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Biochem."},{"key":"10.1016\/j.canlet.2013.02.056_b0375","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3835(99)00098-1","article-title":"Anti-metastatic activity of curcumin and catechin","volume":"141","author":"Menon","year":"1999","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2013.02.056_b0380","doi-asserted-by":"crossref","first-page":"14487","DOI":"10.1074\/jbc.M207309200","article-title":"Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha \/IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways","volume":"278","author":"Philip","year":"2003","journal-title":"J. Biol. 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