volume":"35","author":"Adachi","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2012.04.015_b0035","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1111\/j.1349-7006.2007.00621.x","article-title":"Phosphorylated retinoid X receptor alpha loses its heterodimeric activity with retinoic acid receptor beta","volume":"98","author":"Yoshimura","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2012.04.015_b0040","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1349-7006.2008.01045.x","article-title":"Strategy and mechanism for the prevention of hepatocellular carcinoma: phosphorylated retinoid X receptor alpha is a critical target for hepatocellular carcinoma chemoprevention","volume":"100","author":"Shimizu","year":"2009","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2012.04.015_b0045","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199606133342402","article-title":"Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma prevention study group","volume":"334","author":"Muto","year":"1996","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.canlet.2012.04.015_b0050","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1056\/NEJM199904013401315","article-title":"Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma","volume":"340","author":"Muto","year":"1999","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.canlet.2012.04.015_b0055","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.canlet.2009.05.019","article-title":"Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells","volume":"285","author":"Tatebe","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2012.04.015_b0060","first-page":"3997","article-title":"Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1","volume":"62","author":"Suzui","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2012.04.015_b0065","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/cr.2008.289","article-title":"FXR: a metabolic regulator and cell protector","volume":"18","author":"Wang","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.canlet.2012.04.015_b0070","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1121435","article-title":"Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration","volume":"312","author":"Huang","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.canlet.2012.04.015_b0075","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1158\/0008-5472.CAN-06-1078","article-title":"Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor","volume":"67","author":"Yang","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2012.04.015_b0080","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/carcin\/bgl249","article-title":"Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice","volume":"28","author":"Kim","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2012.04.015_b0085","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1124\/jpet.111.179390","article-title":"Increased activation of the Wnt\/{beta}-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid x receptor knockout mice","volume":"338","author":"Wolfe","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.canlet.2012.04.015_b0090","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1053\/jhep.2002.36369","article-title":"Synergistic induction of apoptosis by acyclic retinoid and interferon-beta in human hepatocellular carcinoma cells","volume":"36","author":"Obora","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2012.04.015_b0095","doi-asserted-by":"crossref","first-page":"6710","DOI":"10.1158\/1078-0432.CCR-04-0659","article-title":"Synergistic effects of acyclic retinoid and OSI-461 on growth inhibition and gene expression in human hepatoma cells","volume":"10","author":"Shimizu","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2012.04.015_b0100","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1349-7006.2006.00384.x","article-title":"Synergistic growth inhibition by acyclic retinoid and vitamin K2 in human hepatocellular carcinoma cells","volume":"98","author":"Kanamori","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2012.04.015_b0105","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1158\/1078-0432.CCR-07-4708","article-title":"Synergistic growth inhibition by 9-cis-retinoic acid plus trastuzumab in human hepatocellular carcinoma cells","volume":"14","author":"Tatebe","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2012.04.015_b0110","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1172\/JCI18945","article-title":"Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis","volume":"112","author":"Liu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.canlet.2012.04.015_b0115","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1194\/jlr.M700330-JLR200","article-title":"Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine","volume":"48","author":"Kim","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.canlet.2012.04.015_b0120","doi-asserted-by":"crossref","DOI":"10.1038\/onc.2011.124","article-title":"Farnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growth through downregulation of HER2 expression","author":"Giordano","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2012.04.015_b0125","doi-asserted-by":"crossref","first-page":"10120","DOI":"10.1158\/0008-5472.CAN-06-2399","article-title":"The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression","volume":"66","author":"Swales","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2012.04.015_b0130","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1042\/BJ20071136","article-title":"Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells","volume":"410","author":"Kaeding","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2012.04.015_b0135","doi-asserted-by":"crossref","first-page":"7994","DOI":"10.1158\/1078-0432.CCR-04-1087","article-title":"Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses","volume":"10","author":"Zhao","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2012.04.015_b0140","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/1471-2407-11-281","article-title":"Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL\/KsJ-db\/db obese mice","volume":"11","author":"Shimizu","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canlet.2012.04.015_b0145","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1158\/1078-0432.CCR-0714-3","article-title":"Effects of acyclic retinoid on growth, cell cycle control, epidermal growth factor receptor signaling, and gene expression in human squamous cell carcinoma cells","volume":"10","author":"Shimizu","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2012.04.015_b0150","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.22342","article-title":"Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation","volume":"48","author":"Zhang","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2012.04.015_b0155","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1124\/jpet.108.145409","article-title":"Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development","volume":"328","author":"Maran","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.canlet.2012.04.015_b0160","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1128\/MCB.01076-09","article-title":"Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth","volume":"30","author":"Zhang","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2012.04.015_b0165","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1210\/er.2003-0034","article-title":"Interaction of nuclear receptors with the Wnt\/beta-catenin\/Tcf signaling axis: Wnt you like to know?","volume":"26","author":"Mulholland","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.canlet.2012.04.015_b0170","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/mc.2940100306","article-title":"Positive and negative regulations of albumin gene expression by retinoids in human hepatoma cell lines","volume":"10","author":"Yamada","year":"1994","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.canlet.2012.04.015_b0175","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1158\/1535-7163.309.3.3","article-title":"Acyclic retinoid activates retinoic acid receptor beta and induces transcriptional activation of p21(CIP1) in HepG2 human hepatoma cells","volume":"3","author":"Suzui","year":"2004","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.canlet.2012.04.015_b0180","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1158\/1940-6207.CAPR-10-0163","article-title":"Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS\/J- +(db)\/+Lepr(db) mice","volume":"4","author":"Shimizu","year":"2011","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.canlet.2012.04.015_b0185","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1006\/bbrc.1995.1471","article-title":"Retinoid agonist activities of synthetic geranyl geranoic acid derivatives","volume":"209","author":"Araki","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.canlet.2012.04.015_b0190","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1207\/s15327914nc5102_10","article-title":"Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-alpha-expressing oval-like cells and activated hepatic stellate cells","volume":"51","author":"Sano","year":"2005","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.canlet.2012.04.015_b0195","doi-asserted-by":"crossref","first-page":"753","DOI":"10.2174\/138955711796355258","article-title":"Farnesoid X Receptor Agonist for the Treatment of Liver and Metabolic Disorders: Focus on 6-ethyl-CDCA","volume":"11","author":"Fiorucci","year":"2011","journal-title":"Mini Rev. Med. Chem."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383512002637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383512002637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T17:00:18Z","timestamp":1687453218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383512002637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0304383512002637"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2012.04.015","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}