{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T12:01:39Z","timestamp":1772712099239,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["cancerletters.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.canlet.2013.02.050","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T03:19:29Z","timestamp":1363231169000},"page":"412-420","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Minnelide reduces tumor burden in preclinical models of osteosarcoma"],"prefix":"10.1016","volume":"335","author":[{"given":"Sulagna","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venugopal","family":"Thayanithy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veena","family":"Sangwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany N.","family":"Mackenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok K.","family":"Saluja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subbaya","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2013.02.050_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/dna.2006.0505","article-title":"Molecular pathogenesis of osteosarcoma","volume":"26","author":"Kansara","year":"2007","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.canlet.2013.02.050_b0010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/107327480801500103","article-title":"Orthopedic surgery options for the treatment of primary osteosarcoma","volume":"15","author":"Marulanda","year":"2008","journal-title":"Cancer Control"},{"key":"10.1016\/j.canlet.2013.02.050_b0015","article-title":"Perspectives on cancer stem cells in osteosarcoma","author":"Basu-Roy","year":"2012","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2013.02.050_b0020","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.2106\/JBJS.G.00075","article-title":"What\u2019s new in musculoskeletal oncology","volume":"89","author":"Lewis","year":"2007","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.canlet.2013.02.050_b0025","doi-asserted-by":"crossref","first-page":"9616","DOI":"10.1074\/jbc.M512044200","article-title":"Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death","volume":"281","author":"Westerheide","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2013.02.050_b0215","doi-asserted-by":"crossref","first-page":"G948","DOI":"10.1152\/ajpgi.00346.2010","article-title":"Pro-survival role of heat shock factor 1 (HSF1) in the pathogenesis of PancreatoBiliary tumors","volume":"300","author":"Dudeja","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.canlet.2013.02.050_b0035","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0304-3835(98)00222-5","article-title":"Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters","volume":"133","author":"Tengchaisri","year":"1998","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2013.02.050_b0040","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1139\/o93-054","article-title":"A heat-shock-like response with cytoskeletal disruption occurs following hydrostatic pressure in MG-63 osteosarcoma cells","volume":"71","author":"Haskin","year":"1993","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.canlet.2013.02.050_b0045","first-page":"557","article-title":"Effects of heat shock on glucocorticoid receptor","volume":"37","author":"Song","year":"1994","journal-title":"Sci. China B"},{"key":"10.1016\/j.canlet.2013.02.050_b0050","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1080\/07357900802438577","article-title":"Comparative proteomic analysis of osteosarcoma cell and human primary cultured osteoblastic cell","volume":"27","author":"Liu","year":"2009","journal-title":"Cancer Invest."},{"key":"10.1016\/j.canlet.2013.02.050_b0055","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1126\/scitranslmed.3004334","article-title":"A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancer","volume":"4","author":"Chugh","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.canlet.2013.02.050_b0060","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.4161\/cc.5.22.3448","article-title":"Heat shock proteins 27 and 70: Anti-apoptotic proteins with tumorigenic properties","volume":"5","author":"Garrido","year":"2006","journal-title":"Cell. Cycle"},{"key":"10.1016\/j.canlet.2013.02.050_b0065","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/nrd2154","article-title":"Mining the wnt pathway for cancer therapeutics","volume":"5","author":"Barker","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.canlet.2013.02.050_b0070","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1476-4598-8-72","article-title":"Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times","volume":"8","author":"Selvarajah","year":"2009","journal-title":"Mol. Cancer."},{"key":"10.1016\/j.canlet.2013.02.050_b0075","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/jcb.23048","article-title":"Wnt10b activates the Wnt, Notch, and NFkappaB pathways in U2os osteosarcoma cells","volume":"112","author":"Modder","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.canlet.2013.02.050_b0080","first-page":"3750","article-title":"Metastasis-associated differences in gene expression in a murine model of osteosarcoma","volume":"61","author":"Khanna","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2013.02.050_b0085","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s10585-009-9259-6","article-title":"Establishment and characterization of a new highly metastatic human osteosarcoma cell line","volume":"26","author":"Su","year":"2009","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.canlet.2013.02.050_b0090","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/jnci\/djs210","article-title":"Glycogen synthase kinase-3beta, NF-kappaB signaling, and tumorigenesis of human osteosarcoma","volume":"104","author":"Tang","year":"2012","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.canlet.2013.02.050_b0095","doi-asserted-by":"crossref","first-page":"13443","DOI":"10.1074\/jbc.274.19.13443","article-title":"Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box\/nuclear factor of activated T-cells and NF-kappaB transcriptional activation","volume":"274","author":"Qiu","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2013.02.050_b0100","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2165\/00148581-200810050-00005","article-title":"Therapy for osteosarcoma: where do we go from