{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:39:06Z","timestamp":1791041946240,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["cancerletters.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.canlet.2013.06.015","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T03:45:55Z","timestamp":1371613555000},"page":"317-327","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ascorbic acid derivatives as a new class of antiproliferative molecules"],"prefix":"10.1016","volume":"338","author":[{"given":"Benoit","family":"Bordignon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Chiron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Font\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2013.06.015_b0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1753-4887.1986.tb07553.x","article-title":"A proposition: megadoses of vitamin C are valuable in the treatment of cancer","volume":"44","author":"Pauling","year":"1986","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.canlet.2013.06.015_b0010","doi-asserted-by":"crossref","first-page":"13604","DOI":"10.1073\/pnas.0506390102","article-title":"Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues","volume":"102","author":"Chen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2013.06.015_b0015","doi-asserted-by":"crossref","first-page":"8749","DOI":"10.1073\/pnas.0702854104","article-title":"Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo","volume":"104","author":"Chen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.canlet.2013.06.015_b0020","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1600-0420.2004.00317.x","article-title":"Ascorbic acid reversibly inhibits proliferation of retinal pigment epithelial cells","volume":"82","author":"Heckelen","year":"2004","journal-title":"Acta Ophthalmol. Scand."},{"key":"10.1016\/j.canlet.2013.06.015_b0025","doi-asserted-by":"crossref","first-page":"5185","DOI":"10.1073\/pnas.82.15.5185","article-title":"Effect of dietary ascorbic acid on the incidence of spontaneous mammary tumors in RIII mice","volume":"82","author":"Pauling","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.canlet.2013.06.015_b0030","doi-asserted-by":"crossref","first-page":"e4409","DOI":"10.1371\/journal.pone.0004409","article-title":"Antiproliferative effect of ascorbic acid is associated with the inhibition of genes necessary to cell cycle progression","volume":"4","author":"Belin","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2013.06.015_b0035","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0009-2797(74)90019-2","article-title":"The orthomolecular treatment of cancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer","volume":"9","author":"Cameron","year":"1974","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.canlet.2013.06.015_b0040","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1056\/NEJM198501173120301","article-title":"High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison","volume":"312","author":"Moertel","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2013.06.015_b0045","first-page":"956","article-title":"High-dose vitamin C therapy: renewed hope or false promise?","volume":"174","author":"Assouline","year":"2006","journal-title":"C.M.A.J."},{"key":"10.1016\/j.canlet.2013.06.015_b0050","doi-asserted-by":"crossref","first-page":"533","DOI":"10.7326\/0003-4819-140-7-200404060-00010","article-title":"Vitamin C pharmacokinetics: implications for oral and intravenous use","volume":"140","author":"Padayatty","year":"2004","journal-title":"Ann. Int. Med."},{"key":"10.1016\/j.canlet.2013.06.015_b0055","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.nmd.2006.12.008","article-title":"Ascorbic acid inhibits PMP22 expression by reducing cAMP levels","volume":"17","author":"Kaya","year":"2007","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.canlet.2013.06.015_b0060","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/mus.21071","article-title":"Analysis of the benefits of vitamin cocktails in treating Charcot-Marie-Tooth disease type 1A","volume":"38","author":"Kaya","year":"2008","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.canlet.2013.06.015_b0065","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1016\/j.febslet.2008.09.040","article-title":"Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?","volume":"582","author":"Kaya","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.canlet.2013.06.015_b0070","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.carres.2005.12.010","article-title":"Synthesis, structural studies, and cytostatic evaluation of 5,6-di-O-modified L-ascorbic acid derivatives","volume":"341","author":"Gazivoda","year":"2006","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.canlet.2013.06.015_b0075","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/0502-514","article-title":"Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival","volume":"8","author":"Sotiriou","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2013.06.015_b0080","doi-asserted-by":"crossref","first-page":"17180","DOI":"10.1523\/JNEUROSCI.3457-11.2011","article-title":"Sodium-dependent vitamin C transporter 2 deficiency causes hypomyelination and extracellular matrix defects in the peripheral nervous system","volume":"31","author":"Gess","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.canlet.2013.06.015_b0085","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3892\/ol.2012.615","article-title":"Carcinostatic effects of diverse ascorbate derivatives in comparison with aliphatic chain moiety structures: promotion by combined hyperthermia and reduced cytotoxicity to normal cells","volume":"3","author":"Asada","year":"2012","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.canlet.2013.06.015_b0090","first-page":"2577","article-title":"Tumor-specific cytotoxicity and type of cell death induced by sodium 5,6-benzylidene-L-ascorbate","volume":"28","author":"Kishino","year":"2008","journal-title":"Anticancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2013.06.015_b0095","doi-asserted-by":"crossref","first-page":"e29794","DOI":"10.1371\/journal.pone.0029794","article-title":"Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer","volume":"7","author":"Monti","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2013.06.015_b0100","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.freeradbiomed.2011.03.007","article-title":"Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer","volume":"50","author":"Espey","year":"2011","journal-title":"Free Radic. Biol. Med."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383513004655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383513004655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T21:18:08Z","timestamp":1563225488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383513004655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0304383513004655"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2013.06.015","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ascorbic acid derivatives as a new class of antiproliferative molecules","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2013.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}