here?","volume":"10","author":"Chou","year":"2008","journal-title":"Paediatr. Drugs"},{"key":"10.1016\/j.canlet.2013.02.050_b0105","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1158\/0008-5472.CAN-06-1567","article-title":"Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma","volume":"67","author":"Aghdassi","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2013.02.050_b0110","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.surg.2009.04.023","article-title":"Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo","volume":"146","author":"Antonoff","year":"2009","journal-title":"Surgery"},{"key":"10.1016\/j.canlet.2013.02.050_b0115","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jss.2010.03.067","article-title":"Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma","volume":"163","author":"Clawson","year":"2010","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.canlet.2013.02.050_b0120","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jss.2010.04.047","article-title":"Role of HSP-70 in triptolide-mediated cell death of neuroblastoma","volume":"163","author":"Antonoff","year":"2010","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.canlet.2013.02.050_b0125","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.phymed.2012.02.014","article-title":"Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21","volume":"19","author":"Liu","year":"2012","journal-title":"Phytomedicine"},{"key":"10.1016\/j.canlet.2013.02.050_b0130","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0344-0338(00)80118-1","article-title":"Expression of heat shock proteins in osteosarcoma and its relationship to prognosis","volume":"196","author":"Uozaki","year":"2000","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.canlet.2013.02.050_b0135","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tibs.2006.01.006","article-title":"Heat shock proteins in cancer: chaperones of tumorigenesis","volume":"31","author":"Calderwood","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.canlet.2013.02.050_b0140","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S0046-8177(98)90412-9","article-title":"Heat shock protein 72 expression in osteosarcomas correlates with good response to neoadjuvant chemotherapy","volume":"29","author":"Trieb","year":"1998","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.canlet.2013.02.050_b0220","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jss.2009.07.002","article-title":"Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors","volume":"168","author":"Johnson","year":"2009","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.canlet.2013.02.050_b0150","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1101\/gad.1424006","article-title":"Wnt signaling: is the party in the nucleus?","volume":"20","author":"Willert","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2013.02.050_b0155","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/j.1460-2075.1992.tb05043.x","article-title":"A novel complex between the p65 subunit of NF-kappa B and c-rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene","volume":"11","author":"Hansen","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2013.02.050_b0160","first-page":"F123","article-title":"Dual regulation of IL-1 beta-mediated matrix metalloproteinase-9 expression in mesangial cells by NF-kappa B and AP-1","volume":"270","author":"Yokoo","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.canlet.2013.02.050_b0165","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1128\/MCB.17.7.4015","article-title":"Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis","volume":"17","author":"Yoshida","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.canlet.2013.02.050_b0170","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1535-6108(02)00154-X","article-title":"Beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer","volume":"2","author":"Deng","year":"2002","journal-title":"Cancer. Cell."},{"key":"10.1016\/j.canlet.2013.02.050_b0175","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1080\/10428190902801838","article-title":"Interleukin-6-independent expression of glucocorticoid receptor is upregulated by triptolide in multiple myeloma","volume":"50","author":"Yang","year":"2009","journal-title":"Leuk. Lymphoma."},{"key":"10.1016\/j.canlet.2013.02.050_b0180","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.taap.2006.03.013","article-title":"Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB","volume":"216","author":"Hafeez","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.canlet.2013.02.050_b0185","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1158\/1078-0432.CCR-06-1559","article-title":"Parthenolide, a natural inhibitor of nuclear factor-kappaB, inhibits lung colonization of murine osteosarcoma cells","volume":"13","author":"Kishida","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2013.02.050_b0190","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.canlet.2008.03.045","article-title":"BAY 11\u20137082 induces cell death through NF-kappaB-independent mechanisms in the ewing\u2019s sarcoma family of tumours","volume":"268","author":"White","year":"2008","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2013.02.050_b0195","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/cgt.2010.75","article-title":"Transfection of NF-kappaB decoy oligodeoxynucleotide suppresses pulmonary metastasis by murine osteosarcoma","volume":"18","author":"Nishimura","year":"2011","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.canlet.2013.02.050_b0200","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.tiv.2011.09.014","article-title":"Okadaic acid induces apoptosis through the PKR, NF-kappaB and caspase pathway in human osteoblastic osteosarcoma MG63 cells","volume":"25","author":"Chen","year":"2011","journal-title":"Toxicol. In. Vitro."},{"key":"10.1016\/j.canlet.2013.02.050_b0205","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/1471-2407-10-241","article-title":"Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-kappaB","volume":"10","author":"Grotterod","year":"2010","journal-title":"BMC Cancer."},{"key":"10.1016\/j.canlet.2013.02.050_b0210","first-page":"409","article-title":"Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells","volume":"40","author":"Tomonaga","year":"2012","journal-title":"Int. J. Oncol."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383513002139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383513002139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T23:53:26Z","timestamp":1562802806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383513002139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0304383513002139"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2013.02.050","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Minnelide reduces tumor burden in preclinical models of osteosarcoma","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2013.02.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}